1309 6ﾑ806ｦﾐ 縺06 ﾞ02 ﾇ 096ﾑ806ｦﾐ09ｦ 036ｾ4 ﾇ6ｾ4 6ﾑ8070ｷ3036ｧ90ｹ0 0000080707060409 6ｧ86 5090ｹ0 0400 0208036ｧ9020406 0000 046ｦ007 03080008 Wolf-Hirschhorn ﾞ. 0103060402080808036ｧ9 090ｹ0, 09. 0409000902030607 080ｸ7, A. 09 apple 036ｧ9ｨB080ｸ7,. 09 03 03fi0ｹ0,. ﾒ 02ｨBfi0ｹ0 A00 09 06 06 020306026ｧ8 ﾒ03060706026ｧ8, ﾞ0905, 05000404 0308076ｧ90209 Christoforidis ﾞ, Dimitriadou 09, Paparizou A, Pardalos G, Katzos G. Early onset of puberty in a girl with Wolf- Hirschhorn syndrome. 1 st Dept of Pediatrics, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece. Paediatr N Gr 2010, 22: 55-59. 0900036ｧ903096 709. ｦ 08 046ｦ007 03080008 Wolf- Hirschhorn apple08020003006ｧ9 04apple07-0706 06 02 03 046ｧ8, 09 08apple086ｧ9 apple030802 03006ｧ902 06 applefi apple06030006000ｹ0 040208 6 503 046ｦ0 0402 閨03080ｹ0 02080ｸ7 04030ｷ30008040600 02080ｹ0 4 02 06 04 03 020209036ｧ9ｨB0002 06 applefi 020907 02fi03080ｸ70309 0200020307 : 0708090206026ｧ8 0ｸ70402 閨03090409, 00apple0603096 76ｧ9, 02 030ｸ70402 閨03090409 6ｦ0010904090ｹ0 02 06 0ｸ70400080308060207 04 03 02020903060402060207 apple03080406apple080ｸ7. ﾇ 040300076ｧ80ｹ0 00 0ｹ0 6ｧ802 07 閨07 0208036ｧ9020406 8 00020607 02 06 10 0009070607 0000 020ｸ7apple0602fi 08 0607fi020ｸ7apple08 02080ｸ7 040ｸ707 03fi00080ｸ7 Wolf- Hirschhorn 02 06 0000080707060409 030903 03046ｧ80ｹ0 applefi 06006ｧ807080ｸ7. ﾇ 08020600 046ｧ9 LHRH 6ｧ802 07 0007 0006020206026ｧ8 6ｧ86 5090ｹ0 0001 030206000007090ｹ0 applefi 02060ｹ0 090807 08-020308apple6ｧ907000ｹ0, 09 08apple086ｧ9 apple 03fi0206 0007 000008 076ｧ90402090200 apple 0308030809060207 apple03060600, 0ｷ30402fi0408 0100026ｧ907090400 00070ｷ3036ｧ9020003 applefi 020907 090306026ｧ9 020ｷ307 10 00020607, 090306026ｧ9 09 08apple086ｧ9 apple08020003006ｧ9 0208 00 閨0408 0403fi0708 閨07 0301090ｹ0 02090ｹ0 6ｧ86 5090ｹ0 020ｷ307 020803060204060607 04020907 6ﾑ8030307. ｦ 08 08 0607fi00000708 0ｸ702fi 02 03006ｧ902 06 0000070ｷ3036ｧ90ｹ0 0000080707060409 02090ｹ0 6ｧ86 5090ｹ003 02 06 0400 0803060400 閨07000ｹ0 apple00-0306apple02060400060ｹ0, fiapple0ｷ30ｹ0 0400 04030007006ｧ90ｹ0 0000 07000ｸ70308-07 apple020ｸ70106 02 閨0ｹ0 06-02 03 04 閨0ｹ0, 04036ｧ8ｨB0006 030003 apple000ｸ70206026ｧ80ｹ0 apple 03 閨006 5 04090ｹ0. 閨0100060ｹ0-02030006 0607: Wolf-Hirschhorn 046ｦ007 03080008, 00070ｷ3036ｧ90ｹ0 0000-080707060409 6ｧ86 5090ｹ0, 0707030809 GnRH. Abstract. Wolf- Hirschhorn syndrome is a rare disorder caused by deletions in the short arm of chromosome 4 and characterized by the following quartet: mental retardation, epilepsy, growth delay and cranio-facial dysgenesis. This is a case of an 8 years and 10 months old girl with typical phenotype of Wolf Hirschhorn syndrome and thelarche since 2 months. LHRH test was indicative of gonadotropin-dependent puberty that, although not pathologically precocious, it started earlier than the age of 10 years which is the mean age for onset of puberty in greek girls. This phenomenon is termed as early onset of puberty and in certain circumstances, as in patients with neurodevelopmental disabilities, need to be considered for treatment intervention. Key words: Wolf-Hirschhorn syndrome, early onset of puberty, GnRH. 6ﾑ80604 090ｷ3096ｧ8 ｦ 08 046ｦ007 03080008 Wolf-Hirschhorn 006ｧ907 06 04apple07070608 (040ｸ70407fi- 020902 1:50.000 090007076ｧ80400060ｹ0) 02 06 0808006ｧ9030002 06 0400 apple06030006 0900-0700020602086ｦ0 0ｸ7030602086ｦ0 040208 020003080000030602fi 02006ｧ800 02080ｸ7 6 503 04 閨080ｹ0 0402 閨03080ｸ70ｹ0 02080ｸ7 04030ｷ30008040600 02080ｹ0 4 1. 09030ｷ30208apple00030609030708090200 0208 1965 applefi 02080ｸ70ｹ0 Hirschhorn 02 06 Wolf 02 06 00 閨040306 046ｧ8-000003 006ｧ907 06 02 02 09000903 0000 閨07 04020907 apple 0902fi040006 6 5066 5030608-0903 086ｧ9 apple00036ｧ9apple080ｸ7 200 apple0003060402 02060207 2. ﾌ06 apple070404080702000ｹ0 applefi 0208 046ｦ007 03080008 000008 076ｧ9ｨB080ｸ707 0607040ｸ70209 07000ｸ70308 07 apple020ｸ70106 026ｧ8 06 02 03 046ｧ8, 0900090807fi0ｹ0 apple080ｸ7 02080ｸ70ｹ0 02 0306040207 000ｸ7 6ｧ904030902080ｸ70ｹ0 040209 06 04006ｧ903090409 03000007020ｷ307 0008096 5006ｧ9 0ｹ0. 030ｹ0 閨07 030109 6ｧ86 5090ｹ0 0402 0208036ｧ9020406 08036ｧ9ｨB0002 06 09 000008070706-0409 000ｸ7020003000ｸ7fi07020ｷ307 04 03 0202090306040206020607 02080ｸ7 086ｦ003080ｸ7, apple080ｸ7 080ｸ7040608030809060207 040ｸ7006 5 6ｧ9070006 00000207 020907 090306026ｧ9 020ｷ307 8 00020607. 030402fi0408, 09 00 閨0409 090306026ｧ9 00000807070604090ｹ0 02090ｹ0 6ｧ86 5090ｹ0 apple 03080ｸ7-040607ｨB0006 000ｸ703006ｧ9 06 026ｦ000 070409 0402060ｹ0 0607080803000ｹ0 000307fi020902000ｹ0, 020ｸ7-00 0607fi00000709 applefi 8,8-11,2 閨0209 3. ﾇ 00 閨0409 090306026ｧ9 000008070706-04090ｹ0 6ｧ86 5090ｹ0 02 06 0000000907 03046ｧ80ｹ0 04020807 6ﾑ8030309070602fi apple0309030ｸ70400fi 006ｧ907 06 02 10,6 02 06 12,3 閨0209 07026ｧ90402080604 3. ｦ 020003000ｸ702 6ｧ9 0403fi0706 096ｧ9070002 06 080308 閨07 02 06 apple0003060404fi020003080ｹ0 03fi09080ｹ0 0906 020907 0000070ｷ3036ｧ90ｹ0 0000080707060409 6ｧ86 5090ｹ003 0ｸ7apple08 09030607080702 0ｹ0 閨020406 020907 0000-080707060409 02090ｹ0 6ｧ86 5090ｹ0 000002 016ｦ0 020ｷ307 8-10 00020607, 0903 6ｧ8 fi0406
1356 09 06 06 020306026ｧ8 B ﾌ066ﾑ8I ﾌ08 6ﾑ8 ﾞ04 ﾌ6ｾ4, 22, 1 apple 0308030809060207 apple03060600, 030307 00070ｷ3036ｧ9020003 applefi 020907 07 0000-07fi00000709 00 閨0409 090306026ｧ9 00000807070604090ｹ04. ﾇ 00070ｷ3036ｧ90ｹ0 0000080707060409 02090ｹ0 6ｧ86 5090ｹ0 apple08020003006ｧ9 040ｸ7040707 6ｧ9020608 apple03086 5030900 02060400086ｦ0 020ｷ307 090807-0ｷ307, 000706 0803060400 閨07000ｹ0 080803 閨0ｹ0 04036ｧ8ｨB0006 apple 03 閨006 5 04090ｹ0. 09000306090307080002 06 09 apple00036ｧ9apple020ｷ30409 04030007086ｦ00ｹ0 0000 046ｦ007-03080008 Wolf-Hirschhorn 03fi090ｷ3 02090ｹ0 04apple 0706fi020902 0ｹ0 02090ｹ0 apple00-036ｧ9apple020ｷ304090ｹ0, 030307 02 06 03fi090ｷ3 02090ｹ0 00070ｷ3036ｧ90ｹ0 00000807070604090ｹ0 6ｧ86 5090ｹ0 02 06 020ｷ307 040006030604000607 apple080ｸ7 apple 06026ｧ8030902 07. 090003060903 086ｧ8 apple00036ｧ9apple020ｷ304090ｹ0 ﾒ08036ｧ9020406 090306026ｧ9 0ｹ0 8 00020607 02 06 10 0009070607, 0000 09070ｷ30402fi 046ｦ007-03080008 Wolf-Hirschhorn, 0006046ｧ8040309 apple03080903 0000 02060400 閨07 04020907 ﾒ03060706026ｧ8 0906 0007 0802030607080308090602fi 閨0300090408 02090ｹ0 apple03fi040306 0ｹ0 0ｸ7applefi080ｸ704090ｹ0 02 06 0002026ｧ900090409 02090ｹ0 6ｧ86 5090ｹ0. ﾇ 060709070ｷ30409 02080ｸ7 040ｸ707-03fi00080ｸ7 02 閨03090200 apple0308090007070902060207, fi02 07 0400 090306026ｧ9 026ｦ00904090ｹ0 32 006 5 080007 0ｷ307, 0001 06026ｧ9 0ｹ0 0007 08006ｧ8020306 0ｹ0 0ｸ704020308086ｧ9 0ｹ0, 0600-070003096ｧ803090200 00070608apple 03 02 閨0702090409. ﾌ 00006 5030ｸ70602fi0ｹ0 02 030ｸ7fi- 020ｸ7apple080ｹ0 [460101,del (4)(p16.1)(WHSCR-)], 02080ｸ7 08apple086ｧ9080ｸ7 09 0203060706026ｧ8 040ｸ707 鐶pple0006 006ｧ907 06 0208 046ｦ007 03080008 Wolf-Hirschhorn, 09070ｷ3040208apple08066ｧ803090200 00000207 0209 09 閨0707090409 02080ｸ7 apple 06 06086ｦ0, 09 08apple086ｧ9 閨09060700 0400 090306026ｧ9 026ｦ00904090ｹ0 35 006 5 080007 0ｷ307 02 06 0000 02 0604-0306026ｧ8 0208006ｧ8 03fi090ｷ3 02090ｹ0 apple0308 07 080003fi000007090ｹ0 0007 08006ｧ8020306 0ｹ0 0ｸ704020308086ｧ9 0ｹ0. ﾌ 閨03000904080ｹ0 02080ｸ7 02 030ｸ708026ｦ0apple080ｸ7 020ｷ307 090807 閨0ｷ307 6ｧ802 07 080ｸ70406080308090602fi0ｹ0, 08applefi0200 02 06 09 apple06030006 02080ｸ7 090007000206-02086ｦ0 0ｸ7030602086ｦ0 03000ｷ3036ｧ803090200 de novo. ﾒ 0207 0209 070008090706026ｧ8 09-0306026ｧ9 0708040903006ｦ002090200 0400 00080707 000702 0206026ｧ80ｹ0 0708040903006ｧ9 0ｹ0 0906 060704020900 31 090000030607 03fi090ｷ3 6ｧ8apple06 0ｹ0 apple00030609000707090206026ｧ80ｹ0-04080ｸ7016ｧ9 0ｹ0, apple 0308 06026ｧ80ｹ0 02 046ｦ0apple070806 0ｹ0 02 06 0007 08006ｧ8020306 0ｹ0 0ｸ7-04020308086ｧ9 0ｹ0, 000706 0402 apple03 6ｧ90406 02080ｸ7 0900070602fi020003080ｸ7 0003 閨0904080ｸ7 02080ｸ7 040ｸ707 03fi00080ｸ7 07 006ｧ904030902 07 00060203086ｦ0 000009 閨03080ｸ70ｹ0 0700-0803086ｧ9 000808020003fiapple03000ｸ703 02 06 0009 0006 060207 000ｸ7036ｧ800 02 0ｸ70109-00 閨07090ｹ0 09040809 閨070006 0ｹ0 02090ｹ0 0306040200036ｧ80ｹ0 020806036ｧ9 0ｹ0 02080ｸ7 000902000807-03080ｸ7. 6ｾ400 090306026ｧ9 13 0009070607, 0000080707060400 04apple 0400086ｦ00ｹ0 apple080ｸ7 040ｸ70708 006ｦ0080702 07 applefi apple 0308030809060207 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02 06 07070ｷ3 04006ｧ903080ｹ0, 0000 090ｷ3076ｧ90ｷ30409 apple03080ｹ0 02 0207020ｷ3 02080ｸ7 0402fi00 02080ｹ0, 04 0009036ｧ8 apple03fi- 04080ｸ70409 06020ｷ307 02 06 000602030808apple060403080907 03060400fi (6ﾑ80602. 1), 000706 6ｧ802 07 閨02 090309 09 02 030ｸ70402 閨03090409 02090ｹ0 040ｷ300 0206026ｧ80ｹ0 0707apple020ｸ7-01090ｹ0, 0000 02060ｹ0 040ｷ300 0208000002030602 閨0ｹ0 02090ｹ0 apple 03 00 閨0203080ｸ70ｹ0 07 6 5036ｧ9-0402080702 06 000202fi0ｹ0 080ｸ704060803080906020607 08036ｧ90ｷ307 [ｦﾌ0703080ｹ0: 20,8 Kg (<3 09 6ﾑ8.05.), 6ｨ86 7080ｹ0: 110,4 cm (<3 09 6ﾑ8.05.)]. 6ﾑ8apple06apple03 閨0807, 0000-08070706ｨB00 apple03 020ｸ7apple08 6ｧ9 02 06 閨010ｷ3 04020308086ｧ8 02090ｹ0 08070ｸ7040808fi03080ｸ7 080703 0909 0ｹ0 02080ｸ7 006ｧ9020209 02090ｹ0 030604020003070ｹ0 070203 0ｹ0 04000603fi0ｹ0 (6ﾑ80602. 2). 6ﾑ8apple06020806070ｷ307086ｦ00400 0000 03 030ｸ70909060400086ｦ00ｹ0 02 06 06046ｦ00303 6 5080ｸ70ｹ0 6ｧ804080ｸ70ｹ0, 6 507 06ｨB00 0000 0ｸ7apple0804026ｧ803060109, 040ｷ3036ｧ90ｹ0 閨0300090408 020ｷ307 040806-0902026ｧ8030ｷ307. ﾇ 0402 0608apple086ｧ9090409 02090ｹ0 6ｧ86 5090ｹ0 02 0207 ｦ anner, 00020206006ｧ8-03090200 0ｷ30ｹ0 00016ｧ80ｹ0: 00 閨090003080ｹ0 00 ｨB0602086ｦ0 閨07 : 2, 02036ｧ9040ｷ30409 00086ｧ8-6 5 06080ｸ7: 2, 02036ｧ9040ｷ30409 00 04040703090ｹ0: 2. ﾇ 08040206026ｧ8 02090ｹ0 090306026ｧ9 6ﾑ80602. 1. ﾇ 040300076ｧ80ｹ0 apple 03080ｸ7046ｧ9 ｨB00 0208 04 03 020209030604020602fi apple0308040ｷ3apple006ｧ908 02080ｸ7 040ｸ707 03fi00080ｸ7: 0ｸ7apple00030200030803060400fi0ｹ0, apple03 020607 03 0008080006 6ｧ8 006ｦ00209, 04020007fi 086ｧ903020308, 04020007fi 07070ｷ3 04006ｧ903080ｹ0 0000 090ｷ3076ｧ90ｷ30409 apple03080ｹ0 02 0207020ｷ3 02080ｸ7 0402fi00 02080ｹ0, 04 0009036ｧ8 apple03fi04080ｸ70409 06020ｷ307 02 06 000602030808apple060403080907 03060400fi.
1309 06 06 020306026ｧ8 B ﾌ066ﾑ8I ﾌ08 6ﾑ8 ﾞ04 ﾌ6ｾ4, 22, 1 57 6ﾑ80602. 2. 6ﾑ8030704040807000ｹ0 000ｸ7080402000300020602 閨0ｹ0 apple 03 00080308060400060ｹ0 fiapple0ｷ30ｹ0 閨010ｷ3 04020308086ｧ8 02090ｹ0 08070ｸ7040808fi03080ｸ7 080703 0909 0ｹ0 02080ｸ7 006ｧ9020209 02090ｹ0 030604020003070ｹ0 070203 0ｹ0 04000603fi0ｹ0 02 06 apple03 020ｸ7apple08 6ｧ9. 6ｧ802 07 040ｸ7006 5 026ｧ8 0000 0209 040308070803080906026ｧ8 02090ｹ0 090306026ｧ9. ｦ apple080200-03 閨0400 02 02080ｸ7 0007 0802030607080308090602086ｦ0 0003 閨0904080ｸ7 陦000601 07 080ｸ7-04060803080906026ｧ8 閨020203060409 0ｸ701090206026ｧ80ｹ0 080300fi07090ｹ0, 0008096 50602086ｦ0 026ｦ0- apple080ｸ7 apple070702090409 040209 08020600 046ｧ9 LHRH 02 06 080ｸ704060803080906026ｧ8 030ｸ70300080006 06026ｧ8 03000602080ｸ703096ｧ9. ﾇ 00 0907090206026ｧ8 020800080903 086ｧ9 0ｸ7apple0803 030700080ｸ7-0ｸ7applefi080ｸ704090ｹ0 6ｧ802 07 080ｸ704060803080906026ｧ8 02 06 000807 0602fi 006ｦ0030900 applefi 020907 MRI 00090200080703080ｸ7 6ｧ802 07 0208 apple 03080308090602fi MR 046ｧ800 040209 03000ｸ7026ｧ8 080ｸ7046ｧ9 020ｷ307 0000020ｷ3apple06 6ｧ90ｷ307 03086 50607. 6ﾑ801 06026ｧ9 0ｹ0 02090ｹ0 00070ｷ3036ｧ90ｹ0 00000807070604090ｹ0 6ｧ86 5090ｹ0 02090ｹ0 04030007086ｦ00ｹ0, 0000 0209 046ｦ000080ｷ30709 0907060009 020ｷ307 090807 閨0ｷ307, apple0808 046ｧ90402090200 09 07 040208036ｧ8 02090ｹ0 6ｧ86 5090ｹ0 0000 040ｸ7070300020602fi 070703080908 02090ｹ0 0002030ｸ70206-026ｧ80ｹ0 080300fi07090ｹ0 020ｷ307 090807 08020308apple06070607 (GnRH). 6ｾ40ｸ7ｨB6ｧ802090409 縺000700020602fi 閨0303000600 02080ｸ7 020003080000030602086ｦ0 02006ｧ800 02080ｹ0 02080ｸ7 6 503-04 閨080ｹ0 0402 閨03080ｸ70ｹ0 040208 04030ｷ300fi040ｷ300 4 0002080307ｨB0002 06 02030607060207 0ｷ30ｹ0 046ｦ007 03080008 Wolf-Hirschhorn, 040ｸ7076ｧ8030ｷ30ｹ0 090006080ｸ703-09006ｧ902 06 de novo, 000706 04apple 0706fi020003 006ｧ907 06 090807000ｸ8026ｧ80ｹ0 apple0308-03000ｸ704090ｹ0. ﾌ 6 5 040602fi0ｹ0 08 0607fi020ｸ7apple080ｹ0 02080ｸ7 040ｸ707 03fi00080ｸ7 040ｸ7076ｧ9-0402 02 06 04020907 0200020307 : ) 020ｸ7apple0602fi apple0308040ｷ3apple006ｧ908, 6 5) 0708090206-026ｧ8 0ｸ70402 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0307 020907 閨030300066 709 00apple6ｧ90409-000ｷ307 02 02000ｸ7030ｸ707026ｧ803060ｷ307 08 0909060607 0906 0209 030003 apple000ｸ70206026ｧ8 07-040208036ｧ8 02090ｹ0 00070ｷ3036ｧ90ｹ0 00000807070604090ｹ0 6ｧ86 5090ｹ0, 0806 0ｸ7apple070304080ｸ704000ｹ0 040ｸ7-0402070400060ｹ0 000603086ｦ007 0906 0001 0208006ｧ902000ｸ70409 02090ｹ0 02070300 apple00036ｧ9apple020ｷ3-04090ｹ04. 03020406 0000 0209 046ｦ000080ｷ30709 0907060009 020ｷ307 090807 閨0ｷ307, apple0808-046ｧ90402090200 09 07 040208036ｧ8 02090ｹ0 6ｧ86 5090ｹ0 02090ｹ0 04030007086ｦ00ｹ0 06040200 07 0803006ｧ9 08 apple 03 6ｧ9020902080ｹ0 0403fi07080ｹ0 apple030804 030008096ｧ80ｹ0 02 06 0800-036ｧ80ｹ0 000002076 5 04090ｹ0 040209 07 陦 0ｸ7026ｧ8 apple00036ｧ908 08. ﾇ apple03fi09070ｷ30409 02080ｸ7 040ｸ707 03fi00080ｸ7 Wolf-Hirschhorn, 00000207 02 apple030602 0403fi0706 ｨB0ｷ36ｧ80ｹ0, apple080ｸ7 apple08020003086ｦ007 apple00036ｧ908 08 0ｸ76 70903086ｦ0 020607 6ｦ007080ｸ7 03070902fi020902 0ｹ0 (21%), 040400026ｧ9ｨB0002 06 0000 02-03fi apple030804 fi02060008 00apple066 56ｧ90ｷ304090ｹ0 02 06 0001000306020206026ｧ8 apple0803006ｧ9 04020907 applefi0202090409 00010608026ｧ8020ｷ307. ﾇ 閨030300066 709 apple03fi040300020ｷ307, 0009 06040803-0308apple086ｦ00000070ｷ307 000002 03 閨04000ｷ307 09000700020602086ｦ0 0ｸ7030602086ｦ0 02 06 09 apple08-0308006ｧ8 020ｷ307 04apple 04000607 04020907 040300076ｧ8 apple080ｸ7 apple00030609030708090200 apple08020003086ｦ007 02 03086ｦ00ｹ0 apple030809070ｷ304020602086ｦ00ｹ0 apple 030709080702000ｹ0, 08applefi-
1309 06 06 020306026ｧ8 B ﾌ066ﾑ8I ﾌ08 6ﾑ8 ﾞ04 ﾌ6ｾ4, 22, 1 59 0200 09 00 閨03060007 apple06 apple08040208apple006ｧ9 04020907 0001 04080703060409 02 036ｦ0-020003090ｹ0 apple0806fi020902 0ｹ0 ｨB0ｷ36ｧ80ｹ0. ｦﾌ066 50306080903 086ｧ9 1. Zollino M, Murdolo M, Marangi G, Pecile V, Galasso C, Mazzanti L, et al. On the nosology and pathogenesis of Wolf-Hirschhorn syndrome: genotype-phenotype correlation analysis of 80 patients and literature review. Am J Med Genet C Semin Med Genet 2008, 148: 257-269. 2. Hirschhorn K. A short history of the initial discovery of the Wolf-Hirschhorn syndrome. Am J Med Genet C Semin Med Genet 2008, 148: 244-245. 3. Parent AS, Teilmann G, Juul A, Skakkebaek NE, Toppari J, Bourguignon JP. The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocr Rev 2003, 24: 668-693. 4. Mul D, Oostdijk W, Drop SL. Early puberty in girls. Best Pract Res Clin Endocrinol Metab 2002, 16: 153-163. 5. Battaglia A, Filippi T, Carey JC. Update on the clinical features and natural history of Wolf-Hirschhorn (4p-) syndrome: experience with 87 patients and recommendations for routine health supervision. Am J Med Genet C Semin Med Genet 2008, 148: 246-251. 6. Bergemann AD, Cole F, Hirschhorn K. The etiology of Wolf- Hirschhorn syndrome. Trends Genet 2005, 21: 188-195. 7. Fisch GS, Battaglia A, Parrini B, Youngblom J, Simensen R. Cognitive-behavioral features of children with Wolf- Hirschhorn syndrome: preliminary report of 12 cases. Am J Med Genet C Semin Med Genet 2008, 148: 252-256. 8. Battaglia A, Filippi T, South ST, Carey JC. Spectrum of epilepsy and electroencephalogram patterns in Wolf-Hirschhorn syndrome: experience with 87 patients. Dev Med Child Neurol 2009, 51: 373-380. 9. Titomanlio L, Romano A, Conti A, Genesio R, Salerno M, De Brasi D, et al. Mild Wolf-Hirschhorn phenotype and partial GH deficiency in a patient with a 4p terminal deletion. Am J Med Genet A 2004, 127: 197-200. 10. Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR, Antoniazzi F, et al. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics 2009, 123: e752-762. 11. Lazar L, Kauli R, Pertzelan A, Phillip M. Gonadotropin-suppressive therapy in girls with early and fast puberty affects the pace of puberty but not total pubertal growth or final height. J Clin Endocrinol Metab 2002, 87: 2090-2094. 12. Savasi I, Spitzer RF, Allen LM, Ornstein MP. Menstrual suppression for adolescents with developmental disabilities. J Pediatr Adolesc Gynecol 2009, 22: 143-149. ﾞ03030903080903 086ｧ9 : 09. 0409000902030607 080ｸ7 A03. 6ｾ4080ｸ70306060209 21 546 42-05000404 0308076ｧ90209 ｦ 0903.: 2310 414172 e-mail: meropid@auth.gr Correspondence auth08r: M. Dimitriadou Ath. Soulioti 21 546 42 - Thessaloniki Tel.: 2310 414172 e-mail: meropid@auth.gr Greece