AS No.4/2.™ƒfi⁄Dr.qx

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1 ArteriosclerosisAtherosclerosis ArteriosclerosisAtherosclerosis arteriosclerosis atherosclerosis arteriosclerosis arteriosclerosis arteriosclerosis Lakatta 1, 2 glycosaminoglycan 1. 3 Schlatmann /03/400//JCLS

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3 4 7 diffuse intimal thickeningdit DIT DIT DIT1883Thoma 8 normal intima 9 adaptive intima 10 adaptation French DIT 11 PDAY study Sadoshima

4 13 Leung Sadoshima 15 Fabris

5 05690 Lakatta EG. Arterial and cardiac aging major shareholders in cardiovascular disease enterprises. Part III cellular and molecular clues to heart and arterial aging. Circulation Lakatta EG. Arterial and cardiac agingmajor shareholders in cardiovascular disease enterprises. Part Iaging arteriesa set upfor vascular disease. Circulation B, pp ,, Schlatmann TJ, Becker AE. Histologic changes in the normal aging aorta implications for dissecting aortic aneurysm. Am J Cardiol Nakashima Y, Shiokawa Y, Sueishi K. Alterations of elastic architecture in human aortic dissecting aneurysm. Lab Invest Nakashima Y, Sueishi K. Alteration of elastic architecture in the lathyritic rat aorta implies the pathogenesis of aortic dissecting aneurysm. Am J Pathol Nakashima Y, Chen YX, Kinukawa N, Sueishi K. Distribution of diffuse intimal thickening in human arteries preferential expression in atherosclerosis-prone arteries from an early age. Virchows Arch Thoma R. Ueber die Abhaengigkeit der Bindegewebsneubildung in der Arterienintima von den mechanischen Bedingungen des Blutumlaufes. Virchows Arch Schwartz SM, deblois D, O'Brien ERM. The intima. Soil for atherosclerosis and restenosis. Circ Res Stary HC, Blankenhorn DH, Chandler AB, Glagov S, Insull W, Richardson M, Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD, Wissler RW. A definition of the intima of human arteries and of its atherosclerosis-prone regions.

6 Circulation French JE. Atherosclerosis in relation to the structure and function of the arterial intima, with special reference to the endothelium. Int Rev Exp Pathol Pathobiological Determinants of Atherosclerosis in Youth PDAYResearch Group. Natural history of aortic and coronary atherosclerotic lesions in youth. Findings from the PDAY Study. Arterioscler Thrombos Tanaka K, Masuda J, Imamura T, Sueishi K, Nakashima T, Sakurai I, Shozawa T, Hosoda Y, Yoshida Y, Nishiyama Y, Yutani C, Hatano S. A nation-wide study of atherosclerosis in infants, children and young adults in Japan. Atherosclerosis Imakita M, Yutani C, Strong JP, Sakurai I, Sumiyoshi A, Watanabe T, Mitsumata M, Kusumi Y, Katayama S, Mano M, Baba S, Mannami T, Masuda J, Sueishi K, Tanaka K. Second nation-wide study of atherosclerosis in infants, children and young adults in Japan. Atherosclerosis Sadoshima S, Kurozumi T, Tanaka K, Ueda K, Takeshita M, Hirota Y, Omae T, Uzawa H, Katsuki S Cerebral and aortic atherosclerosis in Hisayama, Japan. Atherosclerosis Leung SY, Ng THK, Yuen ST, Lauder IJ, Ho F. Pattern of cerebral atherosclerosis in Hong Kong Chinese. Stroke Fabris F, Zanocchi M, Bo M, Fonte G, Poli L, Bergoglio I, Ferrario E, Luigi PernigottiCarotid plaque, aging, and risk factors, a study of 457 subjects. Stroke Spagnoli LG,Orlandi A, Mauriello A, Santeusanio G, de Angelis C, Lucreziotti R, Ramacci MTAging and atherosclerosis in the rabbit. 1. Distribution, prevalence and morphology of atherosclerotic lesions. Atherosclerosis

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