1 - d- etc etc d-tc ChE > < < < > > > or 1.1 1 d- < dtc Na + Na + I II ChE ChE ChE ( ) T Ca++ 1 Na + K + Na + Ach Ach Ach BTX Mg 2+ Ach CAT TTX Ach
1.2 M N M d- BBB / ChE etc ChE etc CCh BCh etc Ach ChE 2 Ach ChE PAM ChE
2 O O O O O O O O O O O O B BH + Na + ( )K + N N N Na + ph 1 2 etc pka=8.9 etc PABA 3 pka monoethyl glycinexylidine N- 4-hydroxy-2,6- dimethylaniline!! 1 pka=7 9 ph 3 PABA PABA pka ) 2 NE PABA Adr β 2
p56 fig.7-7 etc
3 N N ( ) ( ) M N N fast EPSP 1 2 C6 N N Ach (CH 3 ) 3 N-(CH 2 )n-n(ch 3 ) 3 6 10 N M But p65 fig.7-14 Na + IPSP 3 slow EPSP 4 1 fast EPSP Ach Ach N N 1msec 35msec Na + n n= n n=α 4 slow EPSP 2 Ach α 2 100msec etc 3 IPSP
4 p50 7-2 4.1 ACh CCh BCh ChE ++ + ± ++ +++ +++ + ++ ++ ++ +++ ± & ACh 4.1.1 > > > < <
5 α 1 Epi>NE Iso β 2 α 2 Epi>NE Iso? Ach β 1 Iso>Epi NE 1 β 2 Iso>Epi NE / ( etc) β 3 p52 fig.7-4 & Ach N N NE Epi NE 1 up up up
5.1 p71 7-17 NE etc COMT α 1 α 2 β 2 α β NE α 1 α 2 β 1 β 2 α 1 α 2 β 1 (β 2 ) β D β 1 β 1 α 1 β 2 α 1 β 2 2 β 1 β 1 β 2 2
5.2 Ch 5-HT D α 1 (sub: ) α 2 (NE ) α 1 α 2 β 1 β 2 β 1 β 2 (sub:β 2 ) α 1 14 48 α 2 NE H 1 Ach Mg-ATP MAO / NE NE NE NE
6 p106 10-1 / etc 2 3 / 6.1 p79 fig8-3
6.2 MAC ED 50 50% 1 MAC 1.5 2 4 / / B/G 12 2.5 0.5 1.4? 0.7 1.3 MAC 2.5 1.0 >100 1.5 0.2 2.0 3.7?? Y Y Y Y Y Y - - - - - - 3 +++ ++ ++ ++ +++ ++? +++ ++ - ++ ++ + + - ++ - ++ ++? ++ - - - - - - / - ++ +++ Glu-gen etc - ± ++ - - - - / / / Epi Ca
: < ( ) = < 80% MAC with GOF with GOE with / / / 6.3 / + 70 / ( ) 10 6.3.1 1 2 / etc < α 2 6.3.2 Epi 1 + etc 2 ;
6.3.3 6 3 6 3 (10 15 ) GABA A GABA Cl Ca 2+ Cl Na + CO 2 CYP450 6.3.4 etc etc
3 6.4 GABA A ( ) GABA A ( ) α 2 GABA : GABA α 2 & α 2 (α 2 α 2 ) 4- K + ( ) 3
7 µ κ + = 7.1 µ = 1 / / / / Ru/ / / CTZ ( / ) 3 4 2 5 6 7.1.1 (µ κ ) µ 1 µ / κ Ach σ δ / 4 2 Ach CO 2 3 5 6
7.2 ( 80 ) & 7.3 µ κ ( ) ( etc ) 7.4 n=narcotic µ κ δ n ++ + + n +++ + + β + + + + + ++ n + +
8 1 etc etc GABA B Ca 2+ K + 1 etc
9 etc D 2 1 GABA ( d) ( d) / ( d) ( ) D 2 GABA A GABA ( ) ++ - ++ - + - α + - D + - + ++ - ++ - ++ ( & ) ( &.+ ) / d=derivative etc & & 1/10 1 - D<ACh
10 / 10.1 10.1.1 m m m +++ +++ + + + ++ ++ +++ +++ +++ + + ++ ++ ++ camp PDE Ca 2+ Ca 2+ His 10.1.2 & / NE/Epi/5-HT
10.2 p95 fig8-7 GABA A GABA GABA ( Cl Cl ) / 1 OK etc Clostridium tetani Renshaw Renshaw 1 :
11 11.1 & / (?) 11.2 1 11.3 β 2 -Adr β 1 NG + 2 1 2 C PGF 2α
12 12.1 / etc d- His-N- etc H 1 H 2 / 3 / / H 1 M( ) +++ ++ ++ ++ ++++ +++ ++ + H 2 ( r ) ( r ) ( r ) Na
12.2 5-5-HT (90%) / ( ) MAO 1 NO 5-HT 1 &5-HT 2 (for ) 5-HT LSD (for / ) 5-HT 1 5-HT 2
12.3 RAA Na Cl II / / Na + PG / / ADH p105 9-5 ACE AT 1
12.4 - ph Hageman XII 2 PGE 2 ( p106) 2 B 2 B 1 des-arg des-arg B 3 etc
12.5 ( p107 PGs PGE 2 PGI 2 TXA 2 PGF 2 α LTB 4 LTC/D/E 4 WBC/ PGI 2 TXA 2 PGI 2 TXA 2 12.6 cf.
13 ( p115) 13.1 NSAIDs 13.1.1 COX( ) COX PGG 2 PGH 2 PG TX 1 PGE PGE ( ) / / etc PG & PGI2( ) TXA 2 ( ) DNA COX TXA 2 PGI 2-13.1.2 COX-1 PGE 2 PGI 2 VitK CTZ NSAID COX PG / ( Na) COX PGE2 PGE2 LT LT PGF 2 α/pge 2 PGs / GABA ( / / / ) 1 PGE PGE
13.1.3 / + ( ) COX ( ) COX etc 13.2 etc 1. A2 2. COX-2 PG/TX 3. 4. WBC / φ 5. 14 15
16 K Vit.K Fib DIC Vit.K Vit.K K etc II IX X ADP Na 2 EDTA Ca 2+ IV iv,im po i.m. p.o. p.o. i.m/v. Vit.B 12 1 Vit.B 12 Vit.B 12 RBC 1 Vit.B 12 RBC
t-pa