頸部リンパ節および耳下腺病変にミノサイクリンが著効したサルコイドーシスの1例
|
|
- そう たけすえ
- 5 years ago
- Views:
Transcription
1 症例報告 ミノサイクリンが著効したサルコイドーシスの1例 頸部リンパ節および耳下腺病変にミノサイクリンが著効した サルコイドーシスの1例 増永愛子 1) 石川理惠 1) 森本耕三 1) 神宮浩之 1) 安藤常浩 1) 生島壮一郎 1) 武村民子 2) 折津 愈 1) 江石義信 3) 要旨 症例; 74歳 女性 右頸部腫瘤を主訴に前医受診 頸部リンパ節摘出術を行い組織診でサルコイドーシスが疑われ 当院紹介 右膝の皮膚生検 気管支肺胞洗浄の結果 サルコイドーシスと診断した 経過観察していたが右頸部リ ンパ節が再度腫大し 右耳下腺腫大も出現した 治療適応と考えたが糖尿病の合併があったためステロイド剤の使 用は見合わせ ミノサイクリンを開始した 直後からリンパ節 耳下腺の著明な縮小が得られた 診断時の組織標 本で に対する単クローン抗体 PAB抗体 陽性の顆粒を認めたため ミノサイクリン投与 後に患者の承諾を得て再度頸部リンパ節生検を行った 組織の中心部は壊死を伴った硝子化が大部分を占めその中 はPAB抗体は陰性であったが 硝子化の周囲の巨細胞内にはPAB抗体陽性像が見られた サルコイドーシスにおける の関与およびミノサイクリンによる治療について報告する 日サ会誌 2008; 28: キーワード サルコイドーシス アクネ菌 ミノサイクリン 抗菌薬 リンパ節 A Case of Sarcoidosis with Marked Improvement of Cervical Lymph Node and Parotid Gland Involvement by Minocycline Hydrochloride Aiko Masunaga1), Rie Ishikawa1), Kozo Morimoto1), Hiroyuki Kamiya1), Tsunehiro Ando1), Soichiro Ikushima1), Tamiko Takemura2), Masaru Oritsu1), Yoshinobu Eishi3) ABSTRACT A 74 year old woman visited a hospital complaining of right cervical lymphadenopathy. The cervical lymph node was removed and histology revealed non-caseating epithelioid cell granuloma, suspicious of sarcoidosis. She was referred to our hospital for further examination. We diagnosed her as having sarcoidosis, based on biopsy of the right knee skin and findings of bronchoalveolar lavage fluid. Later, right cervical lymph node and parotid gland became enlarged. As she did not agree to take corticosteroids because she had diabetes mellitus, we chose Minocycline hydrochloride. Minocycline treatment induced the size reduction of cervical lymph node and parotid gland. A second biopsy of cervical lymph node was carried out with informed consent. Histopathology of lymph node revealed massive hyalinization with remnant of regressive granuloma and giant cells. Immunohistochemical study of monoclonal antibody against lipoteichoic acid (PAB) revealed positive granules in the granuloma before Minocycline treatment, whereas PAB positive granules were found in giant cells around hyalinization and PAB had no reaction in the hyalinization after therapy. This case demonstrates that Minocycline induced reduction of granuloma but PAB positive granules remain, suggesting that Minocycline acts as an immunomodulator in addition to suppressing intracellular bacteria. [JJSOG 2008; 28: 93-97] Keywords: Sarcoidosis, 1 日本赤十字社医療センター呼吸器内科 2 同病理部 3 東京医科歯科大学大学院人体病理学分野 著者連絡先 増永愛子 東京都渋谷区広尾 日本赤十字社医療センター呼吸器内科 TEL FAX aiko.masunaga@ab.auone-net.jp, Minocycline hydrochloride, Antibiotics, Lymph node 1) Department of Respiratory Medicine, Japanese Red Cross Medical Center 2) Department of Pathology, Japanese Red Cross Medical Center 3) Department of Human Pathology, Graduate School, Tokyo Medical and Dental University 93
2
3 症例報告 ミノサイクリンが著効したサルコイドーシスの1例 Figure 1. Cervical MRI before therapy, showing swelling of right cervical lymph nodes and parotid glands. Figure 3. a Figure 2. Five months after initiation of minocycline hydrochloride therapy, right cervical lymph nodes and parotid glands became smaller markedly. The clinical course. b Figure 4. a) Histopathological feature of cervical lymph node biopsy before therapy. Non-caseating epithelioid cell granulomas with giant cells were observed. (HE, 10) b) Immunohistochemical analysis on cervical lymph node biopsy stained with PAB antibody. PAB antibody positive granules were detected in non-caseating epithelioid cell granulomas. ( 100) 95
4 日サ会誌 2008, 28 (1) a b c d Figure 5. Histopathological findings of cervical lymph node biopsy after minocycline treatment. Hyaline degeneration was observed throughout the lymph node (a, HE, 4), with regressive granuloma round the hyalinization. Hyalinized and regressive granulomas were observed. (b, HE, 10) One giant cell and macropharges aggregated. (c, HE, 20) Possitive reaction to PAB was observed in the giant cells. (d, 100) 考察 サルコイドーシスの原因は未だ不明であるが 疾患 感受性のある宿主が環境中の何らかの起因体に暴露さ れて誘導されるTh1タイプの過敏性免疫反応に起因す るらしいと言われている 1) またサルコイドーシスと の関係については以前より報告されているが 日本人サルコイドーシス患者のリンパ節中の の定量系PCRの解析が報告されて以来 2) 病 1) 因説がさらに注目されている また肉芽腫反応は細 胞内停滞性抗原に対する宿主の防御反応であると考え られるが のDNAがサルコイドーシスの肉芽 腫内に集積して存在することが報告されており 3) こ のことも がサルコイドーシスの肉芽腫の形成 に関与していることを示唆している 同様にPAB抗体の検討においても サルコイドーシ スの肉芽腫内の巨細胞や類上皮細胞内に抗体陽性顆粒 96 が充満しているとの報告が多くされている 4,5) その一 方で成熟 陳旧化した肉芽腫内では抗体陽性像は量 強度ともに減弱している 4) 本症例でも PAB抗体は治療前後の組織標本におい て陽性であったが 治療前は肉芽腫内で広範に強く陽 性所見を示したのに対して 治療後は組織の大部分は 硝子化に陥り 同部位はPAB抗体は陰性で 周辺の巨 細胞で陽性所見を示すのみであった PAB抗体では生 菌と死菌あるいはdormant phaseにある菌との区別が 出来ないことから 本症例の治療後のPAB抗体陽性所 見からは のviablityの推定は出来ない ちな みに本症例の治療後の摘出リンパ節の組織培養では は陰性であった しかし これらの結果は肉芽 腫からの完全な抗原除去を目指す場合には より長期 で強力な抗菌療法が必要であることを示唆している可 能性はある
5
36
仮面尿崩症を呈した神経サルコイドーシスの1例 症例報告 不明熱にて発症し 仮面尿崩症を呈した神経サルコイドーシスの1例 笹森 寛 泉山典子 齋藤若奈 宍倉 裕 菊地 正 三木 2 3 4 5 6 鈴木靖士 齋藤泰紀 手塚文明 武村民子 江石義信 祐 菊池喜博 要旨 症例は20歳男性 2007年3月末より38 台の発熱出現し近医受診 CTにて縦隔リンパ節腫脹および両側肺野 に10 mm内外の空洞性病変を複数認めた
More information明海大学歯学雑誌 37‐2/1.秦泉寺
J Meikai Dent Med 37, 153 158, 8 153 1 7 5ml /1 min Wong-Baker Face Rating Scale FS 5 1 9. g 3 5ml /1 min, FS 1 66 6ml /1 min FS 5 1 9. g 3 6ml /1 min, FS 3 Two Cases of Xerostomia that Showed an Improvement
More information日本職業・災害医学会会誌第54巻第6号
Reprint request: A CASE OF PRESENTED VARIOUS FUNCTIONAL DISTURBANCES AFTER AN INJURY Taketoshi NOGAKI, Nobusuke HOUCHI, Tomoko SUGIUCHI, Naohiko WATANABE and Hiroyuki ZUSHO Department of Otolaryngology,
More informationFig. 1 Clinical Appearance on the Left Leg before Therapy Fig. 2 Clinical Appearance after Therapy Fig. 3 Histopathological Features of the Skin Lesio
Ryoji KANDA, M.D. and Seiichiro HATA, M.D. Fig. 1 Clinical Appearance on the Left Leg before Therapy Fig. 2 Clinical Appearance after Therapy Fig. 3 Histopathological Features of the Skin Lesion, Showing
More informationTUBERCULOSIS OF THE PENIS : REPORT OF A CASE AND REVIEW OF THE LITERATURE Katsumi TANIKAWA, Kazuo MATSUSHITA and Masaaki OHKOSHI From the Department o
Title 陰茎結核の 1 例 Author(s) 谷川, 克己 ; 松下, 一男 ; 大越, 正秋 Citation 泌尿器科紀要 (1985), 31(6): 1065-1070 Issue Date 1985-06 URL http://hdl.handle.net/2433/118504 Right Type Departmental Bulletin Paper Textversion publisher
More information上咽頭の検索が診断に有用であったサルコイドーシスの二症例
上咽頭の検索が診断に有用であったサルコイドーシスの二症例 1) 1) 1) 1) 1) 2) 2) 2) 2) 3) 要旨 2 1 68 TBLB BDP 10 2 23 BHL TBLB 10 2 キーワード : Diagnostic usefulness of epipharyngeal examination in sarcoidosis: Report of two cases Tetsuo
More information結核との鑑別が問題となったサルコイドーシスの1例
症例報告 高橋 歩 1) 今野 哲 1) 服部健史 1) 大野重昭 2) 西村正治 1) 要旨 症例は30歳男性 霧視を主訴に北海道大学病院眼科を受診 結核性ぶどう膜炎もしくはサルコイドーシス疑い と診断され 精査目的に当科紹介となった 胸部CTにて 縦隔 両側肺門リンパ節の軽度腫大を認めたが 血清 ACE活性 γグロブリン値は正常範囲内であり また ツベルクリン反応 クオンティフェロン TB-2G
More information28 1 1a 1b 2 MRI T2 3 CT C3 N95 N95 6ml 90
2015 28 1 89 93 CT C3 Tb PCR XP WBC 7 600/mm 3 CRP 4 08mg/dl MRI MRI CT MRI WBC 9 700/mm 3 CRP 6 09mg/dl CT C3 C2 C7 low density area CT 89 28 1 1a 1b 2 MRI T2 3 CT C3 N95 N95 6ml 90 28 1 4 CT C2 C7 low
More information琉 球 医 学 会 Ryukyu Medical Association Title[ 総 説 ] 口 腔 癌 の 潜 在 性 頚 部 リンパ 節 転 移 に 関 する 諸 問 題 Author(s) 平 塚, 博 義 ; 砂 川, 元 ; 仲 盛, 健 治 ; 津 波 古, 判 ; 喜 舎 場, 野, 岳 史 ; 喜 友 名, 淳 子 Citation 琉 球 医 学 会 誌 = Ryukyu Medical
More informationFig. 1. Chest X-ray film on admission showed a mass in the left middle lung field and multiple nodular densities in the bilateral lung fields. Fig. 3.
A Case of Slow-growing Mucous-producing Adenocarcioma of the Lung Key words: Mucous-producing lung adenocarcinoma, Slow-growing, Bronchial gland cell type adenocarcinoma, Adenoid cystic carcinoma Table
More information8 The Bulletin of Meiji University of Integrative Medicine API II 61 ASO X 11 7 X-4 6 X m 5 X-2 4 X 3 9 X 11 7 API 0.84 ASO X 1 1 MR-angio
7-14 2010 1 1 1 2 1 1 1 2 Fontaine II ASO61 3 API ASO ASO ASO API API KKKKKKKKKK ASO Fontaine II API Received April 14, 2009; Accepted July 16, 2009 I arteriosclerosis obliterans: ASO ASO 50 70 1,2 Fontaine
More informationTable 1 Laboratory findings on admission Figure 2. Clinical course after admission 1-a 1-b 1-c 3-a 3-b 3-c Figure 1. CT findings on first admission: S
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF Vol. 32, pp. 105 110, 2004 FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF 1 1 1 1 1 1 1 1 2 2 1 1 16 4 13 72 CRP
More informationDISTRIBUTION OF NEUROPEPTIDES IN THE INFERIOR NASAL TURBINATE MUCOSA OF PATIENTS WITH ALLERGIC RHINITIS KAZUHIRO YAMAMOTO. M.D. Department of Otolaryngology, School of Medicine, Kitasato University, Sagamihara
More information40: 127-130, 1994 11) Damjanov I, Moriber K, Catalano E, et al: Myelolipoma in a heterotopic adrenal gland. Light and electron microscopic findings. Can cer 44: 1350-1356, 1979 12) DeNavasquez S: Case
More informationKey words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection
Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection Table 1. Bacterial cell counts in feces of mice infected with Esclwrichia coli O 157: H7 NK2 before and during oral dosing with fosfomycin
More information無水エタノールによる硬化療法および鼻粘膜癒着処置を施行したオスラー病による難治性鼻出血の1例
119 874 2016 : 0 1cc : : : : : :WBC3 640/μl RBC 247 10 /μl PLT 22 9 10 /μl Hb 7 9g/dl PT APTT : : : 1ml 30G absolute ethanol Et 0 1 0 2ml 2mm 119 875 1 000mg/day Et 0 3ml Al Deen endoglin ALK1 1 3 a b
More informationThe clinical characteristics of Mycoplasma pneumoniae pneumonia in children younger than 6 years old Nobue Takeda1,2),Tomomichi Kurosaki1),Naruhiko Ishiwada2),Yoichi Kohno2) 1)Department of Pediatrics,Chiba
More informationFig. 1 Chemical structure of TE-031 Code number: TE-031 Chemical name: (-) (3R, 4S, 5S, 6R, 7R, 9R, 11R, 12R, 13S, 14R)-4-[(2, 6-dideoxy-3-C-methyl-3-
Fig. 1 Chemical structure of TE-031 Code number: TE-031 Chemical name: (-) (3R, 4S, 5S, 6R, 7R, 9R, 11R, 12R, 13S, 14R)-4-[(2, 6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl) oxy]-14-ethyl-12,
More informationCHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study
CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study VOL. 41 S 1 Table 2. Levels (Đg/ml or Đg/g) of S-1006 in serum, bile, and tissue (gallbladder) after oral administration
More information日本消化器外科学会雑誌第29巻第9号
Table 1 Oligonucleotide primers used for RT-PCR and internal probes used for Southern blot hybridization Cytokine Primer Sequence (5'-3') 5' 3' Internal probe s' 3' Internal probe 5' 3' Internal probe
More informationセンシンレンのエタノール抽出液による白血病細胞株での抗腫瘍効果の検討
Evaluation of anti-tumor activity with the treatment of ethanol extract from Andrographis Paniculata in leukemic cell lines Hidehiko Akiyama 1), Kazuharu Suzuki 2), Toshiyuki Taniguchi 2) and Itsuro Katsuda
More informationsarco2011_1027.indb
における診断 病態 治療 予後因子 における診断 病態 治療 予後因子の解明に ついての研究 千田金吾 要旨 受賞の契機となった当施設の研究を4点に絞って紹介する 1 肉芽腫性疾患の診断法の検討のため 肉芽 腫を特異的に認識する単クローン抗体の作成を行った その結果,肉芽腫形成の存在を病理組織学的に的確に行え るようになった 2 の病因論に関する検討では ラットにおける死菌BCG肉芽腫反応での樹 状細胞の意義を経時的に解析した
More informationJO52-01
52 Bulletin of Hiroshima Jogakuin University : 1 22 Dec. 2002 1 2002 10 A case study: the counseling process of a mother with a difficult child Kyoko YAMASHITA Abstract I carried out 39 sessions of counseling
More information硫酸アルミニウムカリウムタンニン酸注射液(ALTA)による内痔核硬化療法後にフルニエ症候群をきたした1例 第65巻02号0075頁
65 V A Case Report of Fournier s Gangrene after Sclerosing Therapy for Internal Hemorrhoids with Aluminum Potassium Sulfate and Tannic Acid (ALTA) Injection Aluminum potassium sulfate and tannic acid
More informationEffects of Diet Class on Overweight Middle-aged Women Analysis of Nutritional Intake Pattern YAMAGUCHI Shizue*, MATSUMOTO Tomoko**, MIMURA Kan-ichi***, ASAI Hitoshi****, OKUDA Toyoko***** * O saka Shin-ai
More information<95DB8C9288E397C389C88A E696E6462>
2011 Vol.60 No.4 p.332 338 Usefulness of regional education program for dietary salt reduction: Self-monitoring of urinary salt excretion Kenichiro YASUTAKE[1] Kayoko SAWANO[1] Shoko YAMAGUCHI[1] Hiroko
More informationudc-3.dvi
49 UDC 371.279.1 3 4 753 1 2 2 1 2 47 6 2005 11 14 50 No.35, 2006 1 1.1 AO 2003 2004 2005 2005 1 1 2005 1998 1999 2002 12 11 2000 SAT ACT Law School Admission Test LSAT Medical College Admission Test MCAT
More information東洋医学雑誌
Vol.61 No.7 924-929, 2010 a b c d Naoki OKADA ad Masaru NATSUAKI b Takashi NISHIMOTO ac Nishimoto Clinic, 2-8-31 Koshienguchi, Nishinomiya, Hyogo 663-8113, Japan Department of Dermatology, Hyogo College
More information生命倫理100_資料4-7
26 27 Single cell clones picked from swaps12p36 (18) Single cell clones picked from swaps12p18 (24) 1.3% (p0) 1.1% (p58) 28 29 Outline 30 31 32 33 34 Columbia, The New York Stem Cell Foundation Oocyte
More informationCHEMOTHERAPY APRIL 1992 Table 2. Concentration of meropenem in human prostatic fluid Table 1. Background of 21 chronic complicated UTI cases * NB + BPH, NB + Kidney tumor, NB + Kidney tuberculosis Table
More information05_藤田先生_責
This report shows innovation of competency of our faculty of social welfare. The aim of evaluation competency is improvement in the Social welfare education effects, by understanding of studentʼs development
More information明海大学歯学雑誌 43‐1☆/目次(43‐1)
94 J Meikai Dent Med 43 1, 94 100, 2014 1 1 1 1 2 1 1 2 75 2 A Case of Occlusal Discomfort Treated by Fixed Partial Denture Fabricated by Double-cast Technique Takafumi FUJITA 1, Tomoaki IIZUKA 1, Takuya
More information日本消化器病学会雑誌第102巻第8号
χ χ χ χ χ χ χ χ β The Health Administration Center, Tohoku University ; Department of Gastroenterology, Tohoku University Hospital Department of Endoscopic Diagnostics and Therapeutics, Chiba University
More information220 28;29) 30 35) 26;27) % 8.0% 9 36) 8) 14) 37) O O 13 2 E S % % 2 6 1fl 2fl 3fl 3 4
Vol. 12 No. 2 2002 219 239 Λ1 Λ1 729 1 2 29 4 3 4 5 1) 2) 3) 4 6) 7 27) Λ1 701-0193 288 219 220 28;29) 30 35) 26;27) 0 6 7 12 13 18 59.9% 8.0% 9 36) 8) 14) 37) 1 1 1 13 6 7 O O 13 2 E S 1 1 17 0 6 1 585
More informationrectomy as the subjects of study, urinary steroid hormones were measured, and simultaneously the enzyme work and enzyme pattern related to the steroid metabolism, as proposed by Yoshida of our laboratory,
More informationCHEMOTHERAPY
CHEMOTHERAPY VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin CHEMOTHERAPY AUG. 1993 VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin Table 1. Comparative in vitro activity of teicoplanin
More informationFig. 1 Chest X-ray on admission, with infiltrative shadow in the right upper lung field. Fig. 2 Chest CT scan shows an infiltrative shadow, multiple b
congenital bronchial atresia, obstructive pneumonia Fig. 1 Chest X-ray on admission, with infiltrative shadow in the right upper lung field. Fig. 2 Chest CT scan shows an infiltrative shadow, multiple
More information肝硬変を合併し,肝肺症候群をきたしたサルコイドーシスの1例
症例報告 肝硬変を合併し肝肺症候群をきたしたサルコイドーシス 肝硬変を合併し 肝肺症候群をきたしたサルコイドーシスの1例 池田政輝 1) 鈴木研一郎 1) 白井敏博 1) 古橋一樹 1) 須田隆文 2) 千田金吾 2) 要旨 症例は59歳 女性 2002年12月から軽度の労作時呼吸困難を訴え 2003年6月初診時 胸部X線写真でBHLと両 側下肺野の網状影 経気管支肺生検で壊死を伴わない類上皮細胞肉芽腫
More informationON A FEW INFLUENCES OF THE DENTAL CARIES IN THE ELEMENTARY SCHOOL PUPIL BY Teruko KASAKURA, Naonobu IWAI, Sachio TAKADA Department of Hygiene, Nippon Dental College (Director: Prof. T. Niwa) The relationship
More informationBreastfeedin g among Mothers at One Month Postpartum: Structure of Intentions Department of Maternal and Child Health Nursing, Midwifery, School of Nursing, Faculty of Medical Sciences, University of Fukui
More information16_.....E...._.I.v2006
55 1 18 Bull. Nara Univ. Educ., Vol. 55, No.1 (Cult. & Soc.), 2006 165 2002 * 18 Collaboration Between a School Athletic Club and a Community Sports Club A Case Study of SOLESTRELLA NARA 2002 Rie TAKAMURA
More informationJournal of Breast and Thyroid Sonology Journal of Breast and Thyroid Sonology Vol.2, No.1 January 2013 Overview History of JABTSJapan Association of Breast and Thyroid Sonology : Dawn of a JABTS Age; The
More informationA Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, Sc
A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, School of Medicine, Tokushima University, Tokushima Fetal
More information;~ (Summary) The Study on the Effects of Foot Bathing on Urination Kumiko Toyoda School of Human Nursing, University of Shiga Prefecture Background Foot bathing is one of the important nursing care for
More informationTable 1 Laboratory data on admission * : Bacterial examinations were done on February 2, 1995 Fig. 1 Clinical course
Key words : psoas abscess, diabetes mellitus Table 1 Laboratory data on admission * : Bacterial examinations were done on February 2, 1995 Fig. 1 Clinical course 高齢 者 に発 症 した腸 腰 筋 膿 瘍 の1例 Fig. 2 Pelvic
More informationSome Investigations of Urinary Candidiasis Chujiro YAMAMOTO, M. D., Mitsushi MIZUTANI, M. D. and Tokuro SATO, M. D. From the Department of Urology, Ni
Title 尿路 Candida 症に於ける 2,3 の検索 Author(s) 山本, 忠治郎 ; 水谷, 三 ; 佐藤, 徳郎 Citation 泌尿器科紀要 (1961), 7(3): 394-405 Issue Date 1961-03 URL http://hdl.handle.net/2433/112109 Right Type Departmental Bulletin Paper Textversion
More informationTable 1.Concentration of gatifloxacin (Middle-ear) Table 2.Concentration of gatifloxacin (Paranasal sinuses) Table 3.Concentration of gatifloxacin (Tonsil) Table 4.No.of patients studied Table 5.Background
More informationKey words : virus-associated hemophagocytic syndrome (VAHS), Epstein-Barr virus, steroid therapy
Key words : virus-associated hemophagocytic syndrome (VAHS), Epstein-Barr virus, steroid therapy VAHSの1例 Fig. 1 Bone platelets, tiocytes T cell ( marrow smear normoblasts, and (H. E. stein ~ showing Laboratory
More informationTherapy for Asthenopia in Cases of Convergence Insufficiency Hiroko TAKASAKI, C.O.J., Nobuko INAGAMI, C.O.J., and Kayoko TAKENAWA, C.O.J.. Orthoptic c
Therapy for Asthenopia in Cases of Convergence Insufficiency Hiroko TAKASAKI, C.O.J., Nobuko INAGAMI, C.O.J., and Kayoko TAKENAWA, C.O.J.. Orthoptic clinic, Department of Ophthalmology, (Director: Prof
More information日本消化器外科学会雑誌第25巻第11号
Key words: intestinal nerve plexus, hypoxic perfusion, immunohistochemistry, 5-100 protein Table I (A) Sroo staining reactivity of nerve tissue normal partly mildly declined all mildly declined partly
More information理学療法検査技術習得に向けた客観的臨床能力試験(OSCE)の試行
An Application of an Objective Structured Clinical Examination for Learning Skills in Assessment of Physical Therapy A Task Involving Measurements on the Range of Motion Test Chikako Fujita1) Hiroyasu
More information19 OUR EXPERIENCE IN COMBINED BALNEO AND CHRYSOTHERAPY FOR RHEUMATOID ARTHRITIS by Hidemitsu EZAWA (Director: Prof. Hiroshi MORI NAG A), Department ofinternal Medicine, Institute for Thermal Spring Research,
More informationCT 5 HE PSA PAP 6 1 1
45 2140 145 2006 70 PSA 33.32 ng/ml Gleason score 5+4=9 MRIcT4N1M1b 4 PSA 1 4 PSAPAP 1 11.9 1 1.9-70 PSA33.32 ng/ml Gleason score 5+4=9 2006 5 10 570-8540 5-55 1 MRI2 3 ct4n1m1b 4 PSA NSAIDs 11 4 37.4
More information2 10 The Bulletin of Meiji University of Integrative Medicine 1,2 II 1 Web PubMed elbow pain baseball elbow little leaguer s elbow acupun
10 1-14 2014 1 2 3 4 2 1 2 3 4 Web PubMed elbow pain baseball elbow little leaguer s elbow acupuncture electric acupuncture 2003 2012 10 39 32 Web PubMed Key words growth stage elbow pain baseball elbow
More informationClinical Observation and Etiological Aspect on the Thrombocytopenic Purpura after Rubella Toyoji SODA, Masashi KAWANO, Toshihiko KATO*, and Takeshi SH
Clinical Observation and Etiological Aspect on the Thrombocytopenic Purpura after Rubella Toyoji SODA, Masashi KAWANO, Toshihiko KATO*, and Takeshi SHIGEMATSU**, Rubella is an acute viral infectious disease
More informationsemen quality or those without WBC in semen. In the patients with azoospermia and normal FSH levels (normogonadotropic azzospermia), the antibody (IgG
CLINICAL STUDIES OF UROGENITAL INFECTIONS WITH CHLAMYDIA TRACHOMA TIS Report 2. The Epidemiology of Chlamydial Infections in Okayama District in Japan and Detection of Antibodies to Chlamydiae in the Sera
More information原 著 放射線皮膚炎に対する保湿クリームの効果 耳鼻科領域の頭頸部照射の患者に保湿クリームを使用して * 要旨 Gy Key words はじめに 1 70Gy 2 2 QOL
原 著 放射線皮膚炎に対する保湿クリームの効果 耳鼻科領域の頭頸部照射の患者に保湿クリームを使用して * 1 2 1 2 要旨 2011 1 2013 9 33 0 1 6 16 17 60Gy Key words はじめに 1 70Gy 2 2 QOL 3 4 2014 6 16 2015 4 17 連絡先 359 0042 3 2 Phone 04 2995 1511 Fax 04 2995 0633
More informationFig. 1 Chemical structure of DL-8280
Fig. 1 Chemical structure of DL-8280 Fig. 2 Susceptibility of cl in ical isolates to DL4280 Fig. 5 Susceptibility of clinical isolates to DL-8280 Fig. 3 Susceptibility of clinical isolates to DL-8280 Fig.
More information日本職業・災害医学会会誌第51巻第5号
太田ら 同時多発性高血圧性脳葉出血の 1 手術例 図 1 搬入時 CT 上段 単純 CT 下段 造影 CT 図 2 術後の脳血管撮影検査では明らかな出血源は認めない 379 Reprint request: MULTIPLE SIMULTANEOUS HYPERTENSIVE LOBAR HEMORRHAGE Hirotsugu OHTA M.D. 1) and Akira YOKOTA M.D.
More informationPostoperative Assessment by Using a Torque Machine (BIODEX) and MRIs in Patients treated for a Recurrent Anterior Dislocation or Subluxation of the Sh
Postoperative Assessment by Using a Torque Machine (BIODEX) and MRIs in Patients treated for a Recurrent Anterior Dislocation or Subluxation of the Shoulder by HATA Yukihiko MURAKAMI Narumichi Department
More information揃 24 1681 0 20 40 60 80 100 0 21 42 63 84 Lag [hour] Lag [day] 35
Forecasting Model for Electricity Consumption in Residential House Based on Time Series Analysis * ** *** Shuhei Kondo Nobayasi Masamori Shuichi Hokoi ( 2015 7 3 2015 12 11 ) After the experience of electric
More informationCHEMOTHERAPY Silver sulfadiazine (T 107) CHEMOTHERAPY Fig. 1 Item of patients Table 1 Criteria of bacteriological efficacy by the Committee xcellent: E Score of infection becomes to 0% at the end of medication.
More information23 Japanese official medical care system in the Meiji Era and the Ottoman Battleship Ertuğrul : The case study about the medical cares to the foreigners infected with cholera (1890) Nobuo MISAWA 1890 23
More informationJAPANESE SHIP-OWNERS AND WORLD BULK MARKET BETWEEN THE TWO WORLD WARS Mariko Tatsuki Keisen University After World War I, Japanese shipping suffered for a long time from an excess of tonnage and severe
More information顔面神経麻痺を来したMPO―ANCA 陽性の中耳炎2症例
11367 : MPOANCA MPO ANCA MPOANCA 134EU MPO ANCA 67EU MPOANCA ANCA : MPOANCAANCA antineutrophil cytoplasmic antibody ; ANCA Davies IgG ANCA PR3proteinase3ANCA MPOmyeloperoxidaseANCA Wegener PR3ANCA MPO
More information駒田朋子.indd
2 2 44 6 6 6 6 2006 p. 5 2009 p. 6 49 12 2006 p. 6 2009 p. 9 2009 p. 6 2006 pp. 12 20 2005 2005 2 3 2005 An Integrated Approach to Intermediate Japanese 13 12 10 2005 8 p. 23 2005 2 50 p. 157 2 3 1 2010
More informationCore Ethics Vol. Sex Reassignment Surgery SRS SRS GID GID SRS GID GID GID GID GID QOL QOL QOL -- QOL
Core Ethics Vol. MTF Gender Identity Disorder GID GID GID GID QOL GID QOL QOL GID QOL GID QOL QOL QOL GID QOL Gender Identity Disorder QOL GID Core Ethics Vol. Sex Reassignment Surgery SRS SRS GID GID
More informationFig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with blad
Key words: Female with bladder irritability, Subjective symptoms, Pyuria, Bacteriuria Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution
More information短 報 A narrative analysis of nurses uncomfortable feelings and dilemmas experienced in teamwork 1 1 Megumi TAGUCHI Michio MIYASAKA キーワード : 違和感 ジレンマ チーム
短 報 A narrative analysis of nurses uncomfortable feelings and dilemmas experienced in teamwork 1 1 Megumi TAGUCHI Michio MIYASAKA キーワード : 違和感 ジレンマ チームワーク 看護経験 規範 ナラティヴ Key words :uncomfortable feelings,
More information33 NCCN Guidelines Version NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) (NCCN 腫瘍学臨床診療ガイドライン ) 非ホジキンリンパ腫 2015 年第 2 版 NCCN.or
33 NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) (NCCN 腫瘍学臨床診療ガイドライン ) 2015 年第 2 版 NCCN.org NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) (NCCN 腫瘍学臨床診療ガイドライン ) の Lugano
More informationŁ\”ƒ/flwŁš6mm
P F GCR E A I A M A O D E D N P GCR I A transgenerational transmission Kempe, C. H. et al., 1962battered child syndrome ghost in nursery X X X X X Y G B E C A B D P F GCR E A I A M A O D E D N P GCR oppositional
More information48 皮 膚 第29巻 第1号 昭 和62年2月 第1-b図 第1-a図 第1図Micro Trak法 アッ 皮 細 胞 中あ るいは細 pin point sizeの による 胞 外に,アッ 粒子と 直 接 塗 抹 標本から プル グ リ ー ン に光 プル し てelelnentary る 粒子
Chlamydia trachomatis-syphilis-micro Trak Mariko SEISHIMA, M. D., Satoshi OKUMURA, M. D. and Michihiro OHTANI, M. D. Megumi WATANABE, Ph. D., Ryo MATSUMOTO, Ph. D., Masayoshi TSUTSUMI, Ph. D. and Kazumasa
More informationVOL. 34 S-2 CHEMOTH8RAPY 913
VOL. 34 S-2 CHEMOTH8RAPY 913 914 CHEMOTHERAPY APR. 1986 Fig. 1 Chemical structure of T-2588 and T-2525 T- 2588 pivaloyloxymethyl (+ )- (6 R, 7 R)-7-[(Z)-2- (2-amino- 4-thiazolyl)-2-methox yiminoacetamido]-3-[(
More information10 年相対生存率 全患者 相対生存率 (%) (Period 法 ) Key Point 1
(ICD10: C81 85, C96 ICD O M: 9590 9729, 9750 9759) 治癒モデルの推定結果が不安定であったため 治癒モデルの結果を示していない 203 10 年相対生存率 全患者 相対生存率 (%) 71 68 50 53 52 45 47 1993 1997 1998 2001 2002 2006 2002 2006 (Period 法 ) 43 38 41 76
More informationC. S2 X D. E.. (1) X S1 10 S2 X+S1 3 X+S S1S2 X+S1+S2 X S1 X+S S X+S2 X A. S1 2 a. b. c. d. e. 2
I. 200 2 II. ( 2001) 30 1992 Do X for S2 because S1(is not desirable) XS S2 A. S1 S2 B. S S2 S2 X 1 C. S2 X D. E.. (1) X 12 15 S1 10 S2 X+S1 3 X+S2 4 13 S1S2 X+S1+S2 X S1 X+S2. 2. 3.. S X+S2 X A. S1 2
More information尿路結石と後腹膜リンパ節腫脹により両側水腎症を呈したサルコイドーシスの一例
尿路結石と後腹膜リンパ節腫脹により両側水腎症を呈したサルコイドーシスの一例 要旨 42 2001 2 ACE 2004 4 Ca, ACE, CT 30 mg Ca Cr CT 日サ会誌 2005;25:39-43 キーワード : A Case of Sarcoidosis Manifesting Bilateral Hydronephrosis due to Nephrolithiasis and
More information1) Richter, C. P.: Ann. Rev. Physiol., 4, 561 (1942) 2) A. L. Fox: Proc. Nat. Acad. Sci., Wash., 18, 115(1931) 4) Hansen, R. u. W. Langer: Klin. Wschr, 9) Katsch, G. u. H. Pickert: Handb. d. Inn. Med.
More information-1- -2- -1- A -1- -2- -3- -1- -2- -1- -2- -1- http://www.unicef.or.jp/kenri.syouyaku.htm -2- 1 2 http://www.stat.go.jp/index.htm http://portal.stat.go.jp/ 1871.8.28 1.4 11.8 42.7 19.3
More informationThe Journal of the Japan Academy of Nursing Administration and Policies Vol 7, No 2, pp 19 _ 30, 2004 Survey on Counseling Services Performed by Nursi
The Journal of the Japan Academy of Nursing Administration and Policies Vol 7, No 2, pp 19 _ 30, 2004 Survey on Counseling Services Performed by Nursing Professionals for Diabetic Outpatients Not Using
More information1) Delbet P: Retrocissement du choledoque. Cholecysto-duodenostomie. Bull Mem Soc Nat Chir 50: 1144-1146, 1924 2) Wiesner RH, LaRusso NF: Clinicopathologic Features of the Syndrome of Primary Sclerosing
More informationヒト慢性根尖性歯周炎のbasic fibroblast growth factor とそのreceptor
α μ μ μ μ 慢性化膿性根尖性歯周炎の病態像 Ⅰ型 A D Ⅱ型 E H Ⅰ型では 線維芽細胞と新生毛細血管が豊富で線維成分 に乏しく マクロファージ リンパ球や形質細胞を主とす る炎症性細胞の多数浸潤を認める Ⅱ型では Ⅰ型よりも線維成分が多く 肉芽組織中の炎 症性細胞浸潤や新生毛細管血管の減少や Ⅰ型よりも太い 膠原線維束の形成を認める A C E G B D F H A B E F HE
More informationA Case of Sarcoidosis Manifesting Liver Involvement after Disappearance of Muscle Lesion Hirohisa Ichikawa1), Mikio Kataoka2), Yoshiko Ogata1), Masaka
A Case of Sarcoidosis Manifesting Liver Involvement after Disappearance of Muscle Lesion Hirohisa Ichikawa1), Mikio Kataoka2), Yoshiko Ogata1), Masakazu Ohmori1), Junichi Hiramatsu1), Yasusi Tanimoto1),
More informationPrism Therapy and Surgical Correction for a Case of so-colled Phoria-Myopia Makiko KINJO, Kazuyo NAKAMURA, Tamako NAGAO, Satoshi NIKI, Mariko TAWARAYA, Seiichi TSUCHIYA and Sumu SOSHI Department of Opthalmology
More information東洋医学雑誌
Vol.67 No.2 123-130, 2016 Akiyo GUSHI a Chihaya KORIYAMA b Ryo YOSHINAGA c Hiromi YANO c Junichi TSUMAGARI d Eiichi TAHARA c a Gushi Dermatological Clinic, 45-3 Higashiohsyoji, Satsumasendai city, Kagoshima
More informationKey words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S.
Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S. Table 1. Clinical summary of acute uncomplicated cystitis patients treated with 7432-S UTI : Criteria by the
More informationKey words : Adverse reactions, Egg allergy, IgG antibody, Mills allergy, FAST
Key words : Adverse reactions, Egg allergy, IgG antibody, Mills allergy, FAST 13) Danaeus, A., Johansson, S. G. O., Foucard, T. & Ohman, S.: Clinical and immunogical aspects of food allergy in childhood.
More informationTitle 近江湖北の神事をめぐる心理臨床学的研究 Author(s) 井上, 明美 Citation 京都大学大学院教育学研究科紀要 (2009), 55: 267-279 Issue Date 2009-03-31 URL http://hdl.handle.net/2433/72722 Right Type Departmental Bulletin Paper Textversion publisher
More informationPsychosomatical study on five cases with oral cancer committing suicide Masatsugu Shimizu and Keiichiro Ono Abstract: The records of five oral cancer
Psychosomatical study on five cases with oral cancer committing suicide Masatsugu Shimizu and Keiichiro Ono Abstract: The records of five oral cancer cases that committed suicide were studied psychosomatically.
More informationBUN, CRP K mg/ cm, 49.6 kg, BMI /72 mmhg, 92/ Hb 6.7 g/dl PT-INR CT 1 MRI 2a, b T1 T2 T1 MRI
20 2 2015 1 2 3 85 K CT Abstract A case of renal subcapsular hematoma resulting from trigger point injection under excessive effect of anticoagulant YAMANE Tateki, UMEDA Akira and SHIMAO Hitoshi An 85-year-old
More information8y4...l
3 607 67 1 2 3 20 17 68 4 17 17 16101695 5 6 69 1645 1653 8 3 1663 5 7 70 8 9 10 71 1662 1010 13 11 72 12 13 73 1678 16611722 14250 70 90 14 168071 15 1685 16 74 168980 2 17 18 19 20 21 75 22 4 1658 23
More information60 0 0 0 (3) 1. 記 録 されたトラウマ 襲 いかかる 記 憶 2000 30
59 はじめに 2007 (1) 70 1970 (2) UTCP Uehiro Booklet, No. 2, 2013 10 pp. 59 72 60 0 0 0 (3) 1. 記 録 されたトラウマ 襲 いかかる 記 憶 2000 30 61 0 0 0 0 0 0 0 0 ( 2007a: 165) ( 2007a: 165) 62 ( 2007a: 170) 0 0 0 GI 0 GI (
More information1272 CHEMOTHERAPY MAR. 1975
1272 CHEMOTHERAPY MAR. 1975 VOL. 23 NO. 3 CHEMOTHERAPY 1273 Fig. 2 Minimal inhibitory concentration of aminoglycosides against 50 strains of Klebsiella Fig. 1 Minimal inhibitory concentration of aminoglycosides
More information2012 Vol. 23 No pseudothrombophlebitis pseudothrombophlebitis
pseudothrombophlebitis 5 424 163 38.1 26 6.1 5 1.2 230 2 3 66.4 51 80 2 3 2 2 1 2012 23 3 261-265 pseudothrombophlebitis 1 2011 7 11 30 2010 2 5 47 Fig. 1 Ultrasonography showed a low echoic cyst in the
More information‚æ4“ƒ.ren
69 1 1 13 14 70 2 3 1972 4 5 1992 6 7 1980 100 1997 71 226 2100 8 100 50 9 21 21 21 21 10 11 2 1968 12 13 72 1980 14 15 16 17 73 18 18 20 5 2002 12 9 19 1964 1980 20 21 22 74 23 100 10 10 100 101 1 101
More informationLeydig cell tumor TESTICULAR LEYDIG CELL TUMOR IN A CHILD: A CASE REPORT Akio NISHINO, Mitsuhiro TAKASHIMA, Kazuyoshi NAKAJIMA, MitSuo OHKAWA and Haru
Title 小児睾丸 Leydig cell tumor の 1 例 Author(s) 西野, 昭夫 ; 高島, 三洋 ; 中嶋, 和喜 ; 大川, 光央 ; 久住, 橋本, 浩之 ; 宮川, 和彦 ; 佐藤, 保 ; 野々村, 昭孝 Citation 泌尿器科紀要 (1989), 35(12): 2139-2143 Issue Date 1989-12 URL http://hdl.handle.net/2433/116771
More information29 28 39 1936 Acquiring technique and forming character in physical education after 1936 Analysis of articles of Kenji Shinozaki FUJIKAWA Kazutoshi The United Graduate School of Education Tokyo Gakugei
More informationTable 1. Antibacterial spectrum SBT ABPC ABPC CPZ : sulbactamiampicillin : ampicillin : cefoperazone
Table 1. Antibacterial spectrum SBT ABPC ABPC CPZ : sulbactamiampicillin : ampicillin : cefoperazone (inoculum size= 106 CFU/ml) (Ĉ-lactamase producer : 2 strains) Fig. 1. Sensitivity distribution of
More information7 2000b 2000b 2000b A Vol 8, No 2,
The Journal of the Japan Academy of Nursing Administration and Policies Vol 8, No 2, pp 37 _ 47, 2005 The Real and the Factors of Hiyari-hatto Experiences of Nursing Students during Clinical Training Analyzed
More informationEffects of the testosterone on both male and female fowls Shohyoe Tsuda Résumé This study was carried out to test the biological actions of androgen on both male and female fowls. As androgen "Amolisin"
More information第71巻5・6号(12月号)/投稿規定・目次・表2・奥付・背
μ μ μ μ μ γ 1 4 3 クリゾチニブが奏効した PS 不良 ALK 肺癌の1例 図2 入院時胸部 CT a 左鎖骨上窩 縦隔リンパ節腫大を認めた 矢印 b 左腕頭静脈から上大静脈内まで続く血栓 を認めた 矢印 c 左下葉に腫瘤影を認めた d 右肺に内部に空洞を伴う結節影を多数認めた 矢印 率は蛍光 in situ ハイブリダイゼーション FISH 法で 6 8 1 5 であり ALK 蛋白の免疫組織化学染色
More information