1 ORGANIZATION and STAFF as of December, 2017 Department of Microbiology and Immunology Division of Virology Project Associate Project Associate Proje

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1 Preface It is our great pleasure to present our Annual Report 2017 for the Institute of Medical Science, The University of Tokyo (IMSUT). The predecessors to IMSUT was founded in 1892 as the Institute of Infectious Diseases (IID) by Dr. Shibasaburo Kitasato and incorporated into the University of Tokyo in In that era, infectious diseases were the greatest threat to our daily lives and the IID was the center for research into infectious diseases in Asia and a top center for the world, as well. In 1967, our institute received its present name when we reorganized it to encompass a wider range of medical sciences to meet the demands of modern medical care after World War II. In addition to infectious diseases, our research areas have now grown to include cellular and molecular biology, cancer biology, immunology, genome science, tissue engineering, experimental animal disease model research, stem cell/ips biology, vaccine development and other related areas. Thus, our current research spectrum took form and IMSUT gained respect as a research institute focused on medical science. From the IID's very beginning, our scientific forefathers carried out both basic research on pathogens and applied studies to feed their findings back into improved patient care for the prevention and treatment of infectious diseases. This tradition or institutional "DNA" has been passed down to present-day IMSUT: our goal remains discovery through basic medical research and innovation of medical care and prevention through translational research. Reflecting this central paradigm, our affiliated hospital is an important asset for the execution of our mission of "bench to bed" and "bed to bench" research immediately within our institute. In 2017, our institute marked the 125th anniversary of its founding as the IID and the 50th anniversary of its reorganization and renaming to IMSUT. With an eye toward the future beyond our 125th anniversary, we have been pursuing the initiative "IMSUT One to Gogo (125/50)," and are working together under this slogan to transform IMSUT into a yet more advanced, world-leading research institute in medical science. This annual report summarizes our scientific achievements in I sincerely hope that these achievements will inspire yet further advances, promote worldwide collaborations with our scientists, and ultimately contribute to improve health care around the world. January 2018 Yoshinori Murakami, M.D., Ph.D. Dean The Institute of Medical Science The University of Tokyo

2 1 ORGANIZATION and STAFF as of December, 2017 Department of Microbiology and Immunology Division of Virology Project Associate Project Associate Project Associate Project Associate Assistant Assistant Project Assistant Research Associate Yoshihiro Kawaoka, D.V.M., Ph.D. Makoto Yamashita, Ph.D. Masaki Imai, D.V.M., Ph.D. Satoshi Fukuyama, M.D., Ph.D. Tokiko Watanabe, D.V.M., Ph.D. Seiya Yamayoshi, D.V.M., Ph.D. Kiyoko Iwatsuki-Horimoto, D.V.M., Ph.D. Shinya Yamada, Ph.D. Maki Kiso, D.V.M., Ph.D. Yuko Sakai-Tagawa, Ph.D. Division of Infectious Genetics Associate Assistant Assistant Kensuke Miyake, M.D., Ph.D. Shin-Ichiroh Saitoh, Ph.D. Ryutaro Fukui, Ph.D. Takuma Shibata, Ph.D. Division of Mucosal Immunology Assistant Division of Molecular Virology Assistant professor Assistant professor Hiroshi Kiyono, D.D.S., Ph.D. Rika Nakahashi, Ph.D. Yasushi Kawaguchi, D.V.M., Ph.D. Akihisa Kato, Ph.D. Jun Arii, Ph.D.

3 2 Department of Cancer Biology Division of Molecular Pathology Assistant Assistant Yoshinori Murakami, M.D., Ph.D. Takeharu Sakamoto, Ph.D. Takeshi Ito, Ph.D. Division of Cellular and Molecular Biology Associate Assistant Assistant Assistant Jun-ichiro Inoue, Ph.D. Taishin Akiyama, Ph.D. Yuu Taguchi, Ph.D. Yuri Shibata, Ph.D. Mizuki Yamamoto, Ph.D. Division of Genetics Assistant Assistant Assistant Yuji Yamanashi, Ph.D. Tohru Tezuka, Ph.D. Ryo Ueta, Ph.D. Sumimasa Arimura, Ph.D. Division of Cancer Cell Biology Senior Assistant Assistant Makoto Nakanishi, M.D., Ph.D. Atsuya Nishiyama, Ph.D. Yoshikazu Johmura, Ph.D. Department of Basic Medical Sciences Division of Neuronal Network Assistant Assistant Assistant Toshiya Manabe, M.D., Ph.D. Hiroyuki Katagiri, Ph.D. Shizuka Kobayashi, Ph.D. Takahiko Chimura, Ph.D. Division of Cell Signaling and Molecular Medicine Assistant Assistant Mutsuhiro Takekawa, M.D., Ph.D. Yuji Kubota, Ph.D. Takanori Nakamura, Ph.D.

4 3 Affiliated Research Facilities Human Genome Center Laboratory of DNA Information Analysis DNA Laboratory of Sequence Analysis Laboratory of Genome Database Satoru Miyano, Ph.D. Associate Rui Yamaguchi, Ph.D. Assistant Yuichi Shiraishi, Ph.D. Associate Tetsuo Shibuya, Ph.D. Assistant Kotoe Katayama, Ph.D. Project Senior Assistant Yoshinori Tamada Project Assistant Taku Onodera Laboratory of Molecular Medicine Assistant Tatsuhiro Shibata, M.D., Ph.D. Satoshi Yamasaki, Ph.D. Laboratory of Genome Technology Assistant Project Assistant Project Assistant Satoru Miyano, Ph.D. Koichi Matsuda, M.D., Ph.D. Chizu Tanikawa, Ph.D. Takafumi Miyamoto, Ph.D. Makoto Hirata, M.D., Ph.D. Laboratory of Functional Analysis In Silico Kenta Nakai, Ph.D. Senior Assistant Ashwini Patil, Ph.D. Project Senior Assistant Sung-Joon Park, Ph.D. Department of Public Policy Associate Project Assistant Project Assistant Kaori Muto, Ph.D. Yusuke Inoue, Ph.D. Hyunsoo Hong, Ph.D. Akiko Nagai, Ph.D.

5 4 Center for Experimental Medicine and Systems Biology Laboratory of Developmental Genetics Associate Assistant Laboratory of Innate Immunity Nobuaki Yoshida M.D., D.M.Sc. Hirotake Ichise D.V.M., Ph.D. Taeko Ichise Ph.D. Kensuke Miyake, M.D., Ph.D. Laboratory of Reproductive Systems Biology Project Associate Masahito Ikawa Ph.D. Manabu Ozawa Ph.D. Laboratory of Systems Biology Associate Susumu Nakae, Ph.D. Advanced Clinical Research Center Division of Molecular Therapy Associate Assistant Assistant Division of Cellular Therapy Associate Assistant Assistant Arinobu Tojo, M.D., D.M.Sc. Satoshi Takahashi, M.D., D.M.Sc. Muneyoshi Futami, M.D., D.M.Sc. Seiichiro Kobayashi M.D., D.M.Sc. Toshio Kitamura, M.D., D.M.Sc. Susumu Goyama, M.D., D.M.Sc. Tomofusa Fukuyama, M.D., D.M.Sc. Yosuke Tanaka, M.D., D.M.Sc. Division of Infectious Diseases Associate Assistant Assistant Hiroshi Yotsuyanagi, M.D., D.M.Sc. Takeya Tsutsumi, M.D., D.M.Sc. Michiko Koga, M.D., D.M.Sc. Tadashi Kikuchi, M.D, D.M.Sc. Division of Bioengineering Senior Assistant Hideaki Tahara, M.D., Ph.D. Hiroaki Uchida, M.D., Ph.D.

6 5 Division of Clinical Genome Research Associate Project Senior Assistant Yoichi Furukawa M.D., Ph.D. Tsuneo Ikenoue M.D., Ph.D. Kiyoshi Yamaguchi Ph.D. Division of Innovative Cancer Therapy Associate Project Associate Senior Assistant Tomoki Todo, M.D., Ph.D. Yasushi Ino, M.D., Ph.D. Minoru Tanaka, M.D., Ph.D. Hiroyuki Momota, M.D., Ph.D. Division of Advanced Medicine Promotion Associate Fumitaka Nagamura, M.D., D.M.Sc. Masanori Nojima, M.D., Ph.D., M.P.H. Division of Advanced Genome Medicine Associate Project Assistant Yoshihiro Hirata, M.D., Ph.D. Ryosuke Muroyama, M.D., Ph.D. Division of Genetic Therapeutics Project Senior Assistant Division of Bioethics Keiya Ozawa, M.D., D.M.Sc. Shin-ichi Muramatsu, M.D., Ph.D. Sumimasa Nagai, M.D., Ph.D. Associate Ayako Kamisato, Ph.D. Center for Stem Cell Biology and Regenerative Medicine Division of Stem Cell Transplantation Associate Arinobu Tojo, M.D., D.M.Sc. Satoshi Takahashi, M.D., D.M.Sc. Division of Stem Cell Processing Associate Project Assistant Makoto Otsu, M.D., Ph.D. Chen-Yi Lai, Ph.D. Division of Stem Cell Signaling Toshio Kitamura, M.D., D.M.Sc.

7 6 Division of Stem Cell Dynamics Associate Beate Heissig, M.D. Division of Stem Cell Cellomics Project Associate Hiroshi Watarai, Ph.D. Stem Cell Bank Associate Project Assistant Makoto Otsu, M.D., Ph.D. Chen-Yi Lai, Ph.D. FACS Core Laboratory FACS Associated Makoto Otsu, M.D., Ph.D. International Research Center for Infectious Diseases Department of Special Pathogens Chieko Kai, D.V.M., Ph.D. Yoshihiro Kawaoka, D.V.M., Ph.D. Department of Infectious Disease Control Assistant professor Assistant professor Yasushi Kawaguchi, D.V.M., Ph.D. Akihisa Kato, Ph.D. Jun Arii, Ph.D. Department of Infectious Disease Control, Division of Viral Infection Associate Takeshi Ichinohe, Ph.D. Department of Infectious Disease Control, Division of Bacteriology Associate Project Assistant Hitomi Mimuro, Ph.D. Takahito Sanada, Ph.D. Pathogenic Microbes Repository Unit Associate Hitomi Mimuro, Ph.D.

8 7 International Research and Development Center for Mucosal Vaccine Division of Mucosal Barriology Visiting Visiting Associate Project Assistant Hiroshi Kiyono, D.D.S., Ph.D. Koji Hase, Ph.D. Shintaro Sato, Ph.D. Taketoshi Mizutani, Ph.D. Division of Innate Immune Regulation Project Project Assistant Project Assistant Satoshi Uematsu, M.D., Ph.D. Naoki Takemura, Ph.D. Kosuke Fujimoto, M.D., Ph.D. Division of Clinical Vaccinology Project Project Associate Division of Mucosal Vaccines Visiting Visiting Associate Hiroshi Kiyono, D.D.S., Ph.D. Kohtaro Fujihashi, D.D.S., Ph.D. Yosuke Kurashima, Ph.D. Hiroshi Kiyono, D.D.S., Ph.D. Jun Kunisawa, Ph.D. Tomonori Nochi, Ph.D. Division of Mucosal Symbiosis Project Associate Yoshiyuki Goto, Ph.D. Health Intelligence Center Division of Health Medical Data Science Seiya Imoto, Ph.D. Assistant Takanori Hasegawa, Ph.D. Division of Health Medical Computational Science Assistant Satoru Miyano, Ph.D. Atsushi Niida, Ph.D.

9 8 Center for Gene & Cell Therapy Project Project Invited Associate Associate Associate Associate Project Associate Senior Assistant Senior Assistant Assistant Assistant Keiya Ozawa, M.D., D.M.Sc. Tomoki Todo, M.D., Ph.D. Arinobu Tojo, M.D., D.M.Sc. Toshio Kitamura, M.D., D.M.Sc. Hideaki Tahara, M.D., D.M.Sc. Fumitaka Nagamura, M.D., D.M.Sc. Yuji Yamanashi, Ph.D. Chieko Kai, D.V.M., Ph.D. Yoichi Furukawa, M.D., Ph.D. Shin-ichi Muramatsu, M.D., Ph.D. Kenzaburo Tani, M.D., Ph.D. Koji Tamada, M.D., Ph.D. Satoshi Takahashi, M.D., D.M.Sc. Makoto Otsu, M.D., Ph.D. Tokiko Nagamura-Inoue, M.D., Ph.D. Yasushi Ino, M.D., Ph.D. Minoru Tanaka, M.D., Ph.D. Hideyuki Takedani, M.D., D.M.Sc. Sumimasa Nagai, M.D., Ph.D. Kazuaki Yokoyama, M.D., Ph.D. Takaaki Konuma, M.D., D.M.Sc. Laboratory Animal Research Center Associate Assistant Assistant Chieko Kai, D.V.M., Ph.D. Misako Yoneda, D.V.M., Ph.D. Tomoko Fujiyuki, Ph.D. Shotaro Uchida, Ph.D. Amami Laboratory of Injurious Animals Assistant Medical Proteomics Laboratory Chieko Kai, D.V.M., Ph.D. Shinichi Yokota, D.V.M., Ph.D. Jun-ichiro Inoue, Ph.D. Kouhei Tsumoto, Ph.D. Associate Masaaki Oyama, Ph.D. Assistant Makoto Nakakido, Ph.D. Assistant Project Assistant Daisuke Kuroda, Ph.D. Hiroshi Sagara, Ph.D.

10 9 Research Center for Asian Infectious Diseases Project Project Project Associate Project Associate Project Senior Assistant Assistant Assistant Assistant Yasushi Kawaguchi, D.V.M., Ph.D. Jun-ichiro Inoue, Ph.D. Yoshihiro Kawaoka, D.V.M., Ph.D. Mitsue Hayashi, Ph.D. Zene Matsuda, M.D., Ph.D., D.Sc. Takaomi Ishida, Ph.D. Seiya Yamayoshi, D.V.M., Ph.D. Jin Gohda, Ph.D. Mizuki Yamamoto, Ph.D. Akihisa Kato, Ph.D. Jun Arii, Ph.D. Laboratory of Molecular Genetics (Frontier Research Unit) Yoshinori Murakami, M.D., Ph.D. Associate Kazuo Tatebayashi, Ph.D. IMSUT Hospital Department of Medicine (Department of Hematology/Oncology) Associate Associate Project Associate Senior Assistant Assistant Assistant Assistant Assistant Assistant Assistant Assistant Assistant Arinobu Tojo, M.D., D.M.Sc. Satoshi Takahashi, M.D., D.M.Sc. Yoichi Imai, M.D., Ph.D. Hiroshi Yasui, M.D., D.M.Sc. Sumimasa Nagai, M.D., Ph.D. Tomohusa Fukuyama, M.D., D.M.Sc. Seiko Kato, M.D., D.M.Sc. Takaaki Konuma, M.D., D.M.Sc. Seiichiro Kobayashi, M.D., D.M.Sc. Muneyosi Futami, M.D., D.M.Sc. Toyotaka Kawamata, M.D., D.M.Sc. Kazuaki Yokoyama, M.D., D.M.Sc. Junya Makiyama, M.D., D.M.Sc. Department of Infectious Diseases and Applied Immunology Head, Senior Assistant Assistant Assistant Assistant Hiroshi Yotsuyanagi, M.D., D.M.Sc. Tomohiko Koibuchi, M.D., D.M.Sc. Michiko Koga, M.D., D.M.Sc. Eisuke Adachi, M.D., D.M.Sc. Tadashi Kikuchi, M.D., D.M.Sc.

11 10 Department of Rheumatology and Allergy Senior Assistant Project Senior Assistant Assistant Assistant Hirotoshi Tanaka, M.D., D.M.Sc. Noritada Yoshikawa, M.D., D.M.Sc. Noriaki Shimizu, Ph.D. Toshiki Eri, M.D., D.M.Sc. Hiroki Yamazaki, M.D., D.M.Sc. Department of General Medicine Head, Associate Senior Assistant Project Assistant Department of Applied Genomics Associate Department of Radiology Hiroshi Yotsuyanagi, M.D., D.M.Sc. Yoshihiro Hirata, M.D., D.M.Sc. Yasuo Matsubara, M.D., D.M.Sc. Yasuki Hijikata, M.D., D.M.Sc. Yoichi Furukawa, M.D., Ph.D. Yoshinori Murakami, M.D., Ph.D. Tsuneo Ikenoue, M.D., Ph.D. Department of Radiological Technology Associate Senior Assistant Assistant Head Radiologic Technologist Department of Palliative Medicine Assistant Akira Kunimatsu, M.D., D.M.Sc. Hiroyuki Akai, M.D., D.M.Sc. Koichiro Yasaka, M.D., D.M.Sc. Yoshiro Satake, RT Arinobu Tojo, M.D., D.M.S Naoki Shimada, M.D., Ph.D. Department of Diagnostic Pathology Department of Pathology Project Associate Yasunori Ota, M.D., Ph.D. Department of Surgery Associate Senior Assistant Assistant Keiya Ozawa, M.D., Ph.D. Masaru Shinozaki, M.D., Ph.D. Giichiro Tsurita, M.D., Ph.D. Kentaro Yazawa, M.D., Ph.D.

12 11 Department of Anesthesia Associate Assistant Ryo Orii, M.D., Ph.D. Reiko Shibata, M.D. Department of Joint Surgery Senior Assistant Assistant Hideyuki Takedani, M.D., D.M.Sc. Kumiko Ono, M.D., D.M.Sc. Department of Surgical Neuro-Oncology Associate Project Associate Senior Assistant Assistant Tomoki Todo, M.D., Ph.D. Yasushi Ino, M.D., Ph.D. Minoru Tanaka, M.D., Ph.D. Hiroyuki Momota, M.D., Ph.D. Seisaku Kanayama, M.D. Department of Medical Informatics Associate Senior Assistant Assistant Akira Kunimatsu, M.D., D.M.Sc. Hiroyuki Akai, M.D., D.M.Sc. Koichiro Yasaka, M.D., D.M.Sc. Department of Cell Processing and Transfusion Associate Assistant Tokiko Nagamura-Inoue, M.D., Ph.D. Toyotaka Kawamata, M.D., Ph.D. Surgical Center Project Associate Tomoki Todo, M.D., Ph.D. Minoru Tanaka, M.D., Ph.D. Center for Translational Research Fumitaka Nagamura, M.D., D.M.Sc. Asociate Masanori Nojima, M.D., Ph.D., M.P.H. Project Associate Hiroshi Yasui, M.D., Ph.D. Senior Assistant Sumimasa Nagai, M.D., Ph.D. Center for Antibody and Vaccine Therapy Project Project Associate Project Associate Senior Assistant Project Senior Assistant Project Senior Assistant Hirotoshi Tanaka, M.D., D.M.Sc. Kouhei Tsumoto, Ph.D. Yataro Daigo, M.D., D.M.Sc. Hiroaki Taniguchi, M.D., D.M.Sc. Satoru Nagatoishi, Ph.D. Noritada Yoshikawa, M.D., D.M.Sc. Atsushi Takano, M.D., D.M.Sc. Noriaki Shimizu, Ph.D.

13 12 Therapeutic Vector Development Center Associate Tomoki Todo, M.D., Ph.D. Yasushi Ino, M.D., Ph.D. IMSUT Cord Associate Tokiko Nagamura-Inoue, M.D., Ph.D. Department of Nursing Director Deputy Director Deputy Director Nurse Manager Nurse Manager Nurse Manager Nurse Manager Nurse Manager Nurse Manager Koji Kobayashi, RN, Ph.D. Minayo Hisahara, RN. Fumiko Kasuya, RN, CNA. Mayumi Tanii, RN, MSN. Hatsuko Narita, RN. Mika Kogayu, RN. Tomoko Sato, RN. Masako Ozawa, RN. Hiromi Isshiki, RN. Department of Pharmacy Director Seiichiro Kuroda Department of AIDS Vaccine Development Invited Visiting Associate Tetsuro Matano, M.D., D.M.Sc. Ai Kawana-Tachikawa, D.M.Sc. IMSUT Distinguished Unit Division of Stem Cell Therapy Project Project Associate Project Assistant Hiromitsu Nakauchi, M.D., Ph.D Tomoyuki Yamaguchi, Ph.D. Hideki Masaki, Ph.D. Corporate Sponsored Research Programs, Social Cooperation Research Programs Project Division of Molecular and Developmental Biology VICX Project Sumiko Watanabe, Ph.D. Project Senior Assistant Hideto Koso, MD, Ph.D.

14 13 Project Division of RNA Medical Science RNA Project Associate Project Senior Assistant Project Assistant Masaki Takahashi, Ph.D. Masahiko Imashimizu, Ph.D. Jeewoong Park, Ph.D. Project Division of Systems Immunology Research Project Associate Takeshi Satoh, Ph.D. Project Assistant Yasumasa Kimura, Ph.D. Project Division of Advanced Regenerative Medicine Arinobu Tojo, M.D., D.M.Sc. Project Associate Satoshi Yamazaki, Ph.,D. Project Division of International Advanced Medical Research Project Associate Koichiro Yuji, M.D., Ph.D. Project Division of ALA Advanced Medical Research ALASBI Project Kenzaburo Tani, M.D., Ph.D. Project Senior Assistant Hiroshi Kohara, Ph.D. Project Assistant Shohei Miyamoto, Ph.D. Project Division of Fundamental Study on Cutting Edge of Genome Medicine Arinobu Tojo, M.D., D.M.Sc. Project Associate Hiroshi Yasui, M.D., D.M.Sc. Project Division of Advanced Biopharmaceutical Science Hirotoshi Tanaka, Ph.D. Kouhei Tsumoto, Ph.D. Project Associate Satoru Nagatoishi, Ph.D. Dean's Office Project Coordination Office Mutsuhiro Takekawa, M.D., Ph.D. Office of Support for Platforms for Advanced Technologies and Research Resources Chair and Visiting Kohzoh Imai, M.D., Ph.D.

15 14 International Affairs Office Mutsuhiro Takekawa, M.D., Ph.D. Common Research Facilities Animal Center Head Chieko Kai, D.V.M., Ph.D. Culture Media Section Head Jun-ichiro Inoue, Ph.D. Library Head Yasushi Kawaguchi, D.V.M., Ph.D. Radioisotope Center Head Kensuke Miyake, M.D., Ph.D. IT Service Room IT Head Mutsuhiro Takekawa, M.D., Ph.D. Photographic Laboratory Head Mutsuhiro Takekawa, M.D., Ph.D. Genetically Modified Microorganism Support Office Head Yasushi Kawaguchi, D.V.M., Ph.D. Office of Research Ethics Head Kaori Muto, Ph.D. Associate Ayako Kamisato, Ph.D. Office of Health and Safety Head Makoto Nakanishi, M.D., Ph.D. Office of lntellectual Property Head Jun-ichiro Inoue, Ph.D.

16 15 Advisory Room for Conflict of lnterest Head Hirotoshi Tanaka, M.D., D.M.Sc. Pathology Core Laboratory Head of Laboratory I Yoshinori Murakami, M.D., Ph.D. Head of Laboratory II Yasunori Ota, M.D., Ph.D. Gene Manipulated Mouse Section Nobuaki Yoshida, M.D., D.M.Sc. Chieko Kai, D.V.M., Ph.D. Imaging Core Laboratory Head Mutsuhiro Takekawa, M.D., Ph.D. IMSUT Clinical Flow Cytometry Laboratory IMSUT Head Arinobu Tojo, M.D., D.M.Sc. Administration Office General Manager Kiyomi Ueda Manager of Administrative Affairs Division Toshihide Asakawa Manager of Research Support Division Isao Uehara Manager of Hospital Division Makoto Hidai Manager of Strategic Academic Collaboration/ the 125th Anniversary Project Division Toshihide Asakawa

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