研究成果報告書
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2 1 superoxide anion nitric oxide; NO ONOO MDA-LDLLDL DNA 8-OHDG ,9 ST Q T 10,11 2 Q DIC 10 ⑴70 歳以上の高齢者で ⑵ 術前 かの心電図異常があり ⑶ 心胸郭係数が 50 手術中に ⑷ 血圧低下や ⑸ shear stress
3 NO flow-mediated dilatation; FMD 13 Reactive hyperemia index; RHI Endo-PAT RHI RHI NO 14 RHI Framingham Heart Study Circulation 16 EndoPAT RHI control POD0 POD1 4 POD Endo-PAT mmHg RHI P S 35 40mmHg 1.3MAC minimum alveolar concentration BIS MAC Mapleson 17 POD0 RHI RHI RHI POD4 POD0 RHI POD4 control RHI RHI BMI RHI One-way analysis of variance RHI POD0 RHI POD POD RHI
4 3 4 1 ADL CRP thoracic aorta: potential implication for retrograde embolic stroke in hypertension. Hypertension (2013) 62: Ito S, Nagasawa T, Abe M, et al. Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk. Hypertens Res AGE AGE RAGE NADPH oxidase 19,20 21 NO 22 E Dzau VJ. Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. Hypertension (2001) 37: Hashimoto J, Ito S. Aortic stiffness determines diastolic blood flow reversal in the descending (2009) 32: Higashi Y, Sasaki S, Kurisu S, et al. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation (1999) 100: Higashi Y, Sasaki S, Nakagawa K, et al. Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production. Atherosclerosis (2006) 186: Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation (2001) 104: Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation (2005) 111:363-8.
5 8. Mangano DT, Browner WS, Hollenberg M, et al. Association of perioperative myocardial ischemia with cardiac morbidity and mortality in men undergoing noncardiac surgery. The Study of Perioperative Ischemia Research Group. N Engl J Med (1990) 323: Tarhan S, Moffitt EA, Taylor WF, et al. Myocardial infarction after general anesthesia. JAMA (1972) 220: ,,, et al.. (1983) 15: ,,, et al.. Journal of Cardiography (1985) 15: van Waes JA, Nathoe HM, de Graaff JC, et al. Myocardial injury after noncardiac surgery and its association with short-term mortality. Circulation (2013) 127: Joannides R, Haefeli WE, Linder L, et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation (1995) 91: Nohria A, Gerhard-Herman M, Creager MA, et al. Role of nitric oxide in the regulation of digital pulse volume amplitude in humans. J Appl Physiol (2006) 101: Bonetti PO, Pumper GM, Higano ST, et al. Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol (2004) 44: Hamburg NM, Keyes MJ, Larson MG, et al. Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study. Circulation (2008) 117: Mapleson WW. Effect of age on MAC in humans: a meta-analysis. Br J Anaesth (1996) 76: ,, 2013,,. 2013,. 19. Ceriello A. Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabetes (2005) 54: Wright E, Jr., Scism-Bacon JL, Glass LC. Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. Int J Clin Pract (2006) 60: Yoshida K, Okabe E. Selective impairment of endothelium-dependent relaxation by sevoflurane: oxygen free radicals participation. Anesthesiology (1992) 76: Gragasin FS, Davidge ST. The effects of propofol on vascular function in mesenteric arteries of the aging rat. Am J Physiol Heart Circ Physiol (2009) 297:H Yu HP, Lui PW, Hwang TL, et al. Propofol improves endothelial dysfunction and attenuates vascular superoxide production in septic rats. Crit Care Med (2006) 34: ⑴Kohjitani A, Miyata M, Iwase Y, Ohno S, Tohya A, Manabe Y, Hashiguchi T. Associations between the autonomic nervous system and the second derivative of the finger photoplethysmogram indices. J Atheroscler Thromb (2014) 21: ⑵Ohno S, Miyata M, Kohjitani A, Tohya A, Ohishi M. Associations between blood pressure responses to acute stress and impaired renal function and serum uric acid level. Clin Exp Hypertens (2015) 37: ⑴ Ohno S, Kohjitani A, Hashiguchi T, Miyata M, Hijioka H, Matsunaga K, Nakamura N. Endothelial function assessed by reactive hyperemia peripheral arterial tonometry (RH-PAT) during the perioperative period of propofol-remifentanil anesthesia. The 2013 Annual Meeting of the American Society of Anesthesiologists. October 14, 2013, San Francisco, USA. ⑵ Kohjitani A, Miyata M, Yanagibashi K, Ohno S, Tohya A. Preoperative estimated glomerular filtration rate (egfr) predicts hemodynamic responses to anesthesia induction in middle-aged to elderly patients. The 2013 Annual Meeting of the American Society of Anesthesiologists. October 12, 2013, San Francisco, USA. ⑶ RH-PAT ⑷
6 ⑸ egfr ⑹ egfr ⑺ ⑻ ⑼ ⑽ (1) Kohjitani, Atsushi (2) Ohno, Sachi Tohya, Akina (3) Miyata, Masaaki Hashiguchi, Teruto
研究成果報告書
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研究成果報告書
系 レニン 1. Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Shimokawa H, Kohzuki M. Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure.
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392 Vol.34 No.3/May 2014 日本臨床麻酔学会第 32 回大会シンポジウム日臨麻会誌 Vol.34 No.3, 392 396, 2014 長期予後を考えた周術期管理とは? 周術期虚血性心疾患とニコランジル * 木下浩之 [ 要旨 ] ニコランジル投与が狭心症患者の長期予後を改善することは周知の事実である. 一方で, ニコランジル周術期投与の有用性については, 数少ない臨床研究で検討されているにすぎない.
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Changes in Electrodermal Activity Associated with Candies and Chewing Gum Chewing Satoshi Beppu, Takeshi Morita*, Susumu Igarashi **, Kanichi Seto* an
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A 急性冠症候群 1. 日本人の ACS は増えているのか? 欧米に比べて少ないのか? 1 序論 Acute coronary syndrome(acs) は急性心筋虚血による心臓突然死, 急性心筋梗塞, 不安定狭心症を含む疾患概念である. ここでは死亡率も高く疫学的知見が豊富な急性心筋梗塞を中心に述べる. わが国の急性心筋梗塞が増加しているのか, 国際的にみて少ないのかを知るための疫学指標はいくつか存在する.
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;~ (Summary) The Study on the Effects of Foot Bathing on Urination Kumiko Toyoda School of Human Nursing, University of Shiga Prefecture Background Foot bathing is one of the important nursing care for
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