スギ花粉症モデルマウスにおけるユーグレナの効果についての検討
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- なごみ おおかわち
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1 [ 研究ノート ] Effect of euglena on cedar pollen allergies in cry j-sensitized mice Miki Koizumi, Yui Yoshii, Masahiro Yuasa, Hiromi Sawamura, Toshiaki Watanabe, Eriko Yoshida, Kengo Suzuki Department of Dietary Environment Analysis, School of Human Science and Environment, University of Hyogo,, Shinzaike-honcho, Himeji-shi, Hyogo, Euglena Co. Ltd., 7F University of Tokyo, Entrepreneur Plaza,, Hongo, Bunkyo-ku, Tokyo, Cedar pollen allergies are one of the severe health problems in Japan.Recently, it was reported that symptoms of pollen allergies are attenuated by the intake of functional foods.euglena is a unicellular organism classified as algae, which is taking notice as a functional food.in this study, the effect of euglena on experimental pollen allergies in mice was investigated. week-old BALB/c male mice were sensitized using Cry j by intraperitoneal injection and intranasal instillation.ainm was fed to the negative control and positive control group, whereas euglena, paramylon, and amorphous paramylon were fed in AINMto each diet group.we determined the incidence of nasal rubbing, liver weight, spleen weight, white blood cell counts, serum IgE and IFN. In the euglena diet group, the percentage of positive incidences of nasal rubbing mice decreased.it is suggested that euglena may attenuate symptoms of cedar pollen allergies. 1. 諸言 IgE Cry j Cry j T Th Th Th Th Th IL IFN Th
2 Vol.No. IL IL Th Th Th Th Th Euglena gracilis Z D HIV Th ThNC/Nga D IgE IL IFN IgE IgE Cry j g g 2. 実験方法 ( 1 ) 実験動物および飼料組成 BALB/c NCPC EP A n ( 2 ) 飼料組成 Table SDS SDS mol/l mol/l ph NC PC AINM E P A Table 1 ユーグレナの栄養素組成 g/ g g g a g g g b kcal c g a b c
3 AINM Table ( 3 ) 花粉症モデルマウスの作製 Cry j AlOH AlOH mol/l mol/l Fig. PC E P A Cry j g Al OH ml PBS L Cry j g NC AlOH PBS ( 4 ) 試料採取 rpm Table 2 飼料組成 g/ g NC PC E P A L (n=7 8) Fig. 1 実験スケジュール
4 Vol.No. Mean±SD(n=7 8) Scheffeʼs F test Fig. 2 体重の変化 (n=7 8) Scheffeʼs F test Fig. 3 飼料摂取量の変化 ( 5 ) 鼻掻き行動の観察 NC SD ( 6 ) 分析方法 1 ) 白血球数の算定 L L Burker-Turk 2 ) 血清総 IgE 濃度および血清サイトカイン濃度の測定 IgE IgEELISA IFN IFNmouse, ELISA kit ENZO LIFE SCIENCE, INC., USA ( 7 ) 統計処理 Statcel SD p 3. 結果 ( 1 ) 体重および飼料摂取量 Fig. Fig. ( 2 ) 組織重量 NC P ppc E A P Table NC E ppcpa ptable ( 3 ) 鼻掻き行動 PC E p<table ( 4 ) 血液生化学検査 Table IgE NC PCEPA p PC E A P Table IFN NC PCEPA Table
5 Table 3 組織重量および血液生化学的分析値 NC PC E P A Liver weight g Spleen weight mg White blood cell counts /ml Total IgE ng/ml IFNpg/mL Mean SDn Scheffes F test p, p vs NC Table 4 鼻掻き行動の陽性である割合 a 4. 考察 NC IgE Cry j E P A IgE P IgE Th Th Th E IgE Cry j PC E P A # n p vs PC a NC SD IgE T B Cry j P TNF P Th/Th ILIL Th Cry j IgE
6 Vol.No. 文献 Progress in Medicine, 28 Yasueda H., Yui Y., Shimizu T.: Isolation and partial characterization of the major allergen from Japanese cedarcryptomeria japonica, J Allergy Clin Immunol, 71, Sakaguchi M., Inouye S., Taniai M., Ando S., Usui M., Matuhasi T.: Identification of the second major allergen of Japanese cedar pollen, Allergy, 45, Fujiwara D., Wakabayashi H., Watanabe H., Nishida S., Iino H.: A double-blind trial of Lactobacillus paracasei strain KW administration for immunomodulation in patients with pollen allergy, Allergol Int, 54, 19 Sato Y., Akiyama H., Sugamura H., Watanabe T., Hamano- Nagaoka M., Inakuma T., Goda Y., Maitani T.: The feeding of -carotene down- regulates serum IgE levels and inhibits the type allergic response in mice, Biol Pharm Bull, 27, Nat Med55 Kondo Y., Kato A., Hojo H., Nozoe S., Takeuchi M., Ochi K. Cytokine-related immunopotentiating activities of paramylon, a --D-glucan from Euglena gracilis, J Pharmacobio-Dyn, 15, Sugiyma A., Suzuki K., Mitra S., Arashida R., Yoshida E., Nakano R., Yabuta Y., Takeuchi T.: Hepatoprotective effects of paramylon, a --D-glucan isolated from Euglena gracilis Z, on acute liver injury induced by carbon tetrachloride in rats. J Vet Med Sci, 71, Koizumi N., Sakagami H., Utsumi A., Fujinaga S., Takeda M., Asano K., Sugawara I., Ichikawa S., Kondo H., Mori S., Miyatake K., Nakano Y., Nakashima H., Murakami T., Miyano N., Yamamoto N.: Anti-HIV human immunodeficiency virus activity of sulfated paramylon, Antiviral Res, 21, Sakagami H., Kikuchi K., Takeda M., Sato T., Ichikawa S., Fujimaki M., Wada C., Komatsu N.: Macrophage stimulation activity of antimicrobial N, N-dimethylaminoethl paramylon, In Vivo, 5, Sugiyama A., Hata S., Suzuki K., Yoshida E., Nakano R., Mitra S., Arashida R., Asayama Y., Yabuta Y. and Takeuchi T.: Oral administration of paramylon, a --D-glucan isolated from Euglena gracilis Z inhibits development of in NC/Nga mice. J Vet Med Sci, 72, Kimura Y., Sumiyoshi M., Suzuki T. and Sakanaka M. Inhibitory effects of water-soluble low-molecular-weight beta- d-glucan purified from Aureobasidium pullulans GM-NH- A strain on food allergic reactions in mice, Int Immunopharmacol, 7, Yamada J., Hamuro J., Hatanaka H., Hamabata K. and Kinoshita S. Alleviation of seasonal allergic symptoms with superfine beta--glucan: a randomized study, J Allergy Clin Immunol, 119, Watanabe T., Shimada R., Matsuyama A., Yuasa M., Sawamura H., Yoshida E. and Suzuki K.: Antitumor activity of the -glucan paramylon from Euglena against preneoplastic colonic aberrant crypt foci in mice: Food Funct, 4, 11 NOS35 Ogita-Nakanishi H., Nabe T., Mizutani N., Fujii M., Kohno S.: Absence of nasal blockage in a Japanese cedar polleninduced allergic rhinitis model mouse, Allergol Int, 58, Nabe T., Shinoda N., Yamashita K., Yamada M., Yamamura H., Kohno S.: Comparative studies on nebulizers for antigen inhalation in experimental asthma, Allergol Int, 46, Grewe M., Gyufko K., Schöpf E., Krutmann J.: Lesional expression of interferon-gamma in atopic eczema, Lancet, 343, Grewe M., Bruijnzeel-Koomen CA., Schöpf E., Thepen T., Langeveld-Wildschut AG., q Ruzicka T., Krutmann J.: A role for Th and Th cells in the immunopathogenesis of atopic dermatitis, Immunol Today, 19, 61 C Euglena glacilis Z 40 DHA 48
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