好酸球性副鼻腔炎:診断ガイドライン(JESREC Study)

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118 728 2015 : : JESREC Study Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis Study : JESREC Study CT NSAIDs CT : JESREC Study

JESREC Study 118 729 ph CTMRI Caldwell Luc Caldwell Luc Kennedy Stammberer Functional endoscopic sinus surgery endoscopic sinus surgery : ESS Caldwell Luc ESS ESS

118 730 JESREC Study 2015 1 CT CT 1 CT /ml ESS CT CT

JESREC Study 118 731 : Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis Study JESREC Study ESS IgE CT 2 Kaplan Meier ESS Kaplan Meier Cox NSAIDs Cox Cox Cox Kaplan Meier

118 732 JESREC Study 2015 2 Cox p NSAIDs 3 Cox p 4 JESREC Study 3 Kaplan Meier : : : p 0 01 ESS step wise Receiver operating characteristic AUC

JESREC Study 118 733 4 5 Kaplan Meier p 0 01

118 734 JESREC Study 2015 Churg Strauss CT NSAIDs : : : : p 0 01 : : : : p 0 01 ESS JESREC Study 5 ESS endotype Th2 IL 5 IgE allergic fungal sinusitis IL 32 JESREC Study IL 5 IL 13 IgE L plastin IL 17 IL 22 IL 31 IL 33 Yamanaka N, Iino Y, Uno Y, et al : Practical guideline for management of acute rhinosinusitis in Japan. Auris Nasus Larynx 2015 ; 42 : 1 7. Fokkens WJ, Lund VJ, Mullol J, et al : European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl 2012 ; 23 : 3 p preceding table of contents, 1 298. Akdis CA, Bachert C, Cingi C, et al : Endotypes and phenotypes of chronic rhinosinusitis : a PRACTALL document of the European Academy of Allergy and Clinical

JESREC Study 118 735 Immunology and the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol 2013 ; 131 : 1479 1490.,,, : JESREC Study. ; :. Caldwell GW : Diseases of the accessory sinuses of the nose, and an improved method of treatment for suppuration of the maxillary antrum. New York Med J 1893 ; 58 : 526 528. Luc H : Une nouvelle methode operatoire pour la cure radicale et rapide de I empyeme chronique du sinus maxillaire. Arch inernat de laryngol otol rhinol et broncho oesophagoscopie, 1897. Kennedy DW, Zinreich SJ, Rosenbaum AE, et al : Functional endoscopic sinus surgery : Theory and diagnostic evaluation. Arch Otolaryngol 1985 ; 111 : 576 582. Stammberger H : Endoscopic endonasal surgery ; concepts in treatment of recurring rhinosinusitis. Part I. Anatomic and pathophysiologic considerations. Otolaryngol Head Neck Surg 1986 ; 94 : 143 147. :. JOHNS 2004 ; 20 : 1815 1821.,,, :. ; :. Hashiba M, Baba S : Efficacy of long term administration of clarithromycin in the treatment of intractable chronic sinusitis. Acta Otolaryngol Suppl 1996 ; 525 : 73 78.,,, :. ; :. Ishitoya J, Sakuma Y, Tsukuda M : Eosinophilic chronic rhinosinusitis in Japan. Allergol Int 2010 ; 59 : 239 245. Makino S, Miyamoto T, Nakajima S, et al : Survey of recognition and utilization of guidelines for the diagnosis and management of bronchial asthma in Japan. Allergy 2000 ; 55 : 135 140. :. ;.,,, : : JESREC Study. ; :. Tokunaga T, Sakashita M, Haruna T, et al : Novel Scoring system and algorithm for classifying chronic rhinosinusitis ; The JESREC Study. Allergy 2015 May 6 Epub ahead of print. Matsuwaki Y, Ookushi T, Asaka D, et al : Chronic rhinosinusitis : risk factors for the recurrence of chronic rhinosinusitis based on 5 year follow up after endoscopic sinus surgery. Int Arch Allergy Immunol 2008 ; 146 : 77 81. Haruna S, Shimada C, Ozawa M, et al : A study of poor responders for long term, low dose macrolide administration for chronic sinusitis. Rhinology 2009 ; 47 : 66 71. Nakayama T, Yoshikawa M, Asaka D, et al : Mucosal eosinophilia and recurrence of nasal polyps new classification of chronic rhinosinusitis. Rhinology 2011 ; 49 : 392 396. :. JOHNS 2011 ; 27 : 871 874.