CLINICIAN 11 NO. 602 16
Chemical Exchange Saturation Transfer Forsen Hoffman Balaban Exchange Magnetization Transfer CEST agent -NH -OH CEST agent CEST agent 17 CLINICIAN 11 NO. 602
A B Z- CEST CLINICIAN 11 NO. 602 18
CEST agent CEST agent Diamagnetic CEST DIACEST Paramagnetic CEST PARACEST -NH 0ppm +3.5ppm ± 3.5ppm Ssat 3.5ppm Ssat+3.5ppm /S0 Ssat 3.5ppm Ssat+3.5ppm 3.5ppm +3.5ppm S0 19 CLINICIAN 11 NO. 602
AAPT.ppm APT APT Bppm APT CLINICIAN 11 NO. 602 20
A T BAPT APT CT DAPT APT 21 CLINICIAN 11 NO. 602
-OH -OH +0.6ppm 0.6ppm glycocest -OH +0.5 1.5 ppm CLINICIAN 11 NO. 602 22
gag CEST 1ppm 3.2ppm gagcest gagcest Z-..ppm CEST 23 CLINICIAN 11 NO. 602
gagcest slow <_ Eu Tb Dy Yb Tm Gd PARACEST agent Eu-DOTA-4AmCE 3+ +50ppm 5ppm Eu-DOTA-4AmCE - 50 ppm Tb-DOTA-4AmCE - 600ppm in vitro in vivo CLINICIAN 11 NO. 602 24
PARACEST agent Eu-DOTA-AmCE Z- DIACEST ppm 25 CLINICIAN 11 NO. 602
smart Ward, K. M., et al. : A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J. Magn. Reson., 143 (1), 79-87 (2000) Zhou, J., et al. : Using the amide proton signals of intracellular proteins and peptides to detect effects in MRI. Nat. Med., 9 (8), 1085-1090 (2003) Haris, M., et al. : In vivo mapping of brain myo-inositol. NeuroImage, 54 (3), 2079-2085 (2011) Van Zijl, P. C., et al. : MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycocest). Proc. Natl. Acad. Sci. USA, 104 (11), 4359-4364 (2007) Woods, M., et al. : Paramagnetic lanthanide complexes as PARACEST agents for medical imaging. Chem. Soc. Rev., 35 (6), 500-511 (2006) CLINICIAN 11 NO. 602 26