Comparison One of the Method to Select Automatic Dividing and Packing Machine for Powder and Granule Drugs of Efficiency between OMP-90 and YS-63R MASAHIDE YAMASHITA*2,TAKESUKE HIROSE*3,HIROSHI NAKAMURA*3, KEIKI TANNO*4 Department of Pharmacy,Niigata Welfare Agricultural Co-operative Association Tochio-gou Hospital*2 Department of Pharmacy,Niigata Welfare Agricultural Co-operative Association Central and General Hospital*3 Department of Pharmacy, Niigata University Hospital*4 (Received February 22,1989) In order to examine the efficiency of dispensing work in the stage of dividing and packing of powders,by new automatic dividing and packing machines introduced,monte Carlo simulation was carried out by a computer.at the same time,the new machines were tested for error of dividing weight,the accuracy of dividing weight in relation to the number of subpacks,and the rate of loss.the machines tested were TOKYOSYOKAI OMP-90 type(omp)equipped with a linear vibrator to feed powders into the division holes by alternating motion,and YUYAMA YS-63R type(ys)with a linear vibrator to feed into the revolving disk(80rpm),which was formed by gap of V-like.Fine Lactose,SM(R),powder,Crystalline Lactose,MIYA-BM(R),Fine Granule,and Berizyme(R),Granule were selected as the sample for the studies. As a result of simulation,ys was more efficient than OMP in the service system.ys showed smaller variations of dividing weight than OMP tested.in case of OMP,dividing weight of the third and the third last packages at the turn of linear vibrator,was much heavier than that of other packages.in some of these drugs,errors in dividing weight increased with a greater number of subpacks.for the rate of loss,ys was slightly smaller than OMP tested. As for the automatic dividing and packing machine,the accuracy of dividing weight is contrary much to efficiency of dividing and packing speed.therefore,these results suggest that this method is much useful to select a machine by using the two kinds of contrary factors from the practical point of view. Keywords automatic dividing and packing machine; computer; dispensing; Monte Carlo simulation;efficiency; powder;granule;weight variation gaoka,940 Japan Niigata,951 Tochio-shi,Niigata,940-02 Japan Japan
Table 1.Physical Properties of Samples (Mean
1:Feeder 2:The revolving disk [8Orpm] is formed by gap of V-like 3:The roter to divide 1:The R-disk 5:Division hole Fig.1.Diagram of OMP-90 and YS-63R Fig.2.Flow Chart of the Monte Carlo Simulation Signs P1,P2,P3,Judge, and N mean Program 1,Program 2,Program 3, selecting machine,and number of simulation respectively. V21P,V42PA,V42PB,OMP-90 and YS-63R mean name of machine.
Fig. 3. Service Time Distribution at Stage of Dispensing Powders Observed valve Percent of prescriptions stayed in stage of despensing powders more than t seconds
Table 2.The Result of Simulation Analysis (n=5) Fig.4.Service Time Distribution at Stage of Dividing and Packing Percent of prescriptions stayed in dividing and packing stage
Fig.5.Relationship between Pack Number and Weight after Dividing(21 packs) Fine Lactose, Berizym(R)Granule, SM(R)Powder, Miya(R)-BM Fine Granule, Crystalline Lactose
Fig.6.Relationship between Pack Number and Weight after Dividing(56 packs)
Fig.7. Comparison of 2 Types of Machines on Coefficient of Variation of Weight after Dividing Table 3. The Accurancy of Dividing Weight in Relation to the Number of Subpacks and the Rate of Loss :Significant(p<0.05):F(2,6;0.05)=5.14 :Extremely significant (t)<0.01):f(2.6:0.01)=10.9 Signs S,ƒÓ,V,F,A and E mean Sum of Squares,Degrees of Freedom, Unbiased Variance,F-Value, Factor and Residual,respectively.