Worldwide Research Hot News ICGC by Michael D. O Neill International Cancer Genome Consortium ICGC , ICGC ICGC ICGC 2008
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1 QIAGEN eyes News & Topics from QIAGEN 9March 2014 Contents Worldwide Research Hot News ICGC Pathway Application 8 11 Seminar Report Letter from Technical Service QIAGEN 15 Information 16 Sample & Assay Technologies
2 Worldwide Research Hot News ICGC by Michael D. O Neill International Cancer Genome Consortium ICGC , ICGC ICGC ICGC ICGC 8 ICGC 500 ICGC Cancer Genome Project ICGC ICGC ICGC , ICGC ICGC BioMart Data Coordination Center ICGC 3 4 cholangiocarcinoma Issue 9/2014
3 Worldwide Research Hot News ICGC Thomas J. Hudson Ontario Institute for Cancer Research ICGC 2 7 ICGC Hudson NIH The Cancer Genome Atlas TCGA 8 Wellcome Trust Sanger Institute Cancer Genome Project CGP 9 ICGC Hudson ICGC DNA Hudson 600 DNA Hudson Journal of Internal Medicine International Journal of Cancer Cell 12Hudson DNA TCGA ICGC 8,000 ICGC Data Coordination Center ICGC DCC Hudson ICGC ICGC Issue 9/2014 Sample & Assay Technologies 3
4 Worldwide Research Hot News Nature 13 TCGA TCGA ICGC INGENUITY INGENUITY QIAGEN TCGA Institute of Cancer Research Alan Ashworth 14 Hudson 15 Nature ICGC 2 2 INGENUITY Systems QIAGEN INGENUITY Systems INGENUITY Systems IPA omics ireport RNA-Seq PCR Variant Analysis Ingenuity Knowledge Base INGENUITY Systems 1 INGENUITY RNA-Seq INGENUITY Systems ICGC 4 Issue 9/2014
5 Worldwide Research Hot News 1. Cancer Genome Consortium (ICGC) Web Site. International 2. The International Cancer Genome Consortium, International Network of Cancer Genome Projects, Nature 464: (April 15, 2010) Yasushi Totoki, Kenji Tatsuno, Shogo Yamamoto, et al., High-Resolution Characterization of a Hepatocellular Carcinoma Genome, Nature Genetics 43(5): (May, 2011) Akihiro Fujimoto, Yasushi Totoki, Tetsuo Abe, et al., Whole-Genome Sequencing of Liver Cancers Identifies Etiological Influences on Mutation Patterns and Recurrent Mutations in Chromatin Regulators, Nature Genetics 44(7): (July, 2012) ICGC News Release (November 3, 2013) Yuchen Jiao, Timothy M. Pawlik, Robert A. Anders, et al., Exome Sequencing Identifies Frequent Inactivating Mutations in BAP1, ARID1A and PBRM1 in Intrahepatic Cholangiocarcinomas, Nature Genetics 45: (December, 2013) ICGC News Release (December 4, 2012) Cancer Genome Project (CGP) Web Site The Cancer Genome Atlas (TCGA) Web Site T.J. Hudson, Genome Variation and Personalized Cancer Medicine, J. Internal Medicine 274: (November, 2013) Ben Tran, Andrew M.K. Brown, Philippe L. Bedard, et al., Feasibiity of Real Time Net Generation Sequencing of Cancer Genes Linked to Drug Response: Results from a Clinical Trial, International Journal of Cancer 132: (October 1, 2013) Janet E. Dancey, Philippe L. Bedard, Nicole Onetto, and Thomas J. Hudson, The Genetic Basis for Cancer Treatment Decisions, Cell 148: (February 3, 2012) Cyriac Kandoth, Michael D. McLellan, Fabio Vandin, et al., Mutational Landscape and Significance Across 12 Major Cancer Types, Nature 502: (October 17, 2013) Alan Ashworth, Comparisons Across Cancers Order from Disorder Sprung, Nature 502:306 (October 17, 2013) Thomas J. Hudson, Comparisons Across Cancers A Clinical Perspective, Nature 502: (October 17, 2013). BioQuick WORLDWIDE RESEARCH HOT NEWS 30 D. BioQuick 3 UrzymeRNA Neuroscience 2013 MicroRNA pirna Neuroscience 2013 BioQuick Issue 9/2014 Sample & Assay Technologies 5
6 2 MDx 10 3 CDx TR EGFR EGFR KRAS CDx CDx 100 PCR GMP Good Manufacturing Practice GMP FDA 6 Issue 9/2014
7 TR 1 TR CDx CDx 2013 CDx CDx NGS TR NGS TR 大学ベンチャー企業 シーズ ニーズ 治療薬 C 開発 研究所標準化 治療薬 B 開発 製薬企業 診断薬企業 治療薬 A 開発 プロトタイプ診断薬 A 開発 治療薬開発 診断薬 Ver.1.0 治療薬開発 診断薬 Ver.2.0 薬事同時申請 承認 包括開発契約の締結 Phase I Phase II Phase III 1. Issue 9/2014 Sample & Assay Technologies 7
8 Pathway Application Unstructured uncertainty Structured uncertainty 1 1. H Bode-Shannon Bode Shannon 8 Issue 9/2014
9 Pathway Application Elia, N., When bode meets Shannon: control-oriented feedback communication schemes, IEEE Transactions of Automatic Control, 49(9), , 2004; Tatikonda, S., Control under Communication Constraints, Ph.D. Thesis, MIT, Bode-Shannon 2. Bode-Shannon theorem Bode-Shannon NFB 50 Glucose Floor Glucose Ceiling 3 Kitano, et al., Metabolic Syndrome 3. Issue 9/2014 Sample & Assay Technologies 9
10 Pathway Application and Robustness Tradeoffs, Diabetes, 53, S6-S15, Controllability 2 Barabasi Liu, Y-Y., Slotine, J-J., Barabasi, A-L., Controllability of Complex Networks, Nature, 473, , 2011 Barabsi Crespo, et al., Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease, BMC Systems Biology, 6: Controllability analysis APP Amyloid Beta Mizuno, et al., AlzPathway: a comprehensive map of signaling pathways of Alzheimer s disease, BMC Systems Biology, 6: Issue 9/2014
11 Pathway Application 5. AlzPathway Controllability Analysis Complex Systems Ilya Prigogine G. I BZ Belousov-Zhabotinsky Reaction BZ Issue 9/2014 Sample & Assay Technologies 11
12 Seminar Report SNPs GWAS DNA , GWAS 1,000 SNPs SNPs 5 6, RNA DNA 1 SNPs 12 Issue 9/2014
13 Seminar Report NIH 1,000 1,000 NIH NCBI GenBank EMBL DNA EU SPIDIA NCBI EMBL DNA DDBJ BBJ DNA 30 NCBN JPDSC JPDSC 1. DNA DNA JPDSC DNA Issue 9/2014 Sample & Assay Technologies 13
14 Letter from Technical Service Spotlight on Expertise FFPE Q FFPE DNA RNA A DNA RNA AllPrep FFPE AllPrep DNA/RNA FFPE Kit FFPE AllPrep DNA/RNA FFPE Kit microrna 18 nt RNA FFPE FAQ Tips! FAQ QIAGEN AllPrep DNA/ RNA FFPE KitCat. no. FAQ 14 Issue 9/2014
15 Letter from Technical Service QIAGEN Did you know? Supplementary Protocol User Developed Protocol Q FFPE DNA A QIAamp DNA FFPE Tissue Kit Cat. no Deparaffinization Solution Cat. no Supplementary Protocol QIAGEN QIAGEN Supplementary Protocol QSP User Developed Protocol UDPQSP UDP * QSP UDP 1. QIAGEN Deparaffinization Solution Cat. no Supplementary Protocol User Developed Protocol * techservice-jp@qiagen.com QIAGEN FFPE DNA mirna RNA AllPrep DNA/RNA FFPE Kit FFPE? DNA RNA FFPE RNA Human Cell Cycle RT 2 Profile PCR Array 1 MDA Multiple Displacement Amplification 2 OmniScript Reverse Transcriptase 3 QuantiTect Reverse Transcriptase 4 RT 2 FFPE PreAMP AllPrep DNA/RNA FFPE Kit QIAGEN epromo-jp@qiagen.com QIAGEN 3 DNA Issue 9/2014 Sample & Assay Technologies 15
16 Information mirna FFPE QIAGEN n mirna mirna n FFPE FFPE n 1 n URL n mirna n FFPE QIAGEN QIAGEN QIAGEN Trademarks and Disclaimers QIAGEN Handbook User Manual Trademarks: QIAGEN, QIAamp, AllPrep, OmniScript, QuantiTect (QIAGEN Group); INGENUITY, ireport (INGENUITY Corporation) / QIAGEN, all rights reserved n n n Forefront Tower II Tel: n Fax: n techservice-jp@qiagen.com Sample & Assay Technologies
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Integrated Biology Solutions 2009 1 Nature, Science, Am. J. Human Genet. 1 120 mer 2 DNA crna 120 mer crna DNA crna DNA 1 Publication Compendium p/n5990-7233en 2Nat Biotechnol. 2009 Feb;272:182-9. Epub2009
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2 CONTENTS mi/n/na/to Vol.3 2 4 8 10 12 13 14 15 3 mi/n/na/to 5 4 7 6 9 8 10 10 11 11 Vol.3 TOKYO-WAN-DER-LAND Tokyo Bay Data Book Vol.3 1 13 12 1 1 1 1 5 May 4 April 15 14 3 Event Information From Wave
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NEWS LETTER No.5 2006.12 1 No. 2006 2 2006/11/30 2006/11/30 2006/11/29 No. 2006 2006/11/29 2006/11/29 2006/11/28 3 No. 2006 4 No. 2006 2006/11/27 2006/11/27 2006/11/27 2006/11/27 5 No. 2006 2006/11/27
