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10 1) Kulenkampff M, Schwartzman J S, Wilson j : Neurological complications of pertussis inoculation. Arch Dis Child 49 : 46-49, ) Gibbs E L, Fleming M M, Gibbs F A : Diagnosis and prognosis of hypsarhythmia and infantile spasms. Pediatrics 13 : 66-73, ) Baird H W, Borofsky L G : Infantile myoclonic seizures. J Pediat 50 : , ) Jeavons P M, Bower B D : Infantile Spasms. Clin Develop Med No. 15, William Heinemann Med Books, Ltd, London, ) Gastaut H, Soulayrol R, Roger J, et al : L'Encephalopathie Myoclonique Infantile avec Hypsarhythmie (Syndrome de West). Masson, Paris, ) Kringelbach J, Senstius J : Hypsarhythmia after triple-vaccination. Nord Med 76 : 1433, ) Janz D, Akos R : Uber die Rolle praenataler Faktoren bei der Aetiologie der Propulsiv-Petit-Mal- Epilepsie (West-Syndrom). J Neurol Sci 4 : , ) Nielsen J L : Hypsarytmi og triplevaccination. Ugeskr Laeg 130: 234, Cited from Melchior') 12) Melchior J C : Infantile spasmer og vaccinationer. Ugeskr Laeg 131 : 746, Cited from Melchior' 13) StOgmann W : Zur Aetiologie und Nosologie der Blitz-, Nick-, und Salaamkrampfe. Paediat Paedol 5 : , ) Gordon N : Reactions to triple immunization. Neuropaediatrie 2 : , ) Friedmann E, Pampiglione G : Prognostic implications of electroencephalographic findings of hypsarhythmia in first year of life. Brit Med J 4 : , ) Chevri J J, Aicardi J : Le pronostic psychique des spasmes infantiles traites par 1'ACTH ou les corticoides. Analyse statistique de 78 cas suivis plus d'un an. j Neurol Sci 12 : , ) Vassella F, Pavlincova E, Schneider H J, et al : Treatment of infantile spasms and Lennox-Gastaut syndrome with clonazepam (Rivotril). Epilepsia 14 : , ) Jeavons P M, Bower B D, Dimitrakoudi M : Long -term prognosis of 150 cases of "West syndrome". Epilepsia 14 : , ) Melchior J C : Infantile spasmer og tidlige vaccinationer i arene Ugeskr Laeg 135 : , ) Melchior J C : Infantile spasms and immunization in the first year of life. Neuropaediatrie 3 : 1-10, ) Bower B D, Jeavons P M : Letter to the editor. Complications of immunization. Brit Med j 2 : 1453, ) Prensky A L : Pertussis vaccination. Develop Med Child Neurol 16 : , ) Ehrengut W : Uber konvulsive Reaktionen nach Pertussis-Schtitzimpfung. Dtsch Med Wsch 99 : , ) Livingston S : Comprehensive Management of Epilepsy in Infancy, Childhood, and Adolescence. C C Thomas, Springfield, ) Griffith A H : Pertussis vaccine and convulsive disorders of childh000d. Proc Roy Soc Med 67 : , ) Cooper J E : Epilepsy in a longitudinal survey of 5,000 children. Brit Med J 1 : 1020, 1968.
11 Critical Evaluation of The Role of Immunization As An Etiological Factor of Infantile Spasms Noriko TOMORI, M. D., Setsuko TAJIMA, M. D., Mariko SUGITATE, M. D., and Yukio FUKUYAMA, M. D. Department of Pediatrics (Chief : Prof. Yukio FUKUYAMA, M. D.), Tokyo Women's.Medical College, Tokyo. Tohru SEKI, M. D. Department of Pediatrics, (Chief : Prof. Yasuo ICHIHASHI, M. D.), School of Medicine, Keio University Causal relationship of immunization with infantile spasms in each patient was evaluated on the basis of the following three aspects : 1) Any other causal factors except immunization should be ausent. 2) Psychomotor development before onset of the disease should be normal. 3) Interval from immunization to onset of the disease should be lied : a) Within 48 hours, in the case of pertussis vaccine, b) Within 7 days, in the case of anti-polio vaccine, c) Within 18 days, in the case of smallpox vaccine or anti-japanese encephalitis vaccine. Only five cases (4.8% of the total) were able to classify into the compatible group which should fulfill all the above three criteria. The small figure like these may easily be explicable on the assumption that the natural onset of spasms chronologicallysuperposed by chance over immunizations which has been obliged to be done within the first year of life. One hundred and ten cases of infantile spasms with detailed information about immunization available were selected as the material to evaluate the significance of immunization as an etiological factor of infantile spasms. In 80% of the cases, immunization could not be considered to have any relation with causation of infantile spasms, bacause 44 cases (40%) never had innoculations as yet, and other 44 cases (40%) had been immunized by some vaccines over one month before or after the onset of the disease. The remaining 22 cases, in whom immunization had been performed within one month before the onset of the disease, constituted the candidate for further study. The age of onset of the disease of the candidate group distributed from two to 9 months of age with peak incidence at 4 to 5 months old, exactly identical with that of patients with infantile spasms in general. The kind of vaccines concerned included DPT triple vaccines in 15 cases, smallpox vaccine in 4, anti-polio live vaccine in 1, anti-japanese encephalitis vaccine in 2.
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3) Stedmann, E. et al.: Biochem. J., 29; 2107, 1935. 4) Reiss, M.. Hemphill, R. E. E ENature, 161 ; 18, 1948. 5) Tower, D. B. & D. MeEachern: Canada J. Reserch., 27; 105, 120, 132, 1949. 6) Wolleman, M.
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Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究 第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date URL
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