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1 2 Vol. 23 No

2 21 Vol. 23 No

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6 7 Vol. 23 No Evidence-Based MedicineEBM benefit riskevidence 1 critical appraisal Chalmers I & Altman DG pp handsearch

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8 RCT AB A B A1/9B 4/6 1/94/61/60.167AB AB / /6 6 Vol. 23 No

9 10 Vol. 23 No RCT Morton Morton Morton 40 Rasmu-ssen MortonFeldstedt

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21 PTP 20mg mg PTP PTP PTP Sarau HM et al: Molecular Pharmacology 56: 657, 1999 Krell RD et al: Am Rev Respir Dis 141: 978, 1990 Krell RD et al: Ann NY Acad Sci 744: 289, 1994 Laitinen LA et al: Eur. Respir. J. 12 (Suppl 29): 55S, Abs. P423, 1998 Smith LJ et al: Am. J. Respir. Crit. Care Med. 151(4): Part 2; A378, Abs., 1995 Taylor IK et al: Lancet 337: 690, 1991 Richter K et al.: Eur. Respir. J. 15: 693, 2000 Finnerty JP et al : Am Rev Respir Dis 145: 746, (8): 1143, (8): 1295, Nayak AS et al.: J. Allergy Clin. Immunol. 101: S233, Abs. 965, Barnnes NC et al.: Thorax 55: 478, Vol. 23 No

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28 Cytochrome P450 pharmacodynamic interaction K KVK VK 2--1,4- VK1 Bacillus subtilis var. natto VK2 VK 65 80g 30VK65 g30,000g 80gkgg VK K TT K 15 TT K K 10 Kudo 11 K in vivo 35 TT38 100g TT90 Vol. 23 No

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30 14 VK VK 15 VK2in vitro 16 Cytochrome P450 Dorian mg mg/ml Vol. 23 No

31 kcal 22 N-methyltetrazolythilmethylNMTT : ;,, 22 (11) : 40 44, 2000,,,, :,,, p.8081, 1985 : K (3),, 6 : , 2000 Booth SL, Centurelli MA : Vitamin K ; a practical guide to the dietary management of patients on warfarin. Nutr Rev, 57 : ,1999 : 13,, 93 (11) : 2028, 1999 :,, 19 : , 2000 :,,, p510537, 2000 :,,, p.586, 1997, : Warfarin,,, p50 51, , : Warfarin,,, p , Kudo T : Warfarin antagonism of Natto and increase in serum vitamin K by intake of Natto. Artery, 17 : , , : ( ),,, p , :,, 35 : , : K (4),, 6 : , : K,, 57 : 8591, Yaguchi M, Miyazawa K et al : Vitamin K2 and its deribatives induce apoptosis in leukemia cells and enhance the effect of alltrans retinoic acid. Leukemia, 11 : , Dorian P, et al : Triazolam and ethanol interaction ; kinetic and dynamic consequences. Clin Pharmacol Ther, 37 : , :, DI ( ), BP,, p.8990, Davis WC, Ticku MK : Ethanol enhances 32 Vol. 23 No

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