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1 A05002
2
3 A05005
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5 A05017
6 200. CEA B. CA-19 C. CA-125 D. HCG E. α-fetoprotein Papillary serous carcinoma α fetoprotein
7 A05039 KK
8 A05039 KK
9 A 17-year-olf high school senior presents to his local physician for a routine physical prior to the start of the football season. During the physical examination, a non-tender single cervical lymph nod, measuring approximately 2 cm in diameter, is noted. Upon questioning, the patient complains of a 4.5 kg-weight loss over the past summer and occasional night sweats. He also complains of generalized pruritis with no evidence of any rash or skin irritation. the remainder of the physical examination is unremarkable with the exception of a palpable spleen 5 cm below the left costal margin. A biopsy of a lymph node revealed effacement of the node, with nodules composed of mature lymphocytes, plasma cells, eosinophils, and Reed-Sternberg cells(lacunar type). The nodules are separated by large bands of collagen. What is the MOST likely diagnosis? A. non-hodgkin s lymphoma, small lymphocytic type B. Hodgkin s disease, lymphocyte-predominance type C. non-hodgkin s lymphoma, follicular, predominantly large cell, type D. Hodgkin s disease, nodular sclerosing type A05039 KK
10 Subsequent evaluation revealed that the patient s spleen and bone marrow were involved in this process. What is the stage of this patient s disease? A. B. B C. D. B A05039 KK
11 The malignant cell in Hodgkin s disease is the: A. plasma cell B. lymphocyte C. Reed-Sternberg cell D. eosinophil A05039 KK
12 A 32-year-old white woman presents to the emergency room with uncontrollable menstrual bleeding. Laboratory tests reveal: WBC*45000/microlotter with 90% hypergranular promyelocytes containing numerous Auer rods; hemoglobin 7.2 g/dl, Hematocrit 21 ml/dl; platelets 7000/cubic millimeter. The patient is admitted to the hospital. Five days later, a cytogenetics report shows a t(15;17) chromosomal translocation. What is the MOST likely diagnosis? A. acute monocytic leukemia B. acute myelomonocyteic leukemia C. acute promyelocytic leukemia D. acute megakaryocytic leukemia A05039 KK
13 The t(15;17) translocation is associated with which of the following? A. BCR-ABL fusion protein B. E2A-PBX fusion protein activation C. c-myc activation D. PML-RAR-alpha fusion protein activation A05039 KK
14 Select the WRONG sentence concerning breast carcinomas; A. Breast cancer is the 2nd common malignancy worldwide and the 5th common malignancy seen in Japan. B. Early menarche, late menopause, late first delivery, presence of family history, estrogen exposure, contralateral breast and endometrium carcinoma, obesity, lack of exercise, lack of breast feeding are all risk factors for breast cancer C. Cut-off values for staging breast carcinoma are; 2 / 2-5 / 5< cm. and 0/1-3/4-9 metastatic lymph nodes. D. Hormone receptor and HER2 status are important for pathology but have no role for patient management in human breast carcinomas E. Histopathologic diagnosis is mandatory for patient management A05039 KK
15 Select the WRONG sentence concerning gynecologic neoplasms; A. Only few ovarian neoplasms are derived from surface epithelium B. Most common germ cell tumor is benign cystic teratoma (dermoid cyst) C. Surface epithelial tumors have benign, borderline and malignant subgroups D. Uterine leiomyomas are the most common tumors in humans E. Endometrial carcinoma are composed of type and groups (endometrioid and non-endometrioid) with differing pathogenesis, background, clinical-pathological properties and prognosis A05039 KK
16 Which of the following is WRONG: A. Call-Exner bodies are specific for surface epithelial tumors of the ovary B. Granulosa cell tumors of the ovary show inhibin positivity C. Dysgerminoma is the ovarian counterpart of seminoma of the testis D. Immature teratomas are rare and have aggressive behavior E. Serous carcinomas are the most common malignant ovarian tumors A05039 KK
17 31. Select the WRONG sentence concerning uterine cervix carcinoma: A. Uterine cervix cancer is a preventable disease B. Dysplasia is the most recent and preferable term for intraepithelial neoplastic precursor lesions, instead of CIN or SIL C. Human Papilloma Virus is currently considered to be the most important etiologic agent D. Viral E6 and E7 genes of high-risk HPV s disrupt the cell cycle via binding to RB and p53 proteins E. Majority of uterine cervix cancers are preceded by a precancerous lesion Dysplasia CIN 90 SIL ( Terminology ) A
18 Which one is odd? BRCA1 andbrca2 genes: A. have similar functional properties B. are located on chromosome 13 and 17 C. are always abnormal in sporadic and familial breast carcinomas D. deletion or loss of function cause breast and ovarian cancer E. are tumor suppressor genes A05039 KK
19 40 a. b. c. d. A05039 KK
20 a. CEA b. CG c. ALP d. GOT A05039 KK
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