136ﾑ80303090706026ｧ8 03000803080308096ｧ9 2008; 20 (2): 139-147 09030ｷ302fi020ｸ7apple09 000309 046ｧ9 H 00apple6ｧ9 03 0409 02090ｹ0 030804080ｸ76 5 0402 026ｧ907090ｹ0 040209 0700080306026ｧ8 03000602080ｸ703096ｧ9 02 06 040209 0700080306026ｧ8 apple 閨020203060409 apple030ｷ302000ｸ8070607 0400 04030007006ｧ90ｹ0 0000 apple030ｷ30208apple 036ｧ8 0ｸ7040306apple06 06006ｧ9 09. ﾒ0ｷ30402 apple0707080ｹ01 01. 090903060607090ｹ01 ｦﾌ. 6ｾ4 086ｦ00902080ｹ01 01. ﾒ0ｷ30402 0307 2 6ﾑ8. 09apple 0ｸ803 0202070309 2 09. 6ﾑ80306040708 1 0900036ｧ903096 709 6ｾ40208applefi0ｹ0. ﾇ 0002026ｧ900090409 02090ｹ0 00apple6ｧ9 03 04090ｹ0 02090ｹ0 030804080ｸ76 5 0402 026ｧ907090ｹ0, 0400 0607080803000ｹ0 fi0400060ｹ0, 04020907 apple030ｷ302000ｸ807080ｸ7036ｧ9 02 06 040209 0700080306026ｧ8 03000602080ｸ703096ｧ9-040300070607 0000 apple030ｷ30208apple 036ｧ8 0ｸ7040306apple06 06006ｧ9. ﾞ04030007006ｧ90ｹ0 ｨC 09 閨0308 0806. 6ｾ40209 000003 閨0209 040ｸ700000002006ｧ904 07 90 04030007006ｧ90ｹ0 0000 apple030ｷ30208apple 036ｧ8 0ｸ7040306apple06 06006ｧ9 0806 08apple086ｧ90806 020ｸ704 0608apple08066ｧ8030902 07 0400 030804080ｸ76 5-0402 026ｧ90709 10 mg/0900 閨03 (080007 RSV10) 6ｧ8 20 mg/0900 閨03 (080007 RSV20). 09030607 applefi 0209 0408036ｧ809090409 030804080ｸ76 5 0402 026ｧ907090ｹ0, 02 03060ｹ0 02 06 00000207 applefi 12 006 5 080007 000ｹ0 090ｷ3096ｧ80ｹ0 apple030804 0608036ｧ904030902 07 0806 040ｸ7090200070203060400060ｹ0 020ｷ307 080306020607 03000ｸ7020ｷ30007020ｷ307, 02090ｹ0 03000ｸ7020ｷ300 026ｧ907090ｹ0, 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0, 02090ｹ0 07080408-0408 06036ｧ907090ｹ0 G 02 06 02090ｹ0 020300 0206076ｧ907090ｹ0 0400 006ｧ90900 apple030ｷ306070607 086ｦ0030ｷ307. ﾇ 0700-080306026ｧ8 apple 閨020203060409 020ｷ307 apple030ｷ302000ｸ8070607 apple030804 0608036ｧ90403090200 0000 6 5070409 0208 03fi0908 02090ｹ0 040ｸ70902 閨0702030ｷ304090ｹ0 020ｷ307 apple030ｷ302000ｸ8070607 apple03080ｹ0 0209 040ｸ70902 閨0702030ｷ30409 02090ｹ0 020300-0206076ｧ907090ｹ0 020ｷ307 086ｦ0030ｷ307. ﾇ 0700080306026ｧ8 03000602080ｸ703096ｧ9 apple030607 02 06 00000207 0209 030003 apple006ｧ9 00020206006ｧ803090200 0000 020807 apple030804 060803060400fi 02080ｸ7 030ｸ70300086ｦ0 04apple000603 00 0206026ｧ80ｹ0 066ｧ80309-04090ｹ0 (GFR). ﾞapple08020003 閨0400 02. ﾇ 0408036ｧ809090409 030804080ｸ76 5 0402 026ｧ907090ｹ0 040ｸ7040400026ｧ90403090200 0000 006ｧ9 0804080001 03020600000709 6ｦ001090409 02090ｹ0 0700080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 02090ｹ0 1 0006-0203080408 06036ｧ907090ｹ0 (02 0207 17,6% 04020907 080007 02090ｹ0 RSV10, p<0,05 02 06 02 0207 34,9% 04020907 080007 02090ｹ0 RSV20, p<0,01). 040007 apple 03 0209036ｧ803090200 040900 070206-026ｧ8 000002 6 508036ｧ8 02080ｸ7 GFR 0402060ｹ0 080007 000ｹ0 020ｷ307 040300070607, 000202fi0ｹ0 applefi 006ｧ9 0207-0409 6ｦ00109046ｧ80ｹ0 02080ｸ7 04020907 080007 RSV20 (79,3 ﾀ11,5 閨07 070206 82,9 ﾀ13,9 ml/min/1,73 m 2 apple030607 02 06 00000207 0209 030003 apple006ｧ9 07026ｧ90402080604, p=0,08). 6ｾ40ｸ700apple0003070400 02. ﾇ 030804080ｸ76 5 0402 026ｧ90709 apple030802 03006ｧ9 006ｧ9 0804080001 030206-00000709 6ｦ001090409 02090ｹ0 0700080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0 02 06 0007 00apple09030007ｨB0006 0209 0700080306026ｧ8 03000602080ｸ703096ｧ9 0400 04030007006ｧ90ｹ0 0000 apple030ｷ30208apple 036ｧ8 0ｸ7-040306apple06 06006ｧ9. 閨0100060ｹ0 02030006 0607: 1-00060203080408 06036ｧ90709, 0700080306026ｧ8 03000602080ｸ703096ｧ9, apple030ｷ302000ｸ807080ｸ7-036ｧ9, 030804080ｸ76 5 0402 026ｧ90709. 6ﾑ80604 090ｷ3096ｧ8 1 ｦ 0800 陦 0ｹ0 09 03080308096ｧ9 0ｹ0, 2 6ﾑ80309 04026ｧ8030608 ﾒ03060706026ｧ80ｹ0 010900006ｧ9 0ｹ0 ｦﾐ 020306026ｧ8 6ｾ40408036ｧ8 09 0700apple06040209006ｧ9080ｸ7 ｦﾐ0ｷ3 07076ｧ9070ｷ307, ｦﾐ0ｷ30707070607 O06 0402 026ｧ907000ｹ0 apple08020003086ｦ007 020807 020308090ｷ30706 6ｧ908 036ｧ90308 02090ｹ0 08 0300 02000ｸ7-0206026ｧ80ｹ0 07020600000206apple0604090ｹ0 02090ｹ0 0ｸ7040306apple06 06006ｧ9 0ｹ01. 090003 閨02000ｹ0 apple030ｷ30208090007086ｦ00ｹ0 02 06 000ｸ702000308090007086ｦ00ｹ0 apple03fi03096 7090ｹ0 陦000601 07 fi0206 0806 0402 026ｧ907000ｹ0 0000060607080ｸ707 020907 02 03 06 09090006 026ｧ8 0708040903fi020902 02 06 03070902fi020902, 02 03060ｹ0 02 06 0209 040ｸ7-07080306026ｧ8 03070902fi020902 2,3. 6ﾑ8apple06apple03fi04030002, 0000090703000ｹ0 apple08030ｸ702000702030602 閨0ｹ0 000003 -
1309. ﾒ036ｾ4ｦ ﾞ09 ﾞ03O6ｾ4 ﾒ ﾞｦﾐ 6ｾ40803. 6ﾑ80303090706026ｧ8 03000803o03o096ｧ9 20, 2008 02000ｹ0 陦000601 07 fi0206 09 030003 apple006ｧ9 0000 0402 026ｧ907000ｹ0 040ｸ7006 50703030006 040209 6 50003026ｧ90ｷ30409 02090ｹ0 0700080306026ｧ80ｹ0 03000602080ｸ703096ｧ9 0ｹ0 6ｧ8 04020907 00apple06-6 50307 0ｸ7070409 02090ｹ0 閨02apple020ｷ304090ｹ0 02090ｹ0 0700080306026ｧ80ｹ0 03000602080ｸ703096ｧ9 0ｹ0 02fi0408 0400 07020800 0000 000002036ｧ9080ｸ7 6 5 0300086ｦ0 閨02apple020ｷ30409 02090ｹ0 0700-080306026ｧ80ｹ0 03000602080ｸ703096ｧ9 0ｹ04,5 fi0408 02 06 0400 04030007006ｧ90ｹ0 0000 00apple06-6 5006 5 060ｷ300 閨0709 0700080306026ｧ8 07fi0408 apple0806026ｧ903090ｹ0 060206080308096ｧ9 0ｹ06,7. ﾇ 0700080308apple03080402 02000ｸ70206026ｧ8 03070409 020ｷ307 0402 0206070607 000806046 509026ｧ803090200 apple03fi0408 02 0001 06026ｧ9 0ｹ0 02090ｹ0 090008046ｧ9000ｸ7-04090ｹ0 00000300020607 apple080ｸ7 陦000601 07 fi0206 09 030003 apple006ｧ9 0000 0308-04080ｸ76 5 0402 026ｧ90709 0400 0ｸ76 70903 閨0ｹ0 fi0400060ｹ0 (40 02 06 80 mg/0900-03 ) 040ｸ7040400026ｧ9ｨB0002 06 0000 020907 0000080707060409 02030607060207 040900-070206026ｧ80ｹ0 apple030ｷ302000ｸ807080ｸ7036ｧ9 0ｹ0 ( ﾝ2+ 040208 stick 086ｦ0030ｷ307) 8,9. ﾇ 030804080ｸ76 5 0402 026ｧ90709 80 mg/0900 閨03 0007 020ｸ7020308080803006ｧ9 046ｧ8-000003, 08086ｦ0 apple0804080402fi 000009 036ｦ002000308 applefi 0208 12% 020ｷ307 040300070607 apple080ｸ7 apple6ｧ80300 030804080ｸ76 5 0402 026ｧ90709 80 mg/0900 閨03 0000080707060400 02030607060207 040900 070206026ｧ8 apple030ｷ302000ｸ807080ｸ7036ｧ9, 000706 0ｸ7apple070304080ｸ707 02 06 6ｦ008 07 080803 閨0ｹ0 00000807070604090ｹ0 0801006ｧ9 0ｹ0 0700-080306026ｧ80ｹ0 0700apple0703020006 0ｹ0 0400 04030007006ｧ90ｹ0 apple080ｸ7 apple6ｧ803 07 030804080ｸ7-6 5 0402 026ｧ90709 0400 0ｸ7026ｧ8 0209 fi0409 8,9. ﾞ0ｸ70207 02 00 0800 閨07 09-0006086ｦ003090904 07 00030ｷ3020900 02060207 07 080803060207 0000 0208 07 09 040ｸ7-09020002030600 閨0709 0402 026ｧ90709 006ｧ907 06 02080106026ｧ8 0906 0208 07000803fi, 02-03060ｹ0 02 06 fi040807 08080307 0208 02006ｧ800 02080ｸ7 070008030607 (04apple006ｧ9-03 00, 040ｷ3030907 030608 0607000004080ｹ0 060402fi0ｹ0) 0208 08apple086ｧ908 0007 000408-00 閨070ｷ30ｹ0 00apple09030007ｨB0002 06 applefi 0209 0408036ｧ809090409 030804080ｸ76 5 0402-026ｧ907090ｹ08,9. ﾇ 0002026ｧ900090409 02090ｹ0 00apple6ｧ9 03 04090ｹ0 02090ｹ0 030804080ｸ76 5-0402 026ｧ907090ｹ0 040209 0700080306026ｧ8 apple 閨020203060409 apple030ｷ302000ｸ8070607 apple080ｸ7 apple08020003086ｦ007 006ｧ90202000ｹ0 02090ｹ0 04apple000603 00 0206026ｧ80ｹ0 6ｧ8 02090ｹ0 040ｷ30309-07 0306 026ｧ80ｹ0 03000602080ｸ703096ｧ9 0ｹ0 00apple0803006ｧ9 07 6 50809036ｧ8040006 04020907 02-02 07fi090409 02080ｸ7 000904 07060400086ｦ0 0000 020807 08apple086ｧ908 09 030804080ｸ76 5-0402 026ｧ90709 0007 閨040002 06 07 apple030802 03006ｧ9 apple030ｷ302000ｸ807080ｸ7036ｧ9. 6ｾ40208applefi0ｹ0 02090ｹ0 apple 03086ｦ004 0ｹ0 000003 閨02090ｹ0 6ｧ802 07 09 0002026ｧ90009-0409 02090ｹ0 00apple6ｧ9 03 04090ｹ0 02090ｹ0 030003 apple006ｧ9 0ｹ0 0000 030804080ｸ76 5 0402 026ｧ9-0709, 0400 6ｦ008 fi0400060ｹ0 apple080ｸ7 04030904060008apple0806086ｦ00702 06 040ｸ7040707 04020907 0203060706026ｧ8 apple03070109 (10 02 06 20 mg/0900 閨03 ): ) fi040807 08080307 020907 apple030ｷ302000ｸ807080ｸ7036ｧ9, fiapple0ｷ30ｹ0 0ｸ7026ｧ8 apple030804 0608036ｧ9ｨB00-02 06 0000 0209 04036ｧ80409 006ｧ9 0ｹ0 apple0804080206026ｧ80ｹ0 000003fi 080ｸ7 apple030804 0608-03060400086ｦ0 02090ｹ0 0700080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 apple030ｷ302000ｸ8070607, 02-03060ｹ0 02 06 6 5) fi040807 08080307 0209 0700080306026ｧ8 03000602080ｸ703096ｧ9, 0400 04030007006ｧ90ｹ0 0000 apple030ｷ30208apple 036ｧ8 0ｸ7040306apple06 06006ｧ9. ﾞ04030007006ｧ90ｹ0 ｨC 09 閨0308 0806 090309030ｸ70400fi0ｹ0 02090ｹ0 000003 閨02090ｹ0 6ｾ40209 000003 閨0209 040ｸ700000002006ｧ904 07 04030007006ｧ90ｹ0 0000 apple030ｷ30208apple 036ｧ8 0ｸ7040306apple06 06006ｧ9 apple080ｸ7 apple 03 020803080ｸ703086ｦ00702 06 040208 ｦ 02020602fi 6ﾑ8010ｷ30200030602fi ｦﾐ 0203006ｧ908 ﾞ07020600000206apple0604090ｹ0 020ｷ307 0406 02 03 040607 02080ｸ7 090002 6 50803060400086ｦ0 020ｷ307 06apple06 6ｧ90ｷ307 02080ｸ7 09 0700apple060402090006 02086ｦ0 03080408020800006ｧ9080ｸ7 ｦﾐ0ｷ3 07076ｧ9070ｷ307. ﾞapplefi 0209 000003 閨0209 apple080203006ｧ904030902 07: ) 04030007006ｧ90ｹ0 apple080ｸ7 6ｧ802 07 00060203fi0200030806 020ｷ307 18 00020607, 6 5) 04030007006ｧ90ｹ0 apple080ｸ7 006ｧ904 07 0207- apple0806080ｸ7 6 5 0300086ｦ0 閨02apple020ｷ30409 02090ｹ0 0700080306026ｧ80ｹ0 03000602080ｸ703096ｧ9 0ｹ0, fiapple0ｷ30ｹ0 0ｸ7026ｧ8 08036ｧ9ｨB080702 07 applefi 00apple6ｧ9apple00 020300 0206076ｧ907090ｹ0 02080ｸ7 0803086ｦ0 ﾝ1,5 mg/dl 0906 02080ｸ70ｹ0 0707 03000ｹ0 02 06 1,3 mg/dl 0906 02060ｹ0 090ｸ707 6ｧ902000ｹ0, 6ｧ8/02 06 0700080306026ｧ8 apple 閨020203060409 apple030ｷ302000ｸ8070607 >150 mg/240ｷ30308, 09) 04030007006ｧ90ｹ0 0000 04 0204 0306 09 06-6 56ｧ80209 (09030ｸ702fiｨB09 07090402006ｧ9 0ｹ0 0803086ｦ0 ﾝ126 mg/dl 0400 2 6ｧ8 apple0003060404fi020003000ｹ0 020ｸ704 6ｧ9000ｹ0 000002036ｧ80400060ｹ0), ) 04030007006ｧ90ｹ0 0000 0ｸ7010900 閨07 00apple6ｧ9apple00 030ｸ70300080006 080203fiapple080ｸ7 080300fi07090ｹ0 (>5 IU/L), 00) 04030007006ｧ90ｹ0 0000 0007000309fi 09apple 0206026ｧ8 07fi0408 02 06 00apple6ｧ9apple00 0203 0704 000607 040607 02080ｸ7 0803086ｦ0 000009 036ｦ0020003 applefi 0208 020306apple0307040608 02090ｹ0 0706020003090ｹ0 080ｸ704060803080906026ｧ80ｹ0 0206-006ｧ80ｹ0, 0402) 04030007006ｧ90ｹ0 0402080ｸ70ｹ0 08apple086ｧ9080ｸ70ｹ0 閨09060700 020308apple08apple086ｧ909-0409 02090ｹ0 0702060ｸ7apple000302 0406026ｧ80ｹ0 090ｷ3096ｧ80ｹ0 02060ｹ0 020003000ｸ702 6ｧ9000ｹ0 12 006 5 080007 000ｹ0 apple030607 applefi 020907 閨0702 016ｧ8 02080ｸ70ｹ0 040209 000003 閨0209, 02 03060ｹ0 02 06 ｨB) 04030007006ｧ90ｹ0 apple080ｸ7 鐶pple 060307 07 0ｸ7apple080306apple06 060006-026ｧ8 090ｷ3096ｧ8 (070303000ｹ0 0402 026ｧ907000ｹ0, 080600apple030702000ｹ0, 00ｨB000206006ｧ900apple09, 0ｷ3-3-0306apple 0307 0801 陦, 070602080206070602fi 08016ｦ0, 0408030004020ｸ703 006ｧ90709) 02060ｹ0 020003000ｸ702 6ｧ9000ｹ0 4 006 5 080007 000ｹ0 apple030607 applefi 020907 閨0702 016ｧ8 02080ｸ70ｹ0 040209 000003 閨0209. 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O06 04030007006ｧ90ｹ0 00070900000306030902 07 0300apple0208000003060ｹ0 0906 020907 閨0702 016ｧ8 02080ｸ70ｹ0 040209 000003 閨0209 02 06 0ｸ7apple 閨0903 6 7 07 閨07020ｸ7apple08 040ｸ70902 0207030004090ｹ0. 6ﾑ80309 0402090306 02 閨0ｹ0 000002036ｧ80400060ｹ0 09030607 applefi 020907 閨07 030109 02090ｹ0 030003 apple006ｧ9 0ｹ0 (0403fi07080ｹ0 0), 02 03060ｹ0 02 06 00000207 applefi 12 006 5 080007 000ｹ0 090ｷ3096ｧ80ｹ0 (0403fi07080ｹ0 1), 閨09060700 040ｸ7030308096ｧ8 0006090007020ｷ307 6ｧ900 02080ｹ0 00000207 applefi 120ｷ30309 07090402006ｧ9, applefi fi03080ｸ70ｹ0 02080ｸ70ｹ0 04030007006ｧ90ｹ0 0906 020807 apple030804 060803060400fi 02080ｸ7 0306apple06 06000602086ｦ0 apple0308086ｧ903, 02 03060ｹ0 02 06 020ｷ307 00apple06apple 陦0ｷ307 020ｷ307 000002 6 5080306020607 apple 03 00 閨02030ｷ307 02080ｸ7 0803086ｦ0. 6ﾑ8apple06apple03fi04030002, 00036ｧ808030904 07 006ｧ90900 02 apple030ｷ306070607 086ｦ0030ｷ307, 02 08apple086ｧ9 08086ｦ0 080ｸ7090802000702036ｧ8030902 07 0402060ｹ0 3000 0402030808 閨0ｹ0/0300apple02fi, 040209 040ｸ707 閨040006 apple08030902006ｦ0-030902 07 0402080ｸ70ｹ0 ｨC80 08 C 00 閨040306 020907 0707030ｸ7046ｧ8 02080ｸ70ｹ0 (09 08apple086ｧ9 閨09060700 00 閨04 0400 1 006ｧ807 applefi 0209 040ｸ7030308096ｧ8 02080ｸ7 0200-03000ｸ702 6ｧ9080ｸ7 006ｧ90900 02080ｹ0). O apple030804 060803060400fi0ｹ0 02080ｸ7 0306apple06 06000602086ｦ0 apple0308086ｧ903 [00apple6ｧ9apple00 080306026ｧ80ｹ0 0408030904020003fi03090ｹ0 (TC), 02030609030ｸ702000306-6ｧ90ｷ307 (TG), 0408030904020003fi03090ｹ0 020ｷ307 0ｸ76 709036ｧ80ｹ0 apple0ｸ70207fi020902 0ｹ0 0306apple08apple030ｷ302000ｸ8070607 (HDL-C), 0408030904020003fi03090ｹ0 020ｷ307 04-0009036ｧ80ｹ0 apple0ｸ70207fi020902 0ｹ0 0306apple08apple030ｷ302000ｸ8070607 (LDL-C) 02 06 apple080306apple08apple030ｷ302000ｸ8070607 (apo) ﾞ1 02 06 ｦﾌ 02080ｸ7 0803086ｦ0], 02090ｹ0 020300 0206076ｧ907090ｹ0 02080ｸ7 0803086ｦ0 (SCr), 020ｷ307 000002 6 5080306020607 apple - 03 00 閨02030ｷ307, 02 03060ｹ0 02 06 020ｷ307 09030002020308030ｸ7020607 (02 036ｧ9080ｸ7, 07 02036ｧ9080ｸ7, 046 50004026ｧ9080ｸ7, 00 090709046ｧ9080ｸ7, 080ｷ30408080306020607 02 06 04030ｷ30306086ｦ0040ｷ307) 02080ｸ7 0803086ｦ0 閨09060700 0000 0209 04036ｧ80409 02080ｸ7 07-140
136ﾑ80303090706026ｧ8 03000803080308096ｧ9 20, 2008 030ｸ7026ｧ8 0203060706026ｧ80ｹ0 040900006ｧ9 0ｹ0 Olympus AU 600 (Olympus Diagnostica, Hamburg, Germany) 02 06 020ｸ7apple08apple08060900-07000ｹ0 000309 0402090306 02 閨0ｹ0 000003fi 080ｸ70ｹ0 apple080ｸ7 閨04080ｸ70000 apple000306090307-6 70006 10. 09 030703030903, 040208 006ｧ90900 020ｷ307 apple030ｷ306070607 086ｦ0030ｷ307 閨09060700 apple030804 060803060400fi0ｹ0 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 020300 0206076ｧ9-07090ｹ0 (UCr), 020ｷ307 080306020607 03000ｸ7020ｷ30007020ｷ307 (UTpr), 02080ｸ7 080ｸ7030602086ｦ0 0801 閨080ｹ0 (UUA), 02 03060ｹ0 02 06 020ｷ307 09030002020308030ｸ7-020607 apple080ｸ7 apple030804 0608036ｧ904030902 07 02 06 04020807 0803fi, 0000 0209 04036ｧ80409 02080ｸ7 07 030ｸ7026ｧ8 0203060706026ｧ80ｹ0 040900006ｧ9 0ｹ0 Olympus AU 600 (Olympus Diagnostica, Hamburg, Germany) 02 06 020ｸ7apple08apple08060900 閨07000ｹ0 000309 0402090306 02 閨0ｹ0 000003fi 080ｸ70ｹ0 apple080ｸ7 閨04080ｸ70000 apple0003060903076 70006 10. 6ﾑ8apple06apple03fi04030002, 閨09060700 0ｸ7apple080308-09060400fi0ｹ0 02090ｹ0 0203 0400 0206026ｧ80ｹ0 apple 閨0202030604090ｹ0 fi030ｷ307 020ｷ307 090300-02020308030ｸ7020607, 02 03060ｹ0 02 06 02080ｸ7 080ｸ7030602086ｦ0 0801 閨080ｹ0 0000 0209 04036ｧ80409 02090ｹ0 00016ｧ9040ｷ304090ｹ0: FEA (%) = (UA/SA)/ (UCr/ SCr) ﾁ 100, fiapple080ｸ7 ﾞ 08 09030002020308036ｦ002090ｹ0 6ｧ8 0208 080ｸ7030602fi 08016ｦ0, UA 02 00apple6ｧ9apple00 020ｷ307 09030002020308030ｸ7020607 6ｧ8 02080ｸ7 080ｸ70306-02086ｦ0 0801 閨080ｹ0 040208 006ｧ90900 086ｦ0030ｷ307 02 06 SA 02 00apple6ｧ9apple00 020ｷ307 apple 03 00 閨02030ｷ307 0ｸ7020607 04020807 0803fi. 6ﾑ8apple06apple03 閨0807, 040208 006ｧ90900 020ｷ307 apple030ｷ306070607 086ｦ0030ｷ307 apple030804 0608036ｧ904030902 07 02 00apple6ｧ9apple00 02090ｹ0 03000ｸ7020ｷ300 026ｧ907090ｹ0 (UAlb), 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0 (Ua1m), 02 03060ｹ0 02 06 02090ｹ0 070804080408 06036ｧ907090ｹ0 G (UIgG) 0000 0209 04036ｧ80409 02080ｸ7 0700080003fi00000203080ｸ7 Behring Nephelometer BN ProSpec 02 06 070206 03 040209036ｧ90ｷ307 02 06 6 5 03000807080009020607 02090ｹ0 Dade Behring Holding Gmbh (Liederbach, Germany). ﾇ 0700080306026ｧ8 apple 閨020203060409 02fi0408 020ｷ307 080306020607 03000ｸ7-020ｷ30007020ｷ307 fi0408 02 06 020ｷ307 00apple0600 閨03080ｸ70ｹ0 04 000903086ｦ0 02 06 0ｸ76 709-03086ｦ0 00080306 02086ｦ0 6 50703080ｸ70ｹ0 apple030ｷ302000ｸ8070607 apple030804 0608036ｧ90403090200 0000 6 5070409 0208 apple09036ｧ90208 02090ｹ0 040ｸ70902 閨0702030ｷ304090ｹ0 02090ｹ0 02070300 apple030ｷ302000ｹ107090ｹ0 040208 apple030ｷ30607fi 006ｧ90900 086ｦ0030ｷ307 apple03080ｹ0 0209 040ｸ7-0902 閨0702030ｷ30409 02090ｹ0 020300 0206076ｧ907090ｹ0 02080ｸ7 6ｧ9 06080ｸ7 006ｧ90900 02080ｹ0 086ｦ0030ｷ307, 0903 6ｧ8 0000 6 5070409 02080ｸ70ｹ0 03fi09080ｸ70ｹ0: UTpr/UCr, UAlb/UCr, Ua1m/UCr 02 06 UIgG/UCr 11. ｦ 閨03080ｹ0, 000202fi0ｹ0 applefi 020807 apple030804 060803060400fi 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 SCr, 09 0002026ｧ900090409 02090ｹ0 00apple6ｧ9 03 04090ｹ0 02090ｹ0 0308-04080ｸ76 5 0402 026ｧ907090ｹ0 040209 0700080306026ｧ8 03000602080ｸ703096ｧ9 閨09060700 0000 020807 0ｸ7apple08030809060400fi 02080ｸ7 060ｸ70300086ｦ0 6ｾ4apple000603 00 0206026ｧ80ｹ0 04066ｧ80309-04090ｹ0 (GFR), 0000 0209 04036ｧ80409 02090ｹ0 00016ｧ9040ｷ304090ｹ0 MDRD (Modification of Diet in Renal Disease): MDRD GFR=186 ﾁ (SCr 0400 mg/dl) ｨC1.154 ﾁ (090306026ｧ9 0400 閨0209) ｨC0.203 ﾁ (0.742 0906 090ｸ707 6ｧ902000ｹ0) 12. 6ｾ402 0206040206026ｧ8 0707030ｸ70409 O06 apple 0307000002030806 apple080ｸ7 00000300026ｧ8030902 07 0002080307040309-02 07 0ｷ30ｹ0 00 閨0409 0206006ｧ8 ﾀ 020ｸ7apple06026ｧ8 applefi0203060409, 0008fi040807 0208-03080ｸ703086ｦ004 07 02 07080706026ｧ8 02 02 0708006ｧ8 02 06 0ｷ30ｹ0 060700000409 0206-006ｧ8 02 06 006ｦ003080ｹ0 0206000607, 0008fi040807 0007 020803080ｸ703086ｦ004 07 02 07080706026ｧ8 02 02 0708006ｧ8. O06 000002 6 50803 閨0ｹ0 020ｷ307 00apple06apple 陦0ｷ307 020ｷ307 06 08fi030ｷ307 apple 03 00 閨02030ｷ307 00000207 applefi 12 006 5 080007-000ｹ0 090ｷ3096ｧ80ｹ0 00020206006ｧ8030902 07 0000 0209 04036ｧ80409 02080ｸ7 t-test 0906 ｨB006ｦ00909, 0906 apple 03 00 閨0203080ｸ70ｹ0 apple080ｸ7 020803080ｸ703086ｦ004 07 02 0708-0706026ｧ8 02 02 0708006ｧ8 02 06 0000 0209 04036ｧ80409 02080ｸ7 Wilcoxon ｯs rank test 0906 000002 6 5030902 閨0ｹ0 apple080ｸ7 0007 020803080ｸ703086ｦ004 07 02 07080706026ｧ8 02 02 0708006ｧ8. ﾇ 06fi03030ｷ30409 fi040807 08080307 020907 00apple6ｧ9 03 0409 020ｷ307 030406020607 0206000607 02090ｹ0 0700080306026ｧ80ｹ0 apple 閨02-02030604090ｹ0 apple030ｷ302000ｸ8070607 (040ｸ700000002 6 50309026ｧ8, covariate) 0402060ｹ0 000002 6 50803 閨0ｹ0 02090ｹ0 0700080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 apple030ｷ302000ｸ8070607 (0001 03020900 閨0709 000002 6 50309026ｧ8, dependent variable) 00000207 applefi 0209 0408036ｧ809090409 030804080ｸ76 5 0402 026ｧ907090ｹ0 ( 070001070302090209 000002 6 50309026ｧ8, independent variable) 閨09060700 0000 0209 04036ｧ8-0409 02090ｹ0 0707030ｸ704090ｹ0 02090ｹ0 040ｸ707 06 026ｦ000 0704090ｹ0 [one-way analysis of covariance (ANCOVA)]. 縺06 020907 07 09070603060409 000002 6 50309020607 apple080ｸ7 040ｸ7040400026ｧ9- ｨB080702 07 0700010703020902 0000 040900 070206026ｧ8 6ｦ001090409 02090ｹ0 0700-080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0, 0001 06-026ｧ9 0ｹ0 02090ｹ0 0408036ｧ8090904090ｹ0 030804080ｸ76 5 0402 026ｧ907090ｹ0, 040208 046ｦ007080308 020ｷ307 040300070607, 04030904060008apple08066ｧ803090200 閨07 apple08030ｸ7apple 03 0908-07020602fi 00080702 閨0308 03080906040206026ｧ80ｹ0 0707030ｸ704090ｹ0 apple 030607 03fi0009-04090ｹ0 (multivariate logistic regression analysis). ﾇ apple 03080ｸ7046ｧ9 6ｧ8 09 apple080ｸ7046ｧ9 6ｦ0010904090ｹ0 02090ｹ0 0700080306026ｧ80ｹ0 - apple 閨0202030604090ｹ0 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0 6ｧ904090ｹ0 6ｧ8 000009 036ｦ0-020003090ｹ0 applefi 10%, 0001 06026ｧ9 0ｹ0 02090ｹ0 0408036ｧ8090904090ｹ0 030804080ｸ76 5-0402 026ｧ907090ｹ0, apple0802 閨03000400 020907 0001 03020900 閨0709 000002 6 50309026ｧ8 (dependent variable) 0400 0ｸ702fi 0208 00080702 閨0308. 030ｹ0 00apple6ｧ9apple00 08 0402 0206040206026ｧ80ｹ0 040900 07020602fi020902 0ｹ0 08036ｧ9-0403090200 0208 p<0,05. ﾞapple08020003 閨0400 02 06O6ｾ4O08ｦﾌ ﾞ6ｾ4ｦ ﾞｦ ｦﾐ03 ﾇ ﾒ ﾞｦﾐ 090603ｦ 6ﾑ80703O0806ｦﾐ ﾞ 6ｾ40209 000003 閨0209 040ｸ700000002006ｧ904 07 90 04030007006ｧ90ｹ0, 45 applefi 02080ｸ70ｹ0 08apple086ｧ9080ｸ70ｹ0 020ｸ704 0608apple08066ｧ8030902 07 04020907 080007 RSV10 02 06 45 04020907 080007 RSV20. ｦ 02030607060207 02 06 090008-0903 08060207 04 03 02020903060402060207 020ｷ307 040300070607, 02 0207 020907 閨0702 016ｧ8 02080ｸ70ｹ0 040209 000003 閨0209, apple00060208076ｧ9ｨb080702 06 04020807 apple6ｧ907-02 1. 00030806 0806 04030007006ｧ90ｹ0 08030802036ｧ8030ｷ304 07 0209 000003 閨0209. 040007 apple 03 0209036ｧ8030902 07 04086 5 03 閨0ｹ0 0700apple06036ｦ0000902000ｹ0 0007 閨03-090006000ｹ0 apple080ｸ7 07 040ｸ7040400026ｧ9ｨB080702 06 0000 0209 0408036ｧ809090409 030804080ｸ7-6 5 0402 026ｧ907090ｹ0 fiapple0ｷ30ｹ0 6ｦ001090409 020ｷ307 0203 0704 000607 040607 02080ｸ7 0803086ｦ0 [ 04apple 030206026ｧ8 000607080203 0704080003070409 (AST), 0006-07080203 0704080003070409 02090ｹ0 03 076ｧ907090ｹ0 (ALT)] ﾝ3 080803 閨0ｹ0 applefi 02060ｹ0 0706020003000ｹ0 080ｸ70406080308090602 閨0ｹ0 020600 閨0ｹ0 02 06/6ｧ8 6ｦ001090409 02090ｹ0 0206070704090ｹ0 02090ｹ0 020300 026ｧ907090ｹ0 (CK) ﾝ10 080803 閨0ｹ0 applefi 02060ｹ0 0706020003000ｹ0 080ｸ70406080308090602 閨0ｹ0 020600 閨0ｹ0} 0400 02 006ｧ9 applefi 02060ｹ0 6ｦ008 080007 000ｹ0. 040007 閨09060700 020308apple08apple086ｧ9090409 02090ｹ0 0702060ｸ7apple0003-02 0406026ｧ80ｹ0 090ｷ3096ｧ80ｹ0 020ｷ307 040300070607 02 06 020ｷ307 6ｦ008 080007 0ｷ307 02 0207 0209 060703020006 02090ｹ0 000003 閨02090ｹ0. 040007 apple 03 0209036ｧ803090200 02 006ｧ9 000002 6 508036ｧ8 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 00 閨04090ｹ0 040ｸ70402080306-026ｧ80ｹ0, 02 03060ｹ0 02 06 02090ｹ0 00 閨04090ｹ0 06 0402080306026ｧ80ｹ0 0302090306 026ｧ80ｹ0 apple6ｧ90004090ｹ0 ( ﾞ09), 040208 02 閨03080ｹ0 020ｷ307 12 006 5 080007 0ｷ307 02090ｹ0 apple - 141
1309. ﾒ036ｾ4ｦ ﾞ09 ﾞ03O6ｾ4 ﾒ ﾞｦﾐ 6ｾ40803. 6ﾑ80303090706026ｧ8 03000803o03o096ｧ9 20, 2008 096ｧ907 02 0ｹ0 1. 040900080903 08060207 02 06 02030607060207 04 03 02020903060402060207 020ｷ307 040300070607 02090ｹ0 000003 閨02090ｹ0 09 030700000203080ｹ0 O0007 RSV10 (n=45) O0007 RSV20 (n=45) 026ｦ00308 0907 03000ｹ0 24 (53,3%) 23 (51,1%) 縺0ｸ707 6ｧ902000ｹ0 21 (46,7%) 22 (48,9%) ﾇ0306026ｧ9 ( 閨0209) 51,7 ﾀ13,7 52,4 ﾀ12,5 ｦﾌ09ｦﾐ (kg/m 2 ) 26,1 ﾀ5,6 26,6 ﾀ6,1 ﾒ apple07060402 閨0ｹ0 10 (22,2%) 8 (17,8%) 08apple 閨0302 0409 10 (22,2%) 12 (26,7%) ﾞ0302090306 026ｧ8 apple6ｧ9000409 (mm Hg) 6ｾ40ｸ70402080306026ｧ8 121,2 ﾀ7,1 123,4 ﾀ5,2 0406 0402080306026ｧ8 80,9 ﾀ3,7 81,2 ﾀ4,0 ﾞ0702060ｸ7apple000302 0406026ｧ8 090ｷ3096ｧ8 096ﾑ8 ﾞ 7 (15,6%) 8 (17,8%) ﾞｦ 1 apple08020300060402 閨0ｹ0 9 (20,0%) 8(17,8%) ﾞ0702 090ｷ307060402 閨0ｹ0 Ca 2+ 6 (13,3%) 7 (15,6%) 6 5- apple08020300060402 閨0ｹ0 3 (6,7%) 2(4,4%) 0406080ｸ7030902060207 8 (17,8%) 8 (17,8%) T apple08020003 閨0400 02 0002080307ｨB080702 06 0ｷ30ｹ0 00 閨0409 0206006ｧ8 ﾀ 020ｸ7apple06026ｧ8 applefi0203060409 6ｧ8 03060300fi0ｹ0 040300070607 (%) RSV: 030804080ｸ76 5 0402 026ｧ90709, ｦﾌ09ｦﾐ: 04006ｧ90202090ｹ0 0007ｨB 0ｹ0 040600 02080ｹ0, 096ﾑ8 ﾞ: 07 04020803006ｧ90ｹ0 02080ｸ7 000002 020300apple020602086ｦ0 0007ｨB6ｦ000080ｸ7 02090ｹ0 0909000608020007046ｧ907090ｹ0, ﾞｦ 1 apple08020300060402 閨0ｹ0: apple08020300060402 閨0ｹ0 020ｷ307 ﾞｦ 1 0ｸ7apple08 0804 閨0ｷ307 02090ｹ0 0909000608020007046ｧ907090ｹ0 ｦﾐｦﾐ. 03 020803086ｦ0030904090ｹ0 0400 02 006ｧ9 applefi 02060ｹ0 6ｦ008 080007 000ｹ0 040300-070607 (096ｧ907. 2). ﾇ 00apple6ｧ9 03 0409 02090ｹ0 030003 apple006ｧ9 0ｹ0 0000 030804080ｸ76 5 0402 026ｧ9-0709 0402 00apple6ｧ9apple00 020ｷ307 0306apple06 060006020607, 02 03060ｹ0 02 06 0402 00apple6ｧ9apple00 020ｷ307 000002 6 5080306020607 apple 03 00 閨02030ｷ307 02080ｸ7 0803086ｦ0 apple00060208076ｧ9ｨb0002 06 04020807 apple6ｧ907 02 2. ﾇ 0408036ｧ809090409 030804080ｸ7-6 5 0402 026ｧ907090ｹ0 006ｧ90400 0ｷ30ｹ0 apple0802 閨03000400 006ｧ9 040900 070206026ｧ8 6 50003026ｧ90ｷ30409 02080ｸ7 0306apple06 06000602086ｦ0 apple0308086ｧ903 02 06 0402060ｹ0 6ｦ008 080007 000ｹ0 040300070607. 6ｾ40ｸ709020002030600 閨07, 0402060ｹ0 080007 000ｹ0 RSV10 02 06 RSV20, 09 0408036ｧ809090409 030804080ｸ76 5 0402 026ｧ907090ｹ0 096ｧ907 02 0ｹ0 2. 6ﾑ8apple6ｧ9apple00 0302090306 026ｧ80ｹ0 apple6ｧ90004090ｹ0 02 06 0306apple06 06000602 閨0ｹ0 02 06 000002 6 508030602 閨0ｹ0 apple 0307000002030806 0402080ｸ70ｹ0 04030007006ｧ90ｹ0 02090ｹ0 000003 閨02090ｹ0 apple030607 applefi 020907 閨07 030109 02090ｹ0 030003 apple006ｧ9 0ｹ0 (0403fi07080ｹ0 0) 02 06 00000207 applefi 12 006 5 080007 000ｹ0 090ｷ3096ｧ80ｹ0 (0403fi07080ｹ0 1) O0007 RSV10 O0007 RSV20 09 030700000203080ｹ0 0103fi07080ｹ0 0 0103fi07080ｹ0 1 0103fi07080ｹ0 0 0103fi07080ｹ0 1 6ｾ40ｸ70402080306026ｧ8 ﾞ09 (mm Hg) 121,2 ﾀ7,1 120,1 ﾀ8,2 123,4 ﾀ5,2 121,7 ﾀ4,5 0406 0402080306026ｧ8 ﾞ09 (mm Hg) 80,9 ﾀ3,7 81,4 ﾀ2,9 81,2 ﾀ4,0 80,4 ﾀ3,6 TC (mg/dl) 309 ﾀ56 208 ﾀ41** 312 ﾀ52 193 ﾀ32** 6 9 TG (mg/dl) 129 ﾀ37 115 ﾀ36** 127 ﾀ36 106 ﾀ30** 6 9 HDL-C (mg/dl) 64 ﾀ12 66 ﾀ12 63 ﾀ16 65 ﾀ16 LDL-C (mg/dl) 216 ﾀ50 119 ﾀ36** 225 ﾀ48 108 ﾀ27** 6 9 apoa1 (mg/dl) 138 ﾀ30 144 ﾀ31 138 ﾀ18 143 ﾀ17 apob (mg/dl) 135 ﾀ37 89 ﾀ23** 137 ﾀ40 82 ﾀ20** 6 9 SGlc (mg/dl) 91,2 ﾀ7,8 90,2 ﾀ7,4 92,2 ﾀ6,4 91,3 ﾀ7,9 SUre (mg/dl) 35,7 ﾀ8,7 36,2 ﾀ8,4 33,9 ﾀ7,8 35,3 ﾀ9,1 SCr (mg/dl) 0,9 ﾀ0,2 0,9 ﾀ0,2 0,9 ﾀ0,1 0,9 ﾀ0,2 SUA (mg/dl) 5,2 ﾀ1,7 5,0 ﾀ1,6 5,3 ﾀ2,0 5,1 ﾀ1,4 STpr (g/dl) 7,4 ﾀ0,4 7,4 ﾀ0,4 7,4 ﾀ0,3 7,4 ﾀ0,4 SAlb (g/dl) 4,3 ﾀ0,3 4,4 ﾀ0,4 4,4 ﾀ0,4 4,3 ﾀ0,3 O06 020600 閨0ｹ0 0002080307ｨB080702 06 0ｷ30ｹ0 00 閨0409 0206006ｧ8 ﾀ 020ｸ7apple06026ｧ8 applefi0203060409 *p<0,05 閨07 070206 020ｷ307 0206000607 040208 0403fi0708 0, **p<0,01 閨07 070206 020ｷ307 0206000607 040208 0403fi0708 0, 6 9p<0,05 080007 RSV10 閨07 070206 080007 0ｹ0 RSV20 040208 0403fi0708 1 RSV: 030804080ｸ76 5 0402 026ｧ90709, ﾞ09: 0302090306 026ｧ8 apple6ｧ9000409, TC: 080306026ｧ8 0408030904020003fi0309, TG: 02030609030ｸ70200036ｧ9 06, HDL-C: 0408030904020003fi0309 020ｷ307 0ｸ76 709-036ｧ80ｹ0 apple0ｸ70207fi020902 0ｹ0 0306apple08apple030ｷ302000ｸ8070607, LDL-C: 0408030904020003fi0309 020ｷ307 04 0009036ｧ80ｹ0 apple0ｸ70207fi020902 0ｹ0 0306apple08apple030ｷ302000ｸ8070607, apo: apple080306apple08apple030ｷ302000ｹ10709, SGlc: 09030ｸ702fiｨB09 0803086ｦ0, Sure: 080ｸ7036ｧ9 0803086ｦ0, SCr: 020300 0206076ｧ90709 0803086ｦ0, SUA: 080ｸ7030602fi 08016ｦ0 0803086ｦ0, STpr: 08030602 閨0ｹ0 apple030ｷ302000ｹ107000ｹ0 0803086ｦ0, SAlb: 03000ｸ7020ｷ300 026ｧ90709 0803086ｦ0. 142
136ﾑ80303090706026ｧ8 03000803080308096ｧ9 20, 2008 06O6ｾ4O08ｦﾌ ﾞ6ｾ4ｦ ﾞｦ ｦﾐ03 ﾇ ﾒ ﾞｦﾐ 090603ｦ 6ﾑ80703O0806ｦﾐ ﾞ 12 ｦｶｦﾑ0ﾌ2ｦﾍｦﾏ0ﾋ9 0 ｦｶｦﾑ0ﾌ2ｦﾍｦﾏ0ﾋ9 1 10 p<0,01 Ua1m (mg/g UCr) 8 6 4 2 p<0,05 8.2 7.1 5.9 5.8 5 p=ns 5.1 0 Oｦﾌ0ﾋ4ｦﾄｦﾁ RSV 10 Oｦﾌ0ﾋ4ｦﾄｦﾁ RSV 20 Oｦﾌ0ﾋ4ｦﾄｦﾁ ｦﾅｦﾋ0ﾋ5ｦﾃｦﾖｦﾏｦﾔ 6ﾑ80602. 1. 0300080306026ｧ8 apple 閨020203060409 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0 ( 060700000409 0206006ｧ8) 0402080ｸ70ｹ0 04030007006ｧ90ｹ0 020ｷ307 080007 0ｷ307 RSV10 02 06 RSV20, 02-03060ｹ0 02 06 04020907 080007 0003 閨0904080ｸ7 apple030607 applefi 020907 閨07 030109 02090ｹ0 030003 apple006ｧ9 0ｹ0 (0403fi07080ｹ0 0) 02 03060ｹ0 02 06 00000207 applefi 12 006 5 080007 000ｹ0 090ｷ3096ｧ80ｹ0 (0403fi07080ｹ0 1). RSV: 030804080ｸ76 5 0402 026ｧ90709, NS: 0909 0402 02060402060207 040900 070206026ｧ8 000002 6 508036ｧ8, Ua1m: 0300080306026ｧ8 apple 閨020203060409 1-00060203080408 06036ｧ907090ｹ0, UCr: ﾒ0300 0206076ｧ90709 086ｦ0030ｷ307. 00006ｧ90ｷ30400 02 00apple6ｧ9apple00 02090ｹ0 TC 02 0207 31,0% 02 06 38,0% (p=0,03 0906 0209 046ｦ0090203060409 000002 016ｦ0 020ｷ307 6ｦ008 080007 0ｷ307), 02 00apple6ｧ9apple00 020ｷ307 TG 02 0207 10,1% 02 06 16,0% (p=0,03 0906 0209 046ｦ0090203060409 000002 016ｦ0 020ｷ307 6ｦ008 080007 0ｷ307), 02 00apple6ｧ9- apple00 02090ｹ0 LDL-C 02 0207 43,7% 02 06 52,2% (p=0,02 0906 0209 046ｦ0090203060409 000002 016ｦ0 020ｷ307 6ｦ008 080007 0ｷ307) 02 06 02 00apple6ｧ9apple00 02090ｹ0 apob 02 0207 34,1% 02 06 40,1% (p=0,03 0906 0209 046ｦ0090203060409 000002 016ｦ0 020ｷ307 6ｦ008 080007 0ｷ307). ﾇ 0408036ｧ8-09090409 030804080ｸ76 5 0402 026ｧ907090ｹ0 0007 apple0308020703000400 040900 07020602 閨0ｹ0 000002 6 50803 閨0ｹ0 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 HDL-C 02 06 02090ｹ0 apoa1 0400 02 006ｧ9 applefi 02060ｹ0 6ｦ008 080007 000ｹ0 (096ｧ907. 2). 040007 0ｸ7apple6ｧ80304 07 040900 07020602 閨0ｹ0 06 080803 閨0ｹ0 000002 016ｦ0 020ｷ307 6ｦ008 080007 0ｷ307 fi040807 08080307 0209 0700080306026ｧ8 apple 閨02020306-0409 020ｷ307 apple030ｷ302000ｸ8070607, 02 03060ｹ0 02 06 0209 0700080306026ｧ8 03000602080ｸ703-096ｧ9, fiapple0ｷ30ｹ0 0ｸ7026ｧ8 00020206006ｧ803090200 applefi 02 00apple6ｧ9apple00 02090ｹ0 SCr 02 06/6ｧ8 02080ｸ7 GFR-MDRD, 02 0207 020907 閨0702 0109 020ｷ307 040300070607 040209 000003 閨0209. ﾇ 0408036ｧ809090409 030804080ｸ76 5 0402 026ｧ9-07090ｹ0 0007 006ｧ90400 040900 070206026ｧ8 00apple6ｧ9 03 0409 040209 0700080306026ｧ8 030006-02080ｸ703096ｧ9 020ｷ307 040300070607, fiapple0ｷ30ｹ0 0ｸ7026ｧ8 00020206006ｧ803090200 02fi0408 0000 6 5070409 02 00apple6ｧ9apple00 02090ｹ0 SCr (096ｧ907. 2), fi0408 02 06 0000 6 5070409 0209 04apple000603 00 0206026ｧ8 066ｧ803090409, apple030607 02 06 00000207 applefi 0209 0408036ｧ809090409 030804080ｸ76 5 0402 026ｧ907090ｹ0 0402060ｹ0 080007 000ｹ0 RSV10 02 06 RSV20 (83,4 ﾀ15,4 閨07 070206 83,4 ﾀ15,2 ml/min/ 1,73m 2, p=ns 02 06 82,3 ﾀ12,5 閨07 070206 84,9 ﾀ13,9 ml/min/1,73 m 2, p=0,08 07026ｧ90402080604 ). 030402fi0408, 09 0408-036ｧ809090409 030804080ｸ76 5 0402 026ｧ907090ｹ0 040ｸ7040400026ｧ90403090200 0000 006ｧ9 0207-0409 6 50003026ｧ90ｷ304090ｹ0 02090ｹ0 0700080306026ｧ80ｹ0 03000602080ｸ703096ｧ9 0ｹ0, fiapple0ｷ30ｹ0 0ｸ7-026ｧ8 00020206006ｧ803090200 0000 6 5070409 0209 000002 6 508036ｧ8 02080ｸ7 GFR- MDRD, 04020907 080007 RSV20, 040ｷ3036ｧ90ｹ0 fi000ｷ30ｹ0 0ｸ7026ｧ8 09 6ｦ001090409 07 080307070006 0400 00apple6ｧ9apple00 0402 0206040206026ｧ80ｹ0 040900-07020602fi020902 0ｹ0 (p=0,08). ﾇ 00apple6ｧ9 03 0409 02090ｹ0 030804080ｸ76 5 0402 026ｧ907090ｹ0 040209 0700080306-026ｧ8 apple 閨020203060409 apple030ｷ302000ｸ8070607 0402060ｹ0 6ｦ008 080007 000ｹ0 040300-070607 08 6ｧ9070002 06 04020807 apple6ｧ907 02 3. ﾇ 0408036ｧ809090409 030804080ｸ7-6 5 0402 026ｧ907090ｹ0 10 02 06 20 mg/0900 閨03 006ｧ90400 0ｷ30ｹ0 apple0802 閨0300-0400 040900 070206026ｧ8 6ｦ001090409 02090ｹ0 0700080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0 02 0207 17,6% 02 06 34,9% 07026ｧ90402080604 (6ﾑ80602. 1). 090703060402, 09 6ｦ001090409 02090ｹ0 0700080306-026ｧ80ｹ0 apple 閨0202030604090ｹ0 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0, apple080ｸ7 apple - 03 0209036ｧ803090200 04020907 080007 RSV20, 6ｧ802 07 040900 0702060207 000009 036ｦ002000309 applefi 020907 07026ｧ9040208060409 02090ｹ0 080007 0ｹ0 RSV10 (p=0,03 0906 0209 046ｦ0090203060409 000002 016ｦ0 020ｷ307 6ｦ008 080007 0ｷ307). ﾞ0ｸ7026ｧ8 09 06 08080307 000002 016ｦ0 020ｷ307 6ｦ008 080007 0ｷ307 0001 0208-03080ｸ703086ｦ00400 07 006ｧ907 06 0402 02060402060207 040900 070206026ｧ8 02 06 00000207 applefi 06fi03030ｷ30409 fi040807 08080307 020907 030406026ｧ8 0700080306026ｧ8 apple 閨020203060409 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0 (p<0,05). ﾇ 0408-036ｧ809090409 030804080ｸ76 5 0402 026ｧ907090ｹ0 0007 apple0308020703000400 040900 070206-026ｧ8 000002 6 508036ｧ8 02090ｹ0 0700080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 020ｷ307 080306020607 03000ｸ7020ｷ30007020ｷ307, 02090ｹ0 03000ｸ7020ｷ300 026ｧ907090ｹ0 02 06 02090ｹ0 07080408-0408 06036ｧ907090ｹ0 G 0400 02 006ｧ9 applefi 02060ｹ0 6ｦ008 080007 000ｹ0 040300-070607 (096ｧ907. 3). ﾇ 0203 0400 0206026ｧ8 apple 閨020203060409 020ｷ307 090300-02020308030ｸ7020607 02 06 02080ｸ7 080ｸ7030602086ｦ0 0801 閨080ｹ0 0007 000002 6 5036ｧ80309-0200 0400 02 006ｧ9 applefi 02060ｹ0 080007 000ｹ0 020ｷ307 040300070607 00000207 applefi 12 006 5 080007 000ｹ0 030003 apple006ｧ9 0ｹ0 (096ｧ907. 3). 6ｾ4020907 apple08030ｸ7apple 03 0908070206026ｧ8 03080906040206026ｧ8 0707030ｸ70409 apple 030607 03fi000904090ｹ0 (multivariate logistic regression analysis) apple080ｸ7 閨09060700 040208 046ｦ007080308 020ｷ307 040300070607, 000100-020704030902 07 apple 030709080702000ｹ0 apple080ｸ7 040ｸ7040400026ｧ9ｨB080702 07 0000 6ｦ00109-0409 020ｷ307 0700080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 1-00060203080408 06036ｧ907090ｹ0 6ｧ904090ｹ0 6ｧ8 000009 036ｦ0020003090ｹ0 applefi 10%. 6ｾ40208 apple08030ｸ7apple 03 0908070206-02fi 00080702 閨0308 040ｸ700apple000306036ｧ808030902 07 apple 0307000002030806, fiapple0ｷ30ｹ0 09 fi0409 02090ｹ0 030804080ｸ76 5 0402 026ｧ907090ｹ0, 08 006ｧ90202090ｹ0 0007ｨB 0ｹ0 040600-02080ｹ0, 02 0304060207 00apple6ｧ9apple00 020ｷ307 0306apple06 6ｧ90ｷ307 02 06 020ｷ307 apple08-0306apple08apple030ｷ302000ｸ8070607 02080ｸ7 0803086ｦ0, 0806 apple 0307000002030806 0002026ｧ9000904090ｹ0 02080ｸ7 000002 6 50803060400086ｦ0 020ｷ307 0ｸ7 02 07030307020ｷ307 (00apple6ｧ9apple00 09030ｸ702fiｨB090ｹ0 07090402006ｧ9 0ｹ0 0803086ｦ0), 02 03060ｹ0 02 06 0806 000002 6 50803 閨0ｹ0 143
1309. ﾒ036ｾ4ｦ ﾞ09 ﾞ03O6ｾ4 ﾒ ﾞｦﾐ 6ｾ40803. 6ﾑ80303090706026ｧ8 03000803o03o096ｧ9 20, 2008 096ｧ907 02 0ｹ0 3. N00080306026ｧ8 apple 閨020203060409 apple030ｷ302000ｸ8070607, 02 06 0203 0400 020602 閨0ｹ0 apple000202036ｧ90400060ｹ0 09030002020308030ｸ7020607 02 06 080ｸ7030602086ｦ0 0801 閨080ｹ0 04020807 apple0309030ｸ7-0400fi 02090ｹ0 000003 閨02090ｹ0 apple030607 applefi 020907 閨07 030109 02090ｹ0 030003 apple006ｧ9 0ｹ0 (0403fi07080ｹ0 0) 02 06 00000207 applefi 12 006 5 080007 000ｹ0 090ｷ3096ｧ80ｹ0 (0403fi07080ｹ0 1) O0007 RSV10 O0007 RSV20 09 030700000203080ｹ0 0103fi07080ｹ0 0 0103fi07080ｹ0 1 0103fi07080ｹ0 0 0103fi07080ｹ0 1 UTpr/UCr (mg/g) 61 (32-300) 57 (34-280) 59 (26-290) 57 (31-298) UAlb/UCr (mg/g) 6,4 (1,9-149,0) 6,7 (3,3-73,1) 6,2 (2,9-105,0) 6,4 (3,3-76,3) Ua1m/UCr (mg/g) 5,9 (2,2-40,0) 7,1 1 (3,0-68,0) 5,8 (3,1-13,1) 8,2 2-4 (2,9-23,0) UIgG/UCr (mg/g) 3,6 (1,2-23,0) 3,7 (1,5-35,0) 3,6 (1,6-26,1) 3,9 (1,3-39,3) FENa + (%) 0,6 (0,1-3,4) 0,6 (0,1-5,3) 0,5 (0,1-1,1) 0,5 (0,1-2,9) FEK + (%) 6,0 (4,3-35,0) 6,8 (3,5-33,5) 6,5 (1,4-22,0) 6,6 (1,9-33,5) FEMg 2+ (%) 2,5 (0,4-16,4) 2,7 (0,8-9,6) 2,6 (1,7-33,6) 2,8 (1,4-18,7) FECa 2+ (%) 0,7 (0,1-4,7) 0,7 (0,1-3,8) 0,6 (0,2-1,9) 0,7 (0,2-2,3) FECl ｨC (%) 1,2 (0,3-5,0) 1,1 (0,3-7,9) 1,0 (0,1-4,2) 1,0 (0,3-3,6) FEPO4 3ｨC (%) 16,5 ﾀ7,9 17,8 ﾀ6,1 17,0 ﾀ9,7 16,9 ﾀ8,1 FEUA (%) 7,1 ﾀ3,4 7,2 ﾀ4,1 6,9 ﾀ3,2 7,0 ﾀ3,2 ｦ apple08020003 閨0400 02 0002080307ｨB080702 06 0ｷ30ｹ0 00 閨0409 0206006ｧ8 ﾀ020ｸ7apple06026ｧ8 applefi0203060409 6ｧ8 060700000409 0206006ｧ8 (006ｦ003080ｹ0 0206000607) 02 0207 apple00036ｧ9apple020ｷ30409 6ｧ8 080007. 1 p<0,05 閨07 070206 020ｷ307 0206000607 040208 0403fi0708 0, 2 p<0,01 閨07 070206 020ｷ307 0206000607 040208 0403fi0708 0, 3 p<0,05 080007 RSV10 閨07 070206 080007 0ｹ0 RSV20 040208 0403fi0708 1, 4 p<0,05 080007 RSV10 閨07 070206 080007 0ｹ0 RSV20 00000207 applefi 06fi03030ｷ30409 0906 02060ｹ0 03040602 閨0ｹ0 020600 閨0ｹ0. RSV: 030804080ｸ76 5 0402 026ｧ90709, UTpr: 08030602 閨0ｹ0 apple030ｷ302000ｹ107000ｹ0 086ｦ0030ｷ307, UAlb: 03000ｸ7020ｷ300 026ｧ90709 086ｦ0030ｷ307, Ua1m: 1-00060203080408 06036ｧ90709 086ｦ0030ｷ307, UIgG: 070804080408 06036ｧ90709 G 086ｦ0030ｷ307, UCr: 020300 0206076ｧ90709 086ｦ0030ｷ307, FE: 0203 0400 0206026ｧ8 apple 閨020203060409, UA: 080ｸ7030602fi 08016ｦ0. 02080ｸ7 0306apple06 06000602086ｦ0 apple0308086ｧ903 00000207 0209 0408036ｧ809090409 030804080ｸ7-6 5 0402 026ｧ907090ｹ0. ﾞ0ｸ7026ｧ8 09 0707030ｸ70409 陦00060100 fi0206 09 fi0409 02090ｹ0 030804080ｸ76 5 0402 026ｧ907090ｹ0 6ｧ802 07 09 000807 06026ｧ8 apple 030700000203080ｹ0 apple080ｸ7 040ｸ7040400026ｧ9ｨB080702 07 0700010703020902 0000 6ｦ001090409 02090ｹ0 0700080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0 6ｧ904090ｹ0 6ｧ8 000009 036ｦ00200-03090ｹ0 applefi 10% [040400020602fi0ｹ0 026ｧ907 0ｸ707080ｹ0 (OR) 2,51, 95% fi0306 010608apple0604026ｧ9 0ｹ0 (CI) 1,10-6,53, p=0,035]. 6ｾ40ｸ7ｨB6ｧ802090409 6ｾ46ｦ000080ｷ307 0000 02 apple08020003 閨0400 02 02090ｹ0 apple 03086ｦ004 0ｹ0 000003 閨02090ｹ0 09 0408036ｧ809090409 030804080ｸ76 5 0402 026ｧ907090ｹ0, 0402060ｹ0 6ｦ008 fi- 0400060ｹ0 apple080ｸ7 04030904060008apple0806086ｦ00702 06 040ｸ70407fi020003 04020907 0203060706026ｧ8 apple03070109 (10 02 06 20 mg/0900 閨03 ), 08 6ｧ9070002 06 fi0206 apple030802 03006ｧ9 006ｧ9 0804080001 03020600000709 6ｦ001090409 02090ｹ0 0700080306026ｧ80ｹ0 apple 閨02-02030604090ｹ0 02090ｹ0 1-00060203080408 036ｧ907090ｹ0, 040ｷ3036ｧ90ｹ0 07 00apple09030007ｨB0006 0209 0700080306026ｧ8 apple 閨020203060409 020ｷ307 080306020607 03000ｸ7020ｷ30007020ｷ307, 02090ｹ0 03000ｸ7020ｷ300 026ｧ907090ｹ0 02 06 02090ｹ0 070804080408 06036ｧ907090ｹ0 G, 02 03060ｹ0 02 06 0209 0700080306026ｧ8 03000602080ｸ703096ｧ9, 0400 04030007006ｧ90ｹ0 0000 0ｸ7040306apple06-06006ｧ9, apple080ｸ7 0007 006ｧ907 06 06 6 509020602086ｧ9 02 06 0007 apple070404080ｸ707 applefi 00apple066 5006 5 060ｷ300 閨0709 0700080306026ｧ8 07fi0408. ﾇ 0408036ｧ809090409 030804080ｸ76 5 0402 026ｧ907090ｹ0 0400 0ｸ76 70903 閨0ｹ0 fi- 0400060ｹ0 (40 02 06 80 mg/0900 閨03 ) 040ｸ7040400026ｧ90403090200 0000 020907 0000-080707060409 02030607060207 040900 070206026ｧ80ｹ0 apple030ｷ302000ｸ807080ｸ7036ｧ9 0ｹ0, fiapple0ｷ30ｹ0 03000ｷ303006ｧ902 06 09 apple 閨020203060409 080306020607 03000ｸ7020ｷ30007020ｷ307 apple080ｸ7 006ｧ907 06 6ｧ90409 6ｧ8 000009 036ｦ002000309 applefi 2+ 040208 stick 086ｦ0030ｷ307 8,9. ﾞ0707030ｸ70409 02090ｹ0 apple030ｷ302000ｸ807080ｸ7036ｧ9 0ｹ0 0402080ｸ70ｹ0 04030007006ｧ90ｹ0 apple080ｸ7 00000807070604 07 02030607060207 040900 070206026ｧ8 apple030ｷ302000ｸ807080ｸ7036ｧ9 陦0006-0100 fi0206 0ｸ7026ｧ8 apple08020003086ｦ00702 07 02 0207 026ｦ0030608 03fi0908 applefi apple030ｷ302000ｹ107000ｹ0 apple080ｸ7 閨04080ｸ707 00080306 02fi 6 50703080ｹ0 00060203fi02000308 applefi 0208 07026ｧ9040208060408 02090ｹ0 03000ｸ7020ｷ300 026ｧ907090ｹ0. ﾞ0ｸ702fi 0208 0900-090807fi0ｹ0 040ｸ70709090803006ｧ9 0ｸ7apple 閨03 02090ｹ0 040ｷ3030907 0306 026ｧ80ｹ0 apple 0307 02090ｹ0 04apple000603 00 0206026ｧ80ｹ0 apple0308 閨03000ｸ704090ｹ0 0ｸ7026ｧ80ｹ0 02090ｹ0 apple030ｷ302000ｸ807080ｸ7-036ｧ9 0ｹ013. ﾇ 1-00060203080408 06036ｧ90709 006ｧ907 06 006ｧ9 04 000903086ｦ0 0008-0306 02086ｦ0 6 50703080ｸ70ｹ0 apple030ｷ302000ｹ10709, 09 08apple086ｧ9 080ｸ7040608030809060207 060903006ｧ902 06 040208 070008030602fi 04apple006ｧ903 00 02 06 00apple 07 030308080702 06 applefi 02 00apple0603090306 0207 026ｦ00202 03 020ｷ307 0009096ｦ00ｹ0 0004apple000603 0000-070ｷ307 040ｷ3030907 036ｧ90ｷ307 02080ｸ7 07000803086ｦ0 14,15. ﾇ 0700080306026ｧ8 apple 閨02-0203060409 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0 apple08020003006ｧ9 04020907 0203060706026ｧ8 apple03070109 006ｧ9020209 02090ｹ0 0009096ｦ00ｹ0 040ｷ3030907 0306 026ｧ80ｹ0 03000602080ｸ703-096ｧ9 0ｹ015 02 06 0ｸ70107070002 06 0400 02 02 0402070400060ｹ0 apple080ｸ7 apple030802-03086ｦ007 080006026ｧ8 6 503076 509 6ｧ8 0ｸ70403000602080ｸ703096ｧ9 020ｷ307 0009096ｦ00ｹ0 0004apple000603 0000 閨070ｷ307 040ｷ3030907 036ｧ90ｷ307 02080ｸ7 07000803086ｦ0 16,17. ﾒ 0207 040ｸ707 鐶pple0006, 09 apple030802 03086ｦ000000709 applefi 0209 0408036ｧ809090409 0308-04080ｸ76 5 0402 026ｧ907090ｹ0 6ｦ001090409 02090ｹ0 0700080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0, 02 06 fi0406 020ｷ307 0ｸ7apple0803086ｧ9apple0ｷ307 apple030ｷ302000ｸ8070607 apple080ｸ7 apple08020003086ｦ007 006ｧ90202000ｹ0 02090ｹ0 04apple000603 00 0206-026ｧ80ｹ0 03000602080ｸ703096ｧ9 0ｹ0 (03000ｸ7020ｷ300 026ｧ90709, 070804080408 036ｧ90709 G) 18, 0ｸ7apple08040209036ｧ9ｨB0006 020907 0ｸ7applefi03000409 fi0206 09 030804080ｸ76 5 0402-026ｧ90709 0007 00040800 閨070ｷ30ｹ0 apple030802 03006ｧ9 apple030ｷ302000ｸ807080ｸ7036ｧ9 040ｷ30309-07 0306 026ｧ80ｹ0 apple0308 閨03000ｸ704090ｹ013. 030402fi0408, 0007 006ｧ907 06 04 08 閨0ｹ0 07 09 6ｦ001090409 02090ｹ0 0700-080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0, apple080ｸ7 040ｸ7040400026ｧ9ｨB0002 06 0000 0209 0408036ｧ809090409 030804080ｸ76 5 0402 026ｧ907090ｹ0, 006ｧ9-07 06 apple0802 閨03000400 080006026ｧ80ｹ0 6 503076 5090ｹ0 6ｧ8 03000602080ｸ7030906026ｧ80ｹ0 06 02 03 046ｧ80ｹ0 020ｷ307 00apple0603090306 020607 020ｸ7020207030ｷ307 020ｷ307 0009096ｦ00ｹ0 0004apple000603 0000 閨070ｷ307 040ｷ3030907 036ｧ90ｷ307 02080ｸ7 07000803086ｦ0. 00000ｷ30ｹ0, 006ｧ9 0007 0004fi00000709 080006026ｧ8 6 503076 509 020ｷ307 00apple0603090306 020607 020ｸ7020207030ｷ307 020ｷ307 0009096ｦ00ｹ0 0004apple000603 0000 閨070ｷ307 040ｷ3030907 036ｧ90ｷ307 03 07 00 閨07080702 07 07 apple030802 03 閨040006 6ｦ001090409 02090ｹ0 0203-0400 0206026ｧ80ｹ0 apple 閨0202030604090ｹ0 02080ｸ7 080ｸ7030602086ｦ0 0801 閨080ｹ0 02 06 020ｷ307 144
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0009096ｦ00ｹ0 040ｷ3030907 0306 026ｧ80ｹ0 6 503076 5090ｹ0, fiapple0ｷ30ｹ0 09 0700-080306026ｧ8 apple 閨020203060409 020ｷ307 KIM-1 (Kidney Injury Molecule-1, 00fi030608 0700080306026ｧ80ｹ0 6 503076 5090ｹ0) 19 02 06 NAG (N-acetyl-glucosaminidase, 03-0200020ｸ70308-09030ｸ70208ｨB08 00060706 07-0409) 20, 0000 apple0802 閨03000400 07 0009 00apple0803006ｧ9 07 apple08020300060403006ｧ9 0208 0007 0004fi00000708 006ｧ9 0ｹ0 080006026ｧ80ｹ0 6 503076 5090ｹ0 02080ｸ7 00apple060309036ｧ9080ｸ7 020ｷ307 0009096ｦ00ｹ0 0004apple000603 0000 閨070ｷ307 040ｷ3030907 036ｧ90ｷ307 040ｸ70404000206ｨBfi- 000007090ｹ0 0000 0209 0408036ｧ809090409 030804080ｸ76 5 0402 026ｧ907090ｹ0. 046ｦ008 in vitro 000003 閨02000ｹ0 apple080ｸ7 閨090607 07 0000 020907 apple0308-04036ｧ80209 5 06 080803000206020607 0402 0206070607 (0406006 5 0402 026ｧ90709, apple03 6 5 0402 026ｧ90709, 030804080ｸ76 5 0402 026ｧ90709, 0208036 5 0402 026ｧ90709 02 06 0803080ｸ76 5 0402 026ｧ90709) 0400 02 030306 閨03090006000ｹ0 00apple0603090306 020607 020ｸ7020207030ｷ307 07030306apple06070ｷ307 0009096ｦ00ｹ0 0004apple000603 0000 閨070ｷ307 040ｷ3-030907 036ｧ90ｷ307 21, 02 03060ｹ0 02 06 0400 02 030306 閨03090006000ｹ0 0007fi0ｹ0 apple0006-03 00 020602086ｦ0 apple03fi020ｸ7apple080ｸ7 0700080306020607 020ｸ7020207030ｷ307 (opossum kidney cells) 22, 06 026ｦ0apple0ｷ304 07 020907 07apple086 709 02090ｹ0 07 040208036ｧ80ｹ0 02090ｹ0 0007 08026ｦ002020ｷ304090ｹ0 020ｷ307 04 000903086ｦ0 00080306-02086ｦ0 6 50703080ｸ70ｹ0 apple030ｷ302000ｸ8070607, apple080ｸ7 080ｸ7040608030809060207 060903086ｦ0-0702 06 040208 04apple006ｧ903 00, applefi 02 026ｦ00202 03 020ｷ307 0009096ｦ00ｹ0 0004apple000603 0000 閨070ｷ307 040ｷ3030907 036ｧ90ｷ307, 0ｷ30ｹ0 閨07 000904 07060400fi apple080ｸ7 apple0603 0707 03 00apple0803086ｦ00400 07 000109096ｧ8040006 020907 000008070706-0409 apple030ｷ302000ｸ807080ｸ7036ｧ9 0ｹ0 apple080ｸ7 040ｸ7040400026ｧ9ｨB0002 06 0000 0209 0408036ｧ80909-0409 0402 0206070607. ﾞ0ｸ702 閨0ｹ0 0806 000003 閨02000ｹ021,22 陦000601 07 fi0206 09 apple030804036ｧ80209 020ｷ307 apple 03 apple07070ｷ3 0402 0206070607, 0400 0607080803000ｹ0 040ｸ7090200070203060400060ｹ0, 0400 02 030306 閨03090006000ｹ0 020ｷ307 apple 03 apple07070ｷ3 020ｸ7020207030ｷ307, apple0308020703000400 006ｧ9 00006ｧ90ｷ30409 02090ｹ0 0007 08026ｦ002020ｷ3-04090ｹ0 02090ｹ0 0400040900 0400 閨07090ｹ0 036 5080ｸ7006ｧ907090ｹ0, 02 03060ｹ0 006ｧ9 0ｹ0 0703-03090ｹ0 0400040900 0400 閨07090ｹ0 04 000903086ｦ0 00080306 02086ｦ0 6 50703080ｸ70ｹ0 apple030ｷ302000ｹ107090ｹ0 (6 52-00060203080408 06036ｧ90709). 090703060402, 0ｸ7026ｧ8 09 03070409 020ｷ307 0402 0206070607 6ｧ802 07 0804080001 03020600000709, 閨07 006ｦ0030900 apple080ｸ7 00apple066 5006 5 060603090200 02 06 applefi 02 apple08020003-0400 02 02090ｹ0 apple 03086ｦ004 0ｹ0 000003 閨02090ｹ0, 0007 040ｸ7040400026ｧ9ｨB080702 07 0000 0207apple0806 080006026ｧ8 6 503076 509 020ｷ307 020ｸ7020207030ｷ307 (fiapple0ｷ30ｹ0 06 - apple0604020603090200 00000207 applefi 0006020308040208apple06026ｧ8 0001 閨02 0409) 02 06 6ｧ802 07 07 040203 閨6 7060009 0000 0209 040ｸ7090408036ｧ809090409 00006 5 03080706-02086ｦ0 0801 閨080ｹ0 6ｧ8 GGPP (geranylgeranyl pyrophosphate, 090003 070ｸ703090003 070ｸ703 apple0ｸ70308080ｷ30408o030602086ｦ0 21,22. ﾞ0ｸ7026ｧ8 09 apple 03 026ｧ803090409 08 6ｧ809090400 02080ｸ70ｹ0 0003000ｸ7070902 閨0ｹ0 0ｸ7020607 020ｷ307 00000300020607 04020907 0ｸ7applefi03000409 fi0206 09 07 040208036ｧ8 02090ｹ0 00apple 07 03-03fi080904090ｹ0 020ｷ307 04 000903086ｦ0 00080306 02086ｦ0 6 50703080ｸ70ｹ0 apple030ｷ302000ｸ8-070607 apple080ｸ7 040ｸ7040400026ｧ9ｨB0002 06 0000 0209 0408036ｧ809090409 0402 0206070607 0007-06O6ｾ4O08ｦﾌ ﾞ6ｾ4ｦ ﾞｦ ｦﾐ03 ﾇ ﾒ ﾞｦﾐ 090603ｦ 6ﾑ80703O0806ｦﾐ ﾞ 00040800 閨070ｷ30ｹ0 0808006ｧ9030002 06 04020907 07 040208036ｧ8 02090ｹ0 046ｦ007030004090ｹ0 02080ｸ7 00006 5 0308070602086ｦ0 0801 閨080ｹ0 02 06 0803060400 閨070ｷ307 apple03080ｸ8fi07020ｷ307 02080ｸ7 020003000ｸ702 6ｧ9080ｸ7, apple080ｸ7 apple030802 03086ｦ007 0806 0402 026ｧ907000ｹ021,22. ｦ 08 00006 5 0308070602fi 08016ｦ0 apple08020003006ｧ9 閨07 0007 060700000408 apple03080ｸ8fi07 040209 046ｦ00703000409 apple030ｷ302000ｸ8070607, fiapple0ｷ30ｹ0 09 GGPP, 0806 08apple086ｧ9000ｹ0 040ｸ7006 5070303080ｸ707 04020907 060408apple0300070ｸ7036ｧ90ｷ30409 020ｷ307 apple030ｷ302000ｸ8070607 apple080ｸ7 040ｸ707 閨080ｸ707 0208 GTP (GTP-binding proteins), 09 08apple086ｧ9 006ｧ907 06 apple 03 6ｧ902090209 0906 020907 00apple 07 0303fi08090409 020ｷ307 04 000903086ｦ0 00080306 02086ｦ0 6 50703080ｸ70ｹ0 apple030ｷ302000ｸ8070607 applefi 02 00apple0603090306 0207 026ｦ00202 03 020ｷ307 0009096ｦ00ｹ0 0004apple000603 0000 閨070ｷ307 040ｷ3030907 036ｧ90ｷ307 21,22. ﾇ 000009 036ｦ002000309 0602 07fi020902 02090ｹ0 0308-04080ｸ76 5 0402 026ｧ907090ｹ0 0400 046ｦ0090203060409 0000 02060ｹ0 0ｸ7applefi030806apple000ｹ0 0402-026ｧ907000ｹ0, 07 07 0402 閨03030006 0209 046ｦ00703000409 02080ｸ7 00006 5 0308070602086ｦ0 0801 閨080ｹ0, apple0603 0707 00010909006ｧ9 0208 0900090807fi0ｹ0 fi0206 00fi070807 09 0408036ｧ8-09090409 02090ｹ0 040ｸ709020002030600 閨07090ｹ0 0402 026ｧ907090ｹ0 0400 0ｸ76 70903 閨0ｹ0 fi- 0400060ｹ0, 040ｸ7040400026ｧ9ｨB0002 06 0000 020907 0000080707060409 02030607060207 閨02 09-03090ｹ0 apple030ｷ302000ｸ807080ｸ7036ｧ9 0ｹ08. 0307 040900 07020602fi 006ｦ0030900 02090ｹ0 apple 03086ｦ004 0ｹ0 000003-02090ｹ0 006ｧ907 06 0208 0900090807fi0ｹ0 fi0206 09 0408036ｧ809090409 02 06 020ｷ307 6ｦ008 fi04000ｷ307 02090ｹ0 030804080ｸ76 5 0402 026ｧ907090ｹ0 0007 00apple0903 陦 0400 0209 0700-080306026ｧ8 03000602080ｸ703096ｧ9 020ｷ307 040300070607 00000207 applefi 12 006 5 08-0007 000ｹ0 090ｷ3096ｧ80ｹ0. 090703060402, 09 0408036ｧ809090409 030804080ｸ76 5 0402-026ｧ907090ｹ0 040209 fi0409 020ｷ307 20 mg/0900 閨03 040ｸ7040400026ｧ90403090200 0000 006ｧ9 02070409 6 50003026ｧ90ｷ304090ｹ0 02090ｹ0 0700080306026ｧ80ｹ0 03000602080ｸ703096ｧ9 0ｹ0. ﾞ0ｸ7-02fi 0208 006ｦ0030900 006ｧ907 06 040ｸ7006 5 02fi 02 06 0000 070303000ｹ0 000003 閨02000ｹ0 apple080ｸ7 陦000601 07 fi0206 09 030804080ｸ76 5 0402 026ｧ90709 08 6ｧ9070002 06 07 閨040006 080ｸ7 閨02000309 23 6ｧ8 000ｸ707080ｸ8026ｧ8 00apple6ｧ9 03 0409 040209 0700080306026ｧ8 03000602080ｸ703096ｧ9 13,24. ﾒ070206 02 閨02080608 0007 apple08020003006ｧ9 閨02apple03090109 02 03060ｹ0 09 030804080ｸ76 5 0402 026ｧ90709 000202fi0ｹ0 applefi 0208 0900090807fi0ｹ0 fi0206 006ｧ907 06 apple08036ｦ0 apple08020003000400 0206026ｧ8 fi040807 08080307 020907 070206-00000206apple060409 02090ｹ0 0ｸ7040306apple06 06006ｧ9 0ｹ023, apple080ｸ7 apple08020003006ｧ9 0700-01070302090208 apple 030709080702 020607 6ｦ007080ｸ7 0906 020907 0000080707060409 0700-080306026ｧ80ｹ0 07fi04080ｸ75, 08 6ｧ9070002 06 07 閨040006 02 06 apple03000608020308apple0602 閨0ｹ0 03070400060ｹ0 apple080ｸ7 006ｧ907 06 apple03080402 02000ｸ7020602 閨0ｹ0 0906 0208 070008030602fi apple 03 閨09040ｸ700 9,25,26. 6ﾑ8apple06apple03fi04030002, 09 07 040208036ｧ8 02090ｹ0 00- apple 07 0303fi080904090ｹ0 apple030ｷ302000ｸ8070607 applefi 02 026ｦ00202 03 02080ｸ7 0007-080309036ｧ9080ｸ7 020ｷ307 0009096ｦ00ｹ0 0004apple000603 0000 閨070ｷ307 040ｷ3030907 036ｧ90ｷ307 00apple0803006ｧ9 0ｸ7026ｧ8 02 03 0ｸ7026ｧ8 07 apple08020003006ｧ9 閨07 07 apple0603 07fi 00apple06apple03fi0403000208 0700080308apple03080402 02000ｸ7020602fi 000904 07060400fi 02080ｸ7 08 03000702080ｸ727. 6ﾑ86ｧ907 06 09070ｷ30402fi fi0206 09 0ｸ7apple000308fi03020ｷ30409 020ｷ307 0007 0803090306 020607 020ｸ7020207030ｷ307 020ｷ307 0009096ｦ00ｹ0 0004apple000603 0000-070ｷ307 040ｷ3030907 036ｧ90ｷ307 0000 apple030ｷ302000ｹ107000ｹ0 040ｸ7040400026ｧ9ｨB0002 06 0000 080300090008076ｧ8 02 06 0ｸ7010900 閨0708 08010006 0ｷ3020602fi 040203000ｹ0 02080ｸ7 040ｷ3-030907 030608 0607000004080ｸ7 060402086ｦ0, 02 03060ｹ0 02 06 0000 0007 0803090306-026ｧ8 0ｸ70403000602080ｸ703096ｧ9 02080ｸ7 070008030602086ｦ0 04apple0006030700 02080ｹ0 apple080ｸ7 閨040006 0ｷ30ｹ0 apple0802 閨03000400 020907 0ｸ7010900 閨0709 06 apple0003 02fi020902 02080ｸ7 020003000ｸ702 6ｧ9080ｸ7 0402060ｹ0 0607080803000ｹ0 apple030ｷ302000ｹ107000ｹ028. 0900 6 507-0409 02 00 0800 閨07 0ｸ70207 00apple0803006ｧ9 07 0003000907006ｦ00002 06 02 06 0208 0900090807fi0ｹ0 fi0206 0008030807fi0206 09 030804080ｸ76 5 0402 026ｧ90709 0400 fi- 0409 20 mg/0900 閨03 040ｸ7040400026ｧ90403090200 0000 006ｧ9 040900 0702060207 000009 036ｦ002000309 6ｦ001090409 02090ｹ0 0700080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 1-145
1309. ﾒ036ｾ4ｦ ﾞ09 ﾞ03O6ｾ4 ﾒ ﾞｦﾐ 6ｾ40803. 6ﾑ80303090706026ｧ8 03000803o03o096ｧ9 20, 2008 00060203080408 06036ｧ907090ｹ0, 0400 046ｦ0090203060409 0000 020907 07026ｧ9040208060409 6ｦ001090409 apple080ｸ7 apple0308020703000400 09 030804080ｸ76 5 0402 026ｧ90709 0400 fi0409 10 mg/0900 閨03, 09 00apple6ｧ9 03 0409 02090ｹ0 0ｸ76 70903fi020003090ｹ0 fi04090ｹ0 040209 0700080306026ｧ8 03000602080ｸ703096ｧ9 08 6ｧ9070002 06 fi0206 6ｧ802 07 apple00030604-04fi02000308 000ｸ707080ｸ8026ｧ8. 6ｾ40ｸ700apple0003 0400 02060207, 08 6ｧ9070002 06 fi0206 09 030804080ｸ76 5 0402-026ｧ90709 apple030802 03006ｧ9 006ｧ9 0804080001 03020600000709 6ｦ001090409 02090ｹ0 0700-080306026ｧ80ｹ0 apple 閨0202030604090ｹ0 02090ｹ0 1-00060203080408 06036ｧ907090ｹ0 02 06 0007 00apple09030007ｨB0006 0209 0700080306026ｧ8 03000602080ｸ703096ｧ9 0400 04030007006ｧ90ｹ0 0000 apple030ｷ30208apple 036ｧ8 0ｸ7040306apple06 06006ｧ9. Summary M. Kostapanos, Ch. Milionis, V. Saougos, Ch. Kostara, E. Bairaktari, M. Elisaf. The effect of rosuvastatin on renal function and renal protein excretion in patients with primary dislipidaemia. Hellen Nephrol 2008; 20 (2): 139-147. Aim. To investigate the effect of rosuvastatin in different doses on urinary protein excretion and renal function parameters in patients treated for primary hyperlipidemia. Patients-Methods. In this study, 90 patients with primary hyperlipidemia were randomly assigned to rosuvastatin 10 (RSV10 group) or 20 mg/day (RSV20 group). Urinary creatinine and protein (total, albumin, immunoglobulin G, and a1-microglobulin) levels were measured at baseline and after 12 weeks of treatment in all patients. The protein-to-creatinine ratios were used to assess urinary protein excretions. Serum creatinine and estimated glomerular filtration rate (GFR) were used as markers of renal function. Results. A dose-dependent increase in the excretion of a1-microglobulin (17.6% in the RSV10 vs 34.9% in the RSV20 group) was observed. There was no effect on total protein, albumin and immunoglobulin G urinary excretions as well as on the fractional excretions of electrolytes and uric acid in both groups. Rosuvastatin 10mg/day did not affect renal function parameters, whereas a trend towards an increase in GFR (79.3 ﾀ11.5 at baseline vs 82.9 ﾀ13.9 ml/min/ 1.73m 2 post-treatment, p=0.08) was noted in the RSV20 group. Conclusions. Rosuvastatin produces a dose-dependent increase in a1-microglobulin urinary excretion implying a functional disturbance of the proximal tubules without adversely affecting renal function. Key words: a1-microglobulin, proteinuria, renal function, rosuvastatin. B066 50306080903 086ｧ9 1. Ong HT. The statin studies: from targeting hypercholesterolaemia to targeting high-risk patient. Q J Med 2005; 98: 599-614. 2. Athyros VG, Mikhailidis DP, Papageorgiou A, et al. Attaining United Kingdom-European Atherosclerosis Society low-density lipoprotein cholesterol guideline target values in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study. Curr Med Res Opin 2002; 118: 499-502. 3. Sever PS, Dahlof B, Poulter NR, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (AS- COT-LLA): a multicentre randomized controlled trial. Lancet 2003; 361: 1149-1158. 4. Athyros VG, Mikhailidis DP, Papageorgiou AA, et al. The effect of statins on renal function in patients with coronary heart disease. A subgroup analysis of the Greek atorvastatin and coronary heart disease evaluation (GREACE) study. J Clin Pathol 2004; 57: 728-734. 5. Agarwal R, Curley TM. The role of statins in chronic kidney disease. Am J Med Sci 2005; 330: 69-81. 6. Sandhu S, Wiebe N, Fried LF, Tonelli M. 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