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"proteinaceous infectious particles" ( ) (PrP Sc ) (PrP C ) PrP C PrP Sc PrP Sc 9
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(1) (2) 11
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(1) (2) (3) 17
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(1) Creutzfeldt-Jakob - -. Clinical neuroscience2001,19 : 922-925 (2). 11, 2000 25
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( ) CJD CJD CJD (1) (2) (3) (4) (5) (6) (7) 3SDS (8) (9) (10) (11) 60 2 (12) 1N 29
(13) 3SDS (14) (15) (16) (17) BDA : Advice Sheet A12, Infection Control in Dentistry. 2000. Report of the working group on decontamination of instruments in dental services in Scotland. 2002.2. WHO : WHO infection control guidelines for transmissible spongiform encephalopathies. Report of a WHO consultation. Geneva, Switzerland, 23-26 March 1999. CJD Incidents Panel : Management of possible exposure to CJD through medical procedures. A consulting paper. October 2001. CJD Incidents Panel : PUBLIC SUMMARY of the meeting. 17 th April 2002. 2002. 30
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6 (2) (Ziploc) 11 37
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Nalgen 2118 047-421-2181 Nalgen 2116 047-421-2181 TM TM 047-421-2181 41
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CJD (1) CJD CJD CJD CJD CJD DNA (2) 2 46
CJD CJD CJD CJD CDC (3) CJD CJD CJD CJD CJD CJD CJD 47
(4) CJD (1) http://www.med.or.jp/wma/helsinki00_j.html (2) WHO/HGN/ETH/00.4 14 10 7 (3) 13 3 29 http://www2.ncc.go.jp/elsi/index.htm (4) 14 6 17 http://www.niph.go.jp/wadai/ekigakurinri/index.htm/ 48
(CJD Incidents Panel: Management of possible exposure to CJD through medical procedures. October 2001. Department of Health Publications, London ) ACDP Advisory Committee on Dangerous Pathogens 1981 BSE Bovine Spongiform Encephalopathy CDSC Communicable Disease Surveillance Centre CJD Creutzfeldt-Jakob Disease = CWD Chronic Wasting Disease. Cleaning CNS Central Nervous System Contactable Patient CJD CSF Cerebrospinal fluid Decontamination Definite case of CJD ( ) CJD Dose response relationship Dura mater Endoscope 49
Familial CJD FFI Florid plaque GSS HGH Kuru Iatrogenic CJD IVH Lymphoreticular system (LRS) CJD (PrP) Fatal Familial Insomnia CJD Gerstmann-Sträussler-Scheinker syndromegss CJD HGH CJD 1900 CJD intravenous hyperalimentation CJD CJD Median infective dose (ID 50 ) 50% Medical device NCJDSU The National CJD Surveillance Unit CJD 1990 CJD Possible case of CJD ( ) CJD Prion Proteinaceous infectious agent CJD TSE Prion protein (PrP) 50
(1) PrP Sc, (2) PrP C 2 (1) TSE (PrP Sc )(2) PrP (PrP C ) Probable case of CJD ( ) CJD Prophylactic PrP C PrP Sc PSD Scrapie SEAC Single use device PrP PrP C PrP Periodic synchronized discharge Creutzfeldt-Jakob CJD TSE TSE Spongiform Encephalopathy Advisory Committee 1990 4 Sporadic CJD CJD CJD CJD TME Transmissible mink encephalopathy TSE Transmissible Spongiform Encephalopathy (TSE) CJD BSE Variant CJD CJD 1996 BSE CJD new variant CJD 51
( ) 52