/ B B ( ) ( -298) VL VH( ) Very Low( ) Very High( ) ( 10 2 %) (g/l) ( 10 2 %) 0.75 ( 10 2 %) 0.15 ( 10 2 %)

/ B B ( ) ( -298) VL VH( ) Very Low( ) Very High( ) (10 2 %) 0.32 0.55 0.37 0.55 95 165 115 185 (10 2 %) 0.75 (10 2 %) 0.15 (10 2 %) 0.10 10 2 % 0.10 10 2 % 0.15 10 2 % 0.10 Bands(10 2 %) 0.10 (10 9 75 700 10 12 3.0 6.0 3.5 6.5 (10 9 3.0 14.0 25 390 (mmol 12 38 BUN/Urea (mmol 10.71 Ca (mmol 2.05 2.99 Cl mmol 90 118 (µmol 176.80 (mmol 2.5 9.71 (mmol 0.55 1.78 LDH 750 mmol 3.0 6.0 (mmol 126 1 SGOT/ASAT SGPT/ALAT 150 165 (µmol 34.20 45 100 (µmol 505.58 624.54 582

-299 (N=1337) (N=1148) (N=817) 66 (4.9) 835 (62.5) 901 (67.4) 38 (3.3) 736 (64.1) 774 (67.4) 33 (4.0) 531 (65.0) 4 (69.0) 40 (3.1) 693 (51.8) 733 (54.8) 20 (1.7) 596 (51.9) 616 (53.7) 15 (1.8) 453 (55.4) 468 (57.3) 1 (<1) 17 (1.3) 18 (1.3) 0 16 (1.4) 16 (1.4) 0 12 (1.5) 12 (1.5) 1 (<1) 0 1 (<1) 0 1 (<1) 1 (<1) 0 0 0 25 (1.9) 272 (20.3) 297 (22.2) 12 (1.0) 210 (18.3) 222 (19.3) 13 (1.6) 225 (27.5) 238 (29.1) 1 (<1) 2 (<1) 3 (<1) 2 (<1) 1 (<1) 3 (<1) 0 4 (<1) 4 (<1) 22 (1.6) 246 (18.4) 268 (20.0) 13 (1.1) 214 (18.6) 227 (19.8) 12 (1.5) 151 (18.5) 163 (20.0) BUN 16 (1.2) 63 (4.7) 79 (5.9) 6 (<1) 53 (4.6) 59 (5.1) 9 (1.1) 48 (5.9) 57 (7.0) /UREA 0 0 0 0 0 0 0 1 (<1) 1 (<1) 0 2 (<1) 2 (<1) 0 2 (<1) 2 (<1) 0 0 0 4 (<1) 27 (2.0) 31 (2.3) 2 (<1) 21 (1.8) 23 (2.0) 0 25 (3.1) 25 (3.1) 15 (1.1) 242 (18.1) 257 (19.2) 12 (1.0) 209 (18.2) 221 (19.2) 9 (1.1) 133 (16.3) 142 (17.4) 0 2 (<1) 2 (<1) 0 2 (<1) 2 (<1) 0 0 0 2 (<1) 16 (1.2) 18 (1.3) 1 (<1) 14 (1.2) 15 (1.3) 2 (<1) 7 (<1) 9 (1.1) K 0 9 (<1) 9 (<1) 0 7 (<1) 7 (<1) 0 3 (<1) 3 (<1) SGOT 5 (<1) 18 (1.3) 23 (1.7) 5 (<1) 15 (1.3) 20 (1.7) 5 (<1) 13 (1.6) 18 (2.2) /ASAT SGPT 3 (<1) 14 (1.0) 17 (1.3) 3 (<1) 9 (<1) 12 (1.0) 3 (<1) 12 (1.5) 15 (1.8) /ALAT 10 (<1) 25 (1.9) 35 (2.6) 8 (<1) 23 (2.0) 31 (2.7) 6 (<1) 21 (2.6) 27 (3.3) 34 (2.5) 169 (12.6) 203 (15.1) 17 (1.5) 143 (12.5) 160 (13.9) 19 (2.3) 101 (12.4) 120 (14.7) LDH 3 (<1) 17 (1.3) 20 (1.5) 3 (<1) 17 (1.5) 20 (1.7) 2 (<1) 19 (2.3) 21 (2.6) ( ) : 1: 7: : 2 3 4 5 6 8 583

0 16 (51.6) 16 (51.6) 0 16 (29.1) 16 (29.1) 0 16 16 (28.6) 0 5 (16.1) 5 (16.1) 0 2 (3.6) 2 (3.6) 0 4 (7.1) 4 (7.1) / Part ( -300) ICU ( -301-303) Part Part (N=31) (N=55) (N=) 0 23 (74.2) 23 (74.2) 0 38 (69.1) 38 (69.1) 0 32 (57.1) 32 (57.1) 0 20 (64.5) 20 (64.5) 0 29 (52.7) 29 (52.7) 0 29 (51.8) 29 (51.8) 0 17 (54.8) 17 (54.8) 0 24 (43.6) 24 (43.6) 0 21 (37.5) 21 (37.5) 0 10 (32.3) 10 (32.3) 0 15 (27.3) 15 (27.3) 0 17 (30.4) 17 (30.4) Ca 0 3 (9.7) 3 (9.7) 0 7 (12.7) 7 (12.7) 0 7 (12.5) 7 (12.5) 0 2 (6.5) 2 (6.5) 0 0 0 0 0 0 0 0 0 0 2 (3.6) 2 (3.6) 0 0 0 0 7 (22.6) 7 (22.6) 0 25 (45.6) 25 (45.6) 0 15 (26.8) 15 (26.8) 0 1 (3.2) 1 (3.2) 0 2 (3.6) 2 (3.6) 0 2 (3.6) 2 (3.6) 0 0 0 0 1 (1.8) 1 (1.8) 0 0 0 0 1 (3.2) 1 (3.2) 0 2 (3.6) 2 (3.6) 0 1 (1.8) 1 (1.8) SGOT/ASAT 0 1 (3.2) 1 (3.2) 0 5 (9.0) 5 (9.0) 0 4 (7.1) 4 (7.1) SGPT/ALAT 0 1 (3.2) 1 (3.2) 0 2 (3.6) 2 (3.6) 0 2 (3.6) 2 (3.6) Na 0 0 0 0 1 (1.8) 1 (1.8) 0 0 0 0 0 0 0 3 (5.5) 3 (5.5) 0 1 (1.8) 1 (1.8) ( ) : 1: 7: : 2 3 4 5 6 8 Part Part (N=12) (N=6) (N=6) 10 (83.3) 0 10 (83.3) 5 (83.3) 0 5 (83.3) 5 (83.3) 0 5 (83.3) 7 (58.3) 1 (8.3) 8 (66.7) 5 (83.3) 0 5 (83.3) 5 (83.3) 0 5 (83.3) 2 (16.7) 0 2 (16.7) 3 (50.0) 0 3 (50.0) 4 (66.7) 0 4 (66.7) 4 (33.3) 0 4 (33.3) 0 4 (66.7) 4 (66.7) 2 33.3 1 16.7 3 (50.0) 1 (8.3) 0 1 (8.3) 0 0 0 0 0 0 1 (8.3) 5 (41.6) 6 (50.0) 1 (16.7) 0 1 (16.7) 2 (33.3) 0 2 (33.3) 5 (41.6) 0 5 (41.6) 2 (33.3) 0 2 (33.3) 4 (66.7) 0 4 (66.7) 0 4 (33.3) 4 (33.3) 0 0 0 0 0 0 BUN/Urea 6 (50.0) 0 6 (50.0) 2 (33.3) 0 2 (33.3) 4 (66.7) 0 4 (66.7) 1 (8.3) 0 1 (8.3) 0 0 0 1 (16.7) 0 1 (16.7) 0 1 (8.3) 1 (8.3) 0 0 0 0 0 0 ( ) : 1: 7: : 2 3 4 5 6 8 584

Part Part (N=85) (N=178) (N=175) 11 (12.9) 62 (72.9) 73 (85.9) 15 (8.4) 145 (81.5) 160 (89.9) 11 (6.3) 144 (82.3) 155 (88.6) 9 (10.6) 58 (68.2) 67 (78.8) 7 (3.9) 127 (71.3) 134 (75.2) 5 (2.9) 143 (81.7) 148 (84.6) 0 2 (2.4) 2 (2.4) 0 7 (3.9) 7 (3.9) 0 6 (3.4) 6 (3.4) 1 (1.2) 0 1 (1.2) 0 0 0 0 0 0 8 (9.4) 41 (48.2) 51 (60.0) 3 (1.7) 101 (.7) 104 (58.4) 5 (2.9) 116 121 (69.1) 1 (1.2) 0 1 (1.2) 1 (0.6) 1 (0.6) 2 (1.1) 0 2 (1.1) 2 (1.19) 4 (4.7) 20 (23.5) 24 (28.2) 8 (4.5) 46 (25.8) 54 (30.3) 5 (2.9) 46 (26.3) 51 (29.1) 0 0 0 1 (0.6) 0 1 (0.6) 0 0 0 0 0 0 0 0 0 0 1 (0.6) 1 (0.6) 15 (17.6) 40 (47.1) 55 (64.7) 14 (7.9) 109 (61.2) 123 (69.1) 14 (8.0) 106 (60.6) 120 (68.6) AL-P 1 (1.2) 0 1 (1.2) 0 3 (1.7) 3 (1.7) 0 1 (0.6) 1 (0.6) BUN/UREA 3 (3.5) 4 (4.7) 8 (9.4) 1 (0.6) 22 (12.4) 23 (12.9) 2 (1.1) 24 (13.7) 26 (14.9) 0 1 (1.2) 1 (1.2) 0 0 0 0 1 (0.6) 1 (0.6) Ca 26 (30.6) 53 (62.4) 79 (92.9) 50 (28.1) 116 (65.2) 166 (93.3) 37 (21.1) 123 (70.3) 160 (91.4) 0 0 0 0 0 0 0 2 (1.1) 2 (1.1) Cl 1 (1.2) 1 (1.2) 2 (2.4) 4 (2.2) 0 3 (1.7) 0 0 0 0 5 (5.9) 5 (5.9) 0 7 (3.9) 7 (3.9) 0 14 (8.0) 14 (8.0) 1 (1.2) 27 (31.8) 28 (32.9) 7 (3.9) 47 (26.4) 54 (30.3) 4 (2.3) 50 (28.6) 54 (30.9) 1 (1.2) 0 1 (1.2) 1 (0.6) 9 (5.1) 10 (5.6) 1 (0.6) 7 (4.0) 8 (4.6) 1 (1.2) 1 (1.2) 2 (2.4) 2 (1.1) 7 (3.9) 9 (5.1) 2 (1.1) 5 (2.9) 7 (4.0) 0 0 0 0 3 (1.7) 3 (1.7) 1 (0.6) 1 (0.6) 2 (1.1) K 0 1 (1.2) 1 (1.2) 0 4 (2.2) 4 (2.2) 0 0 0 SGOT/ASAT 0 4 (4.7) 4 (4.7) 1 (0.6) 9 (5.1) 10 (5.6) 2 (1.1) 5 (2.9) 7 (4.0) SGPT/ALAT 0 4 (4.7) 4 (4.7) 1 (0.6) 5 (2.8) 6 (3.4) 1 (0.6) 6 (3.4) 7 (4.0) 1 (1.2) 3 (3.5) 4 (4.7) 1 (0.6) 10 (5.6) 11 (6.2) 4 (2.3) 5 (2.9) 9 (5.1) 12 (14.1) 33 (38.8) 45 (52.9) 12 (6.7) 96 (53.9) 108 (60.7) 12 (6.9) 87 (49.7) 99 (.6) Na 0 0 0 0 0 0 0 2 (1.1) 2 (1.1) 0 0 0 1 (0.6) 1 (0.6) 2 (1.1) 1 (0.6) 4 (2.3) 5 (2.9) ( ) : 1: 7: : 2 3 4 5 6 8 Part Part (N=92) (N=203) (N=198) 7 (7.6) 65 (70.7) 72 (78.3) 18 (8.9) 149 (73.4) 167 (82.3) 17 (8.6) 159 (80.3) 176 (88.9) 4 (4.3) 60 (65.2) 64 (69.6) 8 (3.9) 137 (67.5) 145 (71.4) 5 (2.5) 142 (71.7) 147 (74.2) 0 0 0 0 0 0 0 1 (0.5) 1 (0.5) 1 (1.1) 2 (2.2) 3 (3.3) 0 3 (1.5) 3 (1.5) 0 5 (2.5) 5 (2.5) 3 (3.3) 47 (51.1) 50 (54) 6 (3.0) 102 (50.2) 108 (53.2) 4 (2.0) 114 (57.6) 118 (59.6) 0 1 (1.1) 1 (1.1) 1 (0.5) 4 (2.0) 5 (2.5) 0 5 (2.5) 5 (2.5) 1 (1.1) 23 (25.0) 24 (26.1) 4 (2.0) 63 (31.0) 67 (33.0) 4 (2.0) 42 (21.2) 46 (23.2) 0 0 0 1 (0.5) 0 1 (0.5) 0 0 0 1 (1.1) 0 1 (1.1) 0 0 0 1 (0.5) 0 1 (0.5) 3 (3.3) 41 (45) 44 (48) 6 (3.0) 114 (.2) 120 (59.1) 10 (5.1) 108 (54.5) 118 (59.6) Al-P 0 (0 1 (1.1) 1 (1.1) 0 0 0 0 0 0 BUN/UREA 1 (1.1) 5 (5.4) 6 (6.5) 2 (1.0) 13 (6.4) 15 (7.4) 2 (1.0) 15 (7.6) 17 (8.6) 0 (0 0 (0 0 0 1 (0.5) 1 (0.5) 0 1 (0.5) 1 (0.5) Ca 21 (22.8) 61 (66.3) 82 (89.1) 59 (29.1) 127 (62.6) 186 (91.6) 49 (24.7) 142 (71.7) 191 (96.5) 0 0 0 0 1 (0.5) 1 (0.5) 0 0 0 Cl 0 3 (3.3) 3 (3.3) 2 (1.0) 6 (3.0) 8 (3.9) 1 (0.5) 2 (1.0) 3 (1.5) 1 (1.1) 2 (2.2) 3 (3.3) 1 (0.5) 2 (1.0) 3 (1.5) 0 8 (4.0) 8 (4.0) 2 (2.2) 33 (35.9) 35 (38.0) 4 (2.0) 64 (31.5) 68 (33.5) 4 (2.0) 59 (29.8) 63 (31.8) 3 (3.3) 8 (8.7) 11 (12.0) 4 (2.0) 11 (5.4) 15 (7.4) 5 (2.5) 16 (8.1) 21 (10.6) 2 (2.2) 1 (1.1) 3 (3.3) 0 7 (3.4) 7 (3.4) 3 (1.5) 5 (2.5) 8 (4.0) 1 (1.1) 1 (1.1) 2 (2.2) 1 (0.5) 4 (2.0) 5 (2.5) 1 (0.5) 4 (2.0) 5 (2.5) K 0 2 (2.2) 2 (2.2) 0 0 0 0 (0) 2 (1.0) 2 (1.0) SGOT/ASAT 0 3 (3.3) 3 (3.3) 2 (1.0) 5 (2.5) 7 (3.4) 2 (1.0) 3 (1.5) 5 (2.5) SGPT/ALAT 0 3 (3.3) 2 (2.2) 1 (0.5) 1 (0.5) 2 (1.0) 0 1 (0.5) 1 (0.5) Na 0 0 0 0 1 (0.5) 1 (0.5) 0 1 (0.5) 1 (0.5) 1 (1.1) 5 (5.4) 6 (6.5) 6 (3.0) 7 (3.4) 13 (6.4) 2 (1.0) 13 (6.6) 15 (7.6) 5 (5.4) 36 (39.1) 41 (44.6) 4 (2.0) 94 (46.3) 98 (48.3) 7 (3.5) 90 (45.5) 97 (49.0) 1 (1.1) 0 1 (1.1) 1 (0.5) 1 (0.5) 2 (1.0) 0 (0) 2 (1.0) 2 (1.0) ( ) : 1: 7: : 2 3 4 5 6 8 585

B ( -304) CABG 61% RBC VL N=148 N=147 0 0 0 2 (1.4) 0 2 (1.4) 95 (64.2) 43 (29.1) 138 (93.2) 91 (61.6) 40 (27.2) 131 (89.1) 70 (47.3) 51 (34.5) 121 (81.8) 65 (44.2) 51 (34.7) 116 (78.9) 0 0 0 0 1 (0.7) 1 (0.7) 2 (1.4) 3 (2.0) 5 (3.4) 5 (3.4) 1 (0.7) 6 (4.1) RBC 49 (33.1) 46 (31.1) 95 (64.2) (38.1) 35 (23.8) 91 (61.9) 1 (0.7) 1 (0.7) 2 (1.4) 0 1 (0.7) 1 (0.7) WBC 28 (18.9) 13 (8.8) 41 (27.7) 22 (15.0) 12 (8.2) 34 (23.1) 30 (20.3) 22 (14.9) 52 (35) 21 (14.3) 20 (13.6) 41 (27.9) Al-P 0 0 0 1 (0.7) 0 1 (0.7) BUN/Urea 6 (4.1) 5 (3.4) 11 (7.4) 13 (8.8) 8 (5.4) 21 (14.3) 77 (52.0) 32 (21.6) 109 (73.6) 80 (54.4) 32 (21.8) 112 (76.2) 0 0 0 1 (0.7) 0 1 (0.7) 1 (0.7) 4 (2.7) 5 (3.4) 0 2 (1.4) 2 (1.4) GGT 14 (9.5) 3 (2.0) 17 (11.5) 7 (4.8) 1 (0.7) 8 (5.4) 0 0 0 1 (0.7) 0 1 (0.7) 17 (11.5) 20 (13.5) 37 (25.0) 23 (15.6) 16 (10.9) 39 (26.5) 5 (3.4) 7 (4.7) 12 (8.1) 6 (4.1) 9 (6.1) 15 (10.2) 2 (1.4) 0 2 (1.4) 0 0 0 LDH 0 2 (1.4) 2 (1.4) 1 (0.7) 1 (0.7) 2 (1.4) 0 0 0 1 (0.7) 0 1 (0.7) 0 2 (1.4) 2 (1.4) 0 0 0 SGOT/ASAT 2 (1.4) 3 (2.0) 5 (3.4) 1 (0.7) 2 (1.4) 3 (2.0) SGPT/ALAT 0 0 0 1 (0.7) 1 (0.7) 2 (1.4) 3 (2.0) 1 (0.7) 4 (2.7) 1 (0.7) 0 1 (0.7) 14 (9.5) 9 (6.1) 23 (15.5) 11 8 (5.4) 19 (12.9) 1 (0.7) 0 1 (0.7) 0 2 (1.4) 2 (1.4) ( ) : 1: 7: : 2 3 4 5 6 8 586

1 (1.6) 1 (1.6) 2 (3.2) 3 (2.3) 0 3 (2.3) B ( -305) (Loading 6.0g/kg/hr 10 ) (Loading 3.0g/kg/hr 20 ) (6.0g/kg/hr) (N=62) (3.0g/kg/hr) (N=130) 21 (33.9) 33 (53.2) 54 (87.1) 46 (35.4) 65 (50.0) 111 (85.4) 0 0 0 0 1 (0.8) 1 (0.8) 5 (8.1) 26 (41.9) 31 (50.0) 19 (14.6) 61 (46.9) 80 (61.5) 0 0 0 0 1 (0.8) 1 (0.8) 0 0 0 0 1 (0.8) 1 (0.8) 3 (4.8) 21 (33.9) 24 (38.7) 16 (12.3) 47 (36.2) 63 (48.5) 0 0 0 0 1 (0.8) 1 (0.8) 3 (4.8) 13 (21.0) 16 (25.8) 6 (4.6) 29 (22.3) 35 (26.9) 1 (1.6) 11 (17.7) 12 (19.4) 1 (0.8) 21 (16.2) 22 (16.9) 8 (12.9) 20 (32.3) 28 (45.2) 13 (10.0) 46 (35.4) 59 (45.4) 0 0 0 0 1 (0.8) 1 (0.8) BUN/UREA 0 3 (4.8) 3 (4.8) 2 (1.5) 12 (9.2) 14 (10.8) 30 (48.4) 27 (43.5) 57 (91.9) 60 (46.2) 47 (36.2) 107 (82.3) Cl 0 1 (1.6) 1 (1.6) 2 (1.5) 0 2 (1.5) 0 1 (1.6) 1 (1.6) 0 1 (0.8) 1 (0.8) -GTP 4 (6.5) 3 (4.8) 7 (11.3) 9 (6.9) 8 (6.2) 17 (13.1) 0 0 0 0 1 (0.8) 1 (0.8) 2 (3.2) 9 (14.5) 11 (17.7) 4 (3.1) 22 (16.9) 26 (20.0) 2 (3.2) 0 2 (3.2) 1 (0.8) 2 (1.5) 3 (2.3) 0 1 (1.6) 1 (1.6) 1 (0.8) 1 (0.8) 2 (1.5) LDH 0 2 (3.2) 2 (3.2) 0 1 (0.8) 1 (0.8) 1 (1.6) 0 1 (1.6) 1 (0.8) 1 (0.8) 2 (1.5) 0 0 0 1 (0.8) 1 (0.8) 2 (1.5) SGOT/ASAT 1 (1.6) 4 (6.5) 5 (8.1) 0 2 (1.5) 2 (1.5) SGPT/ALAT 0 3 (4.8) 3 (4.8) 2 (1.5) 4 (3.1) 6 (4.6) 0 0 0 0 2 (1.5) 2 (1.5) 0 1 (1.6) 1 (1.6) 0 1 (0.8) 1 (0.8) 0 2 (3.2) 2 (3.2) 0 4 (3.1) 4 (3.1) 0 0 0 1 (0.8) 1 (0.8) 2 (1.5) ( ) : 1: 7: : 2 3 4 5 6 8 587

-306 0.1g/kg 1 0.3 0.6g/kg 0.1g/kg 1 24 PT APTT 72 0.3 0.6g/kg 0.3g/kg 1 0.1 /L N=3 0.3 /L N=3 0.6 /L N=3 1(33.3) 0 1(33.3) 0 1(33.3) 0 1(33.3) 0 3(100.0) 0 0 0 2(66.6) 0 3(100.0) 0 1(33.3) 0 0 0 0 1(33.3) 0 0 0 2(66.6) 0 1(33.3) 0 0 0 0 0 2(66.6) 0 0 1(33.3) 0 0 0 0 0 PT 1(33.3) 1(33.3) 2(66.6) 0 2(66.6) 0 APTT 0 2(66.6) 0 1(33.3) 0 1(33.3) Al-P 0 0 0 1(33.3) 0 1(33.3) 1(33.3) 0 1(33.3) 0 0 1(33.3) 1(33.3) 0 0 0 2(66.6) 0 A/G 0 0 0 0 1(33.3) 0 0 0 0 1(33.3) 0 0 0 2(66.6) 0 2(66.6) 0 1(33.3) 1(33.3) 0 1(33.3) 0 1(33.3) 0 K 1(33.3) 0 0 0 1(33.3) 0 SGOT/ASAT 0 0 1(33.3) 0 0 0 SGPT/ALAT 0 1(33.3) 0 0 0 1(33.3) LDH 0 0 2(66.6) 0 2(66.6) 0 1(33.3) 0 0 0 1(33.3) 0 0 0 0 0 0 1(33.3) BUN 0 0 0 1(33.3) 0 0 Fe 0 0 0 0 2(66.6) 0 0 1(33.3) 0 2(66.6) 0 3(100.0) 0 1(33.3) 0 1(33.3) 0 0 0 0 0 0 0 1(33.3) -307 588

589 (N=30) 0.2g/kg (N=31) 0.4g/kg (N=28) 0.6g/kg (N=25) 0.8g/kg (N=25) 287/1110 312/1147 231/1036 282/925 207/925 0 14 (46.7) 14 (46.7) 3 (9.7) 15 (48.4) 18 (58.1) 1 (3.6) 10 (35.7) 11 (39.3) 0 15 (60.0) 15 (60.0) 0 12 (48.0) 12 (48.0) 0 13 (43.3) 13 (43.3) 2 (6.5) 10 (32.3) 12 (38.7) 0 13 (46.4) 13 (46.4) 0 11 (44.0) 11 (44.0) 0 10 (40.0) 10 (40.0) 0 2 (6.7) 2 (6.7) 0 4 (12.9) 4 (12.9) 0 4 (14.3) 4 (14.3) 0 5 (20.0) 5 (20.0) 0 1 (4.0) 1 (4.0) 1 (3.3) 11 (36.7) 12 (40.0) 1 (3.2) 6 (19.4) 7 (22.6) 1 (3.6) 11 (39.3) 12 (42.9) 0 12 (48.0) 12 (48.0) 0 7 (28.0) 7 (28.0) 0 1 (3.3) 1 (3.3) 0 0 0 0 0 0 0 1 (4.0) 1 (4.0) 0 0 0 0 5 (16.7) 5 (16.7) 1 (3.2) 5 (16.1) 6 (19.4) 0 4 (14.3) 4 (14.3) 0 8 (32.0) 8 (32.0) 0 3 (12.0) 3 (12.0) 2 (6.7) 13 (43.3) 15 (50.0) 4 (12.9) 7 (22.6) 11 (35.5) 3 (10.7) 11 (39.3) 14 (50.0) 0 11 (44.0) 11 (44.0) 0 7 (28.0) 7 (28.0) 0 14 (46.7) 14 (46.7) 3 (9.7) 15 (48.4) 18 (58.1) 2 (7.1) 9 (32.1) 11 (39.3) 0 13 (52.0) 13 (52.0) 0 12 (48.0) 12 (48.0) 0 13 (43.3) 13 (43.3) 2 (6.5) 15 (48.4) 17 (54.8) 2 (7.1) 11 (39.3) 13 (46.4) 0 16 (64.0) 16 (64.0) 0 14 (.0) 14 (.0) 0 5 (16.7) 5 (16.7) 1 (3.2) 6 (19.4) 7 (22.6) 0 2 (7.1) 2 (7.1) 0 3 (12.0) 3 (12.0) 0 1 (4.0) 1 (4.0) 0 6 (20.0) 6 (20.0) 2 (6.5) 11 (35.5) 13 (41.9) 1 (3.6) 8 (28.6) 9 (32.1) 0 15 (60.0) 15 (60.0) 0 11 (44.0) 11 (44.0) 0 9 (30.0) 9 (30.0) 4 (12.9) 4 (12.9) 8 (25.8) 1 (3.6) 6 (21.4) 7 (25.0) 0 9 (36.0) 9 (36.0) 0 5 (20.0) 5 (20.0) 0 2 (6.7) 2 (6.7) 5 (16.1) 3 (9.7) 8 (25.8) 1 (3.6) 0 1 (3.6) 0 3 (12.0) 3 (12.0) 0 2 (8.0) 2 (8.0) 1 (3.3) 21 (70.0) 22 (73.3) 2 (6.5) 22 (71.0) 24 (77.4) 0 17 (60.7) 17 (60.7) 0 20 (80.0) 20 (80.0) 0 14 (.0) 14 (.0) 1 (3.3) 19 (63.3) 20 (66.7) 4 (12.9) 19 (61.3) 23 (74.2) 3 (10.7) 17 (60.7) 20 (71.4) 0 18 (72.0) 18 (72.0) 0 17 (68.0) 17 (68.0) A/G 1 (3.3) 5 (16.7) 6 (20.0) 3 (9.7) 5 (16.1) 8 (25.8) 2 (7.1) 0 2 (7.1) 0 0 0 0 1 (4.0) 1 (4.0) 1 (3.3) 14 (46.7) 15 (50.0) 4 (12.9) 14 (45.2) 18 (58.1) 1 (3.6) 6 (21.4) 7 (25.0) 0 12 (48.0) 12 (48.0) 0 9 (36.0) 9 (36.0) 0 8 (26.7) 8 (26.7) 1 (3.2) 4 (12.9) 5 (16.1) 1 (3.6) 7 (25.0) 8 (28.6) 0 9 (36.0) 9 (36.0) 0 6 (24.0) 6 (24.0) 0 6 (20.0) 6 (20.0) 0 0 0 0 1 (3.6) 1 (3.6) 0 4 (16.0) 4 (16.0) 0 1 (4.0) 1 (4.0) 0 3 (10.0) 3 (10.0) 2 (6.5) 4 (12.9) 6 (19.4) 0 3 (10.7) 3 (10.7) 0 6 (24.0) 6 (24.0) 0 1 (4.0) 1 (4.0) SGOT/ASAT 2 (6.7) 9 (30.0) 11 (36.7) 3 (9.7) 5 (16.1) 8 (25.8) 4 (14.3) 1 (3.6) 5 (17.9) 0 6 (24.0) 6 (24.0) 1 (4.0) 1 (4.0) 2 (8.0) SGPT/ALAT 3 (10.0) 6 (20.0) 9 (30.0) 3 (9.7) 4 (12.9) 7 (22.6) 5 (17.9) 1 (3.6) 6 (21.4) 0 7 (28.0) 7 (28.0) 1 (4.0) 4 (16.0) 5 (20.0) -GTP 1 (3.3) 3 (10.0) 4 (13.3) 0 1 (3.2) 1 (3.2) 1 (3.6) 0 1 (3.6) 0 5 (20.0) 5 (20.0) 0 5 (20.0) 5 (20.0) LDH 0 2 (6.7) 2 (6.7) 1 (3.2) 4 (12.9) 5 (16.1) 2 (7.1) 3 (10.7) 5 (17.9) 0 6 (24.0) 6 (24.0) 0 1 (4.0) 1 (4.0) ALP 1 (3.3) 4 (13.3) 5 (16.7) 2 (6.5) 6 (19.4) 8 (25.8) 1 (3.6) 1 (3.6) 2 (7.1) 0 5 (20.0) 5 (20.0) 0 6 (24.0) 6 (24.0) CPK 1 (3.3) 15 (50.0) 16 (53.3) 2 (6.5) 14 (45.2) 16 (51.6) 3 (10.7) 14 (50.0) 17 (60.7) 0 17 (68.0) 17 (68.0) 0 18 (72.0) 18 (72.0) Na 0 2 (6.7) 2 (6.7) 0 1 (3.2) 1 (3.2) 1 (3.6) 1 (3.6) 2 (7.1) 0 3 (12.0) 3 (12.0) 0 5 (20.0) 5 (20.0) K 0 2 (6.7) 2 (6.7) 0 4 (12.9) 4 (12.9) 0 2 (7.1) 2 (7.1) 0 3 (12.0) 3 (12.0) 1 (4.0) 1 (4.0) 2 (8.0) Cl 0 1 (3.3) 1 (3.3) 0 1 (3.2) 1 (3.2) 1 (3.6) 5 (17.9) 6 (21.4) 0 2 (8.0) 2 (8.0) 0 6 (24.0) 6 (24.0) Ca 0 15 (50.0) 15 (50.0) 3 (9.7) 16 (51.6) 19 (61.3) 1 (3.6) 12 (42.9) 13 (46.4) 0 14 (.0) 14 (.0) 0 11 (44.0) 11 (44.0) P 0 3 (10.0) 3 (10.0) 1 (3.2) 4 (12.9) 5 (16.1) 1 (3.6) 5 (17.9) 6 (21.4) 0 7 (28.0) 7 (28.0) 0 6 (24.0) 6 (24.0) ph 0 2 (6.7) 2 (6.7) 0 2 (6.5) 2 (6.5) 0 1 (3.6) 1 (3.6) 0 2 (8.0) 2 (8.0) 0 1 (4.0) 1 (4.0) 0 5 (16.7) 5 (16.7) 2 (6.5) 4 (12.9) 6 (19.4) 0 3 (10.7) 3 (10.7) 0 3 (12.0) 3 (12.0) 0 1 (4.0) 1 (4.0) 0 2 (6.7) 2 (6.7) 0 3 (9.7) 3 (9.7) 0 0 0 0 1 (4.0) 1 (4.0) 0 0 0 0 14 (46.7) 14 (46.7) 1 (3.2) 12 (38.7) 13 (41.9) 1 (3.6) 2 (7.1) 3 (10.7) 0 8 (32.0) 8 (32.0) 0 4 (16.0) 4 (16.0) 0 3 (10.0) 3 (10.0) 0 0 0 0 0 0 0 2 (8.0) 2 (8.0) 0 0 0 ( ) : :

( -308) N 95% 95% N 95% 95% N 95% 95% 0.4 0.0 0.4-0.1* 0.4 0.0 (10 2 1046 915 641 %) 1077 124.0-17.0 936 126.0-19.0* 673 123.0-18.0 1.5 1.5 1.5 1.5 1.8 1.8 212.0-32.0 214.5-35.0* 212.0-31.0 (x10 9 947 832 579 5.0 3.3 5.5 3.8 6.5 4.5 3.9-0.4 4.0-0.4 3.8-0.3 (x10 12 673 533 469 7.4 3.3 7.2 3.3 7.6 3.3 (x10 9 1075 934 666 0.2 0.3 BUN/Urea 1131 5.0-0.4 976 5.0-0.5 706 5.0-0.4 (mmol 0.1 0.2 1091 23.9 1.2 942 24.0 1.1 685 23.6 1.4 (mmol 1127 74.0-2.0 971 79.0-2.0* 708 70.7 0.0 (umol 1.0 1.2 1.8 1.3 1.7 1.0 1094 6.1 1.2 946 6.0 1.3* 688 6.3 1.2 (mmol 0.2 0.1 0.2 0.1 LDH 598 192.0 24.0 598 192.0 24.0 358 178.5 19.0 12.0 8.0 12.0 8.0 14.0 9.0 1104 4.1-0.1 952 4.1-0.1 696 4.2-0.1 (mmol SGOT/ASAT 1082 21.0 3.0 933 21.0 3.0 683 22.0 2.0 0.5 1.0 0.5 1.0 0.8 1.3 SGPT/ALAT 1067 18.0-1.0 918 18.0-1.0 672 18.0-1.0 0.8 0.8 0.8 0.5 0.8 0.8 10 9.0 1.0 907 9.0 1.7 665 9.3 1.0 (umol 0.3 0.4 0.4 0.4 1083 62.0-8.3 927 64.0-10.0 684 63.0-8.0 1.0 0.8 1.0 0.8 1.3 1.1 *p0.05; van Elteren test 95% Half length ICU GOT N 95% 95% N 95% 95% N 95% 95% 0.3 0.0 0.3 0.0 0.3 0.0 (10 2 419 288 273 %) 443 105.0-2.0 302 105.0 0.0 296 104.0 0.0 2.0 1.8 2.3 2.5 2.3 2.5 181.0-4.0 175.0-2.0 172.0-1.0 (10 9 354 239 222 7.0 4.5 8.5 5.3 8.3 5.8 3.6-0.1 3.5 0.0 3.5 0.0 (10 12 442 302 296 8.4 2.9 8.4 2.7 8.6 2.3 (10 9 443 302 296 0.4 0.4 0.5 0.5 0.5 0.5 BUN/Urea 483 4.9 0.4 328 4.9 0.6 320 4.8 0.6 (mmol 0.2 0.3 0.2 0.3 458 21.7 2.2 309 21.6 2.3 305 21.4 2.3 (mmol 0.3 0.4 0.3 0.4 484 64.0 0.0 328 65.0 2.0 320 65.0 2.0 (umol 2.0 1.5 2.3 1.8 2.5 2.0 457 7.5 0.1 309 7.4 0.1 302 7.7-0.1 (mmol 473 4.1-0.1 321 4.2-0.1 313 4.2-0.1 (mmol 0.0 0.1 0.0 0.1 0.0 0.1 SGOT/ASAT 460 23.0 4.0 311 23.0 5.0* 306 24.0 3.0 1.3 1.8 1.5 2.0 1.8 2.0 SGPT/ALAT 460 16.0 2.0 311 16.0 2.0 306 15.0 1.0 1.3 0.8 1.5 1.0 1.3 1.0 453 1 304 1 302 10.0-1.0 (umol 0.5 0.5 0.8 0.5 1.0 0.5 484 48.0 5.0 328 47.0 5.0 320 46.0 5.0 1.0 1.0 1.3 1.0 1.3 1.0 *p0.05; van Elteren test 95% Half length 590

/ Part ( -310) Part Part Part N Q1Q3 N Q1Q3 N Q1Q3 N Q1Q3 N Q1Q3 N Q1Q3 90% 90% 90% 90% 90% 90% 38.70-6.80 38.05-6.20 40.35-5.65 29 35.1041.50 27-12.30-3.50 54 34.4042.70 48-10.15-1.95 36.5042.65 50-11.60-2.50 (37.1440.45) (-9.12-5.38) (37.3939.73) (-7.57-4.85) (38.5340.63) (-8.13-5.21) 12.80-2.20 12.55-1.95 13.20-2.20 29 11.6013.60 27-3.40-1.20 54 11.2014.00 48-3.15-0.70 (g/dl) 12.0013.90 51-4.10-0.70 (12.2113.33) (-2.94-1.67) (12.2413.02) (-2.45-1.) (12.5813.29) (-2.75-1.73) 20.50-10.70 18.40-9.20 19.10-9.90 29 16.7024.00 26-13.30-7.80 53 13.8024.00 46-13.10-6.00 55 (10000 15.3023.40 45-12.30-7.80 (18.4322.19) (-13.05-9.21) (18.1222.34) (-12.32-8.68) (18.3121.00) (-10.64-8.82) 406.0-61.0 399.0-59.5 423.0-57.5 29 375.0434.0 27-106.0-37.0 54 376.0445.0 48-103.5-23.5 (10000 379.04.0 50-120.0-21.0 (391.1430.5) (-94.9-53.6) (393.0416.8) (-76.4-49.0) (403.9427.8) (-83.6-52.3) 5700.0 8300.0 5400.0 6300.0 5100.0 6150.0 29 5000.07100.0 27 4000.012200.0 54 4400.07000.0 48 4400.09200.0 ( 4150.06400.0 50 4100.09000.0 (5423.96403.7) (6246.010168.8) (5285.26096.3) (6288.68544.8) (5001.495.1) (6131.98220.1) 1.70-1.30 2.60-2.20 2.65-2.30 27 1.003.20 23-2.50-0.90 51 1.704.90 45-4.00-1.00 54 1.604.30 47-4.30-1.00 (1.663.25) (-2.87-1.23) (2.904.38) (-3.70-2.22) (2.493.38) (-3.18-2.20) 65.00 24.40 57.70 23.00 59.70 21.60 27 55.1068.60 23 16.8034.00 51 49.0067.30 45 14.2033.50 54 53.4067.30 47 10.6030.50 (60.3065.83) (19.7228.64) (54.9760.59) (20.5227.52) (.81.62) (17.3023.83) 0.60-0.50 0.80-0.70 0.80-0.70 27 0.001.00 23-1.000.00 51 0.401.30 45-1.00-0.40 54 0.401.30 47-1.20-0.20 (0.490.96) (-0.74-0.24) (0.761.08) (-0.99-0.63) (0.700.99) (-0.93-0.61) 4.80-2.50 6.30-1.00 6.30-1.10 27 3.007.10 23-3.400.00 51 5.007.90 45-3.100.40 54 4.008.20 47-4.300.70 (4.275.73) (-2.52-0.85) (5.706.76) (-1.99-0.65) (5.526.65) (-2.15-0.71) 28.40-19.20 31.40-20.20 30.30-17.50 27 22.7033.70 23-30.50-11.70 51 24.1038.30 45-27.20-9.50 54 22.8036.50 47-26.50-3.00 (25.9131.59) (-24.47-15.58) (28.9533.85) (-21.95-15.85) (28.4733.32) (-19.08-12.27) 591

Part Part Part N Q1Q3 N Q1Q3 N Q1Q3 N Q1Q3 N Q1Q3 N Q1Q3 90% 90% 90% 90% 90% 90% 16.0 0.0 16.0 1.5 17.0 2.0 BUN/Urea 12.021.0 29-4.07.0 14.020.0 54-4.06.0 14.020.0 55-5.06.0 mg/dl 31 55 (15.119.8) (-2.44.1) (16.118.9) (0.34.6) (16.618.9) (-0.72.5) 6.70-2.25 5.60-2.00 6.00-2.30 5.107.70 28-3.30-1.10 4.806.80 54-2.70-0.80 5.057.30 55-3.00-1.50 mg/dl 31 55 (5.937.10) (-2.61-1.59) (5.265.98) (-2.14-1.51) (5.816.53) (-2.62-2.12) 1.00 0.00 1.00 0.00* 0.90 0.00 0.801.20 29-0.100.10 0.901.10 54 0.000.20 0.801.10 55-0.100.10 mg/dl 31 55 (0.941.09) (-0.030.09) (0.951.05) (0.040.14) (0.911.00) (-0.020.06) 95.5 50.0 108.0.5* 103.0 37.0 86.0106.0 28 34.074.5 91.0129.0 54 29.099.0 90.5125.5 55 16.065.0 mg/dl 30 55 (94.7109.3) (44.878.4) (108.2126.5) (55.696.4) (105.1122.2) (33.753.1) 4.10-0.30 4.00-0.30 3.90-0.40 31 3.804.30 29-0.600.00 55 3.704.20 54-0.700.10 3.704.20 55-0.70-0.10 (g/dl) (3.964.20) (-0.43-0.11) (3.874.04) (-0.41-0.18) (3.823.99) (-0.43-0.24) 163.0-52.5 155.0-41.0 155.0-39.0 ALP 31 121.0196.0 28-90.5-22.5 55 133.0201.0 54-67.0-29.0 136.5205.0 55-59.0-21.0 (IU (152.8195.9) (-74.4-40.9) (160.1186.6) (-59.0-40.8) (166.6213.8) (-65.0-39.7) 20.0 20.0 20.0 33.0 18.0 27.0 SGOT/ASAT 31 16.022.0 29 6.053.0 55 16.027.0 54 6.058.0 15.026.5 55 14.044.0 (IU (18.327.6) (6.2114.0) (20.826.5) (31.355.6) (20.425.5) (28.671.3) 19.0-1.0 19.0 0.00 17.0 2.0 SGPT/ALAT 31 13.028.0 29-7.011.0 55 13.033.0 54-7.09.0 13.038.5 55-3.010.0 (IU (19.531.2) (-22.474.9) (20.126.3) (0.825.0) (20.327.6) (-2.941.1) 27.0-6.5 20.0-5.0 19.5-7.0 -GTP 31 9.036.0 28-20.0-1.5 55 11.030.0 54-9.0-2.0 12.032.5 55-13.0-2.0 (IU (23.445.9) (-25.1-5.4) (20.731.2) (-13.9-5.8) (22.940.8) (-15.2-6.2) 0.50 0.40 0.40 0.40 0.40 0.20 0.300.70 29 0.000.80 0.400.70 54 0.100.70 0.300.70 55 0.100.60 mg/dl 31 55 (0.400.85) (0.371.53) (0.460.60) (0.340.57) (0.470.63) (0.280.55) 6.90-0.90 6.80-0.85 6.80-0.90 31 6.407.30 29-1.30-0.60 55 6.507.20 54-1.40-0.50 6.207.05 55-1.20-0.60 (g/dl) (6.606.99) (-1.15-0.72) (6.636.87) (-1.10-0.78) (6.526.79) (-0.98-0.73) 140.0-2.0 140.0-1.0 139.0-1.0 Na 31 139.0141.0 29-3.00.0 55 138.0141.0 54-3.01.0 138.5141.0 55-4.00.0 (meq (138.2140.2) (136.3138.5) (139.0140.1) (-1.8-0.2) (139.2140.1) (-2.3-1.0) 4.30 0.10 4.10 0.00 4.10 0.00 K 31 3.904.70 29-0.600.50 55 4.004.50 54-0.400.30 3.904.40 55-0.400.40 (meq (4.214.59) (-0.310.28) (4.204.45) (-0.170.26) (4.084.28) (-0.140.20) 102.0-3.0 104.0-2.5 104.0 101.0 Cl 31 100.0105.0 29-5.01.0 55 102.0106.0 54-5.00.0 101.0106.0 55-5.01.0 (meq (101.4103.8) (-4.0-1.2) (103.3104.6) (-3.8-2.0) (103.0104.2) (-3.3-1.6) 9.30-0.40 9.20-0.50 9.20-0.50 Ca 31 9.109.60 29-0.60-0.20 55 8.909.60 54-0.80-0.10 8.859.40 55-0.70-0.20 (mg/dl) (9.139.43) (-0.540.62) (9.089.33) (-0.65-0.28) (9.069.27) (-0.58-0.36) 3.50-0.70 3.60-0.60 3.50-0.90 P 31 55 (mg/dl) (3.363.78) (-1.13-0.54) (3.433.67) (-0.75-0.39) (3.433.67) (-0.99-0.66) 6.0 0.0 6.0 0.0 6.0 0.0 ph 29 5.57.0 24-0.81.0 55 5.06.5 52-0.51.5 5.06.0 54-0.51.0 (5.96.6) (-0.30.6) (5.86.2) (0.20.8) (5.76.2) (-0.10.6) *p0.05; Part Wilcoxon 2 3.104.10 29-1.50-0.20 3.203.90 54-1.10-0.10 3.303.85 55-1.30-0.40 ICU (W97-245W97-246) / (J-DEX-99-001) 592