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- けいしょう しのしま
- 7 years ago
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1 13A ﾌ 6ﾑ8ｦﾐ04ｦﾐ ﾒ ﾌ08 6ﾑ80304ｦﾐ ﾞ026ﾑ806 ﾌ03ｦ ﾌ6ｾ4 6ﾑ ｧ90709: fi0ｹ0 030ｸ ｧ80ｹ ｦ ｸ ｧ803080ｸ7 ｦﾌ. 09 apple 09000ｷ303096ｧ9080ｸ7, 09. ﾌ fi00080ｸ7 ﾞ ｧ8 ﾒ ｧ8 ﾞ0905, ｧ908 ｰｦﾐappleapple ｱ, ｧ90209 Papageorgiou V, Ikonomou M. Hepcidin: the principal regulator of iron metabolism. A Paed. Department A.U.TH., ｰIppokration ｱ General Hospital, Thessaloniki,.Greece. Paediatr N Gr 2010, 22: ｧ ﾇ ｧ90709 apple ｧ fi 030ｸ ｧ ｹ fi ｹ ｸ ｧ803080ｸ apple06apple03 閨 閨 閨04080ｸ 閨 apple 閨 ｹ ｧ9 0ｹ ｧ9 0ｹ0 07fi04080ｸ fi fi0709 apple080ｸ7 apple applefi 02 09apple ｦ 閨 ｧ ｹ applefi apple0804fi ｸ7 020ｸ ｦ ｧ803080ｸ7, ｧ8, ｸ7apple08016ｧ ｸ apple ｧ fi ｸ ｦ0. 6ｾ fi 00apple6ｧ9apple ｧ ｦ ｹ apple ｧ90709, 09 08apple086ｧ9 006ｧ ｸ7apple006ｦ0030ｸ applefi ｸ ｧ ｸ7 applefi ｸ apple03080ｹ ｸ ｧ8 020ｸ ｧ9. ﾌ0ｸ , ｧ apple08 6ｧ9ｨB 閨 ｸ ｧ803080ｸ7 applefi 閨07 026ｦ fiapple0ｷ30ｹ ｦ , 02 09apple ｦ ｸ707 apple ｧ9 閨0ｷ30ｹ0 046ｧ ｹ 閨0ｹ0 00 閨 apple fi 020ｷ307 00apple06apple 陦0ｷ ｹ ｧ907090ｹ0, ｧ9 00 閨 ｹ 閨 ｧ ｷ303006ｧ ｧ8 apple fi apple ｸ707, apple 閨0ｹ 閨0ｹ0 apple030808apple 閨0ｹ 閨080ｸ70ｹ ｷ ｦ00ｹ apple000ｸ ｦ00ｹ apple086ｦ00ｹ0 fi 閨 ｹ0 apple080ｸ ｧ9ｨB fi 02080ｸ ｧ803080ｸ7. 閨 ｹ : ｧ90709, 046ｧ ｹ0, apple ｧ90709, ｧ ｧ9 0ｹ0 07fi04080ｸ7. Abstract. Hepcidin is the principal regulator of iron metabolism and simultaneously acts as the key-regulator of anemia of chronic disease. It is a hormone which is produced by the hepatocytes and its production is triggered mainly by the amount of circulating body iron, inflammation, hypoxia and the erythropoietic activity of the body. In molecular level, hepcidin acts via the binding of ferroportin which is the basic cellular exporter of iron from the intracellular space to the systemic circulation. The exact role of hepcidin is the inhibition of iron cellular efflux. Several laboratory methods for hepcidin ｯs quantification have already been proposed but none has been established for clinical use so far. Hepcidin could open new horizons concerning diagnosis and therapy of diseases related to iron metabolism. Key words: hepcidin, iron, ferroportin, anemia of chronic disease. E ｷ3096ｧ8 ｦ ｸ702 6ｧ9 閨0209 閨 ｷ303006ｧ apple03fi08 080ｹ 閨 ｹ fi ｹ ｸ ｧ803080ｸ ｹ0 apple ｹ ｹ ｧ9 0ｹ ｧ9 0ｹ0 07fi04080ｸ7. ﾇ ｧ ｷ303006ｧ ｧ fi0ｹ0 030ｸ ｧ80ｹ ｸ ｦ ｸ ｧ803080ｸ fi0ｹ ｧ80ｹ ｸ apple ｦ0 040ｸ704026ｧ ｹ01, fi ｧ8 apple030ｷ ｹ10709 apple080ｸ7 apple ｧ applefi 00fi03060ｹ 陦 ｸ ｧ applefi 02 09apple ｦ ﾇ 046ｦ ｧ ｹ0 00apple applefi ｸ7apple000300apple ｸ ｦ ｧ applefi ｧ8, ｸ707036ｧ ｹ0 閨 ｹ ｸ apple ｧ80ｹ fi ｹ0. ﾇ ｹ ｧ907090ｹ ｸ ｦ ｹ0 03fi03080ｸ fi 02080ｸ ｧ803080ｸ apple ｦ ｧ 閨080ｸ70ｹ0 03fi00080ｸ70ｹ apple006ｧ ｹ apple ｧ80ｹ ｧ9 0ｹ0, 02090ｹ ｷ ｷ304090ｹ ｹ ｧ9 0ｹ ｧ9 0ｹ0 07fi04080ｸ74,5.
2 ｧ8 B ﾌ066ﾑ8I ﾌ08 6ﾑ8 ﾞ04 ﾌ6ｾ4, 22, 縺 ｹ ｧ907090ｹ0 ｦ 08 fi ｹ fi07090ｹ0 0ｸ7026ｧ80ｹ0 apple0308 閨 applefi 0208 ｰhep ｱ, 03fi090ｷ ｹ0 apple ｷ3096ｧ80ｹ ｹ0 applefi 02 09apple ｦ , ｰ-cidin ｱ, 03fi090ｷ ｹ ｧ80ｹ ｹ ｹ06. ﾞ , LEAP-1 (Liver Expressed Antimicrobial Protein)7. ﾞ ｧ ｦ ｹ ｧ907090ｹ0 閨 apple ｦ ｸ apple080ｸ7, 0806 apple fi ｹ0 apple ｧ9000ｹ ｦ ｹ ｧ907090ｹ0, ｧ ｸ703096ｧ ｹ0 閨04080ｸ707 apple0308 閨 applefi in vitro 閨02000ｹ apple fiｨB0ｷ fi apple030ｷ302000ｹ10709 apple080ｸ7 apple ｧ applefi 陦 ｸ ｦ00ｹ ｦ00ｹ0 (6ﾑ ) apple ｧ fi apple03080ｸ8fi07 6ｦ008 apple03fi ｷ ｹ0: 02090ｹ0 prepro-hepcidin ｹ0 pro-hepcidin 9. ﾒ0ｷ apple ｧ applefi ｧ HAMP apple080ｸ apple6ｧ9ｨB ｦ 閨03080ｹ ｸ ｷ ｹ0 19 (19q13.1) 7,10. ﾒ0ｸ ｧ apple apple ｧ ｦ003. ﾌ fi0ｹ ｸ ｧ803080ｸ7 ﾌ 046ｧ ｹ0 006ｧ apple 03 6ｧ ｧ ｸ ｧ ｸ703096ｧ ｸ ｦ ｹ0 apple ｧ fi fi 040ｸ fi 02090ｹ ｧ907090ｹ0, 02090ｹ0 000ｸ ｧ907090ｹ0, 020ｷ ｸ ｷ ｷ apple ｨB6ｦ0-000ｷ apple ｧ9ｨB fi ｧ8 apple fi ｸ ｦ ｧ ｧ gr, ｷ307 08apple086ｧ90ｷ307 2,5 gr ｧ ｧ90709, 2-3 gr ｸ ｧ 閨07ｨB0ｸ gr 0402 apple ｸ 閨07ｨB0ｸ700. ﾌ ｧ ｹ ｹ ｸ ｦ Fe 006ｧ apple00036ｧ9apple080ｸ7 1 gr. ﾞ0ｸ 閨07000ｹ ｹ ｧ ｧ9ｨB ｹ0 026ｦ ｹ ｹ ｸ7046ｧ9 0ｹ0, ｹ apple ｧ ｧ9 03fi090ｷ ｹ ｧ9 0ｹ0 040ｷ ｧ80ｹ0 6ｦ ｹ0. ﾇ apple080303fi ｸ7 Fe 096ｧ applefi 02 00apple ｦ ｸ ｦ fi07080ｸ7 0ｷ ｦ003080ｸ7-076ｧ ｹ0. ﾌ 046ｧ ｹ0 apple080ｸ7 apple ｧ8 apple 閨0ｹ0: fi fi Fe. O fi0ｹ0 Fe 006ｧ ｧ80ｹ ｦ ｹ0 apple0909 閨0ｹ ｸ7 006ｧ ｧ ｸ ｧ 陦 0ｹ0, 02 apple080ｸ ﾌ fi0ｹ0 Fe 006ｧ ｧ80ｹ apple 閨0ｹ0 080ｸ ｧ80ｹ ｨB0ｷ306026ｧ80ｹ0 apple0308 閨03000ｸ704090ｹ0, apple.04.: fi04apple0306, fi02080ｹ0 0ｸ709086ｦ0. 6ﾑ ｸ Fe 006ｧ90200 apple ｦ ｦ ｧ9ｨB ｹ ｧ90709, 006ｧ 閨 ｸ ｧ8 020ｸ ｧ9. ﾇ ｸ ｸ ｧ9 096ｧ 閨040ｷ ｹ apple ｧ907090ｹ0, 09 08apple086ｧ9 apple ｧ ｧ8 apple030ｷ302000ｹ ｷ309 陦 02080ｸ ｧ803080ｸ7 applefi ｦ ﾞ08086ｦ 閨 apple03 閨 ｸ ｧ9, 08 Fe ｦ applefi apple ｧ ｸ ｦ ｧ9ｨB ｹ ｧ90709 (Tf). 020ｸ , fi0ｹ ｹ ｧ907090ｹ ｧ ｸ700 6ｧ %, apple00036ｧ9apple080ｸ7. ｦ ｨBfi ｦ000apple Fe ｦ fi0408, fiapple080ｸ ｦ applefi ｸ7apple 陦 02090ｹ ｧ907090ｹ0 (TfR1) 閨 fi040ｷ ｸ ｷ ﾑ80702fi0ｹ ｸ ｹ ｸ703006ｧ9 apple08 閨 ｸ ｸ7 Fe applefi Tf, 08 08apple086ｧ9080ｹ ｸ707 閨 閨 ｸ fiapple ｸ7 020ｸ ｸ7-0402fi04080ｸ7, fiapple080ｸ ｸ707- 閨 ｧ ｦ ｷ ｷ ｸ ｧ Tf TfR 00apple apple ｦ ﾇ ｧ ｧ ｧ8 apple030ｷ ｹ10709 apple08036ｧ802000ｸ704090ｹ ｸ7 Fe apple ｧ applefi 閨07 apple030ｷ302000ｸ fi 02 閨030ｸ708080ｹ0 ( apple ｧ90709) 閨07 07 apple0ｸ7036ｧ Fe. ﾇ ｧ ｧ 閨07 0ｸ ｸ apple030ｷ302000ｸ fi 046ｦ000apple apple080ｸ7 apple ｧ9ｨB applefi apple fi ｧ907090ｹ0, 08086ｦ0 0ｸ70207 apple ｸ707 閨07 00 閨03080ｹ ｹ0 apple ｧ907090ｹ0. O Fe 02080ｸ ｦ0 apple applefi ｧ8, , 020ｸ7-036ｧ90ｷ30ｹ0, 00apple apple ｧ applefi 閨 ｸ ｧ ﾇ 00apple apple086ｧ ｧ ｸ7 046ﾑ86ｾ4 (04apple036ｧ807 0ｹ0, 6ｧ8apple 03, 000ｸ70003fi0ｹ0 020ｷ ). 6ｾ fi 03fi ｧ ｸ7 Fe 閨 ｧ8apple 03, 00 閨040ｷ ｹ0 apple ｷ3096ｧ80ｹ ｹ ｧ907090ｹ0, 09 08apple086ｧ apple0804fi ｸ7 020ｸ ｦ ｹ0 Fe, 0000apple08 6ｧ9ｨB ｹ 閨0108 fi 02080ｸ7 applefi ｦ , 02 09apple ｦ 縺 , fi0ｹ 閨 閨07 07 apple08036ｦ ｧ ｸ7 6ｧ ｸ fi fi 036ｦ ｹ ｹ ｸ ｹ0 040ｸ 閨 ｷ304090ｹ apple08036ｧ802000ｸ704090ｹ ｸ ｧ803080ｸ714. 6ﾑ ｧ ｧ ｹ0 ﾇ 040ｸ70404 閨 ｹ ｧ907090ｹ fi 02080ｸ7 Fe applefi 02080ｸ70ｹ0 Pigeon ｸ707. O06 Nicolas ｸ ｸ70ｹ0 apple 閨 fi ｧ apple03fi ｧ803080ｸ7 applefi 0208 閨 apple apple08 閨 ｸ7046ｧ ｸ7 applefi ｾ fi 00apple6ｧ9apple00 08, ｧ ｸ703006ｧ9ｨB ｸ7 Fe 00 閨040ｷ ｹ0 閨 ｸ704090ｹ ｹ apple ｧ907090ｹ0, 02090ｹ ｧ80ｹ0 apple030ｷ302000ｹ107090ｹ0 apple080ｸ7 apple08 6ｧ Fe applefi ｷ fi 020ｷ ｸ ｷ307 apple03080ｹ ｸ ｧ9. ﾇ apple ｧ ｧ apple ｦ ｸ7 0ｷ ｦ003080ｸ7, , apple ｦ ｦ ｸ7 apple ｦ ｧ ｸ ｧ apple ｧ90709, (0400 閨07 040ｸ 閨 ｧ ｦ ｹ0 apple080ｸ ｧ Hepcidin-Binding Domain, HBD) ｸ ｧ 閨07 046ｦ000apple apple086ｧ ｸ ｧ apple08 fi ｹ apple ｧ907090ｹ018,19. ﾇ ｷ ｹ apple ｧ907090ｹ ｧ fi apple ｸ ｷ ｸ7 Fe applefi ｦ apple03080ｹ apple (6ﾑ ). ｦ 08 09apple ｦ ｧ ｸ702fi apple080ｸ ｸ ｧ9 0ｷ30ｹ0 000ｸ7 6ｧ9-
3 13CM YK CM YK ｧ8 B ﾌ066ﾑ8I ﾌ08 6ﾑ8 ﾞ04 ﾌ6ｾ4, 22, 3 T84 N terminus H74 R75 S76 K77 C78 G79 M80 C81 C82 K83 T61 D60 C73 C72 G71 C70 C69 F68 I67 C66 I65 F63 H62 P64 6ﾑ ｧ8 apple00apple0206 6ｧ9080ｸ ｧ907090ｹ ｹ0 ｰ ｧ803 0ｹ ｧ803080ｸ7 ｱ (iron-sensor) fi apple6ｧ9apple ｸ ｦ ｧ ｧ ｸ 閨 apple ｦ , apple08036ｦ0apple ｷ apple ｷ307 (apple080ｸ 閨04080ｸ ｸ ｧ9 apple036ｧ8030ｷ30ｹ0 02fi0009), apple ｧ ｦ ｹ ｧ907090ｹ0. 6ｾ fi 03fi apple ｷ3096ｧ ｹ0 08 6ｧ apple 6ｧ9ｨB GPI-linked hemojuvelin (HJV), 09 ｦﾌ0906 (Bone Morphogenic Protein), 09 HFE, o TfR TfR ｸ ｧ8 0ｸ , apple ｦ apple ｧ902 06, apple ｹ ｷ3096ｧ80ｹ0 046ｧ ｹ ｸ ｸ ｧ8 020ｷ307 apple030ｷ302000ｸ SMAD apple ｧ 閨 ｸ7 apple00apple0206 6ｧ9080ｸ ｹ ｧ907090ｹ0 (6ﾑ ). M ｹ ｸ70ｹ0 apple 03 apple07070ｷ3 0ｸ7apple ｧ90ｹ0 (HJV, TfR2, HFE) ｦ 閨0ｹ 閨0ｹ ｧ907090ｹ , 0ｸ ｷ30ｹ0, ｹ ｸ7apple000308fi03020ｷ ｸ ｦ ｧ ( ｷ ｷ30409) 26,27. 6ﾑ ｧ ｧ ｷ ｷ30409 ﾇ ｧ ｷ ｷ ｧ fi04080ｹ0 apple080ｸ ｧ9ｨB applefi 0ｸ 閨 ｧ8 apple080303fi ｸ7 Fe 鐶pple applefi ｸ ｸ ｸ70ｹ ｦ00ｹ0. ﾌ 0203fiapple080ｹ fi ｹ0 006ｧ ｸ7076ｧ8030ｷ30ｹ0 0ｸ ｷ fi0ｹ0 0ｸ7apple applefi ｹ apple 076ｧ90ｷ30ｹ0 0ｸ ｷ fi0ｹ0 (00apple ｧ80ｹ0) 28. ﾇ ｧ ｷ ｷ ｷ3036ｧ9ｨB ｸ70ｹ0 026ｦ0apple080ｸ70ｹ ｸ ｧ9080ｸ7 apple080ｸ7 apple ｧ fi0408. ﾇ apple ｧ ｸ ｧ9080ｸ7 HFE (C282Y ) 29 apple080ｸ ｨB ｷ300fi040ｷ ﾞ ｧ90ｹ 閨 ｧ 閨04080ｸ apple6ｧ9apple ｧ907090ｹ0, apple apple086ｧ ｦ ｸ70404 閨 ｸ7 HFE ｦ ｹ ｧ907090ｹ apple6ｧ9apple ｧ907090ｹ0 apple ｦ007 0ｸ apple6ｧ9apple apple ｧ907090ｹ ｸ ｧ , 0000 apple0802 閨 ｸ 閨 ｧ8 apple0803- A) 0ﾊ3ｦﾐｦﾁｦﾑ B) 0ﾊ3ｦﾐｦﾁｦﾑ ｦ ｦﾗｦﾉｦﾄ0ﾋ7ｦﾍｦﾇ ｦ ｦﾗｦﾉｦﾄ0ﾋ7ｦﾍｦﾇ Fe Fe Fe-Tf ｦﾅｦﾍｦﾓｦﾅｦﾑｦﾏｦﾊ0ﾌ3ｦﾓｦﾓｦﾁｦﾑｦﾏ Fe Fe-Tf ｦﾅｦﾍｦﾓｦﾅｦﾑｦﾏｦﾊ0ﾌ3ｦﾓｦﾓｦﾁｦﾑｦﾏ ｦﾌｦﾁｦﾊｦﾑｦﾏｦﾕ0ﾋ4ｦﾃｦﾏ ｦﾌｦﾁｦﾊｦﾑｦﾏｦﾕ0ﾋ4ｦﾃｦﾏ ｦﾕｦﾅｦﾑｦﾑｦﾏｦﾐｦﾏｦﾑｦﾓ0ﾋ7ｦﾍｦﾇ ｦﾕｦﾅｦﾑｦﾑｦﾏｦﾐｦﾏｦﾑｦﾓ0ﾋ7ｦﾍｦﾇ 6ﾑ fi0ｹ ｹ ｧ907090ｹ ｸ fi 00apple6ｧ9apple A) 6ｾ ｸ707036ｧ802000ｹ0 00apple ｹ ｧ803080ｸ7 00apple ｦ ｧ907090ｹ0 applefi 02 09apple ｦ , B) ﾇ ｧ ｦ apple ｧ ｸ ｷ ｷ apple08 6ｧ9ｨB ｹ 閨 ｸ ｧ803080ｸ7. CM YK CM YK
4 13CM YK CM YK ｧ8 B ﾌ066ﾑ8I ﾌ08 6ﾑ8 ﾞ04 ﾌ6ｾ4, 22, fi Fe ｸ 閨0709 apple ｸ703 閨030ｷ ｧ803080ｸ7 applefi ｾ4apple 0706fi ｹ 閨0ｹ ｧ80ｹ ｷ ｷ304090ｹ ｦ ｹ ｧ90ｷ307 HJV, TfR ｧ907090ｹ0 (HAMP) 31,32. 6ｾ ｧ ｷ ｷ apple6ｧ9apple ｹ ｧ907090ｹ0 006ｧ ｷ300-07, applefi ｦ0apple ｹ ｹ0. 6ﾑ801 6ｧ apple ｧ ｦ0apple080ｹ0 apple080ｸ ｧ ｸ ｧ9080ｸ ｹ apple ｧ907090ｹ0, fiapple080ｸ ｧ apple ｧ ｧ ｸ 閨0709, 06fi0206 apple03fi ｸ ｧ ｸ7 0ｸ7apple 陦 02090ｹ apple ｧ907090ｹ ｹ ｸ ｧ8 0700apple ｹ fi07090ｹ ﾑ ｷ300 閨0709 閨 ｧ907090ｹ0, 閨 apple ｧ ｧ8030ｷ30409, 0ｸ7apple apple6ｧ904090ｹ apple ｸ7036ｧ9000ｹ0, ｧ8 09apple 0208apple ｧ9000ｷ HCV 36. 6ﾑ ｧ ｧ8 ﾇ ｧ apple ｧ9 00fi ｸ ｧ ｸ ｧ803080ｸ7, fi 040ｸ fi apple ｦ ｹ ｸ707 0ｹ ｸ ｦ ｸ ｦ ｸ ｧ803080ｸ , 02 00apple6ｧ9apple ｹ ｧ907090ｹ0 006ｧ ｸ apple00036ｧ9apple020ｷ ｧ9000ｷ301090ｹ0. 6ｾ apple 閨0709 apple00036ｧ9- apple020ｷ ｦ ｹ0 apple ｷ3096ｧ80ｹ ｹ fi07090ｹ0 096ｧ ｦ00ｹ0 apple080ｸ ｧ9ｨB apple6ｧ9apple ｧ803080ｸ ｧ900, IL ｧ apple 6ｧ9ｨB fi 03fi ｦ ｹ0 apple ｷ3096ｧ80ｹ ｹ038. 6ｾ40ｸ 閨07, 09 IL apple ｧ 閨 ｸ7 apple00apple0206 6ｧ9080ｸ ｹ ｧ907090ｹ039 (6ﾑ ). ﾇ 046ｦ ｹ ｧ907090ｹ ｧ ｧ9000ｷ ｧ fi0ｹ ｧ9090ｷ307 0ｷ ( ｹ0), 08applefi apple ｦ ｧ ｷ30ｹ0 apple030ｷ302000ｹ ｧ9 0ｹ ｹ0. ﾇ 6ｦ ｹ ｧ907090ｹ ｧ9000ｷ ｦ ｧ90ｷ ｹ0 040ｸ apple fi ｹ0 apple0804fi ｹ ｧ803080ｸ fi0708 apple ,41. ﾞ6ｦ ｹ ｧ907090ｹ0 040ｸ ｧ fi fi ｧ9000ｹ fi ｹ ｹ ｹ0 ｨC ｧ ｧ9 0ｹ0 07fi04080ｸ7ｨC (0403fi ｹ ｹ0, ｧ ｹ0, 閨0ｹ apple ｦ0) ﾒ ｧ ｹ ｧ907090ｹ0 applefi ｧ9-0ｸ7apple08016ｧ9 ﾇ apple ｷ3096ｧ ｹ ｧ907090ｹ0 applefi 02 09apple ｦ ｸ ｧ9ｨB apple6ｧ904090ｹ0 applefi ｧ ｸ7apple08016ｧ9 2, apple086ｧ9-000ｹ0 apple ｦ ｧ90ｷ ｹ ｧ907090ｹ ｧ ｧ ｹ0 00apple6ｧ ｧ8 apple080303fi Fe ｸ702fi ｸ ｧ9 09 apple ｸ703 閨030ｷ ｸ7 Fe applefi apple ｦ fiapple08 0ｸ702fi apple fi ｹ0 046ｧ ｹ ｧ 閨 ｹ ｸ 閨 ｸ apple086ｧ , 06fi0206, fiapple0ｷ30ｹ0 006ｧ ｷ30402fi, ｹ0 0ｸ7apple08016ｧ9 0ｹ0 apple ｦ apple fi ｸ ｧ ｸ ｷ ｸ ｦ0. 6ｾ fi 00apple6ｧ9apple ｹ0 0ｸ7apple08016ｧ9 0ｹ0 08 HIF (Hypoxia Inducible Factor) 08 6ｧ 閨 fi 03fi ｦ ｷ apple080ｸ7 040ｸ ｧ907080ｸ707, 040ｸ ｧ ｸ , apple ｸ ｧ apple ｹ0 080ｸ ｧ80ｹ ｸ709fi070ｷ304090ｹ ｸ ｦ0. 6ｾ40ｸ 閨07, apple03fi ｦ apple 03-09fi07020ｷ307 apple080ｸ7 apple ｸ 閨 ｹ ｸ apple ｧ907090ｹ0, 02090ｹ ｧ907090ｹ ｸ7 0ｸ7apple 陦 ｧ907090ｹ0, 閨 ｸ 閨 ｸ ｧ9080ｸ ｹ ｧ907090ｹ0. 6ﾑ8apple0800 閨070ｷ30ｹ0, 08 HIF 02 0ｸ fi070ｷ30ｹ0 ) apple ｧ ｸ apple086ｧ ) apple ｸ 閨 fi ｸ7 Fe 46. 6ｾ46ｦ000080ｷ apple03fi- ｦｴｦﾗｦﾇｦﾋ0ﾋ4 ｦﾅｦﾐ0ﾋ7ｦﾐｦﾅｦﾄｦﾁ Fe ｦｴｦﾐｦﾏｦﾎ0ﾋ7ｦﾁ ｦｶｦﾁｦﾌｦﾇｦﾋ0ﾋ4 ｦﾅｦﾐ0ﾋ7ｦﾐｦﾅｦﾄｦﾁ Fe ｦ ｦﾍｦﾁｦﾉｦﾌ0ﾋ7ｦﾁ ｦｧｦﾐｦﾁｦﾓｦﾏｦﾊ0ﾌ3ｦﾓｦﾓｦﾁｦﾑｦﾏ ｦ ｦﾑｦﾔｦﾈｦﾑｦﾏｦﾐｦﾏ0ﾋ7ｦﾇｦﾒｦﾇ SMAD STAT3 ERK1/2 + HAMP ｨC IL-6 ｦｫｦﾏ0ﾋ7ｦﾌｦﾘｦﾎｦﾇ ｦｵｦﾋｦﾅｦﾃｦﾌｦﾏｦﾍ0ﾋ6 6ﾑ apple ｸ ｹ0 00apple 090ｷ3096ｧ80ｹ0 046ｧ ｹ apple ｦ apple ｷ3096ｧ ｹ ｧ907090ｹ0. CM YK CM YK
5 ｧ8 B ﾌ066ﾑ8I ﾌ08 6ﾑ8 ﾞ04 ﾌ6ｾ4, 22, ｹ 閨02000ｹ ｸ apple ｧ90709 apple080ｸ7 apple apple000306apple ｹ ｧ9 0ｹ0 6ｧ8 0ｸ7apple08016ｧ9 0ｹ apple ｷ3096ｧ ｹ ｧ907090ｹ047. 6ﾑ ｧ ｹ ｸ7apple000308fi03020ｷ ｧ803080ｸ7 ﾒ ｹ ｸ7apple000308fi03020ｷ ｸ ｦ ｧ ｧ ｦ , ｧ ｧ9, ｸ ｸ704apple ｦ , ｸ70308apple ｧ ｹ0 apple080ｸ7 apple ｦ ｧ apple apple ｧ904000ｷ307. 6ｾ400 apple00036ｧ9apple020ｷ30409 fiapple0ｷ30ｹ fiｨB0ｸ ｧ9, ｷ ｹ ｧ907090ｹ0 apple ｧ applefi ｸ 閨 ｸ apple086ｧ ﾌ fi0ｹ0 03fi090ｷ ｹ0 0ｸ 閨07090ｹ ｸ apple ｧ80ｹ fi ｹ0 0ｸ ｧ8 apple080303fi ｸ ｧ803080ｸ 閨 apple ｧ ｦ ｸ ｧ803080ｸ ｸ7 apple ｹ0, 02fi ｧ90ｹ0 apple080ｸ ｧ9ｨB ﾇ 6ｦ ｸ7026ｧ ｧ ｧ8 apple ｷ3096ｧ ｧ907090ｹ0 applefi 02 09apple ｦ ｧ80ｹ ｧ apple6ｧ9apple ｹ ｧ907090ｹ 閨 apple 07 閨 ｸ ｸ 閨0ｹ 閨0ｹ fi0408, 0806 apple apple03 閨0ｹ ｧ ｹ0 apple 03 閨04080ｸ apple0804fi ｧ803080ｸ7, ｹ0 apple ｸ7apple000308fi03020ｷ ｸ ｦ ｧ ｾ46ｦ ｷ 閨02000ｹ0, ｧ90ｹ ｧ ｧ ｸ 閨07080ｹ0 08 GDF15 (Growth Differentiation Factor 15), 08 08apple086ｧ9080ｹ fi 00apple6ｧ9apple ｧ 閨 閨 ｸ ｧ9080ｸ ｹ ｧ907090ｹ fi apple030ｷ302000ｹ10709 apple080ｸ7 076ｧ ｸ7apple 閨 ｷ307 ｦ ransforming-growth Factor beta 48. 6ﾑ 閨0ｹ0 00 閨 apple ｦ ｹ ｧ907090ｹ0 ﾞapplefi ｧ8 apple080ｸ7 06 apple fi0ｹ0 03fi03080ｹ ｹ ｧ907090ｹ fi ｸ ｧ803080ｸ7, ｸ fi 閨 ｦ ｹ0 0106fiapple ｹ fi 080ｸ7 apple ｦ ｹ0 040ｸ 閨07090ｹ fi07090ｹ ｸ ｸ ｹ0. ﾞ , apple08066ｧ 閨 ｹ0 ELISA ｧ ｸ70409 apple ｧ907090ｹ ｦ0 49, 00 閨 ｹ apple086ｧ9 046ｦ apple ｧ , 06fi ｦ ｧ ｧ ｹ fi ｹ0. ﾒ ｦ00ｹ0 apple ｹ0 00 閨 ｹ ｹ ｧ907090ｹ fi 6ｧ ｦ003 17, 50-52, 040ｷ3-036ｧ90ｹ ｧ apple ｧ9 02fi ｧ ｷ303006ｧ ｧ8 apple ﾞ0ｸ702fi ｧ fi 閨 ｹ ｧ apple036ｧ8030ｷ30ｹ0 0106fiapple , 00apple06apple03 閨0807, 0007 閨 fi ｸ ｧ ｧ ｸ7applefi ｧ ｹ ｸ ｹ0 00apple ｨBfi applefi ｸ703-00fi 6ｧ8/ ｧ ｸ ｷ307 52,53, , 02 閨03080ｹ0, ｧ ｷ30402fi applefi ｧ ｹ ｧ907090ｹ ｦ apple02036ｧ9ｨB apple6ｧ9apple ｹ fi07090ｹ apple 閨0ｹ0 apple030808apple 閨0ｹ0 ﾇ ｧ ｧ ｧ fi0ｹ0 030ｸ ｧ80ｹ ｸ ｦ ｸ ｧ803080ｸ apple030ｷ ｷ fi0ｹ ｧ80ｹ ｸ apple ｦ0 040ｸ704026ｧ ｹ apple ｦ apple ｧ9 0ｷ30ｹ0 apple030ｷ302000ｹ ｧ9 0ｹ ｹ0 6ｧ fi0ｹ0 006ｧ ｹ0, ｹ0 00apple6ｧ904090ｹ ｧ 閨080ｸ70ｹ ｧ9ｨB ｹ apple ｷ3096ｧ ｷ307 ( 090ｷ 閨0ｹ0, ｷ 閨0ｹ0) apple006ｧ fi030ｷ ｷ307 fiapple0ｷ30ｹ , ｷ307, ｸ apple ｦ0 040ｸ704026ｧ ｹ apple apple080ｸ7 06fi ｹ ｸ7apple fi fiapple ｧ9 apple ｦ0 020ｷ ｸ ｹ0. ﾞapple ｦ fi 閨0ｹ ｧ ｹ ｧ ｹ ｹ0 apple ｸ 閨0ｹ ｹ0, ｸ ｦ apple 閨 ｷ303006ｧ ｧ 閨 ｷ ｹ0. ｦﾌ ｧ9 1. Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Ann Rev Nutr 2006, 26: Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003, 102: Bergamaschi G, Villani L. Serum hepcidin: a novel diagnostic tool in disorders of iron metabolism. Haematologica 2009, 94: Pak M, Lopez M, Garayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006, 108: ｹ0 罍ﾞ. ﾞ ｧ ｧ8 apple ｦﾐ 閨0ｹ fi ｹ ｧ9 09, 2008, Park C, Valore E, Waring A, Ganz T. Hepcidin, a urinary antimicrobial peptide synhtesized in the liver. J Biol Chem 2001, 276: Krause A, Neitz S, Magert HJ, Schultz A, Forssmann W, Schulz-Knappe P, et al. LEAP-1 a novel highly disulfidebonded human peptide, excibits antimicrobial activity. FEBS Lett 2000, 480: Kemna E, Tjalsma H, Willems H, Swinkels D. Hepcidin from discovery to differential diagnosis. Haematologica 2008, 93: Lee P, Beutler E. Regulation of hepcidin and iron-overload disease. Annu Rev Pathol 2009, 4: ｾ4 fi ｸ7 ｦ, 縺000ｷ ｦ ﾑ8, ﾒfi04040ｸ ﾑ ｧ fi0ｹ ｸ ｧ803080ｸ ｧ8 2009, 72: Munoz M, Villar I, Garcia-Erce J. An update on iron physiology. World J Gastroenterol 2009, 15: Donovan A, Bownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 2000, 403: Zhang A, Enns C. Molecular mechanisms of normal iron homeostasis. Hematology 2009, 2009:
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