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1 Bi-weekly News for Ceramics Research Forum in Medicine, Biomimetics, and Biology THE DIVISION No. 12 February 15, 2001 Editor-in-Chief Associate Editor Editorial Staffs C. Ohtsuki, NAIST S. Nakamura, Tokyo Medical Dental University M. Aizawa, Sophia University T. Ogawa, Asahi Optical Co., Ltd. S. Hayakawa, Okayama University M. Ohgaki, Tokyo Medical Dental Univ. K. Ioku, Yamaguchi University K. Okada, NGK Spark Plug Co., Ltd. K. Ishikawa, Okayama University N. Ozawa, Kyoto University M. Kawashita, Kyoto University H. Takeuchi, Mitsubishi Materials Corp. M. Kikuchi, NIRIM N. Tomita, Kyoto University T. Miyazaki, NAIST H. Unuma, Yamagata University M. Neo, Kyoto University Contents MESSAGE & OPINION...3 INFORMATION ON RESEARCH & DEVELOPMEMT...6 (A)...6 F. Fazan et al., J. Mater. Sci.: Materials in Medicine, 11 [12], (2000)
2 M. J. Dalby et al., J. Mater. Sci.: Materials in Medicine, 11 [12], (2000). HA...6 P. Frayssinet et al., J. Mater. Sci.: Materials in Medicine, 11 [12], (2000). 7 Y. -L. Chang et al., J. Biomed. Mater. Res., 52 [2], (2000) p (HA)...7 H. Gautier et al., J. Biomed. Mater. Res., 52 [2], (2000) p ANNOUNCEMENT The 14th International Symposium on Ceramics in Medicine Composites at Lake Louise 2001 A Composites Odyssey. Oct. 28 Nov. 3, 2001 URL
3 MESSAGE & OPINION The Division Consensus 1986 Consensus Conference 1 1) ) Williams 3) (1) Definitions with consensus Artificial organ 1 Bioactive material 2 Bioadhesion 1 Bioattachement Biocompatibility host response 1 Biodegradation 2 Biomaterial 3
4 2 Bioprosthesis 1 Bone bonding 2 Host response 1 Hybrid artificial organ 1 Implant 1 Inherent thrombogenicity 2 Medical device 1 Prosthesis 1 (2) Provisional definitions Bioresorption 1 Graft 1 Autograft Allograft Xenograft Percutaneous device 1 4
5 Permucosal device 1 Transplant 1 (3) Definitions without consensus Foreign body reaction 1 (4) Terms to be deprecated Antithrombogenic Bioceramic Biometal Ceramic biomaterial Biometal Metallic biomaterial Biopolyer Polymeric biomaterial Biocompatible Biocompatibility Biocompatible Bioinert Biological performance Biocompatiblity 1) "Definition in Biomaterials", Ed. by D. F. Williams, Elsevier, Amsterdam (1987) pp ) D. F. Williams, J. Black and P. J. Doherty, "Biomaterial-Tissue Interfaces", Ed. by P. J. Doherty, R. L. Williams, D. F. Williams and A. J. C. Lee, Elsevier, Amsterdam (1992) pp ) D. F. Williams, The Williams Dictionary of Biomaterials, Liverpool University Press (1999). 5
6 INFORMATION ON RESEARCH & DEVELOPMEMT (A) F. Fazan et al., J. Mater. Sci.: Materials in Medicine, 11 [12], (2000). F. Fazan and P. M. Marquis, J. Mater. Sci.: Materials in Medicine, 11 [12], (2000). Dissolution behavior of plasma-sprayed hydroxyapatite coatings in vitro ph ph 37 C 5% CO UV- Ca/P 3 in vitro M. J. Dalby et al., J. Mater. Sci.: Materials in Medicine, 11 [12], (2000). HA M. J. Dalby, L. Di Silvio, G. W. Davies and W. Bonfield, J. Mater. Sci.: Materials in Medicine, 11 [12], (2000). Surface topography and HA filler volume effect on primary human osteoblasts in vitro HA HAPEX HA 20vol.% 40vol.% HA 6
7 HDPE HAPEX DNA 40vol.% HA / HDPE 20vol.% HA / HDPE P. Frayssinet et al., J. Mater. Sci.: Materials in Medicine, 11 [12], (2000). P. Frayssinet, M. Roudier, A. Lerch, J. L. Ceolin, E. Deprés and N. Rouquet, J. Mater. Sci.: Materials in Medicine, 11 [12], (2000). Tissue reaction against a self-setting calcium phosphate cement set in bone or outside the organism DCPD 8 16 Y. -L. Chang et al., J. Biomed. Mater. Res., 52 [2], (2000) p (HA) Y. -L. Chang, C. M. Stanford and J. C. Keller, J. Biomed. Mater. Res., 52 [2], (2000) p Calcium and Phosphate Supplementation Promotes bone cell mineralization: Implications for hydroxyapatite (HA) - enhanced bone formation (HA) β-(β-gp) 7
8 (Pi) 1.8 mm Ca 2+ 5 mm β-gp Pi in vitro SEM TEM ( µm) (500 ng/ml) (50 µg/ml) RNA DNA β-gp DNA in vitro (HA) HA H. Gautier et al., J. Biomed. Mater. Res., 52 [2], (2000) p H. Gautier, J. Caillon, A. M. Le Ray, G. Daculsu and C Merle, J. Biomed. Mater. Res., 52 [2], (2000) p. 308 Influence of Isostatic compression on the stability of vancomycin loaded with a calcium phosphate - implantable drug delivery device in situ 2 (BCP)- 100, MPa BCP 24 h 8
9 100, MPa 3 2 9
10 ANNOUNCEMENT The 14th International Symposium on Ceramics in Medicine 14 The 14th International Symposium on Ceramics in Medicine Bioceramics 14 The Division (URL: URL: URL: ***************************************************************** The 14th International Symposium on Ceramics in Medicine (Bioceramics 14 ) ***************************************************************** Hilton Hotel, Palm Springs, California, USA Professor I. C. Clarke
11 Bioactive Glass Ceramics Calcium Phosphate Preparation, Properties, Coatings Calcium Phosphate Cements Composite Ceramics Cellular Response to Ceramics Tissue Response to Ceramics Tissue Engineering Dental Ceramics Orthopaedic Ceramics Medical Applications of Ceramics 13 Composites at Lake Louise 2001 A Composites Odyssey. Oct. 28 Nov. 3, 2001 URL CONFERENCE PHILOSOPHY Composites are composite. Gathering scientists from all walks of composites in the sweep of the Rockies,, recognizes that the everyday to some is a hurdle to others. Discussion can ease concern. P.S. Nicholson 11
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