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1 136ﾑ ｧ ｧ9 2008; 20 (2): ｷ302fi020ｸ7apple ｧ9 H 00apple6ｧ ｹ ｸ ｧ907090ｹ ｧ ｸ703096ｧ ｧ8 apple 閨 apple030ｷ302000ｸ ｧ90ｹ apple030ｷ30208apple 036ｧ8 0ｸ apple ｧ9 09. ﾒ0ｷ30402 apple ｹ ｹ01 ｦﾌ. 6ｾ4 086ｦ ｹ ﾒ0ｷ ﾑ8. 09apple 0ｸ ﾑ ｧ ｾ40208applefi0ｹ0. ﾇ ｧ ｹ0 00apple6ｧ ｹ ｹ ｸ ｧ907090ｹ0, ｹ0 fi ｹ0, apple030ｷ302000ｸ807080ｸ7036ｧ ｧ ｸ703096ｧ apple030ｷ30208apple 036ｧ8 0ｸ apple ｧ9. ﾞ ｧ90ｹ0 ｨC 09 閨 ｾ 閨 ｸ ｧ ｧ90ｹ apple030ｷ30208apple 036ｧ8 0ｸ apple ｧ apple086ｧ ｸ apple08066ｧ ｸ ｧ mg/0900 閨03 ( RSV10) 6ｧ8 20 mg/0900 閨03 ( RSV20) applefi ｧ ｸ ｧ907090ｹ0, ｹ applefi ｹ0 090ｷ3096ｧ80ｹ0 apple ｧ ｸ ｹ0 020ｷ ｸ7020ｷ ｷ307, 02090ｹ ｸ7020ｷ ｧ907090ｹ0, 02090ｹ ｧ907090ｹ0, 02090ｹ ｧ907090ｹ0 G ｹ ｧ907090ｹ ｧ90900 apple030ｷ ｦ0030ｷ307. ﾇ ｧ8 apple 閨 ｷ307 apple030ｷ302000ｸ apple ｧ fi ｹ0 040ｸ70902 閨 ｷ304090ｹ0 020ｷ307 apple030ｷ302000ｸ apple03080ｹ ｸ70902 閨 ｷ ｹ ｧ907090ｹ0 020ｷ ｦ0030ｷ307. ﾇ ｧ ｸ703096ｧ9 apple apple006ｧ ｧ apple fi 02080ｸ7 030ｸ ｦ0 04apple ｧ80ｹ0 066ｧ ｹ0 (GFR). ﾞapple 閨 ﾇ ｧ ｸ ｧ907090ｹ0 040ｸ ｧ ｧ ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｹ ｧ907090ｹ0 ( ,6% ｹ0 RSV10, p<0, ,9% ｹ0 RSV20, p<0,01) apple ｧ ｧ ｧ ｸ7 GFR ｹ ｹ0 020ｷ , fi0ｹ0 applefi 006ｧ ｦ ｧ80ｹ ｸ RSV20 (79,3 ﾀ11,5 閨 ,9 ﾀ13,9 ml/min/1,73 m 2 apple apple006ｧ ｧ , p=0,08). 6ｾ40ｸ700apple ﾇ ｸ ｧ90709 apple ｧ9 006ｧ ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｹ ｧ907090ｹ apple ｨB ｧ ｸ703096ｧ ｧ90ｹ apple030ｷ30208apple 036ｧ8 0ｸ apple ｧ9. 閨 ｹ : ｧ90709, ｧ ｸ703096ｧ9, apple030ｷ302000ｸ807080ｸ7-036ｧ9, ｸ ｧ ﾑ ｷ3096ｧ8 1 ｦ 0800 陦 0ｹ ｧ9 0ｹ0, 2 6ﾑ ｧ ﾒ ｧ80ｹ ｧ9 0ｹ0 ｦﾐ ｧ8 6ｾ ｧ apple ｧ9080ｸ7 ｦﾐ0ｷ ｧ9070ｷ307, ｦﾐ0ｷ O ｧ907000ｹ0 apple ｦ ｷ ｧ ｧ ｹ ｸ ｧ80ｹ apple ｹ ｹ0 0ｸ apple ｧ9 0ｹ 閨02000ｹ0 apple030ｷ ｦ00ｹ ｸ ｦ00ｹ0 apple03fi ｹ0 陦 fi ｧ907000ｹ ｸ ｧ fi fi020902, ｹ ｸ ｧ fi ,3. 6ﾑ8apple06apple03fi , ｹ0 apple08030ｸ 閨0ｹ

2 1309. ﾒ036ｾ4ｦ ﾞ09 ﾞ03O6ｾ4 ﾒ ﾞｦﾐ 6ｾ ﾑ ｧ o03o096ｧ9 20, ｹ0 陦 fi apple006ｧ ｧ907000ｹ0 040ｸ ｧ90ｷ ｹ ｧ80ｹ ｸ703096ｧ9 0ｹ0 6ｧ apple ｸ ｹ0 閨02apple020ｷ304090ｹ ｹ ｧ80ｹ ｸ703096ｧ9 0ｹ0 02fi ｧ9080ｸ ｦ0 閨02apple020ｷ ｹ ｧ80ｹ ｸ703096ｧ9 0ｹ04,5 fi ｧ90ｹ apple ｷ300 閨 ｧ8 07fi0408 apple ｧ903090ｹ ｧ9 0ｹ06,7. ﾇ apple ｸ ｧ ｷ ｧ apple03fi ｧ9 0ｹ ｹ ｧ9000ｸ ｹ apple080ｸ7 陦 fi apple006ｧ ｸ ｧ ｸ 閨0ｹ0 fi ｹ0 ( mg/ ) 040ｸ ｧ9ｨB ｧ80ｹ0 apple030ｷ302000ｸ807080ｸ7036ｧ9 0ｹ0 ( ﾝ stick 086ｦ0030ｷ307) 8,9. ﾇ ｸ ｧ mg/0900 閨 ｸ ｧ9 046ｧ , 08086ｦ0 apple fi ｦ applefi % 020ｷ apple080ｸ7 apple6ｧ ｸ ｧ mg/0900 閨 ｧ8 apple030ｷ302000ｸ807080ｸ7036ｧ9, ｸ7apple ｸ ｦ 閨0ｹ ｹ ｧ9 0ｹ ｧ80ｹ0 0700apple ｹ ｧ90ｹ0 apple080ｸ7 apple6ｧ ｸ ｧ ｸ7026ｧ fi0409 8,9. ﾞ0ｸ 閨 ｦ ｷ ｸ 閨 ｧ ｧ ｧ fi, ｹ fi ｧ ｸ (04apple006ｧ , 040ｷ ｹ fi0ｹ0) apple086ｧ 閨070ｷ30ｹ0 00apple ｨB applefi ｧ ｸ ｧ907090ｹ08,9. ﾇ ｧ ｹ0 00apple6ｧ ｹ ｹ ｸ ｧ907090ｹ ｧ8 apple 閨 apple030ｷ302000ｸ apple080ｸ7 apple ｦ ｧ ｹ ｹ0 04apple ｧ80ｹ0 6ｧ ｹ0 040ｷ ｧ80ｹ ｸ703096ｧ9 0ｹ0 00apple ｧ ｧ fi ｸ ｦ apple086ｧ ｸ ｧ 閨 apple ｧ9 apple030ｷ302000ｸ807080ｸ7036ｧ9. 6ｾ40208applefi0ｹ ｹ0 apple 03086ｦ004 0ｹ 閨02090ｹ0 6ｧ ｧ ｹ0 00apple6ｧ ｹ ｹ apple006ｧ9 0ｹ ｸ ｧ9-0709, ｦ008 fi ｹ0 apple080ｸ apple ｦ ｸ ｧ8 apple ( mg/0900 閨03 ): ) fi apple030ｷ302000ｸ807080ｸ7036ｧ9, fiapple0ｷ30ｹ0 0ｸ7026ｧ8 apple ｧ9ｨB ｧ ｧ9 0ｹ0 apple ｧ80ｹ fi 080ｸ7 apple ｦ ｹ ｧ80ｹ0 apple 閨 ｹ0 apple030ｷ302000ｸ , ｹ ) fi ｧ ｸ703096ｧ9, ｧ90ｹ apple030ｷ30208apple 036ｧ8 0ｸ apple ｧ9. ﾞ ｧ90ｹ0 ｨC 09 閨 ｸ70400fi0ｹ ｹ 閨02090ｹ0 6ｾ 閨 ｸ ｧ ｧ90ｹ apple030ｷ30208apple 036ｧ8 0ｸ apple ｧ9 apple080ｸ7 apple ｸ703086ｦ ｦ fi 6ﾑ8010ｷ fi ｦﾐ ｧ908 ﾞ apple ｹ0 020ｷ ｸ ｦ0 020ｷ307 06apple06 6ｧ90ｷ ｸ apple ｦ ｧ9080ｸ7 ｦﾐ0ｷ ｧ9070ｷ307. ﾞapplefi 閨0209 apple ｧ : ) ｧ90ｹ0 apple080ｸ7 6ｧ fi ｷ , 6 5) ｧ90ｹ0 apple080ｸ7 006ｧ apple ｸ ｦ0 閨02apple020ｷ ｹ ｧ80ｹ ｸ703096ｧ9 0ｹ0, fiapple0ｷ30ｹ0 0ｸ7026ｧ ｧ9ｨB applefi 00apple6ｧ9apple ｧ907090ｹ ｸ ｦ0 ﾝ1,5 mg/dl ｸ70ｹ ｹ ,3 mg/dl ｹ0 090ｸ707 6ｧ902000ｹ0, 6ｧ8/ ｧ8 apple 閨 apple030ｷ302000ｸ >150 mg/240ｷ30308, 09) ｧ90ｹ ｧ80209 (09030ｸ702fiｨB ｧ9 0ｹ ｦ0 ﾝ126 mg/dl ｧ8 apple fi ｹ0 020ｸ704 6ｧ9000ｹ ｧ ｹ0), ) ｧ90ｹ ｸ 閨07 00apple6ｧ9apple00 030ｸ fiapple080ｸ fi07090ｹ0 (>5 IU/L), 00) ｧ90ｹ fi 09apple ｧ8 07fi apple6ｧ9apple ｸ ｦ ｦ applefi apple ｹ ｹ0 080ｸ ｧ80ｹ ｧ80ｹ0, 0402) ｧ90ｹ ｸ70ｹ0 08apple086ｧ9080ｸ70ｹ0 閨 apple08apple086ｧ ｹ ｸ7apple ｧ80ｹ0 090ｷ3096ｧ80ｹ ｹ ｸ702 6ｧ9000ｹ ｹ0 apple applefi 閨 ｧ ｸ70ｹ 閨0209, ｹ ｨB) ｧ90ｹ0 apple080ｸ7 鐶pple ｸ7apple080306apple ｧ8 090ｷ3096ｧ8 ( ｹ ｧ907000ｹ0, apple ｹ0, 00ｨB ｧ900apple09, 0ｷ apple 陦, fi 08016ｦ0, ｸ ｧ90709) 02060ｹ ｸ702 6ｧ9000ｹ ｹ0 apple applefi 閨 ｧ ｸ70ｹ 閨0209. O ｧ90ｹ ｹ 閨02090ｹ0, 08086ｦ ｧ8030ｷ 閨07 apple03fi ｸ ｧ80ｹ0 apple 03 閨 ｹ ｹ ｷ307, 020ｸ apple08066ｧ ｸ ｧ mg/0900 閨03 ( RSV10) 6ｧ ｸ ｧ mg/0900 閨03 ( RSV20). O ｧ90ｹ apple ｹ 閨 ｧ ｸ70ｹ 閨 ｸ7apple 閨 閨07020ｸ7apple08 040ｸ ｹ0. 6ﾑ 閨0ｹ ｧ ｹ applefi 閨 ｹ apple006ｧ9 0ｹ0 (0403fi07080ｹ0 0), ｹ applefi ｹ0 090ｷ3096ｧ80ｹ0 (0403fi07080ｹ0 1), 閨 ｸ ｧ ｷ307 6ｧ ｹ applefi 120ｷ ｧ9, applefi fi03080ｸ70ｹ ｸ70ｹ ｧ90ｹ apple fi 02080ｸ7 0306apple ｦ0 apple ｧ903, ｹ ｷ307 00apple06apple 陦0ｷ ｷ apple 閨02030ｷ ｸ ｦ0. 6ﾑ8apple06apple03fi , 00036ｧ ｧ apple030ｷ ｦ0030ｷ307, 02 08apple086ｧ ｦ0 080ｸ ｧ ｹ 閨0ｹ0/0300apple02fi, ｸ707 閨 apple ｦ ｸ70ｹ0 ｨC80 08 C 00 閨 ｸ7046ｧ ｸ70ｹ0 (09 08apple086ｧ9 閨 閨 ｧ807 applefi ｸ ｧ ｸ ｸ702 6ｧ9080ｸ7 006ｧ ｹ0). O apple fi0ｹ ｸ7 0306apple ｦ0 apple ｧ903 [00apple6ｧ9apple ｧ80ｹ fi03090ｹ0 (TC), ｸ ｧ90ｷ307 (TG), fi03090ｹ0 020ｷ307 0ｸ ｧ80ｹ0 apple0ｸ70207fi ｹ0 0306apple08apple030ｷ302000ｸ (HDL-C), fi03090ｹ0 020ｷ ｧ80ｹ0 apple0ｸ70207fi ｹ0 0306apple08apple030ｷ302000ｸ (LDL-C) apple080306apple08apple030ｷ302000ｸ (apo) ﾞ ｦﾌ 02080ｸ ｦ0], 02090ｹ ｧ907090ｹ ｸ ｦ0 (SCr), 020ｷ apple 閨02030ｷ307, ｹ ｷ ｸ (02 036ｧ9080ｸ7, ｧ9080ｸ7, ｧ9080ｸ7, ｧ9080ｸ7, 080ｷ ｷ ｦ0040ｷ307) 02080ｸ ｦ0 閨 ｧ ｸ

3 136ﾑ ｧ ｧ9 20, ｸ7026ｧ ｧ80ｹ ｧ9 0ｹ0 Olympus AU 600 (Olympus Diagnostica, Hamburg, Germany) ｸ7apple08apple ｹ 閨0ｹ fi 080ｸ70ｹ0 apple080ｸ7 閨04080ｸ70000 apple , ｧ ｷ307 apple030ｷ ｦ0030ｷ307 閨 apple fi0ｹ0 020ｷ307 00apple06apple 陦0ｷ ｹ ｧ ｹ0 (UCr), 020ｷ ｸ7020ｷ ｷ307 (UTpr), 02080ｸ7 080ｸ ｦ 閨080ｹ0 (UUA), ｹ ｷ ｸ apple080ｸ7 apple ｧ fi, ｧ ｸ ｸ7026ｧ ｧ80ｹ ｧ9 0ｹ0 Olympus AU 600 (Olympus Diagnostica, Hamburg, Germany) ｸ7apple08apple 閨07000ｹ 閨0ｹ fi 080ｸ70ｹ0 apple080ｸ7 閨04080ｸ70000 apple ﾑ8apple06apple03fi , 閨 ｸ7apple fi0ｹ ｹ ｧ80ｹ0 apple 閨 ｹ0 fi030ｷ ｷ ｸ , ｹ ｸ7 080ｸ ｦ 閨080ｹ ｧ ｹ ｧ9040ｷ304090ｹ0: FEA (%) = (UA/SA)/ (UCr/ SCr) ﾁ 100, fiapple080ｸ7 ﾞ ｦ002090ｹ0 6ｧ ｸ fi 08016ｦ0, UA 02 00apple6ｧ9apple00 020ｷ ｸ ｧ ｸ7 080ｸ ｦ 閨080ｹ ｧ ｦ0030ｷ SA 02 00apple6ｧ9apple00 020ｷ307 apple 閨02030ｷ307 0ｸ fi. 6ﾑ8apple06apple03 閨0807, ｧ ｷ307 apple030ｷ ｦ0030ｷ307 apple ｧ apple6ｧ9apple ｹ ｸ7020ｷ ｧ907090ｹ0 (UAlb), 02090ｹ ｧ907090ｹ0 (Ua1m), ｹ ｹ ｧ907090ｹ0 G (UIgG) ｧ ｸ fi ｸ7 Behring Nephelometer BN ProSpec ｧ90ｷ ｹ0 Dade Behring Holding Gmbh (Liederbach, Germany). ﾇ ｧ8 apple 閨 fi ｷ ｸ7-020ｷ ｷ307 fi ｷ307 00apple0600 閨03080ｸ70ｹ ｦ ｸ ｦ ｦ ｸ70ｹ0 apple030ｷ302000ｸ apple ｧ apple09036ｧ ｹ0 040ｸ70902 閨 ｷ304090ｹ ｹ apple030ｷ302000ｹ107090ｹ apple030ｷ30607fi 006ｧ ｦ0030ｷ307 apple03080ｹ ｸ 閨 ｷ ｹ ｧ907090ｹ ｸ7 6ｧ ｸ7 006ｧ ｹ0 086ｦ0030ｷ307, ｧ ｸ70ｹ0 03fi09080ｸ70ｹ0: UTpr/UCr, UAlb/UCr, Ua1m/UCr UIgG/UCr 11. ｦ 閨03080ｹ0, fi0ｹ0 applefi apple fi 020ｷ307 00apple06apple 陦0ｷ ｹ0 SCr, ｧ ｹ0 00apple6ｧ ｹ ｹ ｸ ｧ907090ｹ ｧ ｸ703096ｧ9 閨 ｸ7apple fi 02080ｸ7 060ｸ ｦ0 6ｾ4apple ｧ80ｹ ｧ ｹ0 (GFR), ｧ ｹ ｧ9040ｷ304090ｹ0 MDRD (Modification of Diet in Renal Disease): MDRD GFR=186 ﾁ (SCr 0400 mg/dl) ｨC1.154 ﾁ ( ｧ 閨0209) ｨC0.203 ﾁ ( ｸ707 6ｧ902000ｹ0) 12. 6ｾ ｧ ｸ70409 O06 apple apple080ｸ ｧ ｷ30ｹ0 00 閨 ｧ8 ﾀ 020ｸ7apple06026ｧ8 applefi , 0008fi ｸ703086ｦ ｧ ｧ ｷ30ｹ ｧ ｦ003080ｹ , 0008fi ｸ703086ｦ ｧ ｧ8. O 閨0ｹ0 020ｷ307 00apple06apple 陦0ｷ ｷ fi030ｷ307 apple 閨02030ｷ applefi ｹ0 090ｷ3096ｧ80ｹ ｧ ｧ ｸ7 t-test 0906 ｨB006ｦ00909, 0906 apple 閨 ｸ70ｹ0 apple080ｸ ｸ703086ｦ ｧ ｧ ｧ ｸ7 Wilcoxon ｯs rank test 閨0ｹ0 apple080ｸ ｸ703086ｦ ｧ ｧ8. ﾇ 06fi03030ｷ30409 fi apple6ｧ ｷ ｹ ｧ80ｹ0 apple 閨 ｹ0 apple030ｷ302000ｸ (040ｸ ｧ8, covariate) ｹ 閨0ｹ ｹ ｧ80ｹ0 apple 閨 ｹ0 apple030ｷ302000ｸ ( 閨 ｧ8, dependent variable) applefi ｧ ｸ ｧ907090ｹ0 ( ｧ8, independent variable) 閨 ｧ ｹ ｸ704090ｹ ｹ0 040ｸ ｦ ｹ0 [one-way analysis of covariance (ANCOVA)]. 縺 apple080ｸ7 040ｸ ｧ9- ｨB ｧ8 6ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｹ ｧ907090ｹ0, ｧ9 0ｹ ｹ ｧ ｹ ｸ ｧ907090ｹ0, ｦ ｷ , apple08066ｧ 閨07 apple08030ｸ7apple fi 閨 ｧ80ｹ ｸ704090ｹ0 apple fi ｹ0 (multivariate logistic regression analysis). ﾇ apple 03080ｸ7046ｧ9 6ｧ8 09 apple080ｸ7046ｧ9 6ｦ ｹ ｹ ｧ80ｹ0 - apple 閨 ｹ ｹ ｧ907090ｹ0 6ｧ904090ｹ0 6ｧ ｦ ｹ0 applefi 10%, ｧ9 0ｹ ｹ ｧ ｹ ｸ ｧ907090ｹ0, apple0802 閨 閨 ｧ8 (dependent variable) ｸ702fi 閨 ｹ0 00apple6ｧ9apple ｧ80ｹ fi ｹ ｧ p<0,05. ﾞapple 閨 O6ｾ4O08ｦﾌ ﾞ6ｾ4ｦ ﾞｦ ｦﾐ03 ﾇ ﾒ ﾞｦﾐ ｦ 6ﾑ80703O0806ｦﾐ ﾞ 6ｾ 閨 ｸ ｧ ｧ90ｹ0, 45 applefi 02080ｸ70ｹ0 08apple086ｧ9080ｸ70ｹ0 020ｸ apple08066ｧ RSV RSV20. ｦ ｷ , 閨 ｧ ｸ70ｹ 閨0209, apple ｧ9ｨb apple6ｧ ｧ90ｹ ｧ8030ｷ 閨 apple ｧ 閨0ｹ0 0700apple06036ｦ ｹ 閨 ｹ0 apple080ｸ ｸ ｧ9ｨB ｧ ｸ ｧ907090ｹ0 fiapple0ｷ30ｹ0 6ｦ ｷ ｸ ｦ0 [ 04apple ｧ (AST), ｹ ｧ907090ｹ0 (ALT)] ﾝ 閨0ｹ0 applefi 02060ｹ ｹ0 080ｸ 閨0ｹ 閨0ｹ /6ｧ8 6ｦ ｹ ｹ ｹ ｧ907090ｹ0 (CK) ﾝ 閨0ｹ0 applefi 02060ｹ ｹ0 080ｸ 閨0ｹ 閨0ｹ0} ｧ9 applefi 02060ｹ0 6ｦ ｹ 閨 apple08apple086ｧ ｹ ｸ7apple ｧ80ｹ0 090ｷ3096ｧ80ｹ0 020ｷ ｷ307 6ｦ ｷ ｹ 閨02090ｹ apple ｧ ｧ ｧ8 020ｷ307 00apple06apple 陦0ｷ ｹ0 00 閨04090ｹ0 040ｸ ｧ80ｹ0, ｹ ｹ0 00 閨04090ｹ ｧ80ｹ ｧ80ｹ0 apple6ｧ ｹ0 ( ﾞ09), 閨03080ｹ0 020ｷ ｷ ｹ0 apple - 141

4 1309. ﾒ036ｾ4ｦ ﾞ09 ﾞ03O6ｾ4 ﾒ ﾞｦﾐ 6ｾ ﾑ ｧ o03o096ｧ9 20, ｧ ｹ ｷ ｹ 閨02090ｹ ｹ0 O0007 RSV10 (n=45) O0007 RSV20 (n=45) 026ｦ ｹ0 24 (53,3%) 23 (51,1%) 縺0ｸ707 6ｧ902000ｹ0 21 (46,7%) 22 (48,9%) ﾇ ｧ9 ( 閨0209) 51,7 ﾀ13,7 52,4 ﾀ12,5 ｦﾌ09ｦﾐ (kg/m 2 ) 26,1 ﾀ5,6 26,6 ﾀ6,1 ﾒ apple 閨0ｹ0 10 (22,2%) 8 (17,8%) 08apple 閨 (22,2%) 12 (26,7%) ﾞ ｧ8 apple6ｧ (mm Hg) 6ｾ40ｸ ｧ8 121,2 ﾀ7,1 123,4 ﾀ5, ｧ8 80,9 ﾀ3,7 81,2 ﾀ4,0 ﾞ ｸ7apple ｧ8 090ｷ3096ｧ8 096ﾑ8 ﾞ 7 (15,6%) 8 (17,8%) ﾞｦ 1 apple 閨0ｹ0 9 (20,0%) 8(17,8%) ﾞ ｷ 閨0ｹ0 Ca 2+ 6 (13,3%) 7 (15,6%) 6 5- apple 閨0ｹ0 3 (6,7%) 2(4,4%) ｸ (17,8%) 8 (17,8%) T apple 閨 ｨB ｷ30ｹ0 00 閨 ｧ8 ﾀ 020ｸ7apple06026ｧ8 applefi ｧ fi0ｹ (%) RSV: ｸ ｧ90709, ｦﾌ09ｦﾐ: 04006ｧ ｹ0 0007ｨB 0ｹ ｹ0, 096ﾑ8 ﾞ: ｧ90ｹ ｸ apple ｦ0 0007ｨB6ｦ000080ｸ ｹ ｧ907090ｹ0, ﾞｦ 1 apple 閨0ｹ0: apple 閨0ｹ0 020ｷ307 ﾞｦ 1 0ｸ7apple 閨0ｷ ｹ ｧ907090ｹ0 ｦﾐｦﾐ ｦ ｹ ｧ9 applefi 02060ｹ0 6ｦ ｹ (096ｧ907. 2). ﾇ 00apple6ｧ ｹ apple006ｧ9 0ｹ ｸ ｧ apple6ｧ9apple00 020ｷ apple , ｹ apple6ｧ9apple00 020ｷ apple 閨02030ｷ ｸ ｦ0 apple ｧ9ｨb apple6ｧ ﾇ ｧ ｸ ｧ907090ｹ0 006ｧ ｷ30ｹ0 apple0802 閨 ｧ ｧ ｧ90ｷ ｸ7 0306apple ｦ0 apple ｧ ｹ0 6ｦ ｹ ｾ40ｸ 閨07, ｹ ｹ0 RSV RSV20, ｧ ｸ ｧ907090ｹ0 096ｧ ｹ0 2. 6ﾑ8apple6ｧ9apple ｧ80ｹ0 apple6ｧ ｹ apple 閨0ｹ 閨0ｹ0 apple ｸ70ｹ ｧ90ｹ ｹ 閨02090ｹ0 apple applefi 閨 ｹ apple006ｧ9 0ｹ0 (0403fi07080ｹ0 0) applefi ｹ0 090ｷ3096ｧ80ｹ0 (0403fi07080ｹ0 1) O0007 RSV10 O0007 RSV ｹ0 0103fi07080ｹ fi07080ｹ fi07080ｹ fi07080ｹ0 1 6ｾ40ｸ ｧ8 ﾞ09 (mm Hg) 121,2 ﾀ7,1 120,1 ﾀ8,2 123,4 ﾀ5,2 121,7 ﾀ4, ｧ8 ﾞ09 (mm Hg) 80,9 ﾀ3,7 81,4 ﾀ2,9 81,2 ﾀ4,0 80,4 ﾀ3,6 TC (mg/dl) 309 ﾀ ﾀ41** 312 ﾀ ﾀ32** 6 9 TG (mg/dl) 129 ﾀ ﾀ36** 127 ﾀ ﾀ30** 6 9 HDL-C (mg/dl) 64 ﾀ12 66 ﾀ12 63 ﾀ16 65 ﾀ16 LDL-C (mg/dl) 216 ﾀ ﾀ36** 225 ﾀ ﾀ27** 6 9 apoa1 (mg/dl) 138 ﾀ ﾀ ﾀ ﾀ17 apob (mg/dl) 135 ﾀ37 89 ﾀ23** 137 ﾀ40 82 ﾀ20** 6 9 SGlc (mg/dl) 91,2 ﾀ7,8 90,2 ﾀ7,4 92,2 ﾀ6,4 91,3 ﾀ7,9 SUre (mg/dl) 35,7 ﾀ8,7 36,2 ﾀ8,4 33,9 ﾀ7,8 35,3 ﾀ9,1 SCr (mg/dl) 0,9 ﾀ0,2 0,9 ﾀ0,2 0,9 ﾀ0,1 0,9 ﾀ0,2 SUA (mg/dl) 5,2 ﾀ1,7 5,0 ﾀ1,6 5,3 ﾀ2,0 5,1 ﾀ1,4 STpr (g/dl) 7,4 ﾀ0,4 7,4 ﾀ0,4 7,4 ﾀ0,3 7,4 ﾀ0,4 SAlb (g/dl) 4,3 ﾀ0,3 4,4 ﾀ0,4 4,4 ﾀ0,4 4,3 ﾀ0,3 O 閨0ｹ ｨB ｷ30ｹ0 00 閨 ｧ8 ﾀ 020ｸ7apple06026ｧ8 applefi *p<0,05 閨 ｷ fi0708 0, **p<0,01 閨 ｷ fi0708 0, 6 9p<0, RSV10 閨 ｹ0 RSV fi RSV: ｸ ｧ90709, ﾞ09: ｧ8 apple6ｧ , TC: ｧ fi0309, TG: ｸ ｧ9 06, HDL-C: fi ｷ307 0ｸ ｧ80ｹ0 apple0ｸ70207fi ｹ0 0306apple08apple030ｷ302000ｸ , LDL-C: fi ｷ ｧ80ｹ0 apple0ｸ70207fi ｹ0 0306apple08apple030ｷ302000ｸ , apo: apple080306apple08apple030ｷ302000ｹ10709, SGlc: 09030ｸ702fiｨB ｦ0, Sure: 080ｸ7036ｧ ｦ0, SCr: ｧ ｦ0, SUA: 080ｸ fi 08016ｦ ｦ0, STpr: 閨0ｹ0 apple030ｷ302000ｹ107000ｹ ｦ0, SAlb: 03000ｸ7020ｷ ｧ ｦ0. 142

5 136ﾑ ｧ ｧ9 20, O6ｾ4O08ｦﾌ ﾞ6ｾ4ｦ ﾞｦ ｦﾐ03 ﾇ ﾒ ﾞｦﾐ ｦ 6ﾑ80703O0806ｦﾐ ﾞ 12 ｦｶｦﾑ0ﾌ2ｦﾍｦﾏ0ﾋ9 0 ｦｶｦﾑ0ﾌ2ｦﾍｦﾏ0ﾋ p<0,01 Ua1m (mg/g UCr) p<0, p=ns Oｦﾌ0ﾋ4ｦﾄｦﾁ RSV 10 Oｦﾌ0ﾋ4ｦﾄｦﾁ RSV 20 Oｦﾌ0ﾋ4ｦﾄｦﾁ ｦﾅｦﾋ0ﾋ5ｦﾃｦﾖｦﾏｦﾔ 6ﾑ ｧ8 apple 閨 ｹ ｧ907090ｹ0 ( ｧ8) ｸ70ｹ ｧ90ｹ0 020ｷ ｷ307 RSV RSV20, ｹ 閨 ｸ7 apple applefi 閨 ｹ apple006ｧ9 0ｹ0 (0403fi07080ｹ0 0) ｹ applefi ｹ0 090ｷ3096ｧ80ｹ0 (0403fi07080ｹ0 1). RSV: ｸ ｧ90709, NS: ｧ ｧ8, Ua1m: ｧ8 apple 閨 ｧ907090ｹ0, UCr: ﾒ ｧ ｦ0030ｷ ｧ90ｷ apple6ｧ9apple ｹ0 TC ,0% ,0% (p=0, ｦ ｦ0 020ｷ307 6ｦ ｷ307), 02 00apple6ｧ9apple00 020ｷ307 TG ,1% ,0% (p=0, ｦ ｦ0 020ｷ307 6ｦ ｷ307), 02 00apple6ｧ9- apple ｹ0 LDL-C ,7% ,2% (p=0, ｦ ｦ0 020ｷ307 6ｦ ｷ307) apple6ｧ9apple ｹ0 apob ,1% ,1% (p=0, ｦ ｦ0 020ｷ307 6ｦ ｷ307). ﾇ ｧ ｸ ｧ907090ｹ apple 閨0ｹ 閨0ｹ0 020ｷ307 00apple06apple 陦0ｷ ｹ0 HDL-C ｹ0 apoa ｧ9 applefi 02060ｹ0 6ｦ ｹ0 (096ｧ907. 2) ｸ7apple6ｧ 閨0ｹ 閨0ｹ ｦ0 020ｷ307 6ｦ ｷ307 fi ｧ8 apple 閨 ｷ307 apple030ｷ302000ｸ , ｹ ｧ ｸ ｧ9, fiapple0ｷ30ｹ0 0ｸ7026ｧ ｧ applefi 02 00apple6ｧ9apple ｹ0 SCr 02 06/6ｧ ｸ7 GFR-MDRD, 閨 ｷ 閨0209. ﾇ ｧ ｸ ｧ ｹ ｧ ｧ8 00apple6ｧ ｧ ｸ703096ｧ9 020ｷ , fiapple0ｷ30ｹ0 0ｸ7026ｧ ｧ fi apple6ｧ9apple ｹ0 SCr (096ｧ907. 2), fi apple ｧ8 066ｧ , apple applefi ｧ ｸ ｧ907090ｹ ｹ ｹ0 RSV RSV20 (83,4 ﾀ15,4 閨 ,4 ﾀ15,2 ml/min/ 1,73m 2, p=ns ,3 ﾀ12,5 閨 ,9 ﾀ13,9 ml/min/1,73 m 2, p=0, ｧ ) fi0408, ｧ ｸ ｧ907090ｹ0 040ｸ ｧ ｧ ｧ90ｷ304090ｹ ｹ ｧ80ｹ ｸ703096ｧ9 0ｹ0, fiapple0ｷ30ｹ0 0ｸ7-026ｧ ｧ ｧ ｸ7 GFR- MDRD, RSV20, 040ｷ3036ｧ90ｹ0 fi000ｷ30ｹ0 0ｸ7026ｧ8 09 6ｦ apple6ｧ9apple ｧ80ｹ fi ｹ0 (p=0,08). ﾇ 00apple6ｧ ｹ ｸ ｧ907090ｹ ｧ8 apple 閨 apple030ｷ302000ｸ ｹ0 6ｦ ｹ ｧ apple6ｧ ﾇ ｧ ｸ ｧ907090ｹ mg/0900 閨03 006ｧ ｷ30ｹ0 apple0802 閨 ｧ8 6ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｹ ｧ907090ｹ ,6% ,9% 07026ｧ (6ﾑ ) , 09 6ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｹ ｧ907090ｹ0, apple080ｸ7 apple ｧ RSV20, 6ｧ ｦ applefi ｧ ｹ ｹ0 RSV10 (p=0, ｦ ｦ0 020ｷ307 6ｦ ｷ307). ﾞ0ｸ7026ｧ ｦ0 020ｷ307 6ｦ ｷ ｸ703086ｦ ｧ ｧ applefi 06fi03030ｷ30409 fi ｧ ｧ8 apple 閨 ｹ ｧ907090ｹ0 (p<0,05). ﾇ ｧ ｸ ｧ907090ｹ apple ｧ ｧ ｹ ｧ80ｹ0 apple 閨 ｹ0 020ｷ ｸ7020ｷ ｷ307, 02090ｹ ｸ7020ｷ ｧ907090ｹ ｹ ｧ907090ｹ0 G ｧ9 applefi 02060ｹ0 6ｦ ｹ (096ｧ907. 3). ﾇ ｧ8 apple 閨 ｷ ｸ ｸ7 080ｸ ｦ 閨080ｹ ｧ ｧ9 applefi 02060ｹ ｹ0 020ｷ applefi ｹ apple006ｧ9 0ｹ0 (096ｧ907. 3). 6ｾ apple08030ｸ7apple ｧ ｧ ｸ70409 apple fi ｹ0 (multivariate logistic regression analysis) apple080ｸ7 閨 ｦ ｷ , apple ｹ0 apple080ｸ7 040ｸ ｧ9ｨB ｦ ｷ ｧ80ｹ0 apple 閨 ｹ ｧ907090ｹ0 6ｧ904090ｹ0 6ｧ ｦ ｹ0 applefi 10%. 6ｾ40208 apple08030ｸ7apple fi 閨 ｸ700apple ｧ apple , fiapple0ｷ30ｹ0 09 fi ｹ ｸ ｧ907090ｹ0, ｧ ｹ0 0007ｨB 0ｹ ｹ0, apple6ｧ9apple00 020ｷ apple06 6ｧ90ｷ ｷ307 apple apple08apple030ｷ302000ｸ ｸ ｦ0, 0806 apple ｧ ｹ ｸ ｦ0 020ｷ307 0ｸ ｷ307 (00apple6ｧ9apple ｸ702fiｨB090ｹ ｧ9 0ｹ ｦ0), ｹ 閨0ｹ0 143

6 1309. ﾒ036ｾ4ｦ ﾞ09 ﾞ03O6ｾ4 ﾒ ﾞｦﾐ 6ｾ ﾑ ｧ o03o096ｧ9 20, ｧ ｹ0 3. N ｧ8 apple 閨 apple030ｷ302000ｸ , 閨0ｹ0 apple ｧ ｹ ｸ ｸ ｦ 閨080ｹ apple ｸ7-0400fi 02090ｹ 閨02090ｹ0 apple applefi 閨 ｹ apple006ｧ9 0ｹ0 (0403fi07080ｹ0 0) applefi ｹ0 090ｷ3096ｧ80ｹ0 (0403fi07080ｹ0 1) O0007 RSV10 O0007 RSV ｹ0 0103fi07080ｹ fi07080ｹ fi07080ｹ fi07080ｹ0 1 UTpr/UCr (mg/g) 61 (32-300) 57 (34-280) 59 (26-290) 57 (31-298) UAlb/UCr (mg/g) 6,4 (1,9-149,0) 6,7 (3,3-73,1) 6,2 (2,9-105,0) 6,4 (3,3-76,3) Ua1m/UCr (mg/g) 5,9 (2,2-40,0) 7,1 1 (3,0-68,0) 5,8 (3,1-13,1) 8,2 2-4 (2,9-23,0) UIgG/UCr (mg/g) 3,6 (1,2-23,0) 3,7 (1,5-35,0) 3,6 (1,6-26,1) 3,9 (1,3-39,3) FENa + (%) 0,6 (0,1-3,4) 0,6 (0,1-5,3) 0,5 (0,1-1,1) 0,5 (0,1-2,9) FEK + (%) 6,0 (4,3-35,0) 6,8 (3,5-33,5) 6,5 (1,4-22,0) 6,6 (1,9-33,5) FEMg 2+ (%) 2,5 (0,4-16,4) 2,7 (0,8-9,6) 2,6 (1,7-33,6) 2,8 (1,4-18,7) FECa 2+ (%) 0,7 (0,1-4,7) 0,7 (0,1-3,8) 0,6 (0,2-1,9) 0,7 (0,2-2,3) FECl ｨC (%) 1,2 (0,3-5,0) 1,1 (0,3-7,9) 1,0 (0,1-4,2) 1,0 (0,3-3,6) FEPO4 3ｨC (%) 16,5 ﾀ7,9 17,8 ﾀ6,1 17,0 ﾀ9,7 16,9 ﾀ8,1 FEUA (%) 7,1 ﾀ3,4 7,2 ﾀ4,1 6,9 ﾀ3,2 7,0 ﾀ3,2 ｦ apple 閨 ｨB ｷ30ｹ0 00 閨 ｧ8 ﾀ020ｸ7apple06026ｧ8 applefi ｧ ｧ8 (006ｦ003080ｹ ) apple00036ｧ9apple020ｷ ｧ p<0,05 閨 ｷ fi0708 0, 2 p<0,01 閨 ｷ fi0708 0, 3 p<0, RSV10 閨 ｹ0 RSV fi0708 1, 4 p<0, RSV10 閨 ｹ0 RSV applefi 06fi03030ｷ ｹ 閨0ｹ 閨0ｹ0. RSV: ｸ ｧ90709, UTpr: 閨0ｹ0 apple030ｷ302000ｹ107000ｹ0 086ｦ0030ｷ307, UAlb: 03000ｸ7020ｷ ｧ ｦ0030ｷ307, Ua1m: ｧ ｦ0030ｷ307, UIgG: ｧ90709 G 086ｦ0030ｷ307, UCr: ｧ ｦ0030ｷ307, FE: ｧ8 apple 閨 , UA: 080ｸ fi 08016ｦ ｸ7 0306apple ｦ0 apple ｧ ｧ ｸ ｧ907090ｹ0. ﾞ0ｸ7026ｧ ｸ70409 陦 fi fi ｹ ｸ ｧ907090ｹ0 6ｧ ｧ8 apple ｹ0 apple080ｸ7 040ｸ ｧ9ｨB ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｹ ｧ907090ｹ0 6ｧ904090ｹ0 6ｧ ｦ ｹ0 applefi 10% [ fi0ｹ0 026ｧ907 0ｸ707080ｹ0 (OR) 2,51, 95% fi apple ｧ9 0ｹ0 (CI) 1,10-6,53, p=0,035]. 6ｾ40ｸ7ｨB6ｧ ｾ46ｦ000080ｷ apple 閨 ｹ0 apple 03086ｦ004 0ｹ 閨02090ｹ ｧ ｸ ｧ907090ｹ0, ｹ0 6ｦ008 fi ｹ0 apple080ｸ apple ｦ ｸ70407fi ｧ8 apple ( mg/0900 閨03 ), 08 6ｧ fi0206 apple ｧ9 006ｧ ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｹ ｧ907090ｹ0, 040ｷ3036ｧ90ｹ apple ｨB ｧ8 apple 閨 ｷ ｸ7020ｷ ｷ307, 02090ｹ ｸ7020ｷ ｧ907090ｹ ｹ ｧ907090ｹ0 G, ｹ ｧ ｸ703096ｧ9, ｧ90ｹ ｸ apple ｧ9, apple080ｸ ｧ ｧ apple ｸ707 applefi 00apple ｷ300 閨 ｧ8 07fi0408. ﾇ ｧ ｸ ｧ907090ｹ ｸ 閨0ｹ0 fi ｹ0 ( mg/0900 閨03 ) 040ｸ ｧ ｧ80ｹ0 apple030ｷ302000ｸ807080ｸ7036ｧ9 0ｹ0, fiapple0ｷ30ｹ ｷ303006ｧ apple 閨 ｸ7020ｷ ｷ307 apple080ｸ7 006ｧ ｧ ｧ ｦ applefi stick 086ｦ0030ｷ307 8,9. ﾞ ｸ ｹ0 apple030ｷ302000ｸ807080ｸ7036ｧ9 0ｹ ｸ70ｹ ｧ90ｹ0 apple080ｸ ｧ8 apple030ｷ302000ｸ807080ｸ7036ｧ9 陦 fi0206 0ｸ7026ｧ8 apple ｦ ｦ fi0908 applefi apple030ｷ302000ｹ107000ｹ0 apple080ｸ7 閨04080ｸ fi ｹ fi applefi ｧ ｹ ｸ7020ｷ ｧ907090ｹ0. ﾞ0ｸ702fi fi0ｹ0 040ｸ ｧ9 0ｸ7apple 閨 ｹ0 040ｷ ｧ80ｹ0 apple ｹ0 04apple ｧ80ｹ0 apple0308 閨03000ｸ704090ｹ0 0ｸ7026ｧ80ｹ ｹ0 apple030ｷ302000ｸ807080ｸ7-036ｧ9 0ｹ013. ﾇ ｧ ｧ ｧ ｦ ｦ ｸ70ｹ0 apple030ｷ302000ｹ10709, 09 08apple086ｧ9 080ｸ ｧ fi 04apple006ｧ apple applefi 02 00apple ｦ ｷ ｦ00ｹ0 0004apple ｷ ｷ ｧ90ｷ ｸ ｦ0 14,15. ﾇ ｧ8 apple 閨 ｹ ｧ907090ｹ0 apple ｧ ｧ8 apple ｧ ｹ ｦ00ｹ0 040ｷ ｧ80ｹ ｸ ｧ9 0ｹ ｸ ｹ0 apple080ｸ7 apple ｦ ｧ ｧ8 0ｸ ｸ703096ｧ9 020ｷ ｦ00ｹ0 0004apple 閨070ｷ ｷ ｧ90ｷ ｸ ｦ0 16,17. ﾒ ｸ707 鐶pple0006, 09 apple ｦ applefi ｧ ｸ ｧ907090ｹ0 6ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｹ ｧ907090ｹ0, fi ｷ307 0ｸ7apple ｧ9apple0ｷ307 apple030ｷ302000ｸ apple080ｸ7 apple ｦ ｧ ｹ ｹ0 04apple ｧ80ｹ ｸ703096ｧ9 0ｹ0 (03000ｸ7020ｷ ｧ90709, ｧ90709 G) 18, 0ｸ7apple ｧ9ｨB ｸ7applefi fi ｸ ｧ 閨070ｷ30ｹ0 apple ｧ9 apple030ｷ302000ｸ807080ｸ7036ｧ9 040ｷ ｧ80ｹ0 apple0308 閨03000ｸ704090ｹ fi0408, ｧ 閨0ｹ ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｹ ｧ907090ｹ0, apple080ｸ7 040ｸ ｧ9ｨB ｧ ｸ ｧ907090ｹ0, 006ｧ apple0802 閨 ｧ80ｹ ｹ0 6ｧ ｸ ｧ80ｹ ｧ80ｹ0 020ｷ307 00apple ｸ ｷ ｷ ｦ00ｹ0 0004apple 閨070ｷ ｷ ｧ90ｷ ｸ ｦ ｷ30ｹ0, 006ｧ fi ｧ ｷ307 00apple ｸ ｷ ｷ ｦ00ｹ0 0004apple 閨070ｷ ｷ ｧ90ｷ 閨 apple 閨 ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｸ7 080ｸ ｦ 閨080ｹ ｷ

7 136ﾑ ｧ ｧ9 20, ｸ ( , , 080ｷ ), apple080ｸ7 080ｸ apple ｸ702fi ｧ ｸ , fi0ｹ0 apple080ｸ apple ｧ apple ｦ 閨 , 09 6ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｧ907090ｹ0 apple080ｸ7 040ｸ ｧ9ｨB ｧ ｸ ｧ907090ｹ0, 08 6ｧ fi ｧ ｸ ｧ ｧ ｸ7 00apple ｧ9080ｸ7 020ｷ ｦ00ｹ0 0004apple 閨070ｷ ｷ ｧ90ｷ fi0408, apple03 鐶pple ｧ9 fi ｸ7026ｧ 閨 apple ｧ apple , apple080ｸ7 006ｧ apple fi ｸ7 6ｧ ｧ ｹ ｹ ｦ00ｹ0 040ｷ ｧ80ｹ ｹ0, fiapple0ｷ30ｹ ｧ8 apple 閨 ｷ307 KIM-1 (Kidney Injury Molecule-1, 00fi ｧ80ｹ ｹ0) NAG (N-acetyl-glucosaminidase, ｸ ｸ70208ｨB ) 20, 0000 apple0802 閨 apple ｧ9 07 apple ｧ fi ｧ9 0ｹ ｧ80ｹ ｹ ｸ7 00apple ｧ9080ｸ7 020ｷ ｦ00ｹ0 0004apple 閨070ｷ ｷ ｧ90ｷ ｸ ｨBfi ｹ ｧ ｸ ｧ907090ｹ0. 046ｦ008 in vitro 閨02000ｹ0 apple080ｸ7 閨 apple ｧ ( ｧ90709, apple ｧ90709, ｸ ｧ90709, ｧ ｸ ｧ90709) 閨 ｹ0 00apple ｸ ｷ apple06070ｷ ｦ00ｹ0 0004apple 閨070ｷ ｷ ｧ90ｷ307 21, ｹ 閨 ｹ0 0007fi0ｹ0 apple ｦ0 apple03fi020ｸ7apple080ｸ ｸ ｷ307 (opossum kidney cells) 22, ｦ0apple0ｷ apple ｹ ｧ80ｹ ｹ ｦ002020ｷ304090ｹ0 020ｷ ｦ ｦ ｸ70ｹ0 apple030ｷ302000ｸ , apple080ｸ7 080ｸ ｦ apple006ｧ903 00, applefi ｦ ｷ ｦ00ｹ0 0004apple 閨070ｷ ｷ ｧ90ｷ307, 0ｷ30ｹ0 閨 fi apple080ｸ7 apple apple ｦ ｧ apple030ｷ302000ｸ807080ｸ7036ｧ9 0ｹ0 apple080ｸ7 040ｸ ｧ9ｨB ｧ ﾞ0ｸ702 閨0ｹ 閨02000ｹ021,22 陦 fi apple ｧ ｷ307 apple 03 apple07070ｷ , ｹ0 040ｸ ｹ0, 閨 ｹ0 020ｷ307 apple 03 apple07070ｷ3 020ｸ ｷ307, apple ｧ ｧ90ｷ ｹ ｦ002020ｷ ｹ ｹ 閨07090ｹ ｸ7006ｧ907090ｹ0, ｹ0 006ｧ9 0ｹ ｹ 閨07090ｹ ｦ ｦ ｸ70ｹ0 apple030ｷ302000ｹ107090ｹ0 ( ｧ90709) , 0ｸ7026ｧ ｷ ｧ , 閨07 006ｦ apple080ｸ7 00apple applefi 02 apple ｹ0 apple 03086ｦ004 0ｹ 閨02090ｹ0, ｸ ｧ9ｨB apple ｧ ｷ ｸ ｷ307 (fiapple0ｷ30ｹ apple applefi apple06026ｧ 閨 ) ｧ 閨 ｸ ｧ ｦ 閨080ｹ0 6ｧ8 GGPP (geranylgeranyl pyrophosphate, ｸ ｸ703 apple0ｸ ｷ30408o ｦ0 21,22. ﾞ0ｸ7026ｧ8 09 apple ｧ ｧ ｸ70ｹ ｸ 閨0ｹ0 0ｸ ｷ ｸ7applefi fi ｧ ｹ0 00apple fi ｹ0 020ｷ ｦ ｦ ｸ70ｹ0 apple030ｷ302000ｸ apple080ｸ7 040ｸ ｧ9ｨB ｧ O6ｾ4O08ｦﾌ ﾞ6ｾ4ｦ ﾞｦ ｦﾐ03 ﾇ ﾒ ﾞｦﾐ ｦ 6ﾑ80703O0806ｦﾐ ﾞ 閨070ｷ30ｹ ｧ ｧ ｹ0 046ｦ ｹ ｸ ｦ 閨080ｹ 閨070ｷ307 apple03080ｸ8fi07020ｷ ｸ ｸ702 6ｧ9080ｸ7, apple080ｸ7 apple ｦ ｧ907000ｹ021,22. ｦ fi 08016ｦ0 apple ｧ9 閨 apple03080ｸ8fi ｦ apple030ｷ302000ｸ , fiapple0ｷ30ｹ0 09 GGPP, apple086ｧ9000ｹ0 040ｸ ｸ apple ｸ7036ｧ90ｷ ｷ307 apple030ｷ302000ｸ apple080ｸ7 040ｸ707 閨080ｸ GTP (GTP-binding proteins), 09 08apple086ｧ9 006ｧ apple 03 6ｧ apple fi ｷ ｦ ｦ ｸ70ｹ0 apple030ｷ302000ｸ applefi 02 00apple ｦ ｷ ｦ00ｹ0 0004apple 閨070ｷ ｷ ｧ90ｷ307 21,22. ﾇ ｦ fi ｹ ｸ ｧ907090ｹ ｦ ｹ0 0ｸ7applefi030806apple000ｹ ｧ907000ｹ0, 閨 ｦ ｸ ｦ 閨080ｹ0, apple ｧ fi0ｹ0 fi fi ｧ ｹ0 040ｸ 閨07090ｹ ｧ907090ｹ ｸ 閨0ｹ0 fi ｹ0, 040ｸ ｧ9ｨB 閨 ｹ0 apple030ｷ302000ｸ807080ｸ7036ｧ9 0ｹ fi 006ｦ ｹ0 apple 03086ｦ004 0ｹ ｹ0 006ｧ fi0ｹ0 fi ｧ ｷ307 6ｦ008 fi04000ｷ ｹ ｸ ｧ907090ｹ apple0903 陦 ｧ ｸ703096ｧ9 020ｷ applefi ｹ0 090ｷ3096ｧ80ｹ , ｧ ｸ ｧ907090ｹ fi ｷ mg/0900 閨03 040ｸ ｧ ｧ ｧ90ｷ304090ｹ ｹ ｧ80ｹ ｸ703096ｧ9 0ｹ0. ﾞ0ｸ7-02fi ｦ ｧ ｸ fi ｹ 閨02000ｹ0 apple080ｸ7 陦 fi ｸ ｧ ｧ 閨 ｸ7 閨 ｧ8 000ｸ707080ｸ8026ｧ8 00apple6ｧ ｧ ｸ703096ｧ9 13,24. ﾒ 閨 apple ｧ9 閨02apple ｹ ｸ ｧ fi0ｹ0 applefi fi0ｹ0 fi ｧ apple08036ｦ0 apple ｧ8 fi apple ｹ0 0ｸ apple ｧ9 0ｹ023, apple080ｸ7 apple ｧ apple ｦ007080ｸ ｧ80ｹ0 07fi04080ｸ75, 08 6ｧ 閨 apple apple0602 閨0ｹ ｹ0 apple080ｸ7 006ｧ apple ｸ 閨0ｹ fi apple 03 閨09040ｸ700 9,25,26. 6ﾑ8apple06apple03fi , ｧ ｹ0 00- apple fi ｹ0 apple030ｷ302000ｸ applefi ｦ ｸ ｧ9080ｸ7 020ｷ ｦ00ｹ0 0004apple 閨070ｷ ｷ ｧ90ｷ307 00apple ｧ9 0ｸ7026ｧ ｸ7026ｧ8 07 apple ｧ9 閨07 07 apple fi 00apple06apple03fi apple ｸ fi fi 02080ｸ ｸ727. 6ﾑ86ｧ ｷ30402fi fi ｸ7apple000308fi03020ｷ ｷ ｸ ｷ ｷ ｦ00ｹ0 0004apple ｷ ｷ ｧ90ｷ apple030ｷ302000ｹ107000ｹ0 040ｸ ｧ9ｨB ｧ ｸ 閨 ｷ fi ｹ ｸ7 040ｷ ｸ ｦ0, ｹ ｧ8 0ｸ ｸ703096ｧ ｸ ｦ0 04apple ｹ0 apple080ｸ7 閨 ｷ30ｹ0 apple0802 閨 ｸ 閨 apple fi ｸ ｸ702 6ｧ9080ｸ ｹ ｹ0 apple030ｷ302000ｹ107000ｹ 閨07 0ｸ apple ｧ ｦ fi0ｹ0 fi fi ｸ ｧ fi mg/0900 閨03 040ｸ ｧ ｧ ｦ ｦ ｹ ｧ80ｹ0 apple 閨 ｹ

8 1309. ﾒ036ｾ4ｦ ﾞ09 ﾞ03O6ｾ4 ﾒ ﾞｦﾐ 6ｾ ﾑ ｧ o03o096ｧ9 20, ｧ907090ｹ0, ｦ ｧ ｦ apple080ｸ7 apple ｸ ｧ fi mg/0900 閨03, 09 00apple6ｧ ｹ0 0ｸ fi ｹ0 fi04090ｹ ｧ ｸ703096ｧ9 08 6ｧ fi0206 6ｧ apple fi ｸ707080ｸ8026ｧ8. 6ｾ40ｸ700apple , 08 6ｧ fi ｸ ｧ90709 apple ｧ9 006ｧ ｦ ｹ ｧ80ｹ0 apple 閨 ｹ ｹ ｧ907090ｹ apple ｨB ｧ ｸ703096ｧ ｧ90ｹ apple030ｷ30208apple 036ｧ8 0ｸ apple ｧ9. Summary M. Kostapanos, Ch. Milionis, V. Saougos, Ch. Kostara, E. Bairaktari, M. Elisaf. The effect of rosuvastatin on renal function and renal protein excretion in patients with primary dislipidaemia. Hellen Nephrol 2008; 20 (2): Aim. To investigate the effect of rosuvastatin in different doses on urinary protein excretion and renal function parameters in patients treated for primary hyperlipidemia. Patients-Methods. In this study, 90 patients with primary hyperlipidemia were randomly assigned to rosuvastatin 10 (RSV10 group) or 20 mg/day (RSV20 group). Urinary creatinine and protein (total, albumin, immunoglobulin G, and a1-microglobulin) levels were measured at baseline and after 12 weeks of treatment in all patients. The protein-to-creatinine ratios were used to assess urinary protein excretions. Serum creatinine and estimated glomerular filtration rate (GFR) were used as markers of renal function. Results. A dose-dependent increase in the excretion of a1-microglobulin (17.6% in the RSV10 vs 34.9% in the RSV20 group) was observed. There was no effect on total protein, albumin and immunoglobulin G urinary excretions as well as on the fractional excretions of electrolytes and uric acid in both groups. Rosuvastatin 10mg/day did not affect renal function parameters, whereas a trend towards an increase in GFR (79.3 ﾀ11.5 at baseline vs 82.9 ﾀ13.9 ml/min/ 1.73m 2 post-treatment, p=0.08) was noted in the RSV20 group. Conclusions. Rosuvastatin produces a dose-dependent increase in a1-microglobulin urinary excretion implying a functional disturbance of the proximal tubules without adversely affecting renal function. Key words: a1-microglobulin, proteinuria, renal function, rosuvastatin. B ｧ9 1. Ong HT. The statin studies: from targeting hypercholesterolaemia to targeting high-risk patient. Q J Med 2005; 98: Athyros VG, Mikhailidis DP, Papageorgiou A, et al. Attaining United Kingdom-European Atherosclerosis Society low-density lipoprotein cholesterol guideline target values in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study. Curr Med Res Opin 2002; 118: Sever PS, Dahlof B, Poulter NR, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (AS- COT-LLA): a multicentre randomized controlled trial. Lancet 2003; 361: Athyros VG, Mikhailidis DP, Papageorgiou AA, et al. The effect of statins on renal function in patients with coronary heart disease. A subgroup analysis of the Greek atorvastatin and coronary heart disease evaluation (GREACE) study. J Clin Pathol 2004; 57: Agarwal R, Curley TM. The role of statins in chronic kidney disease. Am J Med Sci 2005; 330: Sandhu S, Wiebe N, Fried LF, Tonelli M. Statins for improving renal outcomes: a meta-analysis. J Am Soc Nephrol 2006; 2: Fried LF, Orchard TJ, Kasiske BL. Effect of lipid reduction on the progression of renal disease: a meta-analysis. Kidney Int 2001; 59: Tiwari A. An overview of statin-associated proteinuria. Drug Disc Today 2006; 11: Vidt DG. Statins and proteinuria. Curr Atheroscler Rep 2005; 7: Kostapanos MS, Milionis HJ, Filippatos TD, et al. A 12- week prospective, open-label analysis of the effect of rosuvastatin on the triglyceride-rich lipoproteins metabolism in patients with primary dyslipidemia. Clin Ther 2007; 29: Pugia MJ, Lott JA, Luke KE, Shihabi ZK, Wians FH Jr, Phillips L. Comparison of instrument-read dipsticks for albumin and creatinine in urine with visual results and quantitative methods. J Clin Lab Anal 1998; 12: Levey AS, Bosch JP, Lewis Breyer J, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: Vidt DG, Cressman MD, Harris S, Pears JS, Hutchinson HG. Rosuvastatin-induced arrest in progression of renal disease. Cardiology 2004; 102: Yu H, Yanasigawa Y, Forbes MA, Cooper EH, Crockson RA, MacLennan IC. Alpha 1-microglobulin: an inhibitor protein for renal tubular function. J Clin Pathol 1983; 35: Weber MH, Verwiebe R. 1-Microglobulin (protein HC): features of a promising indicator of proximal tubular dysfunction. Eur J Clin Chem Biochem 1992; 30: Nogawa K, Kido T, Yamada Y, et al. Alpha 1-microglobulin in urine as an indicator of renal tubular damage caused by environmental cadmium exposure. Toxicol 146