130900030608 080702080308096ｧ9 6ｾ4TOMA 2008; 36 : 111 - B066 50306080903 0806026ｧ8 07 0402fiapple090409 H apple00030608 08070206026ｧ8 080300090008076ｧ8 0ｷ30ｹ0 apple 030709080702 0ｹ0 00apple06020607 0ｸ707fi020902 0ｹ0 020ｷ307 060404 060006020607 02 03 06 09090006 020607 070804090007020ｷ307 08. ﾒ ﾌ0803 ﾌ0809 ﾇ6ｾ4 1, ｦﾐ. 08 ﾌ0806 ﾌ6ｾ4 2 6ﾑ80309 04026ｧ8030608 0903080309apple0206026ｧ80ｹ0 ﾌ 08070206 020306026ｧ80ｹ0, 0900030608 080702080308096ｧ9 0ｹ0 02 06 0806080308096ｧ9 0ｹ0 6ﾑ800080ｸ702000ｸ70007020ｷ307, ﾌ 08070206 020306026ｧ8 6ｾ40408036ｧ8 ﾞ.09.05. Periodontal inflammation as a risk factor for ischemic cardiovascular diseases V. KOUNOUPIS 1, I. VOUROS 2 Depart. of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki 0900036ｧ903096 709 6ﾒ2 02 03 06 09090006 0207 0708046ｧ800 02 apple08020003086ｦ007 020907 apple03060209 06026ｧ9 03 070702080ｸ7 0402060ｹ0 07 apple020ｸ70900 閨07000ｹ0 040603000ｹ0, 000706 02 02 02070404080702 06 040209 02036ｧ90209 03 閨0409 00000807070604090ｹ0 020ｷ307 03 07 020908fi030ｷ307 0203080ｸ7040007020ｷ307 0402060ｹ0 07 apple020ｸ70404fi000007000ｹ0 040603000ｹ0. 6ﾒ2 020003000ｸ702 6ｧ9 0403fi0706 02 02 6 507030308-0702 06 apple030804apple07030006000ｹ0 0000 0402fi0408 0209 060003006ｦ007090409 02090ｹ0 0000apple0308026ｧ80ｹ0 02080ｸ7 0803000900080706 080ｸ70ｹ0 apple 030709080702 04020907 06020608apple 030809 閨070006 02090ｹ0 030903080402036ｧ8030ｸ70704090ｹ0 02 06 02 0207 040ｸ707 鐶pple0006 02090ｹ0 04020008 0706 6ｧ9 0ｹ0 07fi04080ｸ7. ﾇ 030903080402036ｧ8030ｸ7070409 apple08020003006ｧ9 006ｧ9 apple030808 000ｸ70206026ｧ8 apple 0308-03080906026ｧ8 06000309 046ｧ9 apple080ｸ7 0002 090306070002, 020ｸ7036ｧ90ｷ30ｹ0, 0402060ｹ0 000ｸ70ｸ802 閨0ｹ0 030209036ｧ9000ｹ0 00 閨04080ｸ7 000009 閨03080ｸ70ｹ0. 6ｾ46ｦ000080ｷ307 0000 020907 0ｸ7applefi03000409 apple - 07026ｧ804000ｷ30ｹ0 0400 6 503076 509, 0806 0309030804020309030ｸ707020602 閨0ｹ0 6 503076 5000ｹ0 0100020607086ｦ007 0ｷ30ｹ0 0203 0ｸ700 020809fi07000ｹ0 6 503076 5000ｹ0 02080ｸ7 09090006 02086ｦ0 0007 080309036ｧ9080ｸ7 applefi 030806000809fi07080ｸ70ｹ0 apple 030709080702000ｹ0 02 06 040ｸ70700046ｧ9ｨB080ｸ707 0ｷ30ｹ0 0208apple06026ｧ8 080300090008-0706 090ｹ0 06000309 046ｧ9. 6ｾ402060ｹ0 07fi04080ｸ70ｹ0 02080ｸ7 apple00030608 0807026ｧ9080ｸ7 08 apple00030608 08-07020602fi0ｹ0 036ｦ003 02080ｹ0 apple08020003006ｧ9 0001 0000076ｧ8 apple08030ｸ707030603000ｷ307 apple 030809fi- 070ｷ307 0307090206020607 02 0207 Gram 6 5 020209036ｧ90ｷ307, 020ｷ307 08apple086ｧ90ｷ307 09 06006ｧ904 0ｸ7-0409 04020807 0ｸ7apple0802006ｧ900000708 0ｸ7apple0800apple0603090306 02fi 040ｸ707 00020602fi 060402fi apple080ｸ7 000008 076ｧ9ｨB0006 apple03086ｦ00406 0909006ｧ90ｷ30409 00apple0803006ｧ9 07 apple030802 03 閨040006 0403fi0706 0ｸ7apple080203060706026ｧ8 6 5 0202090306 06006ｧ9. ﾇ 06000309 046ｧ9 0ｸ7026ｧ8 apple030802 03006ｧ9 040ｸ70700046ｧ8 02 06 apple00030608 06026ｧ8 apple0003000ｸ703 閨030ｷ30409 04020907 020ｸ70203080808036ｧ9 020ｷ307 080300090008-070ｷ3 0607 000602020607 apple080ｸ7 07060407006ｦ0080702 06 0400 0ｸ7010900 閨07 00apple6ｧ9apple00 02 0207 020907 0007000309fi 08070409 02090ｹ0 apple00030608 08070206026ｧ80ｹ0 080300090008076ｧ80ｹ0 02 06 apple 030703-030903 apple0603 07fi07 07 000ｸ70708086ｦ007 020907 090006080ｸ703096ｧ9 02 06 0001000306020206026ｧ8 06-0602 046ｧ9 020ｷ307 0309030804020309030ｸ7070206020607 6 503 6 50607. ﾇ apple00030608 08070206026ｧ8 030003 apple006ｧ9 00apple0608 閨030006 00006ｧ90ｷ30409 020ｷ307 00apple06apple 陦0ｷ307 040208 6ｧ900 020ｷ307 08030009-0008070ｷ3 0607 apple 03 09fi07020ｷ307 apple080ｸ7 0007 閨04080702 06 040209 06 0602 046ｧ9 02090ｹ0 030903080402036ｧ8030ｸ70704090ｹ0. 0900 6 5070409 0ｸ702fi 00apple0803006ｧ9 07 06 020ｸ7apple0ｷ303006ｧ9 09 0ｸ7applefi03000409 fi0206 09 030003 apple006ｧ9 02090ｹ0 apple00030608 08070206026ｧ80ｹ0 080300090008076ｧ80ｹ0 040ｸ700-6 50703030006 04020907 00006ｧ90ｷ30409 02080ｸ7 020607 6ｦ007080ｸ7 00000807070604090ｹ0 0906 02 03 06 09090006-02fi 07fi040900. 08apple0703040006 apple0309030603 00000300020607 apple080ｸ7 apple 03 閨04080ｸ707 0007 006ｧ90100060ｹ0, 030307 0007 020002000903060607080ｸ707 00apple 0302060ｹ0 0209 0404 閨0409 apple00030608-0807026ｧ90206 0ｹ0 02 06 02 03 06 09090006 020607 070804090007020ｷ307. 09030802000600 閨07080ｸ7 07 0ｸ7apple070301080ｸ707 020002000903060ｷ300 閨07000ｹ0 apple08 006ｧ90100060ｹ0 02090ｹ0 040ｸ70404 閨020604090ｹ0 02090ｹ0 apple00030608 08070206026ｧ80ｹ0 07fi04080ｸ7 02 06 020ｷ307 02 03 06 09090006 020607 070804090007020ｷ307 apple 0602086ｦ00702 06 apple0003060404fi020003000ｹ0 0003000904fi000007000ｹ0 00apple06 090006080308090602 閨0ｹ0 閨03000ｸ707000ｹ0. E6ｦ1EI6ｾ4 K EI04IA: ﾞ030903080402036ｧ8030ｸ7070409, 006ｧ90202000ｹ0 apple00030608 08070206-026ｧ80ｹ0 080300090008076ｧ80ｹ0, 02 03 06 09090006 0207 0708046ｧ800 02, apple00030608 0807026ｧ90206. Summary It is generally accepted that cigarette smoking, hypertension and hypercholesterolemia have been established as some of the most considerable risk factors for cardiovascular diseases. In developed countries, cardiovascular diseases account for 50% of deaths and are the principle cause of death, while in developing countries it ranks third, accounting for 16% of deaths. In recent years, efforts have been made in order to explore the contribution of inflammatory factor to the pathogenesis of atherosclerosis, and consequently to the coronary heart disease. Atherosclerosis has been defined as a progressive disease process that involves the medium sized muscular arteries. According to the response to injury hypothesis, atherosclerotic lesions initiate as injury on the vascular endothelium from pathogenic microorganisms and then continue as local inflammatory process. The initiation of atherosclerotic plaques is thought to be the local accumulation of lipids and other plasma proteins in the arterial intima. The deposition of atherogenic lipoproteins LDL, 6 5-VLDL and Lp(a) in the intima may induce a series of biological changes, including increased adhesion molecules in endothelial cells, and the adhesion and migration of monocytes and T lymphocytes. The accumulation of lipidloaded cells underlying the endothelium, namely fatty streak, is a hallmark of early-stage atherosclerotic lesion. As fatty steaks progress to intermediate and advanced lesions they tend to form a fibrous cap consisting of a mixture of smooth muscle cells and extracellular matrix that covers the advanced lesion. The rupture of the fibrous cap can rapidly lead to thrombosis and usually occurs at sites of thinning of the fibrous cap. Periodontal pocket contains abundant Gram-negative bacteria which come into contact with subepithelial underlying connective tissue and periodontal blood vessels. KEY WORDS: Atherosclerosis, cardiovascular diseases, periodontal inflammatory markers, periodontitis. 6ｾ402070303090200 0402060ｹ0 3.5.2006. 6ﾑ80902036ｧ903090200 0402060ｹ0 5.9.2007. 1 ﾌ 0807026ｧ9 0203080ｹ0 2 6ﾑ8apple6ｧ902080ｸ703080ｹ0 ﾒ 03090909026ｧ80ｹ0 Received on 3 rd May 2006. Accepted on 5 th Sept., 2007. 1 Dentist 2 Assistant Professor
13112 This may lead to subclinical chronic bacteremia, as a result of which inflammatory markers are periodically and constantly released into the bloodstream. The increased circulating levels of these markers can be found in the active phase of periodontal inflammation and they probably favour the formation and progression of atherosclerotic plaques. Proinflammatory cytokines including IL-1, IL-6 and TNF-a upregulate expression of adhesion molecules and leukocyte-endothelium interactions. IL-6 stimulates release of neutrophil leukocytes and platelets into circulating blood. Also, IL-6 and other cytokines alter hepatic protein synthesis, increasing synthesis and release of C-reactive protein, serum amyloid A, fibrinogen and other hemostatic variables which play a key role in the atherosclerotic process. Especially, CRP is now viewed as a prominent partaker in endothelial dysfunction and atherosclerosis. A strong relationship was demonstrated between increased serum CRP and the presence of subgingival periodontal microorganisms. Multiple periodontal pathogens have been found in the atheromas, including P. gingivalis, P. intermedia, T. forsythensis and A.a. Periodontal therapy induces a reduction in serum inflammatory markers which are associated with atherosclerotic process. Taking this into account, it can be hypothesized that periodontal therapy may reduce the risk for cardiovascular disease. There are many studies which provide indications, but they cannot prove sufficiently the correlation between periodontitis and cardiovascular diseases. More case control and long-term longitudinal studies are needed to confirm the association between periodontal and cardiovascular diseases. 6ﾑ80604 090ｷ3096ｧ8 ﾒ 0207 09000706026ｧ8 0800080308096ｧ9 0208 0207apple07060400, 09 0ｸ7apple 閨0302 0409 02 06 09 0ｸ7apple000304080309040200030607 06006ｧ9 03000ｷ303086ｦ00702 06 applefi 02080ｸ70ｹ0 040900 070206-02fi020003080ｸ70ｹ0 apple 030709080702000ｹ0 020607 6ｦ007080ｸ7 0906 020907 0000080707060409 020ｷ307 02 03 06 09090006 020607 070804090007020ｷ307. 6ﾑ8apple6ｧ904090ｹ0, 09070ｷ30402086ｧ9 02 06 020002-000903060ｷ300 閨070806 apple 030709080702000ｹ0 00apple06020607 0ｸ707fi020902 0ｹ0 006ｧ907 06 08 04 0204-0306 090ｹ0 06 6 56ｧ802090ｹ0, 09 閨030300066 709 040ｷ300 0206026ｧ80ｹ0 0704020904090ｹ0 02 06 0208 0ｸ7apple00036 508030602fi 6 50703080ｹ0. 6ﾑ8apple6ｧ9040900 0402080604006ｧ9 02080ｸ7 09. ﾌ.08 090306-07080ｸ707 fi0206 0208 1995 02 02 03 06 09090006 0207 0708046ｧ800 02 6ｧ802 07 0ｸ7apple006ｦ0030ｸ707 0906 0208 20% 020ｷ307 03 0707020ｷ307 apple 09020804006ｧ90ｷ30ｹ0, apple - 03060300060702 0ｹ0 14 0002 020800006ｦ00306 07030306apple080ｸ70ｹ0. 6ｾ400 07 apple020ｸ70900-07000ｹ0 040603000ｹ0, 02 02 03 06 09090006 0207 0708046ｧ800 02 000ｸ7036ｦ007080702 06 0906 0208 50% 020ｷ307 03 0707020ｷ307 02 06 apple08020003086ｦ007 020907 apple03060209 06026ｧ9, 000706 0400 07 apple020ｸ70404fi000007000ｹ0 040603000ｹ0 02 02 02070404080702 06 040209 02036ｧ90209 03 閨0409 00000807070604090ｹ0 03 07 020908fi030ｷ307 0203080ｸ7040007020ｷ307 1. 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030809 閨070006 02090ｹ0 04020008 0706 6ｧ9 0ｹ0 07fi04080ｸ7, 0000 閨0008 0409 020ｸ7036ｧ90ｷ30ｹ0 040209 0803000900080706 09 060206080308096ｧ9. 0900 6 5070409 070006020003 6 5066 5030608-0903 08060207 00 0800 閨07, 0ｸ7apple070304080ｸ707 0007 006ｧ90100060ｹ0 040ｸ704040002060400086ｦ0 000002 016ｦ0 02090ｹ0 apple00030608 08070206026ｧ80ｹ0 07fi04080ｸ7 02 06 02090ｹ0 090006080ｸ703096ｧ9 0ｹ0 0309030804020309030ｸ7070206020607 6 503 6 50607 0400 0909006ｧ9. ﾇ apple00030608 08070206-026ｧ8 07fi04080ｹ0 006ｧ907 06 006ｧ9 0403fi0706 080300090008076ｧ8 04020907 08apple086ｧ9 0000apple03-02080702 06 02 06 07000ｸ7036ｧ90402080702 06 0400 0ｸ7010900 閨07 00apple6ｧ9apple00 6 5060804090006-02086ｧ9 apple 030709080702000ｹ0 apple080ｸ7 apple0603 07fi 07 000ｸ70708086ｦ007 020907 090006080ｸ703096ｧ9 02 06 07 00apple0602006ｧ907080ｸ707 020907 0001000306020206026ｧ8 06 0602 046ｧ9 020ｷ307 03090308-04020309030ｸ7070206020607 6 503 6 50607. 02 6ｧ9070002 06, 030806applefi07, fi0206 02 06 0806 6ｦ008 apple 036ｧ80400060ｹ0 000008 076ｧ9ｨB080ｸ707 0207apple0806000ｹ0 08000806fi020902000ｹ0 0000 020907 閨07070806 fi0206 閨04080ｸ707 apple08030ｸ7apple 03 0908070206026ｧ8 06020608apple 030809 閨070006, 090007000206026ｧ8 apple0308 060703000409 02 06, apple0603 07060ｹ0, 0008060307ｨB080702 06 0207apple0806-080ｸ70ｹ0 apple 030709080702000ｹ0 020607 6ｦ007080ｸ7, fiapple0ｷ30ｹ0 0208 0207apple07060400, 08 04 0204-0306 090ｹ0 06 6 56ｧ802090ｹ0, 09 06 020308086ｧ8 02 06 0208 stress. 08apple070304080ｸ707 0007 006ｧ90100060ｹ0 fi0206 0806 apple03080803000900080706 00060ｹ0 020ｸ70208-026ｧ907000ｹ0 IL-I, IL-6, TNF 02 06 0806 apple030ｷ302000ｹ107000ｹ0 02090ｹ0 0801006ｧ9 0ｹ0 080704090ｹ0 02090ｹ0 080300090008076ｧ80ｹ0 (C- 070206 030604 apple030ｷ302000ｹ10709 02 06 06070ｷ3 0809fi0708) apple08020003086ｦ007 apple 030709080702000ｹ0 apple080ｸ7 00apple09030007ｨB080ｸ707 020907 apple 030809000700-0206026ｧ8 06 0602 046ｧ9 02090ｹ0 0309030804020309030ｸ7070206026ｧ80ｹ0 6 503076 5090ｹ0. ﾌ06 080ｸ7046ｧ9000ｹ0 0ｸ702 閨0ｹ0 apple08020003086ｦ007 apple 030703030903 040900 07020602086ｧ9 6 506080409-000602086ｧ9 0000040803 6 50902 閨0ｹ0 02090ｹ0 apple00030608 08070206026ｧ80ｹ0 080300090008076ｧ80ｹ0. 6ｾ40208applefi0ｹ0 02090ｹ0 6 5066 50306080903 0806026ｧ80ｹ0 0ｸ7026ｧ80ｹ0 07 0402fiapple0904090ｹ0 006ｧ907 06 09 000003 閨0209 02 06 09 0707030ｸ70409 020ｷ307 apple 03 apple07070ｷ3 apple 03 09fi07020ｷ307 0806 08apple086ｧ90806 07060407006ｦ0080702 06 0400 0ｸ7010900 閨07 00apple6ｧ9apple00 02 0207 020907 0007000309fi 08070409 02090ｹ0 apple00030608 08070206026ｧ80ｹ0 080300090008076ｧ80ｹ0, 02 06 apple 030703-030903 040ｸ700000002 閨04080ｸ707 0402060ｹ0 apple 030809000700020602 閨0ｹ0 06 0602 046ｧ9000ｹ0 02090ｹ0 0309030804020309030ｸ7070206026ｧ80ｹ0 6 503076 5090ｹ0 0000 apple0802 閨03000400 07 090006-080ｸ70309086ｦ007 000ｸ707080ｸ802 閨0ｹ0 040ｸ707036ｧ802000ｹ0 0906 020807 04040900 02060400fi 02090ｹ0. 09 0308090007000206026ｧ8 06 0602 046ｧ9 090006080ｸ703096ｧ9 0ｹ0 02090ｹ0 03090308040309030ｸ7-0206026ｧ80ｹ0 6 503076 5090ｹ0 ﾇ 030903080402036ｧ8030ｸ7070409 apple08020003006ｧ9 006ｧ9 apple030808 000ｸ702060207 000100-03060404fi00000709 apple 030803080906026ｧ8 02 06 apple08030ｸ7apple 03 0908070206026ｧ8 06000309 046ｧ9 0000 000009 036ｦ002000309 040ｸ70407fi020902 00000807070604090ｹ0 0402060ｹ0 000ｸ70ｸ802 閨0ｹ0 030209-036ｧ9000ｹ0 000004 6ｧ9080ｸ7 000009 閨03080ｸ70ｹ0. 6ｾ400 0607080803000ｹ0 07 0208000602 閨0ｹ0 03 閨0400060ｹ0 02080ｸ7 0302090306 02086ｦ0 閨07 03080ｸ7, fiapple0ｷ30ｹ0 0806 06 0203 060400060ｹ0 02 06 0806 0604 0400086ｧ9 020ｷ307 0909006ｧ90ｷ307 09 03086ｧ8 02080ｸ7 6ｧ900 02080ｹ0 006ｧ907 06 040203086 506-0306 090ｹ0 02 06, 02 0207 040ｸ707 鐶pple0006, 090006080ｸ70309086ｦ00702 06 0702060303006ｦ000 -
13H apple00030608 08070206026ｧ8 080300090008076ｧ8 0ｷ30ｹ0 apple 030709080702 0ｹ0 00apple06020607 0ｸ707fi020902 0ｹ0 020ｷ307 060404 060006020607 02 03 06 09090006 020607 070804090007020ｷ307 113 02 02 06 apple000306 06076ｧ80400060ｹ03. 6ｾ46ｦ000080ｷ307 0000 020907 0ｸ7applefi03000409 02090ｹ0 apple 07026ｧ804000ｷ30ｹ0 0400 6 503076 509 02090ｹ0 030903080402036ｧ8030ｸ70704090ｹ0 (response-to injury hypothesis of atherosclerosis) 4ｨC6, 09 000002 6 508036ｧ8 020ｷ307 03000803080906020607 0ｸ7070700000ｷ307 02 06 020ｷ307 04 03 020209-0306040206020607 02090ｹ0 03086ｧ80ｹ0 02080ｸ7 6ｧ900 02080ｹ0 0400 0207apple0806000ｹ0 03 閨0400060ｹ0 02080ｸ7 0302090306 02086ｦ0 020806040600 02080ｹ0, apple08020003006ｧ9 閨07 07 applefi 02080ｸ70ｹ0 apple08030ｸ70703060300080ｸ70ｹ0 apple 030709080702000ｹ0 020607 6ｦ007080ｸ7, 0806 08apple086ｧ90806 006ｧ907 06 040ｸ7070ｸ708 0400 閨070806 0000 020907 030903080402036ｧ8030ｸ7070409 3,7ｨC9. ﾇ 6 503076 509 02080ｸ7 0007 080309036ｧ9080ｸ7 006ｧ907 06 0208 02000702030602fi 046ｦ0006 5 00 04020907 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06-0400030002026ｧ90709 19ｨC21. 09000207 020907 apple03080402fi0303090409 020ｷ307 00080708020ｸ702-0207030ｷ307 02 06 020ｷ307 6ﾒ2-0300000808020ｸ7020207030ｷ307 0402 0007 0803090306 0207 026ｦ002-02 03, apple 03 020903006ｧ902 06 000002 07070402000ｸ70409 0ｸ7020607 04020807 0ｸ7apple0007-0803090306 02fi 04060308 0000 0209 0000040803076 5090409 02090ｹ0 6 506080007000309086ｦ00ｹ0 04090000060802 020206026ｧ80ｹ0 apple030ｷ302006ｧ907090ｹ0-1 020ｷ307 00080708020ｸ7020207030ｷ307 (MCF- 1) 22,23. ﾒ 0207 0209 060703020006 020ｷ307 020003000ｸ702 6ｧ90ｷ307 006ｧ902080406 00020607 070003006ｦ0030904 07 06070808030806 6 506080007000309086ｧ9 0000040803 6 50902 閨0ｹ0 04020807 閨040ｷ3 0406020607 020ｷ307 03020903060607, 0806 08apple086ｧ90806 apple030802 03086ｦ007 040900000608-02 016ｧ9 020ｷ307 00080708020ｸ7020207030ｷ307 040208 0ｸ7apple0007 08036ｧ8030608. ﾌ06 040900 070206-02fi0200030806 0000040803 6 50902 閨0ｹ0 006ｧ907 06 0806 020ｸ70208026ｧ907000ｹ0 IL-1 02 06 TNF-a, 09 MCF-1, 0806 08010006 0ｷ300 閨07000ｹ0 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(6ﾑ80602. 1) 09000207 02060ｹ0 000002 6 50803 閨0ｹ0 apple080ｸ7 0ｸ7086ｧ90402 02 06 0208 09090006 02fi 0007 08036ｧ8030608 02 06 02060ｹ0 00apple 02fi03080ｸ703000ｹ0 06000309 046ｧ9000ｹ0 (apple03080402fi03-03090409 03000ｸ70208020ｸ7020207030ｷ307 040208 0007 08036ｧ8030608, 000002 07070402000ｸ70409 04020807 0ｸ7apple0007 0803090306 02fi 04060308, 06 08080308apple086ｧ9090409 00080708020ｸ7020207-030ｷ307 02 06 000700030908apple086ｧ9090409 6ﾒ2-0300000808020ｸ7020207030ｷ307), 020803080ｸ703006ｧ9 08 04040900 02060400fi0ｹ0 020ｷ307 0306apple0ｷ3 0607 03 6 5 0604000ｷ307 apple080ｸ7 006ｧ907 06 0208 apple030ｷ30600fi02000308 040207 0608 02090ｹ0 030903080402036ｧ8030ｸ70704090ｹ025. ﾌ06 0306apple06-00060ｹ0 03 6 5 060400060ｹ0 040ｸ7076ｧ90402 0702 06, 020ｸ7036ｧ90ｷ30ｹ0, applefi 080308026ｦ00202 03 02 06 000700030908apple08060900 閨07 6ﾒ2-0300000808026ｦ00202 03. 6ｾ40209 040ｸ707 閨040006, 0000 0209 0000040803076 5090409 0ｸ701090206020607 apple 03 09fi07020ｷ307 0806 6 503076 5000ｹ0 0ｸ7010707080ｸ707 0400 00 閨090003080ｹ0, 02 03060ｹ0 apple 03 020903006ｧ902 06 000002 0707-0402000ｸ70409 020ｷ307 03006ｧ90ｷ307 000ｸ70ｸ8020607 020ｸ7020207030ｷ307 applefi 0208 00 閨0408 04020807 閨040ｷ3 0406020607 020ｷ307 03020903060607 02 06 040ｸ704040603000ｸ70409 020ｷ307 020ｸ7020207-030ｷ307 0ｸ7020607 0207020ｷ3 applefi 02 080308026ｦ00202 03 02 06 02 6ﾒ2-0300000808- 026ｦ00202 03 02090ｹ0 0306apple06 080ｸ70ｹ0 03076 5 0ｷ304090ｹ04. ﾇ 06 02 03 046ｧ8 02090ｹ0 0007 0803090306 026ｧ80ｹ0 040ｸ707 閨040006 0ｹ0 08 0909006ｧ9 0400 閨0203000409 040208 020ｸ7020308080803086ｦ007 6ｧ900 020ｷ307 080308020ｸ7020207030ｷ307 02 06 02080ｸ7 02080303 09fi07080ｸ7 02080ｸ7 0ｸ7apple0007 0803090306 02086ｦ0 060402086ｦ0, 0000 apple0802 閨03000400 0209 040ｸ70707030308060409, 040ｸ70902fi0303090409 02 06 000700030908apple086ｧ9090409 020ｷ307 060008apple0002 036ｧ90ｷ307. ﾇ 000700030908apple086ｧ9090409 020ｷ307 060008apple00-02 036ｧ90ｷ307 apple030802 03006ｧ9 020907 apple0003000ｸ703 閨030ｷ30409 applefi 02-020802026ｧ9 020ｷ307 0ｸ701090206020607 apple 03 09fi07020ｷ307, 000ｸ70708060702 0ｹ0 02 0207 020807 0203fiapple08 0ｸ702fi 0209 090006080ｸ703096ｧ9 0303fi006 5080ｸ7. ﾌ06 0ｸ70109020602086ｧ9 apple 0307-6ﾑ80602fi07 1. 0903060600000ｹ0 000002 6 50803 閨0ｹ0 02080ｸ7 09090006 02086ｦ0 0007 080309036ｧ9080ｸ7 (6ﾒ20308apple08apple08060900 閨0709 000602fi07 applefi Ross 1999). ﾒ080ｸ707086ｦ0apple090ｹ0, 08086ｦ003080ｹ0 6ﾑ80602fi07 2. 6ｾ4040900 02060400fi0ｹ0 0306apple06 080ｸ70ｹ0 03076 5 0ｷ304090ｹ0 (6ﾒ20308apple08apple080609-00 閨0709 000602fi07 applefi Ross 1999). 09080702000ｹ0 000202fi0ｹ0 applefi 02 00 020308080709 apple 030709080702 06 02 06 applefi 02 060008apple0002070306, 02 08apple086ｧ9 0000 0209 0400060307 02080ｸ70ｹ0 apple 6ｧ9ｨB080ｸ707 040900 07020602fi 03fi0308 04020907 0309030809 閨07000409 02 06 0001 閨03060109 020ｷ307 apple0308040ｷ3030900 閨070ｷ307 6 503 6 50607 0000 02000306026ｧ8 02 020703090109 0209 036ｧ80109 02090ｹ0 02076 7 0ｹ0 02 06 020907 apple03fi0203090409 0303fi006 50ｷ304090ｹ0 (6ﾑ80602. 2). ﾒ 03060ｹ0 0806 apple03060600000ｹ0 6 503076 5000ｹ0 000100036ｧ90404080702 06 0400 apple0308040ｷ3-030900 閨07000ｹ0, apple030802 03006ｧ902 06 00030702020ｷ30409 02090ｹ0 03086ｧ80ｹ0 02080ｸ7 6ｧ900 02080ｹ0 02 06 0402 閨070ｷ30409 02080ｸ7 0909006ｧ9080ｸ7, 0008 ｯ fi040807 0ｸ702 閨0ｹ0 apple03086 5070303080ｸ707 000702fi0ｹ0 02080ｸ7 09090006 02086ｦ0 0ｸ703086ｦ0. ﾇ apple0308040ｷ3030900 閨0709 6 503076 509 02090ｹ0 030903080402036ｧ8030ｸ70704090ｹ0 02 03006ｧ902 06 060706 090ｹ0 apple030702 (fibrous plaque), 09 08apple086ｧ9 apple08020003006ｧ902 06 applefi apple0ｸ7036ｧ807 0000 00 0203080807-09 02 06 6ﾒ2-0300000808026ｦ00202 03 0900000702 applefi 0306apple6ｧ9 06. ﾌ apple0ｸ7036ｧ807 0ｹ0 02090ｹ0 apple0308040ｷ3030900 閨07090ｹ0 6 503076 5090ｹ0 02 036ｦ0apple020002 06 applefi 020907 060706 09 02076 7 (fibrous cap), 09 08apple086ｧ9 040ｸ7076ｧ90402 02 06 applefi 03006ｧ9 000ｸ70ｸ80207 026ｦ00202 03, 0000 apple0ｸ7020707 0402030600 02 02080303 09fi07080ｸ7 02 06 apple030ｷ3020008-09030ｸ702 070607. 6ﾑ8076ｧ9080200 0207020ｷ3 applefi 020807 apple0ｸ7036ｧ807 apple 03 020903086ｦ00702 06 apple0804fi020902000ｹ0 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13H apple00030608 08070206026ｧ8 080300090008076ｧ8 0ｷ300 apple 030709080702 0ｹ0 00apple06020607 0ｸ707fi020902 0ｹ0 020ｷ307 060404 060006020607 02 03 06 09090006 020607 070804090007020ｷ307 115 0909006ｧ9, 0000 apple0802 閨03000400 0209 090006080ｸ703096ｧ9 0303fi006 5080ｸ7 02 06 閨000803 01090ｹ0 02080ｸ7 0909006ｧ9080ｸ74. 6ﾒ2 6ｦ008 00010ｷ3020003060207 02036ｧ902 02080ｸ7 020806040600 02080ｹ0 020ｷ307 0909006ｧ90ｷ307 0203 閨08080702 06 applefi 02080ｸ70ｹ0 0203080808-08fi03080ｸ70ｹ0 09090006 02086ｦ00ｹ0 020307 080ｸ70ｹ0 apple080ｸ7 0807080007ｨB080702 06 0909006ｧ9 020ｷ307 0909006ｧ90ｷ307 (6ﾑ80602. 4) ﾞ07 020008 03 060607080702 0ｹ0 02 apple 03 apple07070ｷ3 02 02 036ｧ8090006 02 07006ｧ90ｹ0 040208 040ｸ700apple 閨03 0400 fi0206 06070808030806 6 506080409000602086ｧ9 apple 0307-09080702000ｹ0 apple080ｸ7 06 03 00 026ｧ9ｨB080ｸ707 040900 07020602fi 0000040803 6 509020602fi 03fi0308 (ｦﾐL-1, IL-6, TNF) 040209 06 0602 046ｧ9 02090ｹ0 apple00030608 08070206026ｧ80ｹ0 080300090008076ｧ80ｹ0, 040ｸ700000002 閨04080ｸ707 0400 apple080303 閨0ｹ0 08070400060ｹ0 02090ｹ0 apple 0308-09 閨070006 0ｹ0 02090ｹ0 0309030804020309030ｸ7070206026ｧ80ｹ0 6 503076 5090ｹ0 02 06 090006080ｸ703-09086ｦ007 000ｸ707080ｸ802 閨0ｹ0 apple030800apple0803 閨0400060ｹ0 04020907 fi0309 apple 0308090007000206026ｧ8 06 0602 046ｧ9 02090ｹ0. 6ﾑ80602fi07 3. 6ｾ4040900 02060400fi0ｹ0 apple0308040ｷ3030900 閨07090ｹ0 6 503076 5090ｹ0 (6ﾒ20308apple08apple0806-0900 閨0709 000602fi07 applefi Ross 1999). 09000207 020907 08030802036ｧ8030ｷ30409 02 06 0ｷ3036ｧ900 070409 02090ｹ0 0309030ｷ300-0206026ｧ80ｹ0 apple030702 0ｹ0 040209 000803086ｧ8 020ｷ307 apple0308040ｷ3030900 閨070ｷ307 6 503 6 50607 0ｸ7apple0703040006 08 026ｧ907 0ｸ707080ｹ0 apple03fi02030904090ｹ0 030308006 50800006 5080306020607 08 06-070800 閨070ｷ307, 03fi090ｷ3 03 鐶pple020ｸ70704090ｹ0 02 06 036ｧ801090ｹ0 02090ｹ0 060706 080ｸ70ｹ0 02076 7 0ｹ0, 09 08apple086ｧ9 08 0909006ｧ9 0400 090006080ｸ703096ｧ9 0303fi006 5080ｸ7 0000 02080ｸ70ｹ0 00016ｧ80ｹ0 000904 07060400086ｦ00ｹ0 : 1) 09000207 0209 060704apple 0409 02090ｹ0 060706 080ｸ70ｹ0 02076 7 0ｹ0 閨0304080702 06 0400 00apple 086ｧ8 02 040ｸ70402 02060207 02080ｸ7 6ｧ900 02080ｹ0 0000 006ｧ9 apple030ｷ302000ｹ10709 (tissue factor) apple080ｸ7 000202036ｧ9070002 06 applefi 02 080308026ｦ00202 03 04020907 apple00030608046ｧ8 02090ｹ0 6 503076 5090ｹ0, 000700030908apple080606-0702 0ｹ0 02080ｸ70ｹ0 000904 07060400086ｦ00ｹ0 apple6ｧ801090ｹ0 02080ｸ7 6ｧ900 02080ｹ0 02 06 0209 090006-080ｸ703096ｧ9 0303fi006 5080ｸ717,28. 2) ﾌ06 030ｷ30900 閨0ｹ0 02 06 036ｧ80100060ｹ0 020ｷ307 apple0308-040ｷ3030900 閨070ｷ307 6 503 6 50607 0007000309086ｦ007 0ｷ30ｹ0 03 閨0400060ｹ0 apple030804020803036ｧ80400-0ｷ30ｹ0 020ｷ307 060008apple0002 036ｧ90ｷ307 02 06 04040900 02060400086ｦ0 020806040ｷ300 020602086ｦ0 02 06 0ｸ7070902060207 apple080803 02020602086ｦ0 0303fi006 5080ｸ7, 08 08apple086ｧ9080ｹ0 08 0909006ｧ9 0400 0402 036ｧ8 0402090307090409 6ｧ8 閨000803 0900 02080ｸ7 000ｸ70802 03 6ｧ9080ｸ73. 3) 6ﾑ8apple06apple03 閨0807, 09 apple08 fi00090409 020ｷ307 040ｸ70402 0206020607 02090ｹ0 00010ｷ3020ｸ7020207-0306 0ｹ0 080ｸ7046ｧ9 0ｹ0 02090ｹ0 060706 080ｸ70ｹ0 02076 7 0ｹ0 00apple0803006ｧ9 07 08 09096ｧ8040006 0400 0600080303 096ｧ9 applefi 02080ｸ70ｹ0 020308080808fi03080ｸ70ｹ0 09090006 02086ｦ00ｹ0 020307-080ｸ70ｹ0 (vasa vasorum) apple080ｸ7 apple0308 閨0304080702 06 applefi 02 090006020807060207 6ﾑ80602fi07 4. 066ｧ80109 060706 080ｸ70ｹ0 02076 7 0ｹ0 (6ﾒ20308apple08apple08060900 閨0709 000602fi07 applefi Ross 1999). 04006ｧ90202000ｹ0 apple00030608 08070206026ｧ80ｹ0 080300090008076ｧ80ｹ0 02 06 040ｸ704040002060400fi0ｹ0 0ｸ7020607 0000 020907 0309030804020309030ｸ7070206026ｧ8 6 503076 509 ﾌ06 apple03080803000900080706 00060ｹ0 020ｸ70208026ｧ907000ｹ0 apple 6ｧ9ｨB080ｸ707 02 03080306040206-02fi 03fi0308 0402060ｹ0 020ｸ70202 030602 閨0ｹ0 0303090300apple06 03070400060ｹ0 apple080ｸ7 apple080200-03086ｦ007 03000000030606 00060ｹ0 6 506080308090602 閨0ｹ0 06000309 046ｧ9000ｹ0 04020907 apple 030809-070006 02090ｹ0 030903080402036ｧ8030ｸ70704090ｹ0. 00apple0ｷ30ｹ0 apple0308 07 08 閨0303090200, 04020907 apple00030608046ｧ8 02090ｹ0 6 503076 5090ｹ0 02080ｸ7 0007 080309036ｧ9080ｸ7 000202036ｧ907080702 06 applefi 02 00 020308080709, 02 0300000808026ｦ00202 03 02 06 02 0007 080309-0306 0207 026ｦ00202 03 0806 apple03080803000900080706 00060ｹ0 020ｸ70208026ｧ907000ｹ0 IL-1, IL-6 02 06 08 TNF-a. O06 080ｸ7046ｧ9000ｹ0 0ｸ702 閨0ｹ0 02 02000ｸ7036ｦ007080ｸ707 02 06 030ｸ703006ｧ9- ｨB080ｸ707 0209 0803000900080706 09 06 0602 046ｧ9, 02 06 040208 apple03 6ｧ9040608 02090ｹ0 0708040803080906026ｧ80ｹ0 apple0707020904090ｹ0 0806 0000040803 6 50902 閨0ｹ0 0ｸ702086ｧ9 02090ｹ0 080300090008076ｧ80ｹ0 060009006ｧ903080ｸ707 020907 00 閨020803 040903 0008036ｧ90ｷ307 apple0308-0402fi03030904090ｹ0 040208 0007 08036ｧ8030608 02 06 020308apple08apple0806086ｦ007 020907 09apple 0206026ｧ8 6ｧ8 0007 0803090306 026ｧ8 046ｦ00703000409 02 06 閨020203060409 020ｷ307 apple030ｷ302000ｸ8070607 02080ｸ7 apple03070400 02080ｹ0. 6ﾑ8apple06apple03 閨0807, 0806 apple03080803000900080706 00060ｹ0 020ｸ70208026ｧ907000ｹ0 060009006ｧ903080ｸ707 020907 閨020203060409 02 06 apple0003000ｸ703 閨030ｷ30409 03000ｸ70208020ｸ7020207-030ｷ307 02 06 060008apple0002 036ｧ90ｷ307 040208 apple0003060800030602fi 6ｧ900 applefi 020807 000ｸ70003fi 020ｷ307 0804020607 29. ﾇ apple03080803000900080706 090ｹ0 020ｸ70208026ｧ90709 IL-6 040208 apple03 6ｧ9040608 02090ｹ0 0803000900080706 080ｸ70ｹ0 applefi02030604090ｹ0 040208 00060203086 506 02fi apple 030709080702, 060009006ｧ9030006 020907 閨020203060409 020ｷ307 080ｸ7 00020003fi0806030ｷ307 03000ｸ70208020ｸ7020207-030ｷ307 02 06 020ｷ307 060008apple0002 036ｧ90ｷ307 applefi 0208 000ｸ70003fi 020ｷ307 0804020607 040208 apple0003060800030602fi 6ｧ900. ﾇ 6ｦ001090409 02080ｸ7 040ｸ70708030602086ｦ0 03060300086ｦ0 020ｷ307 03000ｸ7020607 0600080408 06036ｧ90ｷ307 006ｧ907 06 0ｸ707 02fi 07 apple030807090006 020907 apple03fi0203090409 030903080402036ｧ8030ｸ70704090ｹ0, 0303fi006 50ｷ304090ｹ0 02 06 060404 06006ｧ9 0ｹ0 00 閨040ｷ3 06 08fi030ｷ307 000904 070604000607, fiapple0ｷ30ｹ0 09 apple 03 0206030ｸ70409 02090ｹ0 0600 0206026ｧ80ｹ0 03086ｧ80ｹ0 0402 02030604080006 6ｧ8 0909006ｧ9 30,31. ﾞ07026ｧ90402080604 006ｧ907 06 02 06 02 000ｸ7036ｧ800 02 00apple06 0900060803080906026ｧ80ｹ0 000003 閨02090ｹ0 09 08apple086ｧ9 07 08 閨030006 fi0206 02 0207 020907 0303090300apple6ｧ9 03 0409 020ｷ307 080ｸ7 00020003fi0806-030ｷ307 03000ｸ70208020ｸ7020207030ｷ307 0000 0208 09090006 02fi 0007 08036ｧ8030608 040ｸ707026ｧ90300-0702 06 02 06 000202036ｧ907080702 06 6 503 apple020602086ｧ9 08010006 0ｷ3020602086ｧ9 000002 6 508036ｧ902000ｹ0 applefi 02 080ｸ7 00020003fi080603 32. ﾌ06 apple 030709080702000ｹ0 0ｸ702086ｧ9 fiapple0ｷ30ｹ0 0806 0003006ｦ0030003000ｹ0 036ｧ9ｨB000ｹ0 02080ｸ7 08010ｸ709fi07080ｸ7, 0806 02 020608070602 閨0ｹ0 apple030ｷ3-02000ｹ107000ｹ0 02 06 09 apple0003000ｸ703 閨030ｷ30409 020ｷ307 apple030ｷ3020008030ｸ70206020607 0007ｨB6ｦ0-000ｷ307 (030ｸ70408ｨB6ｦ00009, 0003 0402070409) 0007 閨040002 06 07 00apple06 03086ｦ007 6 503 - apple02060207 0402 0007 0803090306 0207 026ｦ00202 03. ﾇ 6ｦ001090409 02080ｸ7 03060300086ｦ0 020ｷ307 080ｸ7 00020003fi0806030ｷ307 apple08020003006ｧ9 apple030809070ｷ304020602fi 006ｧ9020209 0906 閨000803 0900 02080ｸ7 000ｸ70802 03 6ｧ9080ｸ733, 000706 0ｸ7apple070304080ｸ707 07 080803 閨0ｹ0 00apple06 0900060803080906020607 00000300020607 apple080ｸ7 0208076ｧ9ｨB080ｸ707 0209 040ｸ70404 閨02060409 02080ｸ7 040ｸ70708030602086ｦ0 03060300086ｦ0 020ｷ307 03000ｸ7020607 0600080408 06036ｧ90ｷ307 02 06
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000ｸ703080006 086ｦ00ｹ0 ﾞ, 02080ｸ7 06070ｷ3 0809fi07080ｸ7 02 06 0703030ｷ307 0600080402 0206020607 apple 03 09fi07020ｷ307 29. ﾇ 09030806fi020902 02080ｸ7 apple03070400-02080ｹ0 0001 03020702 06 applefi 020907 apple0003060002020602fi02090207 02080ｸ7 0400 apple030ｷ3-02000ｹ107000ｹ0 02 06 0ｸ70107070002 06 applefi 0208 06070ｷ3 0809fi0708, 0208 08apple086ｧ908 00apple06-08 閨030006 040ｸ70902fi0303090409 020ｷ307 00030ｸ7030308020ｸ7020207030ｷ307. ﾇ 09030806fi020902 02080ｸ7 apple03070400 02080ｹ0 02 06 09 040ｸ70902fi0303090409 020ｷ307 00030ｸ703030607 060008-0408 06036ｧ90ｷ307 apple00030608036ｧ9ｨb080ｸ707 020907 03000ｸ70402fi020902 02080ｸ7 6ｧ900 02080ｹ037, 000706 09 6ｦ001090409 020ｷ307 00apple06apple 陦0ｷ307 02080ｸ7 06070ｷ3 0809fi07080ｸ7 apple0308 06 03-020006 0400 00006ｧ90ｷ30409 02090ｹ0 03086ｧ80ｹ0 02080ｸ7 6ｧ900 02080ｹ0, 0400 0303fi006 50ｷ30409 02 06 0309030809 閨07000409 38,39. ﾇ 046ｦ007 000409 02080ｸ7 06070ｷ3 0809fi07080ｸ7 04020907 020ｸ70202 0306026ｧ8 0000006 503070709 020ｷ307 060008apple0002 036ｧ90ｷ307 apple08020003006ｧ9 07-0902 6ｧ9 apple030800applefi03000409 02090ｹ0 040ｸ70902fi03030904090ｹ0 020ｷ307 060008apple0002 036ｧ90ｷ307 in vivo 40. 6ﾑ8apple06apple03 閨0807, fi02 07 0208 06070ｷ3 0809fi0708 0007040ｷ300 0206070002 06 0402060ｹ0 0309030804020309030ｸ707020602 閨0ｹ0 6 503076 5000ｹ0 000002 0203 鐶pple0002 06 0400 060706-000ｹ0 02 06 0400 apple03080ｸ8fi0702 06 04apple0704000ｷ30ｹ0 02080ｸ7 060706 080ｸ70ｹ0 02 08apple086ｧ9 060009006ｧ903080ｸ707 020907 000002 07070402000ｸ70409 02 06 020807 apple080303 apple03 0406 0400fi 020ｷ307 03006ｧ90ｷ307 000ｸ70ｸ8020607 020ｸ7020207030ｷ307 41,42. 6ﾒ2 000ｸ7036ｧ800 02 0ｸ70207 006ｧ907 06 0007 00060202060207 02090ｹ0 0007000309086ｦ0 040ｸ70000000208046ｧ80ｹ0 02080ｸ7 06070ｷ3 0809fi- 07080ｸ7 0402 0304060207 040207 06 02080ｸ7 04040900 02060400086ｦ0 02090ｹ0 0309030ｷ300-0206026ｧ80ｹ0 apple030702 0ｹ0. 096ｧ9 07030309 apple030ｷ302000ｹ10709 02090ｹ0 08apple086ｧ9 0ｹ0 09 apple 03 090ｷ3096ｧ8 applefi 02 09apple 0208026ｦ00202 03 000700030908apple0806006ｧ902 06 00 閨040ｷ3 02090ｹ0 IL-6 006ｧ907 06 09 C- 070206 030604 apple030ｷ302000ｹ10709 (CRP). ﾇ apple030ｷ302000ｹ10709 0ｸ7026ｧ8 000202036ｧ90700-02 06 fi02 07 08 080309 07060400fi0ｹ0 0702060000020ｷ3apple6ｧ9ｨB0006 03086ｧ9000ｷ30109, 0203 6ｦ000, 03000300fi020902 02 06 0ｸ7apple08016ｧ9 43. 0903fi0408 02 000ｸ7036ｧ800 02 07 08-03080ｸ707, fi0206 09 CRP apple 0307090002 06 applefi 02 03006ｧ9 000ｸ70ｸ80207 026ｦ00202 03 02 06 02 00 020308080709 02090ｹ0 0309030804020309030ｸ7070206026ｧ80ｹ0 6 503076 5090ｹ0, applefi 02 0700080307, 02 0300000808026ｦ00202 03 02 06 02080ｸ70ｹ0 07000ｸ7030607000ｹ044,45. 6ﾑ80202fi0ｹ0 applefi 020907 040ｸ7006 508036ｧ8 02090ｹ0 IL-6 04020907 09apple 0206026ｧ8 046ｦ00703000409 02 06 閨020203060409 02090ｹ0 CRP, 07 08 閨030002 06 02 06 09 040ｸ70000000208046ｧ8 02090ｹ0 IL-1 02 06 02080ｸ7 TNF (tumor necrosis factor) 040209 06 0602 046ｧ9 0ｸ7026ｧ8 46. ﾇ C- 070206 030604 apple030ｷ302000ｹ10709 apple08020003006ｧ902 06 applefi apple 閨070200 0ｸ7apple0800080707 000ｹ0 23Kda 02 06 006ｧ907 06 0006 apple00070203 016ｧ90709, 09 08apple086ｧ9 04 03 020209036ｧ9ｨB0002 06 applefi 006ｧ9 020ｸ7020306026ｧ8 apple000702 0000036ｧ8 08006ｧ8 02 06 0202060706026ｧ8 040ｸ700000002036ｧ9 0000 040900 6ｧ907080702 03fi0308 04020907 030406-026ｧ8 0708040803080906026ｧ8 apple070702090409 47. ﾇ apple030ｷ302000ｹ10709 0ｸ7026ｧ8 apple080200-03006ｧ9 閨07 026ｦ0apple08 0008036ｧ9080ｸ7 07 090706030604090ｹ0, apple080ｸ7 040ｸ707 閨0002 06 0400 0006 0602 閨0ｹ0 00080306 02 閨0ｹ0 03 閨0400060ｹ0 0806 08apple086ｧ9000ｹ0 0002026ｧ903000702 06 02 0207 0209 060703020006 02080ｸ7 020ｸ70202 030602086ｦ0 03 070702080ｸ7 6ｧ8 6 5036ｧ90402080702 06 0400 apple 030809fi07 6 5 02026ｧ80306.6ﾑ8apple06apple03 閨0807, 006ｧ907 06 02 020703030903080ｹ0 apple0308-09070ｷ304020602fi0ｹ0 006ｧ90202090ｹ0 0000 000009070308 0403fi0708 09006ｧ9040006 0ｹ0 ｨB0ｷ36ｧ80ｹ0 040208 apple03070400 02 06 00apple6ｧ9apple00 0402 03000307 040208 6ｧ900 48. ﾇ apple03080402 02000ｸ70206026ｧ8 03070409 02090ｹ0 CPR 040ｸ7076ｧ90402 02 06 04020907 07 09070603060409 02 06 0001080ｸ7 0002 閨030ｷ30409 020ｷ307 apple 030809fi070ｷ307 6 5 020209-036ｧ90ｷ307 apple0603 07fi07 00 閨040ｷ3 02090ｹ0 000700030908apple086ｧ90904090ｹ0 02080ｸ7 040ｸ700apple03090306- ﾒ080ｸ707086ｦ0apple090ｹ0, 08086ｦ003080ｹ0 00 02080ｹ0 0000 020907 0203 0406026ｧ8 08 fi 49. 6ﾒ208 040ｸ700apple036ｧ8030ｷ300 apple08020003006ｧ9 046ｦ004020900 apple030ｷ302000ｸ8070607 02 06 09030ｸ70208apple030ｷ302000ｸ8070607 02080ｸ7 0803086ｦ0 02 06 040ｸ70706040207 閨07 0700000408 000ｸ707020602fi 000904 07060400fi 02 0207 020ｷ307 6 5 0202090306 020607 030806000601000ｷ307, 09 000700030908apple086ｧ9090409 02080ｸ7 08apple086ｧ9080ｸ7 apple08020003006ｧ9 0402080604006ｧ908 04 03 020209030604020602fi 02090ｹ0 030406026ｧ80ｹ0 07080408-03080906026ｧ80ｹ0 07026ｧ9 03 04090ｹ0 02080ｸ7 0100070604026ｧ8 閨07 070206 020ｷ307 6 5 020209036ｧ90ｷ307. ﾒ 0207 040ｸ707 鐶pple0006 09 046ｦ00703000409 0400 apple08036ｦ0 0000090703000ｹ0 apple0804fi020902000ｹ0 02 06 09 閨020203060409 0ｸ7026ｧ80ｹ0 02090ｹ0 apple030ｷ302000ｹ107090ｹ0 applefi 02 09apple 0208026ｦ00202-03 0007 00040800 閨070ｷ30ｹ0 07 apple 03 020903006ｧ902 06 04020907 0801006ｧ9 08070409 02090ｹ0 080300090008076ｧ80ｹ0. ﾌ06 020ｸ70208026ｧ907000ｹ0 (IL-6, IL-1 02 06 TNF-a) apple080ｸ7 000202036ｧ907080702 06 applefi 02 00 020308080709 04020907 apple00030608046ｧ8 020ｷ307 6 503-6 50607 000700030908apple0806086ｦ007 00 閨040ｷ3 02090ｹ0 020ｸ70203080808036ｧ9 0ｹ0 020907 apple 03 090ｷ3-096ｧ8 02090ｹ0 CRP applefi 0208 6ｧ8apple 03. 00000ｷ30ｹ0, 09 0ｸ7apple0003apple 03 090ｷ3096ｧ8 02090ｹ0 CRP 096ｧ9070002 06 00060ｹ0 6 50703080ｹ0 02090ｹ0 036 5080ｸ7006ｧ907090ｹ0 02 06 0207apple08060ｷ307 0703030ｷ307 apple030ｷ302000ｸ8070607 02090ｹ0 0801006ｧ9 0ｹ0 080704090ｹ0 02090ｹ0 080300090008076ｧ80ｹ050. 6ｾ4020907 apple00036ｧ9apple020ｷ30409 020ｷ307 07fi040ｷ307 02080ｸ7 apple00030608 0807026ｧ9080ｸ7 02 040207 06 02090ｹ0 030406026ｧ80ｹ0 02 06 apple03060600090ｹ0 6 503076 5090ｹ0 0702060402080604086ｦ007 04020907 0801006ｧ9 0803000900080706 09 07026ｧ9 03 0409 0903 6ｧ8 0208 03040602fi 040207 0608 02090ｹ0 080ｸ7036ｧ90206 0ｹ0. ｮ00000ｷ30ｹ0, 0ｸ7010900 閨07 00apple6ｧ9apple00 02090ｹ0 CRP 0706-0407006ｦ0080702 06 02 06 0400 0403fi0706000ｹ0 0803000900080706 00060ｹ0 07fi04080ｸ70ｹ0 fiapple0ｷ30ｹ0 09 apple00030608 0807026ｧ90206, 09 0403fi0706 6 5030809046ｧ90206 02 03060ｹ0 02 06 0400 0403fi0706 080300090008076ｧ8 applefi C.pneumoniae 02 06 H. pylori 51. ﾇ CRP apple08020003006ｧ9 020807 0604040ｸ703fi02000308 apple030809070ｷ304020602fi 006ｧ9-020209 020ｷ307 02 03 06 09090006 020607 070804090007020ｷ307 52. 6ﾑ8apple06apple03fi04030002, 006ｧ907 06 02 03080306040206026ｧ8 09 040ｸ7006 508036ｧ8 02090ｹ0 040209 0ｸ70403000602080ｸ703096ｧ9 02080ｸ7 09090006 02086ｦ0 0007 080309036ｧ9080ｸ7 02 06 04020907 030903080402036ｧ8030ｸ707-0409 53,54. ﾇ apple030ｷ302000ｹ10709 0ｸ7026ｧ8 0007 閨040006 apple030809070ｷ3040206026ｧ8 016ｧ9 00fi0708 0906 00apple0602006ｧ900000708 閨000803 0900 000ｸ70802 03 6ｧ9080ｸ7 02 06 02 03-06 09090006 02fi 030707 0208, 030307 00apple6ｧ904090ｹ0 02 06 0906 0ｸ7010900 閨0708 026ｧ907-0ｸ70708 00000807070604090ｹ0 0009020008 030602086ｦ0 060404 06000602086ｦ0 00apple00060408 6ｧ9080ｸ7 02 06 apple00030608000306026ｧ80ｹ0 030209030608apple07030006 0ｹ055ｨC58. 6ﾒ2 00apple6ｧ9apple00 02090ｹ0 CRP 040208 apple03070400 fi02 07 006ｧ907 06 <1mg/L, 1-3mg/L 02 06 >3mg/L, 0ｸ7apple08 000602076ｦ0080ｸ707 080007 000ｹ0 04 0009036ｧ80ｹ0, 00 閨04090ｹ0 02 06 0ｸ76 709036ｧ80ｹ0 00apple06020607 0ｸ707fi020902 0ｹ0 07026ｧ90402080604. 6ｾ40ｸ709020002030600 閨07, fi040807 08080307 020907 0602 07fi020902 apple 03 090ｷ3-096ｧ80ｹ0 02090ｹ0 C- 070206 030604 0ｹ0 apple030ｷ302000ｹ107090ｹ0, 閨040006 apple08 00060403006ｧ9 fi0206 006ｧ907 06 09000700020602060ｹ0 apple030802 030803060400 閨0709 02 06 000703060402 040ｸ707 閨0002 06 0000 apple00030608046ｧ8 09080706 6ｧ90ｷ307 040208 04030ｷ300fi040ｷ300 1 59. 090308040807020ｷ30ｹ0, 閨04080ｸ707 020002000903060ｷ303006ｧ9 020300060ｹ0 apple08030ｸ700080308060400086ｧ9 09080706 6ｧ90ｷ307 ( 06-08080307 03030903080ｸ7046ｧ9 0ｹ0 DNA 0ｷ30ｹ0 apple03080ｹ0 閨07 07080ｸ702030008026ｧ9 0608) apple080ｸ7 030ｸ703006ｧ9ｨB080ｸ707 020907 apple 03 090ｷ3096ｧ8 02090ｹ0 C- 070206 030604 0ｹ0 apple030ｷ3-02000ｹ107090ｹ0 02 06 040ｸ707 閨080702 06 07000004 0000 0303 09 閨0ｹ0 0402 00apple6ｧ9apple00 02090ｹ0 CRP 040208 apple03070400 60ｨC62. 6ﾑ86ｧ907 06 apple08036ｦ0 apple0603 07fi 07020800 apple080ｸ7 076ｧ802080ｸ707 04020907 080007 0ｸ76 709036ｧ80ｹ0 00apple06020607 0ｸ707fi020902 0ｹ0 00000807070604090ｹ0 02 03 06 09090006 020607 070804090007020ｷ307, 07 閨04080ｸ707 apple08030ｸ700080308060400fi apple080ｸ7 00000606070006 020907 0402 030003fi020902 02090ｹ0 apple000702 000003086ｦ00ｹ0 08006ｧ80ｹ0 02090ｹ0 CRP. H CRP 060009006ｧ9030006 020907 apple0003000ｸ703 閨030ｷ30409 02090ｹ0 IL-6 02 06 02090ｹ0 0007 080309036ｧ907090ｹ0 applefi 02 0007 0803090306 0207 026ｦ00202 03, 000706-04046ｦ0080702 0ｹ0 020907 閨020803 0409 02080ｸ7 06 020ｸ70202 030602086ｦ0 0008036ｧ9080ｸ7 apple0308-0402fi03030904090ｹ0-1, 02080ｸ7 0008036ｧ9080ｸ7 apple03080402fi03030904090ｹ0-1 020ｷ307 09090006-020607 020ｸ7020207030ｷ307 02 06 02090ｹ0 6ﾑ8-0400030002026ｧ907090ｹ063,64. 0002 07 apple0308-04020803030903086ｦ007 02 03000ｸ70208026ｦ00202 03 040208 0007 08036ｧ8030608, 09 CRP 060009006ｧ9030006 020907 apple0003000ｸ703 閨030ｷ30409 02090ｹ0 04090000060802 020206026ｧ80ｹ0 apple030ｷ3-02006ｧ907090ｹ0-1 applefi 02 00080708026ｦ00202 03, 09 08apple086ｧ9 0000 0209 0400060307 02090ｹ0 06000ｸ70208036ｦ0070006 0209 000002 07070402000ｸ70409 020ｷ307 03000ｸ70208020ｸ7020207030ｷ307
13H apple00030608 08070206026ｧ8 080300090008076ｧ8 0ｷ30ｹ0 apple 030709080702 0ｹ0 00apple06020607 0ｸ707fi020902 0ｹ0 020ｷ307 060404 060006020607 02 03 06 09090006 020607 070804090007020ｷ307 117 04020807 0ｸ7apple0007 0803090306 02fi 04060308 65. 6ﾑ8apple06apple03080403 閨020ｷ30ｹ0, 07 0402 閨03-030002 06 applefi 020907 CRP 09 apple 03 090ｷ3096ｧ8 02080ｸ7 070602030602086ｦ0 08010006 6ｧ9080ｸ7 (03 ﾌ) applefi 02 0007 0803090306 0207 026ｦ00202 03. ﾌ apple 030709080702 0ｹ0 0ｸ702fi0ｹ0 06 03 00 026ｧ9ｨB0006 apple030ｷ302 03040602fi 03fi0308 04020907 06 026ｧ803090409 02080ｸ7 09090006 02086ｦ0 02fi07080ｸ7 02 06 07 0402 閨03030006 020807 apple080303 apple03 0406-0400fi 020ｷ307 03006ｧ90ｷ307 000ｸ70ｸ8020607 020ｸ7020207030ｷ307, 020907 0801006ｧ9 0ｷ30409 020ｷ307 0306apple08apple030ｷ302000ｸ8070607 04 0009036ｧ80ｹ0 apple0ｸ70207fi020902 0ｹ0, 020907 apple03080402fi030309-0409 02 06 040ｸ70902fi0303090409 020ｷ307 060008apple0002 036ｧ90ｷ307, 02 03060ｹ0 02 06 020907 apple03080402fi0303090409 020ｷ307 03000ｸ70208020ｸ7020207030ｷ307 040208 0007 08036ｧ8030608 6,67. 6ﾑ80202fi0ｹ0 020ｷ307 apple0308 07 08000303 閨07020ｷ307, 09 CRP 00070604046ｦ00006 020907 閨020803 0409 02080ｸ7 apple0ｸ70309070602086ｦ0 apple 030709080702-0208, 08 08apple086ｧ9080ｹ0 apple08-020003006ｧ9 040900 07020602fi 0000040803 6 509026ｧ8 02090ｹ0 030903080402036ｧ8030ｸ70704090ｹ0 02 03060ｹ0 apple 0300006 5 6ｧ9070006 07 0402 0302060207 040208 000904 07060400fi 070206-0402 030006040206026ｧ80ｹ0 090900060809 閨070004090ｹ0 040209 0403fi0706 060404 06006ｧ9 68. 6ﾒ2 閨03080ｹ0, 0ｸ7apple070304080ｸ707 07 080803 閨0ｹ0 02090ｹ0 030704090ｹ0 02090ｹ0 CRP 0402 03006ｧ9 000ｸ70ｸ80207 026ｦ00202 03 020ｷ307 0909006ｧ90ｷ307, 09 08apple086ｧ9 00070604046ｦ00006 020907 閨020803 0409 02 06 020807 03060300fi 020ｷ307 0ｸ7apple08 0804 閨0ｷ307 02090ｹ0 0909000608020007-046ｧ907090ｹ0 026ｦ0apple080ｸ7 1 in vitro 02 06 in vivo 69. ﾇ 0909000608020007046ｧ90709 ｦﾐｦﾐ 006ｧ907 06 閨07 0ｹ0 applefi 02080ｸ70ｹ0 040900 07020602fi020003080ｸ70ｹ0 6 506080007000309086ｦ00ｹ0 apple 030709080702000ｹ0 apple080ｸ7 0000apple03 閨02080702 06 04020907 090006080ｸ703096ｧ9 02 06 0001-03060109 02090ｹ0 030903080402036ｧ8030ｸ70704090ｹ0. ﾇ apple030006086 709086ｧ9 020ｷ307 03090308-04020309030ｸ7070206020607 000700030900060607 02090ｹ0 0909000608020007046ｧ907090ｹ0 II 00apple06020ｸ709-0407070002 06 00 閨040ｷ3 020ｷ307 0ｸ7apple08 0804 閨0ｷ307 02090ｹ0 0909000608020007046ｧ907090ｹ0 I. 6ｾ404 閨0409 apple00030608 08070206026ｧ80ｹ0 080300090008076ｧ80ｹ0 02 06 060404 060006026ｧ80ｹ0 02 03 06 09090006 026ｧ80ｹ0 07fi04080ｸ7 ﾌ06 0403fi0706000ｹ0 03080600060100060ｹ0 040ｸ700apple00030603 006 5 070800 閨07090ｹ0 02 06 02090ｹ0 apple00030608 08070206026ｧ80ｹ0 07fi04080ｸ7 006ｧ907 06 0ｸ707 02fi 07 apple030802 03 閨04080ｸ707 000000 閨040ｷ30ｹ0 02 02 04020308086ｧ8 applefi 020907 apple0003000ｸ703 閨030ｷ30409 020ｷ307 0000040803 6 509020607 02090ｹ0 080300090008076ｧ80ｹ0, fiapple0ｷ30ｹ0 0806 apple03080803000900080706-00060ｹ0 020ｸ70208026ｧ907000ｹ0 ｦﾐL-1, IL-6 02 06 6ﾒ2NF-a. 09 閨040ｷ3 02080ｸ7 00060203086 506-02086ｦ0 000300036ｧ90400 02080ｹ0 02 06 02090ｹ0 040ｸ704020900 0206026ｧ80ｹ0 0708040803080906026ｧ80ｹ0 apple0707020904090ｹ0, 0ｸ70107070002 06 09 046ｦ00703000409 02 06 閨020203060409 020ｷ307 6 50608-030809060207 03 040206020607 020ｸ702080206070607 040ｸ7006 5070303080702 0ｹ0 04020907 6ｦ00109-0409 020ｷ307 00apple06apple 陦0ｷ307 040208 6ｧ900 02090ｹ0 C- 070206 030604 0ｹ0 apple030ｷ3-02000ｹ107090ｹ0. 0906 0400060307 applefi 00apple06 090006080308090602 閨0ｹ0 000003 閨02000ｹ0 閨04080ｸ707 006ｧ9-010006 fi0206 09 apple00030608 0807026ｧ90206 0000 02060ｹ0 070804080308090602 閨0ｹ0 070206 0307-0400060ｹ0 apple080ｸ7 apple030802 03006ｧ9 02 06 020907 00apple 02fi03080ｸ70309 閨02030ｸ70409 020ｷ307 0000040803 6 5090206020607 apple 03 09fi07020ｷ307 02090ｹ0 080300090008076ｧ80ｹ0 006ｧ907 06 0ｸ707 02fi 07 040ｸ704040002060403006ｧ9 0000 020907 0000080707060409 02090ｹ0 060404 060006026ｧ80ｹ0 02 03 06 09090006 026ｧ80ｹ0 07fi04080ｸ7. 6ｾ400 006ｧ9 040ｸ7090403080706026ｧ8 000003 閨0209 apple080ｸ7 apple03 0900 0208apple08066ｧ803090200 0402060ｹ0 ﾇ.09. ﾞ, 09 apple00030608 08070206026ｧ8 07fi04080ｹ0 040ｸ707 閨0002 06 0000 0ｸ7010900 閨07 00apple6ｧ9apple00 apple030809070ｷ3040206020607 000602020607 02090ｹ0 00000807070604090ｹ0 020ｷ307 02 03 06 09090006 020607 070804090007020ｷ307 70. 6ｾ40ｸ709020002030600 閨07, 0400 apple00030608 0807020602086ｦ00ｹ0 04030007006ｧ90ｹ0 apple 03 0209036ｧ8-03090200 6ｦ001090409 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 C- 070206 030604 0ｹ0 apple030ｷ3-02000ｹ107090ｹ0 02 0207 30% 0400 046ｦ0090203060409 0000 0ｸ709066ｧ8 07020800. 6ﾑ8apple06apple03 閨0807, 09 apple00030608 08070206026ｧ8 07fi04080ｹ0 040ｸ707 閨0002 06 0000 006ｧ90202000ｹ0 0007 0803090306-026ｧ80ｹ0 0ｸ70403000602080ｸ703096ｧ9 0ｹ0 02 06 0ｸ7040306apple06 06006ｧ9 0ｹ0 apple080ｸ7 006ｧ907 06 09070ｷ3-0402086ｧ9 apple 030709080702000ｹ0 020607 6ｦ007080ｸ7 0906 0000080707060409 02 03 06 09090006-020607 070804090007020ｷ307. 6ﾑ8apple0006 6ｧ8, fi000ｷ30ｹ0, apple03fi02000602 06 0906 040ｸ7090403080706-026ｧ8 000003 閨0209, 02 apple08020003 閨0400 02 0ｸ7026ｧ80ｹ0 00 006ｧ90407080ｸ707 0604040ｸ703fi 040ｸ704040002060400fi, 030307 apple0603 076ｧ8 040ｸ70404 閨02060409 000002 016ｦ0 02090ｹ0 apple00030608-08070206026ｧ80ｹ0 07fi04080ｸ7 02 06 020ｷ307 02 03 06 09090006 020607 070804090007020ｷ307 apple080ｸ7 0808006ｧ903080702 06 0400 0309030804020309030ｸ707020602 閨0ｹ0 6 503076 5000ｹ0. 6ｾ400 040ｸ709040308070602 閨0ｹ0 000003 閨02000ｹ0 (cross-sectional trials) 02 06 06 040308070602 閨0ｹ0 apple 03 020803080ｸ7036ｧ80400060ｹ0 00 閨0303080702080ｹ0 (prospective trials) 02 0ｸ7010900 閨07 00apple6ｧ9apple00 040208 apple0003060800030602fi 6ｧ900 06 08fi- 030ｷ307 080300090008070ｷ3 0607 000602020607, fiapple0ｷ30ｹ0 09 CRP, 0208 06070ｷ3 0809fi- 0708 02 06 0806 020ｸ70208026ｧ907000ｹ0 IL-1, IL-6 02 06 TNF-a 040ｸ707 閨080702 06 0000 020907 6 5 036ｦ0020902 02090ｹ0 030903080402036ｧ8030ｸ70704090ｹ0 02 06 020807 026ｧ907 0ｸ70708 00000807070604090ｹ0 02 03 06 09090006 020607 070804090007020ｷ307 71ｨC73. ﾇ apple00030608-0807026ｧ90206 040ｸ7006 50703030006 04020907 6ｦ001090409 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 CRP, 02090ｹ0 IL-6 02 06 020ｷ307 080ｸ7 00020003fi0806030ｷ307 03000ｸ70208020ｸ7020207030ｷ307 040208 apple0003060800030602fi 6ｧ900. 6ｾ402080ｸ70ｹ0 apple00030608 0807020602086ｦ00ｹ0 04030007006ｧ90ｹ0 09 apple 03 020903086ｦ000000709 0ｸ7026ｧ8 6ｦ001090409 020ｷ307 080300090008070ｷ3 0607 apple 03-09fi07020ｷ307 0007 閨040002 06 07 00apple0602006ｧ9070006 020907 0803000900080706 09 03-0402090306fi020902 0402060ｹ0 0309030804020309030ｸ707020602 閨0ｹ0 6 503076 5000ｹ0, 0ｸ701070708-0702 0ｹ0 020807 026ｧ907 0ｸ70708 00000807070604090ｹ0 02 03 06 09090006 020607 070804090007-020ｷ307 74. 6ｾ400 006ｧ9 07030309 040ｸ7090403080706026ｧ8 000003 閨0209 6 503 閨03090200 040ｸ70404 閨02060409 000002 016ｦ0 00apple06apple 陦0ｷ307 02090ｹ0 080306026ｧ80ｹ0 0408030904020003fi03090ｹ0 02 06 020ｷ307 0306apple08apple030ｷ302000ｸ8070607 04 0009036ｧ80ｹ0 apple0ｸ70207fi020902 0ｹ0 040208 6ｧ900 02 06 0206000607 02080ｸ7 006ｧ9020209 07 09020607 apple00030608 08070206026ｧ80ｹ0 08030807026ｧ9 0ｹ0 02080607fi020902 0ｹ0 (C.P.I.T.N.) 02 06, 040ｸ709020002030600 閨07, 0000 020907 apple 03080ｸ7046ｧ9 apple00030608 08070206020607 030ｸ70307020ｷ307 75. 6ﾒ2 000ｸ7036ｧ800 02 02090ｹ0 000003 閨02090ｹ0 0ｸ7026ｧ80ｹ0 0ｸ7apple08040209036ｧ9ｨB080ｸ707 020907 6ｦ001090409 02080ｸ7 00apple06apple0803-0400086ｦ0 020ｷ307 02 03 06 09090006 020607 070804090007020ｷ307 0400 04030007006ｧ90ｹ0 0000 apple00030608 08070206026ｧ8 07fi0408. ﾞ0707030809 6ｧ802 07 02 06 02 000ｸ7036ｧ800 02 000003 閨02090ｹ0 09 08apple086ｧ9 07 08 閨030006 0ｸ7010900 閨07 00apple6ｧ9apple00 02090ｹ0 CRP 0400 04030007006ｧ90ｹ0 0000 02 03 06 09090006 02fi 07fi040900 02 06 apple 03080ｸ7046ｧ9 apple00030608 08070206020607 030ｸ70307020ｷ307 > 4mm 76, 000706 0400 04030007006ｧ90ｹ0 0000 02 03 06 09090006 02fi 07fi040900 apple 03 0209036ｧ803090200 006ｧ9 0402 020604020602060ｹ0 040900 070206026ｧ8 6ｦ001090409 02090ｹ0 CRP 02 06 02080ｸ7 06070ｷ3 0809fi07080ｸ7 0400 046ｦ0090203060409 0000 02 0009 070804086ｦ00702 07020800 77. 6ｾ400 04030007006ｧ90ｹ0 0000 apple00030608 0807026ｧ90206 07060407006ｦ0030902 07 0ｸ70109-00 閨07 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T 00apple6ｧ9apple00 02080ｸ7 apple 030709080702 02080ｸ7 apple 030709080702 von Willebrand 04020807 0803fi 02080ｸ7 6ｧ900 02080ｹ0 040ｸ7040400026ｧ9ｨB080702 06 0000 02 00apple6ｧ9apple00 020ｷ307 0008036ｧ90ｷ307 apple03080402fi03030904090ｹ0, 0ｸ7apple08 000602076ｦ0080702 0ｹ0 apple0603 076ｧ8 040ｸ70404-02060409 000002 016ｦ0 02080ｸ7 apple 030709080702 02080ｸ7 von Willebrand 02 06 020ｷ307 0303090300apple06 030704000ｷ307 03000ｸ70208020ｸ7020207030ｷ307-0007 0803090306 020607 020ｸ702-0207030ｷ307 80. 08apple070304080ｸ707, 0ｷ30402fi0408, 02 06 07 080803 閨0ｹ0 apple080ｸ7 0007 0ｸ7apple08040209-036ｧ9ｨB080ｸ707 0000 閨0008 0409 020907 0404 閨0409 000002 016ｦ0 020ｷ307 02 03 06 09090006-020607 070804090007020ｷ307 02 06 02090ｹ0 apple00030608 0807026ｧ90206 0ｹ0. 6ｾ40ｸ709020002030600 閨07, 0806 Hujoel 02 06 040ｸ707. 81 07 08 閨03080ｸ707 0006 fi0406 0604040ｸ7036ｧ8 0404 閨0409 000002 016ｦ0 02090ｹ0 apple00030608 0807026ｧ90206 0ｹ0 02 06 020ｷ307 02 03 06 09090006 020607 070804090007020ｷ307, 000706 07026ｧ90402080604 000ｸ7036ｧ800 02 apple 03080ｸ7040607ｨB080702 06 02 06 applefi 02080ｸ70ｹ0 Joshipura 02 06 040ｸ707. 82. 08apple070304080ｸ707 03020002 閨0ｹ0 0007 006ｧ90100060ｹ0 fi0206 09 040ｸ707020903090206026ｧ8
13118 ﾒ080ｸ707086ｦ0apple090ｹ0, 08086ｦ003080ｹ0 apple00030608 08070206026ｧ8 030003 apple006ｧ9 040300070607 0000 04020008 0706 6ｧ9 07fi0408 00apple0608 閨030006 00006ｧ90ｷ30409 020ｷ307 00apple06apple 陦0ｷ307 020ｷ307 080300090008070ｷ3 0607 02 06 0600080402 0206020607 apple 03 09fi07020ｷ307, 000202fi0ｹ0 02080ｸ7 apple 030709080702 02080ｸ7 von Willebrand. 090002 016ｦ0 020ｷ307 080300090008070ｷ3 0607 02 06 0600080402-0206020607 apple 03 09fi07020ｷ307, apple 03 0209036ｧ803090200 006ｧ9 0402 020604020602060ｹ0 040900 070206026ｧ8 00006ｧ90ｷ30409 0906 020907 CRP 02 06 02060ｹ0 08010006 0ｷ300 閨07000ｹ0 0306apple08apple030ｷ302000ｹ107000ｹ0 04 0009036ｧ80ｹ0 apple0ｸ70207fi020902 0ｹ0 (Ox-LDL) 020300060ｹ0 006ｧ807000ｹ0 00000207 020907 08030802036ｧ8030ｷ30409 02090ｹ0 030003 apple006ｧ9 0ｹ083. 6ｾ46ｦ000080ｷ3-07 0000 070303000ｹ0 000003 閨02000ｹ0 0806 Ox-LDL 6 503 閨030902 07 0400 0ｸ76 70903fi0200-03 00apple6ｧ9apple00 040208 apple03070400 040300070607 0000 04020008 0706 6ｧ9 07fi0408 02 06 09 040ｸ70404 閨02060409 000002 016ｦ0 02090ｹ0 0801006ｧ9 0ｷ304090ｹ0 020ｷ307 LDL 02 06 02090ｹ0 0309030809 閨070004090ｹ0 apple08 fi03090200 04020907 6 503076 509 apple080ｸ7 apple030802 03086ｦ007 0806 Ox-LDL 0402 0007 0803090306 0207 02 06 0ｸ7apple0802006ｧ9000007 026ｦ00202 03 02080ｸ7 0302090306 02086ｦ0 020806040600 02080ｹ084,85. 6ﾑ8apple6ｧ904090ｹ0 006ｧ9 apple03fi0408 0209 000003 閨0209 00apple06040900 6ｧ9070006 fi0206 09 00apple06020ｸ7040900 閨0709 apple00030608 08070206026ｧ8 030003 apple006ｧ9 0000 020907 00030702020ｷ30409 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 CRP 04020807 0803fi 00apple0803006ｧ9 07 08 09096ｧ8040006 0400 00006ｧ90ｷ30409 02080ｸ7 020607 6ｦ007080ｸ7 00000807-070604090ｹ0 020ｷ307 02 03 06 09090006 020607 070804090007020ｷ307 apple080ｸ7 040400026ｧ9ｨB080702 06 0000 020907 CRP, 03 006 50707080702 0ｹ0 0ｸ7applefi6 709 020907 apple0603 076ｧ8 040ｸ7006 508036ｧ8 02090ｹ0 040ｸ704020900 0206026ｧ80ｹ0 0803000900080706 080ｸ70ｹ0 02 06 0708040803080906026ｧ80ｹ0 07026ｧ9 03 04090ｹ0 040209 06 0602 046ｧ9 02090ｹ0 030903080402036ｧ8030ｸ70704090ｹ086. 6ｾ400 04030007006ｧ90ｹ0 0000 0403fi0706 0900070602000ｸ700 閨0709 apple00030608 0807026ｧ90206 09 00006ｧ90ｷ3-0409 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 C- 070206 030604 0ｹ0 apple030ｷ302000ｹ107090ｹ0 02 06 02090ｹ0 ｦﾐL-6 040ｸ707 閨03090200 0000 0208 6 5 0300fi 0702 applefi02030604090ｹ0 020ｷ307 apple00030608-08070206020607 0604020607 04020907 0008 030008ｨBfi00000709 040ｸ707020903090206026ｧ8 030003 - apple006ｧ9. ﾌ06 000006060400060ｹ0 020ｷ307 00apple06apple 陦0ｷ307 020ｷ307 000602020607 6ｧ802 07 040900 07020602 閨0ｹ0 0402060ｹ0 apple000306apple02060400060ｹ0 apple080ｸ7 06 apple0604020603090200 6 50003026ｧ90ｷ3-0409 020ｷ307 0203060706020607 apple 03 00 閨02030ｷ307 87. 6ﾑ8apple6ｧ904090ｹ0, 0ｸ7apple070304080ｸ707 07 080803 閨0ｹ0 04040002060207 0000 020907 000ｸ70003-09000206026ｧ8 03070409 020ｷ307 07020600060203086 506 020607 apple 03 09fi07020ｷ307 040208 apple03 6ｧ9040608 02090ｹ0 040ｸ707020903090206026ｧ80ｹ0 apple00030608 08070206026ｧ80ｹ0 030003 apple006ｧ9 0ｹ0 0400 0404 閨0409 0000 02 00apple6ｧ9apple00 02090ｹ0 CRP 02080ｸ7 0803086ｦ0. 03020406, 030806applefi07, 09 0208apple06026ｧ8 0008 030008096ｧ8 10mg 02080ｸ7 0702066 50608020602086ｦ0 00060708020ｸ702036ｧ90709 0906 040308070602fi 060704020900 0007fi0ｹ0 000907fi0ｹ0 0402080ｸ70ｹ0 030ｸ7030702080ｸ70ｹ0 15 040300070607 0000 0403fi0706 apple00030608 0807026ｧ90206 apple0308020703000400 00006ｧ90ｷ30409 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 CRP 02 06 02080ｸ7 TNF-a. 6ｾ40ｸ709020002030600 閨07, fi040807 08080307 02060ｹ0 00 閨04000ｹ0 020600 閨0ｹ0 02090ｹ0 C- 070206 030604 0ｹ0 apple030ｷ3-02000ｹ107090ｹ0 apple 03 0209036ｧ803090200 00006ｧ90ｷ30409 applefi 1,6+1,7ng/mL 0400 0,93+1,0 ng/ml 88. 6ﾒ2 000ｸ7036ｧ800 02 0006 0ｹ0 070303090ｹ0 000003 閨02090ｹ0 07 08 閨03080ｸ707 0209 0404 閨0409 000002 016ｦ0 0ｸ7010900 閨070ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 CRP 04020807 0803fi 02 06 02090ｹ0 apple 03080ｸ7046ｧ9 0ｹ0 020ｷ307 apple00030608apple 030809fi070ｷ307 6 5 020209036ｧ90ｷ307 P. gingivalis, T.forsythensis 02 06 P.intermedia 0ｸ7apple08080ｸ703060207. 6ﾒ2 00apple6ｧ9apple00 02090ｹ0 CRP 6 503 閨030902 07 0ｸ7010900 閨07 0400 07020800 030002060207 04020907 apple 03080ｸ7046ｧ9 apple00030608apple 030809fi070ｷ307 04020907 0ｸ7apple08080ｸ70306026ｧ8 04030ｷ3-036ｧ9 040ｸ70902030602060207 0000 0002006ｧ907 apple080ｸ7 6ｧ802 07 03070902060207 89. 6ｾ4020907 apple030804apple07030006 0200020009036ｧ90ｷ304090ｹ0 02090ｹ0 040ｸ70404 閨020604090ｹ0 02090ｹ0 apple00030608 08070206026ｧ80ｹ0 07fi04080ｸ7 0000 02 0ｸ7010900 閨07 00apple6ｧ9apple00 020ｷ307 apple030ｷ3-02000ｸ8070607 02090ｹ0 0801006ｧ9 0ｹ0 080704090ｹ0 02090ｹ0 080300090008076ｧ80ｹ0, 0207apple0806000ｹ0 0003000ｸ70709020602 閨0ｹ0 000003 閨02000ｹ0 04030904060008apple086ｧ90904 07 apple000603 00 020602fi 00080702 閨0308 0607 0602086ｦ0 0408060306 6ｧ9080ｸ7 040208 08apple086ｧ908 apple 03 040602086ｦ00400 0208 apple00030608apple 030809fi0708 06. gingivalis 90ｨC93. 6ｾ46ｦ000080ｷ307 0000 020807 apple0006-03 00 020602fi 040400 06 0400fi 020ｷ307 00000300020607 0ｸ7020607 apple 03 0209036ｧ80309-0200 00000207 applefi 0007080803 0300060400fi 02080ｸ7 P. gingivalis 0400 0607 060207 040806036ｧ9 06 090006080ｸ703096ｧ9 0309030ｷ300 0206020607 apple03 020607 0402 0909006ｧ9. 09 030703030903, 6 503 閨030902 07 0ｸ7010900 閨07 00apple6ｧ9apple00 02090ｹ0 CRP, 02o0ｸ7 000ｸ703080006 086ｦ00ｹ0 ﾞ, 02090ｹ0 ｦﾐL-6, 02080ｸ7 0008036ｧ9080ｸ7 apple03080402fi03030904090ｹ0-1 020ｷ307 09090006 020607 020ｸ7020207030ｷ307 02 06 02090ｹ0 000002 030308apple030ｷ302000ｸ8070704090ｹ0 ｨB0003 0206070704090ｹ0 04020807 0803fi. 6ﾑ80202fi0ｹ0 02080ｸ7 P. gingivalis 07 08 閨030002 06 02 06 09 apple 03080ｸ7046ｧ9 0703030ｷ307 apple00030608apple 030809fi070ｷ307 6 5 020209036ｧ90ｷ307, fiapple0ｷ30ｹ0 02090ｹ0 T. forsythensis, 02090ｹ0 P. intermedia 02 06 02080ｸ7 ﾞ. 0400 0ｸ7applefi0402030ｷ3-00 0309030ｷ300 0206020607 apple03 020607 94,95. 6ﾑ8apple06apple03 閨0807, 0806 S. sanguis 02 06 P. ginginalis 00apple0803086ｦ007 07 00apple0608 閨03080ｸ707 000700030908apple086ｧ9090409 02 06 040ｸ70902fi0303090409 020ｷ307 060008apple0002 036ｧ90ｷ307 00 閨040ｷ3 020ｷ307 02080303 0908-07086ｦ0040ｷ307 apple030ｷ302000ｸ8070607 apple080ｸ7 06 03 閨02080ｸ707 040209 020ｸ70202 0306026ｧ8 02080ｸ70ｹ0 00apple060807070006 (PAAP, platelet aggregation-associated proteins) 96,97. ﾌ06 0306apple08apple08030ｸ704 0204 036ｧ902000ｹ0 020ｷ307 apple00030608apple 0308-09fi070ｷ307 6 5 020209036ｧ90ｷ307 02 06 070303 030806000809fi07 040ｸ70402 02060207 006ｧ907 06 0ｸ707 02fi 07 00apple0903000704080ｸ707 020907 020003 06fi020902 02080ｸ7 09090006 02086ｦ0 0007 080309036ｧ9080ｸ7 000002 6 5070303080702 0ｹ0 0209 08006ｧ8 020ｷ307 apple030ｷ302000ｸ8070607 020ｷ307 0007 0803090306 020607 020ｸ7020207030ｷ307 02 06 00apple0608 閨03080702 0ｹ0 apple080303 - 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apple07070ｷ3 03 apple03 鐶pple0006 07 010608030809086ｦ00702 06 0000 00apple06086ｦ003 0109 02 000ｸ7036ｧ800 02 020ｷ307 00apple06 0900060803080906020607 00000300020607 apple080ｸ7 040ｸ707 閨080ｸ707 0209 0803000900080706 09 06000309 046ｧ9, 0007 apple030802000600 閨070ｷ3 020907 apple00030608 08-070206026ｧ8 07fi0408 0000 020907 060404 060006026ｧ8 02 03 06 09090006 026ｧ8 07fi0408. 0307 000306020900 apple080ｸ7 026ｧ9030002 06 02 06 09 apple070702090409 02080ｸ7 08apple086ｧ9-080ｸ7 apple0603 07060ｹ0 07 00070604046ｦ0040006 0209 040ｸ70404 閨02060409 000002 016ｦ0 020ｷ307 6ｦ008 070804090007020ｷ307, 006ｧ907 06 02 0207 applefi0408 09 030003 apple006ｧ9 02090ｹ0 apple00030608 08-07026ｧ90206 0ｹ0 02 06 0006 0602fi020003 09 07020600060203086 506 026ｧ8 apple030804 閨0909060409 02080ｸ7 apple03086 5036ｧ800 02080ｹ0 040ｸ7006 50703030006 040209 00006ｧ90ｷ30409 02080ｸ7 020607 6ｦ007080ｸ7 00000807070604090ｹ0 02 03 06 09090006 02086ｦ0 00apple00060408 6ｧ9080ｸ7. 縺06 07 0803006ｧ9 0006 020002000903060ｷ300 閨0709 apple070702090409 040208 apple 03 apple07070ｷ3 000306020900 apple 0602006ｧ902 06 000009 036ｦ0020003080ｹ0 03060300fi0ｹ0 00000300020607 0000 02 036ｦ002000308 040400 06 0400fi, 0906 閨0300090408 020ｷ307 apple 03 09fi07020ｷ307 0002006ｧ9070ｷ307 apple080ｸ7 0000apple03 閨02080702 06 04020907 06020608apple 030809 閨070006 020ｷ307 6ｦ008 070804090007-020ｷ307. ﾞ0ｸ702fi 03 00apple0803086ｦ00400 07 00apple0602000ｸ70403006ｧ9 07 090607fi02 07 06-040ｷ303060400fi0ｹ0 02080ｸ7 0ｸ7030602086ｦ0 020ｷ307 00000300020607 0400 0ｸ7apple08080007 000ｹ0 0000 06 0808030002060207 04 03 02020903060402060207, 閨020406, 06040200 07 apple0808006ｦ00900-02 06 02 0207 0208 0ｸ707 02fi07 09 0303090300apple6ｧ9 03 0409 000002 016ｦ0 020ｷ307 06-08fi030ｷ307 apple0308 06 03000406020607 apple 03 09fi07020ｷ307 02090ｹ0 02 03 06 09090006-026ｧ80ｹ0 07fi04080ｸ7 02 06 020ｷ307 0702060402086ｧ9040ｷ307 02090ｹ0 apple00030608 08070206026ｧ80ｹ0 080300090008076ｧ80ｹ0. 08066 50306080903 086ｧ9 1.World Health Organization.The world health report 1995: bridging the gaps. 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