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7 4) Thorp MA, Gardiner IB, Prescot CAJ: Burow's solution in the treatment of active mucosal chronic suppurative otitis media: determining an effective dilution. J Laryngol Otol 2000; 114: ) Thorp MA, Oliver SP, Kruger J, Prescot CAJ: Determination of the lowest dilution of aluminum acetate solution able to inhibit in vitro growth of organisms commonly found in chronic suppurative otitis media. J Laryngol Otol 2000; 114: ) Lucente TE: Fungal infection of the external ear. Otolaryngol Clin North Am 1993; 26: chronic otitis media. Laryngoscope 1985; 95: ) Nadol JBJr: Causes of failure of mastoidectomy for 15) Thorp MA, Kruger J, Oliver S, Nilssen ELK, Prescott CAJ: The antibacterial activity of acetic acid and Bu. row's solution as topical otological preparati ons. J Laryngol Otol 1998; 112: 10: ) El-Seifi A, Fouad B: Granular myringitis: Is it a surgi -
8 cal problem?. Am J Otol 2000; 21: ) Hoshino T. Yam T, Ichimura K, Hashimoto H, Nosue M: Chronic myringitis and chronic suppurative otitis media. Arch Oto-Rhino-Laryngol; 1982; ) Nicholas HB, Karmody CS: Chronic myringitis: Prevalence, presentation, and natural history. Otol Neurotol 2001; 22: ) Jung HH, Cho SD, Yoo CK, Lim HH, Chare SW: Vinegar treatment in the management of granular myringitis. J Iaryngol Otol 2002; 116: ) Ikeda K, Morizono T: The preparation of acetic acid for use in otic drops and its effect on endocochlear potential and ph in inner ear fluid. Am J Otol 1989; 10: ) Gerber ME: The evolving role of ototopical therapy. Curr Opinion in Otolaryngology & Head Neck Surg 2000; 8: ) Aminifarshidmehr N: The management of chronic suppurative otitis media with acid media solution. Am J Otol 1996; 17: Effects of Burow's Solution as an Ear Drop on Intractable Chronic Suppurative Diseases of the External Ear Canal and Middle Ear Yoshihiko Terayama, M.D., Masahiko Takizawa, M.D., Hiroyuki Gotouda, M.D. Department of Otolaryngology, Teine Keijinkai Hospital, Sapporo Obj ective: Burow's solution was developed by Karl August von Burow in the 19th century as an ear drop. Thorp et al. reported its excellent effect on chronic suppurative otitis media in We applied Burow's solution to intractable chronic purulent diseases of the external and middle ear in the 12 months from February Subjects: Subjects were 25 ears of 21 patients years old, 10 men's ears and 15 women's ears-whose disease has continued for an average of 3.78 years. Diseases and patients are as follows: 1) 11 ears with postoperative mastoid cavity problems, 2) 7 ears with chronic external otitis and chronic eczema of the external ear canal, 3) 7 ears with fungal otitis externa, 4) 6 ears with chronic otitis media with perforation, and 5) 2 ears of chronic granulated myringitis. Method: The solution was dropped into the ear canal once a day for 10 min or cotton balls soaked with the solution were applied to the canal wall. Criteria of efficacy were divided into cured, effective and unchanged. Results: 8/11 ears with a cavity problem were cured (72.7%) and 3 ears showed treatment to be effective. All 7 ears with chronic external otitis and chronic eczema were cured. All 7 ears with fungal otitis externa were cured. 4/6 ears (66.6%) with chronic perforated otitis media were cured and 1 ear each showed treatment to be effective and 1 unchanged. Two chronic granurated myringitis were cured. Twenty of 25 ears (80%) were cured. Pre- and posttreatment audiometries showed almost the same. The cure appeared within 3 days to 3 weeks. The solution was not effective against mucoid secretion, cholesteatoma, or residual mastoid cells. The day after treatment, serous secretion appears temporarily. Conclusion: Burows's solution is seemed to be very effective and nonototoxic as an otic drop for treating suppurative ear diseases. Keywords: Burow's solution, intractable suppurative otitis, non-ototoxic eardrop, cavity problem J Otolaryngol Jpn 106: 28-33, 2003
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