by Kazacky 2007 3 12 1 1.1 1.1.1 Enterobacteriaceae Vibrionaceae Pasteurellaceae Enterobacteriaceae Escherichia Shigella Salmonella Yersinia Klebsiella Proteus Serratia Escherichia E. coli O LPS H EPEC; Enteropathogenic E. coli Intimin EIEC; Enteroinvasive E. coli ETEC; Enterotoxigenic E. coli LT L = heat-labile; ST(S = heat-stable; ) EHEC; Enterohaemorrhagic E. coli VTEC; Verotoxin-producing E. colistec; Shigatoxin-producing E. coli VT1 VT2 Stx1 Stx2 HUS; Haemolytic uremic syndrome O157 EAggEC; Enteroaggregative E. coli 1
Shigella Tenesmus 1 4 1 DHL E. coli SIM M S. dysenteriae A S. flexneri B S. boydii C S. sonnei D Salmonella 8 48-1 Salmonella 2 S. enterica 6 S. enterica subsp. enterica Serovar S. enterica serovar Typhi S. enterica serovar Typhimurium S. enterica serovar Enteritidis Yersinia Y. pestis 3 7 - Y. enterocolitica Y. pseudotuberculosis Klebsiella K. pneumoniae Proteus P. vulgaris P. mirabilis Serratia S. marcescens 2
Vibrionaceae Vibrio Aeromonas Plesiomonas Vibrio V. cholerae, V. parahaemolyticus V. vulnificus 2 TCBS V. cholerae TCBS 1 3 ORS GES V. parahaemolyticus TCBS TDH; Thermostable direct haemolysintrh; TDH-related haemolysin V. vulnificus Aeromonas A. hydrophila Plesiomonas P. shigelloides Pasteurellaceae Haemophilus Pasteurella Haemophilus H. influenzae H. ducreyi STD Pasteurella P. multocida 1.1.2 Pseudomonas Bordetella Brucella Francisella Legionella 3
Pseudomonas P. aeruginosa Bordetella B. pertussis Brucella B. melitensis Francisella F. tularensis Legionella L. pneumophila ARDS MOF 1.1.3 Listeria Corynebacterium Lactobacillus Mycobacterium Actinomyces Nocardia Listeria L. monocytogenes Corynebacterium C. diphtheriae Lactobacillus ph 4
Mycobacterium M. tuberculosis TB TB M. avium complex M. kansasii 25% M. leprae Actinomyces A. israelii Nocardia N. asteroides 1.1.4 Bacillus Clostridium Bacillus B. anthracis 2 24 B. cereus Clostridium C. tetani C. botulinum C. perfringens 5
C. difficile 1.1.5 Treponema Helicobacter Treponema T. pallidum subsp. Pallidum Helicobacter H. pylori 1.1.6 Staphylococcus Streptococcus Enterococcus Staphylococcus 2 S. aureus Staphylococcal scalded skin syndrome; SSSS-1 Toxic shock syndrome toxin 1; TSST-1 Toxic shock syndrome; TSS MRSA (Methicillin-resistant S. aureus) VRSA (Vancomycin-resistant S. aureus) Streptococcus S. pyogenes A Streptococcal toxic shock syndrome; STSS MOF S. agalactiae B S. sanguis viridans streptococci S. pneumoniae PRSP (Penicillinresistant S. pneumoniae) Enterococcus E. faecalis E. faecium VRE (Vancomycin-resistant Enterococci) 6
1.1.7 Neiseria Neiseria N. gonorrhoeae N. meningitidis 1.2 1.2.1 RNA Picornaviridae Enterovirus Poliovirus Coxsackievirus Rhinovirus Rhinovirus Hepatovirus A Hepatitis A virus A Flaviviridae Flavivirus Japanese encephalitis virus Yellow fever virus Dengue virus West Nile virus Hepacivirus C Hepatitis C virus C Togaviridae Rubivirus Rubella virus 7
Rabdoviridae Lyssavirus Rabies virus Orthomyxoviridae Influenzavirus A A Influenza A virus RNA 8 2 HA NA HA 13 NA 9 Paramyxoviridae Rubulavirus Mumps virus Morbillivirus Measles virus SSPE; Subacute sclerosing panencephalitis Reoviridae Rotavirus Rotavirus Coronaviridae Coronavirus SARS Severe acute respiratory syndrome coronavirus SARS Bynyaviridae Hantavirus Hantaan virus Arenanviridae Arenavirus Lassa virus 8
Filoviridae Marburgvirus Lake Victoria marburgvirus Ebolavirus Zaire ebolavirus Caliciviridae Norovirus Norwalk virus Retroviridae Deltaretrovirus HTLV-1 Human T-lymphotropic virus 1 T HTLV-1 HAM; HTLV-1 associated myelopathy Lentivirus HIV-1 Human immunodeficiency virus 1 AIDS STD HIV 1.2.2 DNA Poxviridae Orthopoxvirus Variola virus Vaccinia virus Parvoviridae Erythrovirus B19 Human parvovirus B19 Papillomaviridae Papillomavirus HPV Human Papillomavirus 9
Polyomaviridae Polyomavirus JC JC polyomavirus PML; Progressive multifocal leukoencephalopathy Adenoviridae Mastadenovirus Human adenovirus Herpesviridae Alphaherpesvirinae Simplexvirus HSV-1 (Human simplexvirus-1) Human herpesvirus 1 HSV-2 Human herpesvirus 2 HSV-1 Varicellovirus VZV (Varicella zoster virus) Human herpesvirus 3 Betaherpesvirinae Cytomegalovirus CMV (Cytomegalovirus) Human herpesvirus 5 HIV IM; Infectious Mononucleosis Roseolovirus HHV-6 Human herpesvirus 6 HHV-7 Human herpesvirus 7 Gammaherpesvirinae Lymphocryptovirus EBV (Epstein-Barr virus) Human herpesvirus 4 Rhadinovirus KSHV (Kaposi s sarcoma-associated herpesvirus) Human herpesvirus 8 10
Hepadnaviridae Orthohepadnavirus B Hepatitis B virus B B HBe (+) HBs HBs 1.3 Trypanosomatidae Trypanosoma T. brucei T. cruzi Leishmania L. donovani complex L. tropica complex L. mexicana complex L. braziliensis complex Entamoebidae Entamoeba E. histolytica Sarcocystidae Toxoplasma T. gondii Cryptosporidiidae Cryptosporidium C. parvum Plasmodiidae Plasmodium P. falciparum 11
P. vivax P. malariae 2 2.1 IFN MHC Class II T cross presentation MHC Class I CD8 + CTL Toll-like receptor (TLR) PRR; Pattern recognition receptor PRR LPS CpG-DNA dsrna PAMP; Pathogen-associated moleculer pattern IL-6 IL-12 TNF-α IFN-α/β PRR CD80 CD86 MHC Class II 2.2 2 2 4 Y Fab Fc Fab B V,J 2 V,D,J 3 B 1 Fc IgG IgA IgM IgE IgD 5 IgG ADCC IgA 2 12
IgM IgM B BCR IgM 5 IgE IgD B IgM IgM IgG B B BCR IgM BCR B BCR- MHC class II B professional APC Fc FcR MAC ADCC FcγRIII CD16 NK δγt FcɛRI IgE 13
2.3 2.4 2.5 3 Tight junction α-defensin M PRR IL-6 IL-12 TNF IFN-α/γ MHC Class I NK T M αβt γδt B T IgA 14