Table 1 Components of corn dietary fibers

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1 Effects of Purified Corn Dietary Fiber on Blood Glucose, and Serum and Liver Lipids in Normal Rats and Mice Sachie Ikegami *1, Saeko Ohsawa *1, Shouko Machida *2 and Akiko Hada *2 The National Institute of Health and Nutrition, *2 Tokyo Kasei Gakuin College *1 Effects of soluble corn dietary fiber ( SCDF) and insoluble corn dietary fiber (ICDF ) on blood glucose, serum and liver lipid components were studied in normal rats (4-week old Sprague-Dawley males) and mice (4-week old ICR males ). 1) Postprandial blood glucose at 45 minutes was significantly lower in rats fed SCDF diet than the control group, but not significantly low in rats fed ICDF diet. 2) Triglycerides, phospholipids and total cholesterols in serum significantly decreased in rats fed SCDF diet compared with the control group, but there was observed no change in hepatic lipids. 3) Fasting blood glucose was significantly higher in mice fed SCDF diet than the control group, but postprandial blood glucose at 45 minutes was significantly lower in mice fed SCDF diet. 4) Hepatic total lipids, triglyceride and total cholesterols were significantly lower in mice fed SCDF diet than the control group, but there was observed no change in hepatic lipids. Jpn. J. Nutr., 55 (3) (1997) Key words: soluble corn dietary fiber, insoluble corn dietary fiber, blood glucose, serum lipids, liver lipids

2 Table 1 Components of corn dietary fibers

3 Table 2 Composition of diets

4 Table 3 Effect of corn dietary fibers on body and liver weights in rats*1 at day 7 or 8 at day 32 or 33 Fig.1 Effect of corn dietary fibers on postprandial blood glucose in rats Rats were fed each diet of control ( œ), SCDF ( ) and ICDF ( ). After 7 or 8 days and 32 or 33 days, fasted rats were administered 3g /kg body weight of glucose. The points not sharing a common letter is significantly different by Duncan multiple range test at p< 0.05.

5 Table 5 Effect of corn dietary fibers on body and liver weights in mice*1 Table 6 Effect of corn dietary fibers on fasting blood glucoce and postprandial glucose after 45 minutes in mice*1

6 Table 7 Effect of corn dietary fibers on serum and liver lipids in mice*1

7 2 ) Dintzis, F. R., Legg, L. M., Deatherage, W. L., Baker, F. L., Inglet, G. E., Jacob, R. A., Reck, S. J., Munoz, J. M., Klevay, L. M., Sandstead, H. H. and Shuey, W. C.: Human gastrointestinal action on wheat, corn, and soy hull bran-preliminary findings, Cereal Chem., 56, 123 `127 (1979) 5 ) Sugawara, M. Suzuki, K., Endo, K., Kumemura, M., Takeuti, M. and Mituoka, T. : Effect of the dietary supplementation of corn hemicellulose on fecal flora and bacterial enzyme activities in human adults, Agric. Biol. Chem., 54, 1683 `1688 (1990) 6) Earll, L., Earll, J. M., Naujokaitis, S., Pyle, S., Falls, K. M. and Altschul, A. M.: Feasibility and metabolic effects of purified corn fiber food supplement, J. Am. Dietetic Assoc., 88, 950 `952 (1988)

8 10) Munoz, J. M., Sandstead, H. H., Jacob, R. A., Logan, G. M., Reck, S. J., Klevay, L. M. Dintzis, F. R., Inglet, G. E. and Shuey, W. C.: Effects of some cereal brans and textured vegetable protein on plasma lipids, Am. J. Clin. Nutr., 32, 580 `592 (1979) 11) Lee, W. Y., Bennink, M. R. and Chenoweth, W. L.: Steroid metabolism, transit time, and cecal bacteria in rats fed corn or wheat bran, Cereal Chem., 56, 279 `283 (1979) 13) Mahalko, J. R., Sandstead, H. H., Johnson, L., Inman, L. F., Milne, D. B., Warner, R. C. and Haunz, E. A.: Effect of consuming fiber from corn bran, soy hulls, or apple powder on glucose tolerance and plasma lipids in type II diabetes, Am. J. Clin. Nutr., 39, 25 `34 (1984) 14) Munoz, J. M., Sandstead, H. H. and Jacob, R. A.: Effects of dietary fiber on glucose tolerance of normal men, Diabetes, 28, 49 `502 (1979) 16) Prosky, L., Asp, N. G., Schweizer, T. F., De Vries, J. W. and Furda, I.: Determination of insoluble, soluble, and total dietary fiber in foods and food products ; International study, J. Assoc. Off. Anal. Chem., 71, 1017 `1023 (1988) 18) Folch, J., Lees, M. and Stanley, G. H. S.: A simple method for the isolation and purification of total lipids from animal tissues, J. Biol. Chem., 226, 497 `509 (1957)

CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation

CHEMOTHERAPY CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation CHEMOTHERAPY Table 1 Preliminaly test of AM- 715 1): Mean } SD *: Significant difference