Efficacy of Several Oximes on Organophosphorus Poisoning Sumie Yamanaka, Yuji Suyama and Masao Nishimura Department of Hygiene, Tokyo Dental College,

Size: px
Start display at page:

Download "Efficacy of Several Oximes on Organophosphorus Poisoning Sumie Yamanaka, Yuji Suyama and Masao Nishimura Department of Hygiene, Tokyo Dental College,"

Transcription

1 Efficacy of Several Oximes on Organophosphorus Poisoning Sumie Yamanaka, Yuji Suyama and Masao Nishimura Department of Hygiene, Tokyo Dental College, Tokyo Various organophosphorus compounds, particularly those with low acute toxicity levels, such as Fenitrothion (common name; Sumithion), Fenthion (common name; Baycid) and Pyridaphenthion (common name; Ofunack), are widely used as insecticides around the world. PAM (2-Pyridinum aldoxime methiodide), the specific antidote against Parathion, is not very effective against poisoning by these organophosphates. This paper reports on the efficacy of PAM and other oximes (Pro-PAM, Toxogonin, TMB-4, and PAD) on toxic symptoms and inhibition of ChE (Cholinesterase) by organophosphates (Dichlorvos, Fenthion, Fenitrothion and Pyridaphenthion). The results were as follows. 1. PAD, a high lipid soluble oxime, was not suitable as an antidote against organophosphorus poisoning because it caused irritation and had its own high toxicity. 2. TMB-4 reactivated blood ChE inhibited by organophosphates to the same level as PAM. But the oxime is no practical use as an antagonist because of high toxicity. 3. Pro-PAM, the prodrug of PAM, and Toxogonin, which has been used practically in Germany, could lighten the toxic symptoms of organophosphorus poisoning to the same level as PAM. The efficacy of these oximes was maintained for 2-3hrs. 4. Pro-PAM, Toxogonin and PAM were able to reactivate blood ChE inhibited by Pyridaphenthion and Fenitrothion, but these oximes couldn't reactivate ChE in brain and other tissues. 5. There was no difference in the antidotal action of PAM, Pro-PAM and Toxogonin because of the same reactivation level of blood ChE and the same recovery pattern of serum ChE isoenzyme. Therefore, it became clear that Pro-PAM and Toxogonin were not more effective against organophosphorus poisoning than PAM. It seemed that a continuous dose of PAM was more effective, and furthermore, that the antidotal effect of PAM should be potentiated by atropine and other therapy. Key words: Organophosphorus poisoning, PAM, Toxogonin, Pro-PAM, Cholinesterase

2 Table 1 Trade names, chemical names and LD50 values of organophosphorus compounds used in this experiment.

3 Table 2 Chemical structure and acute toxicity of oximes used in this experiment.

4

5

6

7

8 Fig. 6 Effects of oximes on serum ChE isoenzyme of rats at 3hrs after administration of Pyridaphenthion. Oximes were given 10mins after Pyridaphenthion. Fig. 8 Effects of oximes on serum ChE isoenzyme of rats at 90mins after administration of Fenitrothion. Oximes were given 10mins after Fenitrothion. Fig. 7 Effects of oximes on serum ChE isoenzyme of rats at 21hrs after administration of Pyridaphenthion. Oximes were given 18hrs after Pyridaphenthion.

9 4) Skrinjaric-Spoljar, M., Simeon, V. and Reiner, E.: with HI-6 and related treated with armin and obidoxime, Biochem. 8) Natoff, I. L. and Reiff, B.: Quantitative studies of Spontaneous reactivation and aging of dimethylphospholylated acetylcholinesterase and cholinesterase, Biochemica et Biophysica. Acta, 315, (1973). 5) Jong, L. P. A. and Wolrng, G. Z.: Reactivation of acetylcholinesterase inhibited by 1, 2, 2'-Trimethylpropyl methylphosphonofluoridate (Soman) oximes, Biochem. Pharmacol., 29, (1980). 6) Erdmann, W. D.: Antidotbehandlung bei Alkylphosphatvergflungen, Arch. Toxicol., 24, (1968). 7) Vasic, B. V., Milosevic, M. P. and Terzic, M. R.: Acethylcholine content and cholinesterase activity in the ponto-medullary Pharmacol., 26, (1977). the effect of antagonists region of brain in rats on the acute toxicity of organophosphates in rats, Br. J. Pharmacol., 40, (1970). 9) Hobbiger, F. and Vojvodic: The reactivating and antidotal actions of N, N'-Trimethylenebis (pyridinum-4-aldoxime) (TMB-4) and N, N' - Oxydimethylenebis (pyridinum-4-aldoxime) (Toxogonin), with particular reference to their effect on phosphorylated acetylcholinesterase in the brain, Biochem. Pharmacol., 15, (1966). 10) Mayer, O. and Michalek, H.: Effects of DFP and Obidoxime on brain acetylcholine levels and on brain and peripheral cholinesterase, Biochem. Pharmacol., 20, (1971). 11) Neef, J. H. and Porsius, A. J.: The influence of Obidoxime, Diacetylmonoxime, Pralidoxime and two less hydrophilic derivatives of Pralidoximes upon the cholinesterase inhibition and the pressor effect by paraoxon in the rat, Toxicol. Appl. Pharmacol., 66, (1982). 12) Vasic, B. V., Milosevic, M. P. and Terzic, M. R.: Acetylcholine and cholinesterase in submandibullar glands of rats given armin and obidoxime, J. Dent. Res., 57, (1978).

10 13) Bodor, N., Shek, E. and Higuchi: Delivery of a quarternary pyridinum salt across the bloodbrain barrier by dihydropyridine derivative, Science, 190, (1975). 14) Clement, J. G.: Efficacy of Pro-PAM (N-methyl -1, 6-dihydropyridine-2-carbaldoxime hydrochloride) as a prophylaxis against organophosphate poisoning, Toxicol. Appl.. Pharmacol., 47, (1979). 15) Boskovic, B., Tadic, V. and Kusic, R.: Reactivating and protective effects of Pro-2-PAM in mice poisoned with paraoxon, Toxicol. Appl. Pharmacol., 55, (1980). 16) Heffron, P. F. and Hobbiger, F.: Does reactivation of phosphorylated acetyl cholinesterase (AChE) in the brain enhance the antidotal actions of pyridinum aldoximes?, Brit. J. Pharmacol., 69, (1980). 18) Harris, L. W., Stitcher, D. L., Heyl, W. C., Lieske, C. N., Lowe, J. R., Clark, J. H. and Broomfield, C. A.: The effects of atropine-oxime therapy on cholinesterase activity and survival of animals intoxicated with p-nitrophenyl Di-n-butylphosphinate, Toxicol. Appl. Pharmacol., 49, (1979). 19) Clement, J. G.: Toxicology and pharmacology of bispyridinum oximes insight into the mechanism of action vs soman poisoning in vivo, Fundamental and applied Toxicology, 1, (1981). 22) Ellin, R. I. and Wills, J. H.: Oximes antagonistic to inhibitors of cholinesterase (Part 1), Journal of Pharmaceutical Science, 53, (1964).

A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, Sc

A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, Sc A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, School of Medicine, Tokushima University, Tokushima Fetal

More information

b) Gram-negative bacteria Fig. 2 Sensitivity distribution of clinical isolates : E. coli Fig. 3 Sensitivity distribution of clinical isolates : Pseudomonas Fig. 1 Sensitivity distribution of clinical isolates

More information

Visual Evaluation of Polka-dot Patterns Yoojin LEE and Nobuko NARUSE * Granduate School of Bunka Women's University, and * Faculty of Fashion Science,

Visual Evaluation of Polka-dot Patterns Yoojin LEE and Nobuko NARUSE * Granduate School of Bunka Women's University, and * Faculty of Fashion Science, Visual Evaluation of Polka-dot Patterns Yoojin LEE and Nobuko NARUSE * Granduate School of Bunka Women's University, and * Faculty of Fashion Science, Bunka Women's University, Shibuya-ku, Tokyo 151-8523

More information

840 Geographical Review of Japan 73A-12 835-854 2000 The Mechanism of Household Reproduction in the Fishing Community on Oro Island Masakazu YAMAUCHI (Graduate Student, Tokyo University) This

More information

Web Stamps 96 KJ Stamps Web Vol 8, No 1, 2004

Web Stamps 96 KJ Stamps Web Vol 8, No 1, 2004 The Journal of the Japan Academy of Nursing Administration and Policies Vol 8, No 1, pp 43 _ 57, 2004 The Literature Review of the Japanese Nurses Job Satisfaction Research Which the Stamps-Ozaki Scale

More information

The Effect of the Circumferential Temperature Change on the Change in the Strain Energy of Carbon Steel during the Rotatory Bending Fatigue Test by Ch

The Effect of the Circumferential Temperature Change on the Change in the Strain Energy of Carbon Steel during the Rotatory Bending Fatigue Test by Ch The Effect of the Circumferential Temperature Change on the Change in the Strain Energy of Carbon Steel during the Rotatory Bending Fatigue Test by Chikara MINAMISAWA, Nozomu AOKI (Department of Mechanical

More information

untitled

untitled 11-19 2012 1 2 3 30 2 Key words acupuncture insulated needle cervical sympathetick trunk thermography blood flow of the nasal skin Received September 12, 2011; Accepted November 1, 2011 I 1 2 1954 3 564-0034

More information

CHEMOTHERAPY AUG. 1982 VOL. 30 NO. 8 CHEMOTHERAPY Fig.1 Relation between various-closis of cefazolin and detection rate of organisms in heart blood of dying mice with E. coli and P. aeruginosa infection

More information

The Japanese Journal of Experimental Social Psychology. 2003, Vol. 42, No. 2, 146-165 Discoursive Strategy for the Commitment to Adoption with Infants Who Had Been Reared at Residential

More information

Table 1. Acute toxicity of Folin on mice. (Litchfield-Wilcoxon method) Numbers in parenthesis indicate 95% fiducial limits. Fig. 1. Analgesic effect of Folin on mice (1% acetic aid-induced writhing). Each

More information

Fig. 1 Chemical structure of DL-8280

Fig. 1 Chemical structure of DL-8280 Fig. 1 Chemical structure of DL-8280 Fig. 2 Susceptibility of cl in ical isolates to DL4280 Fig. 5 Susceptibility of clinical isolates to DL-8280 Fig. 3 Susceptibility of clinical isolates to DL-8280 Fig.

More information

16_.....E...._.I.v2006

16_.....E...._.I.v2006 55 1 18 Bull. Nara Univ. Educ., Vol. 55, No.1 (Cult. & Soc.), 2006 165 2002 * 18 Collaboration Between a School Athletic Club and a Community Sports Club A Case Study of SOLESTRELLA NARA 2002 Rie TAKAMURA

More information

DOUSHISYA-sports_R12339(高解像度).pdf

DOUSHISYA-sports_R12339(高解像度).pdf Doshisha Journal of Health & Sports Science, 4, 41-50 2012 41 A Case Study of the Comprehensive community sports clubs that People with Disability Participate in. Motoaki Fujita In this study, the interview

More information

(43) Vol.33, No.6(1977) T-239 MUTUAL DIFFUSION AND CHANGE OF THE FINE STRUCTURE OF WET SPUN ANTI-PILLING ACRYLIC FIBER DURING COAGULATION, DRAWING AND

(43) Vol.33, No.6(1977) T-239 MUTUAL DIFFUSION AND CHANGE OF THE FINE STRUCTURE OF WET SPUN ANTI-PILLING ACRYLIC FIBER DURING COAGULATION, DRAWING AND (43) Vol.33, No.6(1977) T-239 MUTUAL DIFFUSION AND CHANGE OF THE FINE STRUCTURE OF WET SPUN ANTI-PILLING ACRYLIC FIBER DURING COAGULATION, DRAWING AND DRYING PROCESSES* By Hiroshi Aotani, Katsumi Yamazaki

More information

1) i) Barber, M. et al.: Brit. Med J, 2, 565, 19'49. ii) Barber, M.F.G. J. Hayhoe and J. E. M. Whithead: Lancet, 1120 `1125, 1949.-2) Bergey: Bergey's Manual of Determinative Bacteriology 7 th Ed: (1958).-3)

More information

DISTRIBUTION OF NEUROPEPTIDES IN THE INFERIOR NASAL TURBINATE MUCOSA OF PATIENTS WITH ALLERGIC RHINITIS KAZUHIRO YAMAMOTO. M.D. Department of Otolaryngology, School of Medicine, Kitasato University, Sagamihara

More information

988 CHEMOTHERAPY NOV. 1971

988 CHEMOTHERAPY NOV. 1971 988 CHEMOTHERAPY NOV. 1971 VOL. 19 NO. 8 CHEMOTHERAPY 989 Effect of medium-ph and inoculum size on activity of SB-PC heart infusion agar, mcg/ml Sensitivity distribution of Staphylococci to SB-PC in surgical

More information

Kansai University of Welfare Sciences Practical research on the effectiveness of the validation for the elderly with dementia Naoko Tsumura, Tomoko Mi

Kansai University of Welfare Sciences Practical research on the effectiveness of the validation for the elderly with dementia Naoko Tsumura, Tomoko Mi Practical research on the effectiveness of the validation for the elderly with dementia Naoko Tsumura, Tomoko Mitamura and Takeshi Hashino 2 1 Abstract : The present conditions to surround the elderly

More information

VOL.32 S-9 CHEMOTHERAPY Table 1 Minimum inhibitory concentrations of AC-1370, CPZ and CAZ Table 2 Efficacy of AC-1370 and CPZ against systemic infections in mice *Inoculum size: 106 cells/ml * 95% confidence

More information

Table 1 Patients with various renal function * Ccr, Creatinine clearance ml/min per 1. 48 m2 ** C.V.D., Cerebral vascular disease ; C.R F., Chronic renal failure ; H.D., Hemoclialysis ; D., Dialyzer ;

More information

1272 CHEMOTHERAPY MAR. 1975

1272 CHEMOTHERAPY MAR. 1975 1272 CHEMOTHERAPY MAR. 1975 VOL. 23 NO. 3 CHEMOTHERAPY 1273 Fig. 2 Minimal inhibitory concentration of aminoglycosides against 50 strains of Klebsiella Fig. 1 Minimal inhibitory concentration of aminoglycosides

More information

;~ (Summary) The Study on the Effects of Foot Bathing on Urination Kumiko Toyoda School of Human Nursing, University of Shiga Prefecture Background Foot bathing is one of the important nursing care for

More information

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study VOL. 41 S 1 Table 2. Levels (Đg/ml or Đg/g) of S-1006 in serum, bile, and tissue (gallbladder) after oral administration

More information

Table 1 Survival rates of infected mice given antibiotic doses producing peak serum a) S. aurcus Smith Challenge dose :7 ~10 (5% mucin) CFU/mouse. LD50: 1 ~103 (5% mucin) CFU/mouse. Table 2 Survival rates

More information

Experimental and Clinical Studies of Pregnant Hypertension Takashi SHIMAZU Department of Obstetrics and Gynecology, Osaka City University Medical Scho

Experimental and Clinical Studies of Pregnant Hypertension Takashi SHIMAZU Department of Obstetrics and Gynecology, Osaka City University Medical Scho Experimental and Clinical Studies of Pregnant Hypertension Takashi SHIMAZU Department of Obstetrics and Gynecology, Osaka City University Medical School While the problem of late pregnant hypertension

More information

Fig. 1 Structure of a Sebaceous Follicle (Ref.1).

Fig. 1 Structure of a Sebaceous Follicle (Ref.1). Importance and Countermeasures for Sebum Control in Application of Makeup Cosmetics Koichi NOMURA POLA Chemical Industries, Inc., R&D Planning Department 27-1, Takashimadai, Kanagawa-ku, Yokohama 221-0833,

More information

CHEMOTHERAPY FEB Table 1 Background of volunteers

CHEMOTHERAPY FEB Table 1 Background of volunteers CHEMOTHERAPY FEB. 1985 Table 1 Background of volunteers Table 3 Reproducibility of saisomicln In the EIA and the RIA Fig.1 Comparison of the EIA with the RIA or bioassay of sisomicin Table 4 Blood levels

More information

VOL. 34 S-2 CHEMOTH8RAPY 913

VOL. 34 S-2 CHEMOTH8RAPY 913 VOL. 34 S-2 CHEMOTH8RAPY 913 914 CHEMOTHERAPY APR. 1986 Fig. 1 Chemical structure of T-2588 and T-2525 T- 2588 pivaloyloxymethyl (+ )- (6 R, 7 R)-7-[(Z)-2- (2-amino- 4-thiazolyl)-2-methox yiminoacetamido]-3-[(

More information

lagged behind social progress. During the wartime Chonaikai did cooperate with military activities. But it was not Chonaikai alone that cooperated. Al

lagged behind social progress. During the wartime Chonaikai did cooperate with military activities. But it was not Chonaikai alone that cooperated. Al The Development of Chonaikai in Tokyo before The Last War Hachiro Nakamura The urban neighborhood association in Japan called Chonaikai has been more often than not criticized by many social scientists.

More information

Effects of the testosterone on both male and female fowls Shohyoe Tsuda Résumé This study was carried out to test the biological actions of androgen on both male and female fowls. As androgen "Amolisin"

More information

Fig. 1 Chemical structure of TE-031 Code number: TE-031 Chemical name: (-) (3R, 4S, 5S, 6R, 7R, 9R, 11R, 12R, 13S, 14R)-4-[(2, 6-dideoxy-3-C-methyl-3-

Fig. 1 Chemical structure of TE-031 Code number: TE-031 Chemical name: (-) (3R, 4S, 5S, 6R, 7R, 9R, 11R, 12R, 13S, 14R)-4-[(2, 6-dideoxy-3-C-methyl-3- Fig. 1 Chemical structure of TE-031 Code number: TE-031 Chemical name: (-) (3R, 4S, 5S, 6R, 7R, 9R, 11R, 12R, 13S, 14R)-4-[(2, 6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl) oxy]-14-ethyl-12,

More information

先端社会研究 ★5★号/4.山崎

先端社会研究 ★5★号/4.山崎 71 72 5 1 2005 7 8 47 14 2,379 2,440 1 2 3 2 73 4 3 1 4 1 5 1 5 8 3 2002 79 232 2 1999 249 265 74 5 3 5. 1 1 3. 1 1 2004 4. 1 23 2 75 52 5,000 2 500 250 250 125 3 1995 1998 76 5 1 2 1 100 2004 4 100 200

More information

March IT PR March March p p p PR March Vol. March p p p SN March SN PR PR March Potential Needs of Specialized Foster Parents for Abused Children: Analyzinga questionnaire survey on foster parents needs

More information

On the Wireless Beam of Short Electric Waves. (VII) (A New Electric Wave Projector.) By S. UDA, Member (Tohoku Imperial University.) Abstract. A new e

On the Wireless Beam of Short Electric Waves. (VII) (A New Electric Wave Projector.) By S. UDA, Member (Tohoku Imperial University.) Abstract. A new e On the Wireless Beam of Short Electric Waves. (VII) (A New Electric Wave Projector.) By S. UDA, Member (Tohoku Imperial University.) Abstract. A new electric wave projector is proposed in this paper. The

More information

ON A FEW INFLUENCES OF THE DENTAL CARIES IN THE ELEMENTARY SCHOOL PUPIL BY Teruko KASAKURA, Naonobu IWAI, Sachio TAKADA Department of Hygiene, Nippon Dental College (Director: Prof. T. Niwa) The relationship

More information

R R S K K S K S K S K S K S Study of Samuhara Belief : Transformation from Protection against Injuries to Protection against Bullets WATANABE Kazuhiro Samuhara, which is a group of letters like unfamiliar

More information

rectomy as the subjects of study, urinary steroid hormones were measured, and simultaneously the enzyme work and enzyme pattern related to the steroid metabolism, as proposed by Yoshida of our laboratory,

More information

Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S.

Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S. Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S. Table 1. Clinical summary of acute uncomplicated cystitis patients treated with 7432-S UTI : Criteria by the

More information

CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX

CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX Fig. 1 Chemical structure of CXM-AX NOV. 1986 Fig. 2 Sensitivity distribution of clinical isolates organisms (106 cells/ml) a Smurcus 27 strains d) P.m irabilis 15 strains b Ecol i 27 strains 111.morganii

More information

CHEMOTHERAPY Table 1 Urinary excretion of mezlocillin Fig. 4 Urinary excretion of mezlocillin Fig. 3 Blood levels of mezlocillin

CHEMOTHERAPY Table 1 Urinary excretion of mezlocillin Fig. 4 Urinary excretion of mezlocillin Fig. 3 Blood levels of mezlocillin CHEMOTHERAPY Fig. 2 Urinary excretion of mezlocillin Fig. 1 Blood levels of mezlocillin CHEMOTHERAPY Table 1 Urinary excretion of mezlocillin Fig. 4 Urinary excretion of mezlocillin Fig. 3 Blood levels

More information

PDF用-表紙.pdf

PDF用-表紙.pdf 51324544612009. 6 1 2 3 1 2 1 2 3 3 1 km 2 3 4 5 6 7 44 8 9 1700 1800 17001800 400km 1 45 1879 1903 1728 1734 10 11 1700 2 13199991995 12199821 200420101967 46 12 1771 1903 1 13 14 15 16 1819 2 17801860

More information

Endocrinological and statistical analysis of ovarian function in hysterectomized patients Masaya HAYAFUJI, Kazuaki KATAYAMA and Matsuto MOCHIZUKI Depa

Endocrinological and statistical analysis of ovarian function in hysterectomized patients Masaya HAYAFUJI, Kazuaki KATAYAMA and Matsuto MOCHIZUKI Depa Endocrinological and statistical analysis of ovarian function in hysterectomized patients Masaya HAYAFUJI, Kazuaki KATAYAMA and Matsuto MOCHIZUKI Department of Obstetrics and Gynecology, Kobe University

More information

CHEMOTHERAPY APR. 1984

CHEMOTHERAPY APR. 1984 VOL.32 S-3 CHEMOTHERAPY dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine- CHEMOTHERAPY APR. 1984 VOL.32 S-3 CHEMOTHERAPY Table 1 Implantation rates and post- implantation survival rates in females mated

More information

„h‹¤.05.07

„h‹¤.05.07 Japanese Civilian Control in the Cold War Era Takeo MIYAMOTO In European and American democratic countries, the predominance of politics over military, i.e. civilian control, has been assumed as an axiom.

More information

AUTONOMIC FUNCTIONAL STATE IN RENAL TUBERCULOSIS REPORT III. SERUM CHOLINESTERASE ACTIVITY IN RENAL TUBERCULOSIS Sanai Yamamura The Department of Urol

AUTONOMIC FUNCTIONAL STATE IN RENAL TUBERCULOSIS REPORT III. SERUM CHOLINESTERASE ACTIVITY IN RENAL TUBERCULOSIS Sanai Yamamura The Department of Urol AUTONOMIC FUNCTIONAL STATE IN RENAL TUBERCULOSIS REPORT III. SERUM CHOLINESTERASE ACTIVITY IN RENAL TUBERCULOSIS Sanai Yamamura The Department of Urology, Kumamoto University College of Medicine (Director:

More information

22 1,936, ,115, , , , , , ,

22 1,936, ,115, , , , , , , 21 * 2 3 1 1991 1945 200 60 1944 No. 41 2016 22 1,936,843 1945 1,115,594 1946 647,006 1947 598,507 1 60 2014 501,230 354,503 5 2009 405,571 5 1 2 2009 2014 5 37,285 1 2 1965 10 1975 66 1985 43 10 3 1990

More information

10-渡部芳栄.indd

10-渡部芳栄.indd COE GCOE GP ) b a b ) () ) () () ) ) .. () ) ) ) ) () ........... / / /.... 交付税額 / 経常費 : 右軸交付税額 /( 経常費 授業料 ): 右軸 . ) ()... /.. 自治体負担額 / 交付税額 : 右軸 ()......... / 自治体負担額 / 経常費 : 右軸 - No. - Vol. No. - IDE

More information

19 OUR EXPERIENCE IN COMBINED BALNEO AND CHRYSOTHERAPY FOR RHEUMATOID ARTHRITIS by Hidemitsu EZAWA (Director: Prof. Hiroshi MORI NAG A), Department ofinternal Medicine, Institute for Thermal Spring Research,

More information

bosai-2002.dvi

bosai-2002.dvi 45 B-2 14 4 Annuals of Disas. Prev. Res. Inst., Kyoto Univ., No. 45 B-2, 22 5 m 5 m :,,, 1. 2. 2.1 27 km 2 187 km 2 14 % 77 % 47 7, 9 2, 54 6 7, 9 16, 57 8 1, 9 47 2 1 57 5 2.2 45 2 Fig. 1 2 2.3 Fig. 2

More information

29 jjencode JavaScript

29 jjencode JavaScript Kochi University of Technology Aca Title jjencode で難読化された JavaScript の検知 Author(s) 中村, 弘亮 Citation Date of 2018-03 issue URL http://hdl.handle.net/10173/1975 Rights Text version author Kochi, JAPAN http://kutarr.lib.kochi-tech.ac.jp/dspa

More information

40B: 43-54 2010 43 2010 1 27 Satoshi Shimai 1 and Shigehiro Fujimoto 2 1 Center for Liberal Arts and Education, Minami-Kyushu University, Miyakonojo,

40B: 43-54 2010 43 2010 1 27 Satoshi Shimai 1 and Shigehiro Fujimoto 2 1 Center for Liberal Arts and Education, Minami-Kyushu University, Miyakonojo, 40B: 43-54 2010 2010 1 27 Satoshi Shimai 1 and Shigehiro Fujimoto 2 1 Center for Liberal Arts and Education, Minami-Kyushu University, Miyakonojo, Miyazaki 885-0035, Japan; 2 Miyakonojo Public Health Institute,

More information

Compatibility of Ophthalmic Solutions õ1 MUTSUMI END0 õ2, NOBUHIRO YASUNO õ2, KAORI TANAGAM1 õ2, ASAKA ONDA õ2, MIHO IMOT0 õ2, NAOMI IIDA õ2, YUKO SEKINE õ2, NORIO MIYAZAKI õ2, SHIGEKAZU WATANABE õ2, YUKO

More information

The Phase Behavior of Monooleoylglycerol-Water Systems Mivoshi Oil & Fat Co.. Ltd. Faculty of Science and Technology, Science University of Tokyo Inst

The Phase Behavior of Monooleoylglycerol-Water Systems Mivoshi Oil & Fat Co.. Ltd. Faculty of Science and Technology, Science University of Tokyo Inst The Phase Behavior of Monooleoylglycerol-Water Systems Mivoshi Oil & Fat Co.. Ltd. Faculty of Science and Technology, Science University of Tokyo Institute of Colloid and Interface Science, Science University

More information

A comparison of abdominal versus vaginal hysterectomy for leiomyoma and adenomyosis Kenji ARAHORI, Hisasi KATAYAMA, Suminori NIOKA Department of Obstetrics and Gnecology, National Maizuru Hospital,Kyoto,

More information

126 学習院大学人文科学論集 ⅩⅩⅡ(2013) 1 2

126 学習院大学人文科学論集 ⅩⅩⅡ(2013) 1 2 125 126 学習院大学人文科学論集 ⅩⅩⅡ(2013) 1 2 127 うつほ物語 における言語認識 3 4 5 128 学習院大学人文科学論集 ⅩⅩⅡ(2013) 129 うつほ物語 における言語認識 130 学習院大学人文科学論集 ⅩⅩⅡ(2013) 6 131 うつほ物語 における言語認識 132 学習院大学人文科学論集 ⅩⅩⅡ(2013) 7 8 133 うつほ物語 における言語認識 134

More information

【人】⑥入谷好樹先生【本文】/【人】⑥入谷好樹先生【本文】

【人】⑥入谷好樹先生【本文】/【人】⑥入谷好樹先生【本文】 Naranjo, C. Perls, F. Perls Perls Claudio Naranjo Naranjo Cattel, R. Perls, F. Simkin, J. Human Potential Movement Naranjo Naranjo P. Gestalt Naranjo actuality awareness responsibility Naranjo, C. Naranjo

More information

Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究 第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date URL

Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究 第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date URL Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究 第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date 1958-01 URL http://hdl.handle.net/2433/111559 Right Type Departmental Bulletin

More information

CHEMOTHERAPY aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Prote

CHEMOTHERAPY aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Prote aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Proteus mirabilis 3.13, Proteus vulgaris 1.56, Citrobacter freundii 0.39,

More information

The research,consciousness of the mother who used temporary child care at the day nursery MATSUOKA Tomoko, SAKURADANI Mariko Research for the mother who has the experience which temporary child care was

More information

<8ED089EF8B D312D30914F95742E696E6464>

<8ED089EF8B D312D30914F95742E696E6464> * 1 The problem of privacy in the news of newspapers and weekly magazines The analysis of the articles on the child serial killing incidents in Kobe Akihiko SHIMAZAKI Kenzo SHIDA Toshihiko KATANO *2 1

More information

29 33 58 2005 1970 1997 2002, pp.3-8 2001 2002 2005b 2000 pp.137-146 2005c 7 34 Ma and Cartier eds. 2003 1970 1980 1979 2002 2000 1) 1980 1990 1991 1993 1995 1998 1994 1993 20031972 2003 2005 1997 2005a

More information

NINJAL Research Papers No.8

NINJAL Research Papers No.8 (NINJAL Research Papers) 8: 177 196 (2014) ISSN: 2186-134X print/2186-1358 online 177 3 3 3 1940 3 late adoption real time 3 apparent time * 1. 1 2 3 1.1 3 1 1953 * 2014 3 18 2014 5 13 109 NINJAL 2012

More information

CHEMOTHERAPY JUNE 1986

CHEMOTHERAPY JUNE 1986 VOL. 34 S-3 CHEMOTHERAPY Fig. 1 Structural formula of L-105 CHEMOTHERAPY JUNE 1986 VOL. 34 S-3 CHEMOTHERAPY Table 1 Antibacterial spectra of L-105 against gram negative anaerobic rods Inoculum 106 cells/ml

More information

IPSJ SIG Technical Report Vol.2016-CE-137 No /12/ e β /α α β β / α A judgment method of difficulty of task for a learner using simple

IPSJ SIG Technical Report Vol.2016-CE-137 No /12/ e β /α α β β / α A judgment method of difficulty of task for a learner using simple 1 2 3 4 5 e β /α α β β / α A judgment method of difficulty of task for a learner using simple electroencephalograph Katsuyuki Umezawa 1 Takashi Ishida 2 Tomohiko Saito 3 Makoto Nakazawa 4 Shigeichi Hirasawa

More information

soturon.dvi

soturon.dvi 12 Exploration Method of Various Routes with Genetic Algorithm 1010369 2001 2 5 ( Genetic Algorithm: GA ) GA 2 3 Dijkstra Dijkstra i Abstract Exploration Method of Various Routes with Genetic Algorithm

More information

A5 PDF.pwd

A5 PDF.pwd DV DV DV DV DV DV 67 1 2016 5 383 DV DV DV DV DV DV DV DV DV 384 67 1 2016 5 DV DV DV NPO DV NPO NPO 67 1 2016 5 385 DV DV DV 386 67 1 2016 5 DV DV DV DV DV WHO Edleson, J. L. 1999. The overlap between

More information

Effect of Trimoprostil on Gastric Secretion Takeshi KAWAMURA * Hiroko EBINA * Fumiaki KOIZUMI * and Akira ISHIMORI * *Department of Clinical and Labor

Effect of Trimoprostil on Gastric Secretion Takeshi KAWAMURA * Hiroko EBINA * Fumiaki KOIZUMI * and Akira ISHIMORI * *Department of Clinical and Labor Effect of Trimoprostil on Gastric Secretion Takeshi KAWAMURA * Hiroko EBINA * Fumiaki KOIZUMI * and Akira ISHIMORI * *Department of Clinical and Laboratory Medicine University School of Medicine, Tohoku

More information

49148

49148 Research in Higher Education - Daigaku Ronshu No.24 (March 1995) 77 A Study of the Process of Establishing the Student Stipend System in the Early Years of the PRC Yutaka Otsuka* This paper aims at explicating

More information

Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with blad

Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with blad Key words: Female with bladder irritability, Subjective symptoms, Pyuria, Bacteriuria Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution

More information

Continuous Cooling Transformation Diagrams for Welding of Mn-Si Type 2H Steels. Harujiro Sekiguchi and Michio Inagaki Synopsis: The authors performed

Continuous Cooling Transformation Diagrams for Welding of Mn-Si Type 2H Steels. Harujiro Sekiguchi and Michio Inagaki Synopsis: The authors performed Continuous Cooling Transformation Diagrams for Welding of Mn-Si Type 2H Steels. Harujiro Sekiguchi and Michio Inagaki Synopsis: The authors performed a series of researches on continuous cooling transformation

More information

A Contrastive Study of Japanese and Korean by Analyzing Mistranslation from Japanese into Korean Yukitoshi YUTANI Japanese, Korean, contrastive study, mistranslation, Japanese-Korean dictionary It is already

More information

(1) Fujioka T, Nara F, Tsujita Y, Fukushige J, Fukami M and Kuroda M: The mechanism of lack of hypocholesterolemic effects of pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor,

More information

.D.q

.D.q March a b b b b b b a a a a aaaa March b a b a a March b b b b a a a March a c a aaaa b b b a c c b b b b b March b a a a a b b a a b b a a a March a a b b b b March b a b b b b b March a b a b a b a b

More information

Oda

Oda No.53 pp.2334, 2017 Komazawa Journal of Geography Distribution of Christianity and the Division of the Region in Prewar Japan ODA Masayasu Oda1999 1. 18991939 1 2. 18991939 1918 3. 190019391939 4. 5. 6.

More information

Housing Purchase by Single Women in Tokyo Yoshilehl YUI* Recently some single women purchase their houses and the number of houses owned by single women are increasing in Tokyo. And their housing demands

More information

An Aspect of Development in Clothing Education in Japan (Part 2) The Method of Teaching Sewing in the Meiji Era ( 2 ) Tetsuko HIGUCHI 1. Following Part 1, here I have analyzed and discussed some characteristic

More information

36) D. Lee (1948): Are basic needs ultimate? Journal of Abnormal & Social Psychology., 43. 37) J, A. Quinn (1950): Human Ecology. 279 `282. THE CHARACTER OF TOSHIMA ISLAND, IZU ARCHIPELAGO FROM THE VIEWPOINT

More information

Osamu NEMOTO, M.D. Clinical and Bacteriological Research of Sucrose/ Povidone-Iodine Ointment (U-PASTA kowa) for Pressure Sores and Skin Ulcers Osamu Nemoto Department of Dermatology,Tonan Hosptal

More information

Vol. 5, 29 39, 2016 Good/Virtue actions for competitive sports athlete Actions and Choices that receive praise Yo Sato Abstract: This paper focuses on

Vol. 5, 29 39, 2016 Good/Virtue actions for competitive sports athlete Actions and Choices that receive praise Yo Sato Abstract: This paper focuses on Vol. 5, 29 39, 2016 Good/Virtue actions for competitive sports athlete Actions and Choices that receive praise Yo Sato Abstract: This paper focuses on actions taken by athletes in competitive sports, building

More information

A Study of the Comprehensive Framework of Action for Job Retention amongst the Deaf and Hard of Hearing Makoto IWAYAMA Abstract The purpose of this pa

A Study of the Comprehensive Framework of Action for Job Retention amongst the Deaf and Hard of Hearing Makoto IWAYAMA Abstract The purpose of this pa Title 聴覚障害者の職場定着に向けた取り組みの包括的枠組みに関する考察 Author(s) 岩山, 誠 Citation 地域政策科学研究, 10: 1-24 Issue Date 2013-03-23 URL http://hdl.handle.net/10232/16661 http://ir.kagoshima-u.ac.jp A Study of the Comprehensive Framework

More information

54-4.ren

54-4.ren 200454 4 604-619 1,3) 1,3) 1,3) 1) 1) 1) 2) 1) 2) 3) 2004.8.1 1) 2) 1) 3) 1 50 4) 2 BC 581 3 4) 4 54 4 2004.8.1 1 1 2 3 3 7 3 1 4 5 5 7 2 3 1 54 4 10 15 4 4) 5 1 6 ) 7) 7) 2004.8.1 8) 8) 8) 8 ) 2 9) c

More information

1) Topley & Wilsons: Principles of Bacterio- 583-591.-5) Huddleson, I.F.: Brucellosis in man and animals, 1943. -6) Wilson, G. S. & encountered in certain Br. abortus agglutinating sera, J. Path. & Bact.,

More information

01-加藤 実-5.02

01-加藤 実-5.02 Bull. Natl. Mus. Nat. Sci., Ser. E, 30, pp. 1 13, December 21, 2007 1 2 3 1 169 0073 3 23 1 2 523 0058 961 3 248 0036 3 5 6 The Mechanism of the Automatic Wari-koma Dial in the Japanese Clocks and its

More information

VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains )

VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains ) CHEMOTHERAPY OCT. 1984 Fig. I Chemical structure of CTRX VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains ) CHEMOTHERAPY Fig. 3 Cumulative

More information

B5 H1 H5 H2 H1 H1 H2 H4 H1 H2 H5 H1 H2 H4 S6 S1 S14 S5 S8 S4 S4 S2 S7 S7 S9 S11 S1 S14 S1 PC S9 S1 S2 S3 S4 S5 S5 S9 PC PC PC PC PC PC S6 S6 S7 S8 S9 S9 S5 S9 S9 PC PC PC S9 S10 S12 S13 S14 S11 S1 S2

More information

Adams, B.N.,1979. "Mate selection in the United States:A theoretical summarization," in W.R.Burr et.al., eds., Contemporary Theories about the Family, Vol.1 Reserch - Based Theories, The Free Press, 259-265.

More information

VOL. 37 NO. 3 Key words: Drug allergy, LMIT, Penams, Cephems, Cross-reactivity

VOL. 37 NO. 3 Key words: Drug allergy, LMIT, Penams, Cephems, Cross-reactivity VOL. 37 NO. 3 Key words: Drug allergy, LMIT, Penams, Cephems, Cross-reactivity CHEMOTHERAPY MAR. 1989 Mble 1. Allcrgy in parients nduced by penams VOL. 37 NO. 3 Table 2. Allergy in patients induced by

More information

) ,

) , Vol. 2, 1 17, 2013 1986 A study about the development of the basic policy in the field of reform of China s sports system 1986 HaoWen Wu Abstract: This study focuses on the development of the basic policy

More information

1) Michaelis L. Biochem Z., 59, 78, 1914. 2) Ferris H. C. Dent. Cosmos Phila., 63, 10, 93, 1921. 3) Bloomfield A. L. Bull Johns Hopk. Hosp. Bait., 31, 118, 1920. 4) Starr H. C. J. Biol. Chem. Bait., 54,

More information

Among 83 patients who had undergone the operation for intermittent exotropia, 15 patients had esotropia persisting longer than one month after the ope

Among 83 patients who had undergone the operation for intermittent exotropia, 15 patients had esotropia persisting longer than one month after the ope Among 83 patients who had undergone the operation for intermittent exotropia, 15 patients had esotropia persisting longer than one month after the operation. We followed up these 15 patients and analyzed

More information

29 28 39 1936 Acquiring technique and forming character in physical education after 1936 Analysis of articles of Kenji Shinozaki FUJIKAWA Kazutoshi The United Graduate School of Education Tokyo Gakugei

More information

The Journal of the Japan Academy of Nursing Administration and Policies Vol 7, No 2, pp 19 _ 30, 2004 Survey on Counseling Services Performed by Nursi

The Journal of the Japan Academy of Nursing Administration and Policies Vol 7, No 2, pp 19 _ 30, 2004 Survey on Counseling Services Performed by Nursi The Journal of the Japan Academy of Nursing Administration and Policies Vol 7, No 2, pp 19 _ 30, 2004 Survey on Counseling Services Performed by Nursing Professionals for Diabetic Outpatients Not Using

More information

The Eevaluation One Bottle Type Silane Coupling Agents Masahiro Aida, Hideo Kanaya, Taira Kobayashi, Keiji Utsugizaki, Yoshizumi Murata, Tohru Hayakaw

The Eevaluation One Bottle Type Silane Coupling Agents Masahiro Aida, Hideo Kanaya, Taira Kobayashi, Keiji Utsugizaki, Yoshizumi Murata, Tohru Hayakaw The Eevaluation One Bottle Type Silane Coupling Agents Masahiro Aida, Hideo Kanaya, Taira Kobayashi, Keiji Utsugizaki, Yoshizumi Murata, Tohru Hayakawa* and Kozo Horie* Abstract: Here is investigated the

More information

Instability of Aerostatic Journal Bearings with Porous Floating Bush at High Speeds Masaaki MIYATAKE *4, Shigeka YOSHIMOTO, Tomoaki CHIBA and Akira CH

Instability of Aerostatic Journal Bearings with Porous Floating Bush at High Speeds Masaaki MIYATAKE *4, Shigeka YOSHIMOTO, Tomoaki CHIBA and Akira CH Instability of Aerostatic Journal Bearings with Porous Floating Bush at High Speeds Masaaki MIYATAKE *4, Shigeka YOSHIMOTO, Tomoaki CHIBA and Akira CHIBA Department of Mechanical Engineering, Tokyo University

More information

日本消化器外科学会雑誌第31巻第7号

日本消化器外科学会雑誌第31巻第7号 Key words: obstructive jaundice, biliary drainage, bile refeeding, hepatectomy Fig. 1 Animal models a: experiment I b: experiment 2 silicon tube Fig. 2 Experimantal design Sham Ope J - l r bile duct Zweeks

More information

NotePC 8 10cd=m 2 965cd=m 2 1.2 Note-PC Weber L,M,S { i {

NotePC 8 10cd=m 2 965cd=m 2 1.2 Note-PC Weber L,M,S { i { 12 The eect of a surrounding light to color discrimination 1010425 2001 2 5 NotePC 8 10cd=m 2 965cd=m 2 1.2 Note-PC Weber L,M,S { i { Abstract The eect of a surrounding light to color discrimination Ynka

More information

Motivation and Purpose There is no definition about whether seatbelt anchorage should be fixed or not. We tested the same test conditions except for t

Motivation and Purpose There is no definition about whether seatbelt anchorage should be fixed or not. We tested the same test conditions except for t Review of Seatbelt Anchorage and Dimensions of Test Bench Seat Cushion JASIC Motivation and Purpose There is no definition about whether seatbelt anchorage should be fixed or not. We tested the same test

More information

The Change of Newspaper Reports of "Juvenile Crimes" Ukyo Sakiyama ABSTRUCT The aim of this paper is to clarify the change of reports of juvenile crimes in newspaper. Juvenile crimes were treated as social

More information

( ) fnirs ( ) An analysis of the brain activity during playing video games: comparing master with not master Shingo Hattahara, 1 Nobuto Fuji

( ) fnirs ( ) An analysis of the brain activity during playing video games: comparing master with not master Shingo Hattahara, 1 Nobuto Fuji 1 1 2 3 4 ( ) fnirs () An analysis of the brain activity during playing video games: comparing master with not master Shingo Hattahara, 1 Nobuto Fujii, 1 Shinpei Nagae, 2 Koji Kazai 3 and Haruhiro Katayose

More information

Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (45)

Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (45) Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 2305(45) 2306(46) THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Dec. Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 2307(47) 2308(48) THE JAPANESE

More information