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136ム80303090706026ァ8 03000803080308096ァ9 2011; 23 (1): 15-27 ゙07 0402fiapple090409 03 閨000ケ0 06 0402070400060ケ0 0906 0209 03000602080ク703096ァ9 02080ク7 040ク704026ァ800 02080ケ0 0300076ァ907090ケ0 ィC 0909000608020007046ァ907090ケ0 ィC 03 0804020003fi07090ケ0 6セ4. ニ06070202 03. 09 apple 09 030707090ケ0 0900036ァ903096 709 00apple0キ30ケ0 040ク7006 5 6ァ9070006 040ク7040707 04020907 00apple0604026ァ80009, 09 apple036ァ8 00016ァ809090409 0906 020907 0000apple0308026ァ8 02090ケ0 apple03080300076ァ907090ケ0 04020907 0006020308 0909000608apple07030006 02080ク7 04 0204 0306 080ク70ケ0 06 6 56ァ802080ク7 閨040006 00010003060403006ァ9 0400 閨07 03 6 56ヲ00306070308 apple08036ヲ0apple0308020キ307 030309030001 03-026ァ804000キ307 000002 016ヲ0 02090ケ0 apple03080300076ァ907090ケ0, 02080ク7 0800fi030809080ク7 0ク7apple08 0804 陦 02 06 020キ307 apple00apple0206 6ァ90キ307 apple080ク7 0702 090キ3076ァ9ィB080702 06 020907 閨070キ30409 apple03080300076ァ907090ケ0-0ク7apple08 0804 陦. ヲ apple08020003 閨0400 02 applefi 0209 046ヲ0090403080709 閨03000ク707 fi0406 00fi0708 02 02 閨0303066 7 07 apple 0306 閨0ケ0 apple00apple0806036ァ80400060ケ0 00 0ケ0 030307 090006086ヲ003090904 07 00030キ3026ァ800 02 0402 08apple086ァ9 apple03 鐶pple0006 07 0803086ヲ007 apple 07026ァ80400060ケ0 apple030802000600 閨07080ク7 07 096ァ9070006 02 036ヲ0020003 02 02 070809026ァ8 09 apple 0308080ク70406080308096ァ9 02090ケ0 000ク702000308apple 03086ヲ00ケ0 06040206026ァ80ケ0 6 503076 5090ケ0. 6セ40208 apple03 6ァ9040608 0ク702fi 0806 apple 030709080702000ケ0 apple080ク7 02 0308036ァ9ィB080ク707 0209 000002 0903 086ァ8, 020907 閨020803 0409 04020907 020ク70202 0306026ァ8 0000006 503070709 02 06 020907 apple000ク7 060403090208apple086ァ9090409 020キ307 0ク7apple08 0804-0キ307 02090ケ0 0909000608020007046ァ907090ケ0 006ァ907 06 0ク76 76ァ90402090ケ0 040900 046ァ9 0ケ0. ヲ 020003000ク702 6ァ9 0403fi0706 07 02 036ヲ00803090200 0006 0400060307 apple030キ302000ク8070607 apple080ク7 070206 03086ヲ007 0000 02080ク70ケ0 0ク7apple08 08-04006ァ90ケ0 02 06 02 0308036ァ9ィB080ク707 0208 00apple6ァ9apple00 08 030704090ケ0 02080ク70ケ0 02 06 020907 000002 016ヲ0 02080ク70ケ0 03-03090300apple6ァ9 03 0409. 0003000ケ0 0806 apple 03 apple07070キ3 apple03fi0408 02000ケ0 07 02 036ヲ06 700060ケ0 apple000306090307-08080702 06 04020907 apple 03086ヲ004 07 0402fiapple090409 0000 020907 apple00apple086ァ903090409 fi0206 apple08036ヲ0 046ヲ0-07020800 0806 07 02 036ヲ06 700060ケ0 0ク702 閨0ケ0 03 apple08020003086ヲ007 ー02000203060000 閨07000ケ0 ア 0907060400060ケ0. 閨0100060ケ0 02030006 0607: apple03080300076ァ90709, 0300076ァ90709, 0ク7apple08 0804 陦 0ケ0 02090ケ0 0300076ァ907090ケ0. 6ム80604 090キ3096ァ8 03000803080308090602fi ヲ 006ァ800 090003060800030006 02fi 縺00070602fi 03080408020800006ァ908 ゙0309070607 00 メ08030906 03 閨07000608-09apple00070702000608-6ム86ム86セ403, A036ァ807 ヲ 08 046ヲ004020900 0300076ァ907090ケ0 ィC 0909000608020007046ァ907090ケ0 ィC 03 0804020003fi07090ケ0 (6セ406 ゙ ゙) 6 5036ァ904020002 06 040208 02 閨07020308 02080ク7 0007 06 08 閨03080702080ケ0 02090ケ0 06 020306026ァ80ケ0 閨03000ク707 0ケ0 02 06 apple03 020206026ァ80ケ0 02 020003000ク702 6ァ9 100 0403fi0706 02080ク70307040604020807. 09 閨040306 apple08036ヲ0 apple03fi- 0408 02 0208 0007 06 08 閨030807 0ク702fi 080803086ヲ00400 apple08020300060402060207 0209 040900 046ァ9 02080ク7, 0906 0209 036ヲ00300060409 02090ケ0 0302090306 026ァ80ケ0 apple6ァ90004090ケ0 ( ゙09), 046ァ8000003 fi000キ30ケ0 09 閨03000ク707 00apple06020007020306070002 06 040209 040ク70000000208046ァ8 02080ク7 0400 0006 0400060307 ィB0キ30206020607 03000602080ク70309060607 02080ク7 080309 07060400086ヲ0. メ 02 03046ァ807 0208 6セ406 ゙ ゙ 006ァ907 06 apple 03 6ァ9-02090208 0906 0209 070008030809 閨07000409. ヌ 07 040208036ァ8 apple 03 090キ3096ァ80ケ0 0909000608020007046ァ907090ケ0 (angiotensin, Ang) 04020907 0007 08006ァ8020306 ィB0キ36ァ8, 006ァ90200 applefi 000002070303 0109 02080ク7 09080706 6ァ9080ク7, 006ァ90200 applefi 0408036ァ809090409 07 04020803 閨0キ307 02080ク7, 040ク70700apple07090002 06 0900-0700046ァ9 020キ307 0700080306020607 040キ3030907 036ァ90キ307 02080ク7 00006 5036ヲ0080ク7, 02fi0408 04020807 070703030キ3apple08 fi0408 02 06 0402 apple000603 00 02fiィB0キ3, 02 06 0402060ケ0 apple0003060404fi020003000ケ0 apple000306apple0206-0400060ケ0 006ァ907 06 046ヲ0006 5 0209 0000 0209 ィB0キ36ァ8 1,2. ゙applefi 02060ケ0 3-6 apple080303 apple03 閨0ケ0 03070400060ケ0 02080ク7 6セ406 ゙ ゙ 0002006ァ90709 apple080ク7 閨040006 020ク70306 030406026ァ8 040900 046ァ9 04020907 0203060706026ァ8 apple0307-0109, 030307 006ァ907 06 02 06 apple0608 6ヲ00402080308 07 apple08 00060403006ァ9, apple 0307 0208 apple036ァ803080ケ0 020キ307 0007 006ァ901000キ307 0906 020907 6ヲ0apple 03016ァ8 02090ケ0, 006ァ907 06 09 0700000409 02 02 040203080806026ァ8

136セ4. ニヲミ ゙ メ メ ゙, 03. 09 ゙09 ゙ 罍゙ ゙03 ヌ6セ4 6ム80303090706026ァ8 03000803o03o096ァ9 23, 2011 03070409 0400 040ク709020002030600 閨07080ク70ケ0 060402086ヲ00ケ0, fiapple0キ30ケ0 0806 07000803086ァ9, 0208 000ク708020703 0608 02 06 02 0909006ァ9, 0700010703020902 applefi 0209 00000904 0706026ァ803 6 503076 509 03fi090キ3 6ヲ0010904090ケ0 02090ケ0 ゙09 (blood pressure independent effect) 3-6. ヲ 0907 apple03060209 閨07 00060109 fi0206 09 0300076ァ90709 0ク7026ァ8 02 0300 0ク7-026ァ8 006ァ907 06 0ク7apple006ヲ0030ク70709 0906 0209 6 503076 509 020キ307 apple 03 apple07070キ3 06-04020607 apple 03006ァ904 07 02 apple08020003 閨0400 02 02090ケ0 000003 閨02090ケ0 020キ307 Luetscher 02 06 040ク707. 0208 1985 7 0806 08apple086ァ90806 07 閨080003 07 fi0206 02 00apple6ァ9apple00 02090ケ0 000009-03 040206026ァ80ケ0 0300076ァ907090ケ003 (inactive renin), 0903 6ァ8 02090ケ0 apple0308 0300076ァ907090ケ0, apple08020003086ヲ007 006ァ9020209 02090ケ0 apple0308046 508036ァ80ケ0 020キ307 0909006ァ90キ307 040208 04 0204 0306 09 06 6 56ァ80209 026ヲ0apple080ク7 2, 02 06 000703060402 fi0206 09 6ヲ001090409 020キ307 00apple06apple 陦0キ307 02090ケ0 04020807 0803fi, apple03080909006ァ902 06 020キ307 apple 0308030809 07 02080006020607 03-0308060604000キ307. 09000207 applefi 02036ァ9 0403fi0706 09 apple 03 026ァ803090409 0ク7026ァ8 00apple066 5006 5 060603090200 02 06 applefi 070303080ク70ケ08, 02 06 閨020406 0208 0007 06 08 閨030807 0402030708090200 04020907 apple0804 086ァ807060409 02080ク7 0009-04 07060400086ヲ0 0000 020807 08apple086ァ908 09 apple03080300076ァ90709 02 06 09 0300076ァ90709 (0806 08apple086ァ9000ケ0 0007 0ク7010707080ク707 020907 apple6ァ9000409) apple030802 03086ヲ007 6 503076 509 020キ307 0909006ァ90キ307. ヌ 07 0207030ク76 709 02080ク7 0ク7apple08 0804 陦 02090ケ0 apple03080300076ァ907090ケ0, [prorenin receptor, PRR] (08 08apple086ァ9080ケ0 040ク707 閨0002 06 0000 0209 0300076ァ90709 030307 02 06 020907 apple03080300076ァ90709 apple030802 03060702 0ケ0 000703060402 0009-apple030キ3020008030ク70206026ァ8 000700030908apple086ァ9090409 02090ケ0 0200-03000ク702 6ァ9 0ケ0) 9, 0ク7apple6ァ8030100 0208 apple03060208 6 56ァ800 0906 0209 06000ク702036ァ9-07060409 02090ケ0 000604020802080106026ァ80ケ003 030704090ケ0 020キ307 080ク704060607 0ク7020607, 00 0800 閨07080ク7 fi0206 09 046ヲ007 00046ァ8 02080ク70ケ0 0000 020807 0ク7apple08 0804 陦 6 503 閨03090200 07 0ク70107070006 020907 apple 03 090キ3096ァ8 02080ク7 07 04020803 陦 02080ク7 000700030908apple080609026ァ8 02080ク7 apple03 040006070809fi07080ク7 (plasminogen activator inhibitor, PAI). ヲ 08 006ヲ0030900 0ク702fi 陦0キ3-0400 02 06 0006 00016ァ809090409 0402 apple08020003 閨0400 02 02090ケ0 000003 閨02090ケ0 020キ307 Vィヲniant 02 06 040ク707. 10 046ヲ000080キ307 0000 02 08apple086ァ9, 06-09080706 06 02086ァ9 03080ク703 6ァ90806 0000 閨020803 0409 02080ク7 09080706 6ァ9080ク7 02090ケ0 apple03080300076ァ907090ケ0 apple08020300060402060207 040208 6ァ8apple 03 apple 03080ク7046ァ9 - ィB 07 400-apple03070406 040ク70902 閨0702030キ30409 apple03080300076ァ907090ケ0 04020907 020ク7-0203080808036ァ9, 09 08apple086ァ9 000706 0007 apple030802 03086ヲ00400 0ク7apple 閨0302 0409, 040ク707 0ク7 ィBfi02 07 0000 0002020002 00 閨0709 6ァ9070キ30409 02080ク7 000ク70802 03 6ァ9-080ク7, 020キ307 0909006ァ90キ307 02 06 020キ307 070008030607. 6セ40209 040ク707 閨040006 06 apple0604020603090200 fi0206 09 046ヲ007 000409 02090ケ0 apple03080300076ァ907090ケ0 0000 0208 0ク7apple08 0804 陦, 040ク70700apple07090002 06 080007fi0ケ0 000007 020907 000700030908apple086ァ909046ァ8 02090ケ0 02 06 020907 apple 03 090キ3096ァ8 0208apple060207 04020907 00apple060807-070006 02080ク7 020ク702020703080ク7, 0909000608020007046ァ907090ケ0 ヲミヲミ, 080002 閨03080ク7 00, 020907 020607090208apple086ァ9090409 0006 06026ァ80ケ0 040900 0208 080206026ァ80ケ0 08 086ヲ0, 0000 apple0802 閨03000400 020907 000700030908apple086ァ9090409 02090ケ0 08 086ヲ0 020キ307 MAPK 020607 040607, 04020907 08apple086ァ9 02 06 0808006ァ9030002 06 09 00 0700-01070302090209 02090ケ0 0909000608020007046ァ907090ケ0 02 02 04020308086ァ8 020キ307 06-0402060703 (angiotensin-independent toxicity). 08apple 閨03 0ク702086ヲ0 040ク70709090803086ヲ007 02 apple08020003 閨0400 02 0803060400 閨070キ307 00000300020607 046ヲ000080キ307 0000 02 08apple086ァ9 09 020607090208apple086ァ9090409 02090ケ0 apple 03 apple07070キ3 08 086ヲ0 040ク7006 5 6ァ9070006 02 06 apple 03080ク7046ァ9 07 040208-03 閨0キ307 02080ク7 6セ406 ゙ ゙ [ 07 04020803006ァ90ケ0 02080ク7 000002 020300apple020602086ヲ0 0007ィB6ヲ000080ク7 02090ケ0 0909000608020007046ァ907090ケ0 ( -096ム8 ゙) 02 06 0702 090キ3-07060402 閨0ケ0 020キ307 026ヲ0apple080ク7 1 ( ゙ヲ 1) 0ク7apple08 0804 閨0キ307 02090ケ0] 11-13. 6セ400 apple03fi0408 0209 090008046ァ9000ク7046ァ8 00 0ケ014 07 040208apple6ァ80309-0200 0300apple0208000003060ケ0 09 080ク70406080308096ァ9 02080ク7 6セ406 ゙ ゙ 02 06 0006 060207 02080ク7 0ク7apple08 0804 陦 02090ケ0 apple03080300076ァ907090ケ0, 02 03060ケ0 02 06 09 0007 00-04fi00000709 040900 046ァ9 02090ケ0 08 086ヲ0 0ク7026ァ80ケ0, 04020907 apple0308046 508036ァ8 02080ク7 000ク70802 03 6ァ9080ク7, 020キ307 0909006ァ90キ307 02 06 020キ307 070008030607. 00- apple0キ30ケ0 07 08 閨03 0000, 09 046ヲ00703000409 0006 0ケ0 04000603070ケ0 apple00apple0206 6ァ90キ307 0707030809090ケ0 08006ァ80ケ0 0000 02006ァ800 02080ク7 apple0308apple00apple0206 6ァ9080ク7 (prosegment) 02090ケ0 apple03080300076ァ907090ケ0, 02 08apple086ァ9 6 503 閨03090200 fi0206-07 0402 閨0303080ク707 0209 046ヲ007 000409 02080ク7 0ク7apple08 0804 陦 02090ケ0 apple03080300-076ァ907090ケ0 0000 020907 apple03080300076ァ90709 02 06 020907 0300076ァ90709, 020803080ク7036ァ8-03090200 applefi 0006 0400060307 00000300020607 020キ307 Ichihara 02 06 040ク707. apple080ク7 陦000601 07 fi0206 09 0408036ァ809090409 020キ307 apple 03 apple07070キ3 apple00apple0206 6ァ90キ307 006ァ90400 0キ30ケ0 apple0802 閨03000400, fi0406 00fi0708 020907 apple03fi03096 709 02090ケ0 apple 0308030809 07 02080006026ァ80ケ0 6 503076 5090ケ0 020キ307 0604020607 (000ク708-02 03 06 026ァ8 6ァ9070キ30409, 06 6 5090206026ァ8 0700080308apple07030006 ) 030307 02 06 020907 0ク7apple0804020308086ァ8 02090ケ0 000902 020004020900 閨07090ケ0 6ァ8 09 6 50307-6 5090ケ0. ヌ 03070409 020キ307 apple00apple0206 6ァ90キ307 0ク7020607 (apple00apple026ァ9 0608 02090ケ0 apple00030608046ァ80ケ0 0003 6 56ァ803 ィC handle region peptides, HRP; - apple080203000604026ァ80ケ0 02080ク7 0ク7apple08 0804 陦 02090ケ0 apple03080300076ァ907090ケ0 ィC prorenin receptor blocker, PRRB; 07 04020803 陦 0ケ0 02090ケ0 apple0308-0300076ァ907090ケ0 ィC prorenin inhibitor, PRAM-1) 0007 0808000603fi- 02 07 04020907 07 040208036ァ8 apple 03 090キ3096ァ80ケ0 0909000608020007046ァ907090ケ0 ヲミヲミ (03fi090キ3 07 040208036ァ80ケ0 02090ケ0 0009-apple030キ3020008030ク70206026ァ80ケ0 000700030908apple086ァ90904090ケ0 02090ケ0 apple030キ30300076ァ907090ケ0), 6ァ802 07 0903 6ァ8 070001070302090209 applefi 020907 03070409 02090ケ0 0909000608020007046ァ907090ケ0 (angiotensin II- Independent), 030307 apple0603 07fi02 02 0808006ァ903080702 07 04020907 06 0208apple6ァ8 02090ケ0 0006 06026ァ80ケ0 040900 0208 080206026ァ80ケ0 08 086ヲ0 02080ク7 PRR, 0903 6ァ8 020907 000700030908apple086ァ9090409 02090ケ0 08 086ヲ0 020キ307 020607 040607. ヲ apple 03 apple07070キ3 apple08020003 閨0400 02 0007 00apple066 5006 5 0606030902 07 apple0802 applefi 07030309 080007 02 06 0ク702fi 0ク7apple08026ァ907090400 06 00070409 0906 020907 6ヲ0apple 030109 02 06 0209 03070409 020キ307 apple00apple0206 6ァ90キ307 0ク7-020607 14. 6ム8apple0006 6ァ8 0208 03 閨00 006ァ907 06 06 06 6ァ9020003 040900 07020602fi ( 00 0800 閨07080ク7 fi0206 0806 apple 03 apple07070キ3 apple 030709080702000ケ0 03 6ァ802 07 04036ァ80406000806 04020907 apple03fi03096 709 02 06 04020907 07020600000206apple060409 02090ケ0 06 6 5090206026ァ80ケ0 0700080308apple07030006 0ケ0), 09 閨03000ク707 000702 02060208apple0806-6ァ803090200 02 020003000ク702 6ァ9 0403fi0706 apple03080ケ0 020907 02 02006ヲ0030ク7070409 0ク7026ァ8, apple 03 閨04080702 0ケ0 07 閨000ケ0 06 0402070400060ケ0 040208 046ヲ004020900 0300076ァ907090ケ0 ィC 0909000608020007046ァ907090ケ0 ィC 03 0804020003fi07090ケ0. ヌ 03070409 020キ307 apple00apple0206 6ァ90キ307 02090ケ0 apple00030608046ァ80ケ0 0003 6 56ァ803 ヲ 08 2008 0806 Susic 02 06 040ク707 15 07 02086ァ9070キ304 07 fi0206 09 0408036ァ809090409 PRAM-1 0400 SHR (spontaneoulsy hypertensive rat) 00000207 applefi 8 006 5 080007 0キ307 6ァ9 0602 0ク76 709036ァ80ケ0 apple0003060002020602fi020902 0ケ0 0400 070702030608, 00030702020キ30400 020907 040ク707080306026ァ8 02 03 06 026ァ8 0007ィB 02 06 020907 020300 0206076ァ90709 02080ク7 0803086ヲ0 apple080ク7 006ァ904 07 00apple090300 0402006ァ9 applefi 020907 0ク7apple 閨0302 0409 apple080ク7 apple030802070300-0400 09 0ク7010900 閨0709 apple03fi0403096 709 07 02036ァ9080ク7. ヌ 000ク7000309000206026ァ8 0ク7026ァ8 00apple6ァ9 03 0409 000703060402 0002 09030603090200 040キ3036ァ90ケ0 07 00apple09-16

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070001 閨02 04 07 0208 ィB6ァ8020900 02090ケ0 0700010703020902090ケ0 030704090ケ0 applefi 020907 0909000608020007046ァ90709 020キ307 HRP. 6セ400 Sprague-Dawley 03080ク703 6ァ9080ク70ケ0 apple080ク7 閨090607 07 06 6 509020602086ァ9 0000 0408036ァ809090409 04020300apple0208ィB080208026ァ907090ケ0, apple030804 0608036ァ90403090200 09 00apple6ァ9 03 0409 02090ケ0 090キ3096ァ80ケ0 0000 6 5 0304 0302070709 6ァ8 PRRB 6ァ8 040ク707 0ク7 0400fi0ケ0 020キ307 6ヲ008, 04020907 閨020803 0409 040208 070008030602fi 060402fi 02080ク7 apple - 030709080702 07 閨02030キ304090ケ0 020キ307 fi09020キ307 (tumor necrosis factor-, TNF- ), 02090ケ0 060702000303000ク7026ァ907090ケ0-16 5 (interleukin- 1beta, IL16 5) 02 06 02080ク7 0ク7apple08 0804 陦 02090ケ0 apple03080300076ァ907090ケ0, 04020907 apple086 508036ァ8 0000 02 086ヲ003 036 5080ク7006ァ907090ケ0, TNF- 02 06 IL-16 5, 000706 apple 030703030903 apple030804 0608036ァ904020902 07 040208 0ク70903fi 02080ク7 0607000004080ク7 060402086ヲ0 0806 040ク7090200070203060400060ケ0 020キ307 apple 03 - apple07070キ3 apple 03 09fi07020キ307 02 06 02090ケ0 0909000608020007046ァ907090ケ0 ヲミヲミ. 6セ400 046ヲ0090203060409 0000 02080ク70ケ0 070803000809030ク702 06000602086ヲ00ケ0 03080ク703 6ァ9080ク70ケ0 000703020ク703000ケ0, 0806 06 6 509020602086ァ9, apple030607 020907 090キ3096ァ8 006ァ904 07 0409-00 0702060207 0ク76 70903fi020003 00apple6ァ9apple00 fi030キ307 020キ307 apple030804 06080306-0403 閨07020キ307 apple 03 09fi07020キ307. ヌ 090キ3096ァ8 0000 6 5 0304 0302070709, 0000 HRP 02 06 040ク707 0ク7 0400fi 020キ307 6ヲ008, apple0308020703000400 0409-00 070206026ァ8 00030702020キ30409 020キ307 apple 03 09fi07020キ307 0ク7020607. 09 03fi- 000806 0000060603090200 02 06 09 閨020803 0409 020キ307 080300090008070キ3 0607 020ク70202 03080206070607 (TNF-, IL-16 5) 09 08apple086ァ9 6ァ802 07 040900-0702060207 0ク7010900 閨0709 0402080ク70ケ0 06 6 509020602086ヲ00ケ0 0400 046ヲ0090203060409 0000 02080ク70ケ0 070803000809030ク702 06000602086ヲ00ケ0 03080ク703 6ァ9080ク70ケ0 apple030607 020907-090キ3096ァ8. 0400 040ク707 閨6 509 fi000キ30ケ0 0208 6ァ9 0608 0000 020907 閨020803 0409 02080ク7 PRR 09 08apple086ァ9 6ァ802 07 00apple6ァ904090ケ0 0ク7010900 閨0709 0402080ク70ケ0 06 6 509-020602086ヲ00ケ0 03080ク703 6ァ9080ク70ケ0 apple030607 020907 090キ3096ァ8, apple 03 閨0000060700 fi000キ30ケ0 0402 6ァ9 06 00apple6ァ9apple00 00000207 020907 090キ3096ァ8 0000 PRRB 000706 0003 02020603090200 040900 0702060207 00000207 020907 090キ3096ァ8 0000 6 5 0304 0302070709. 0307 07030308 040900 07020602fi 006ヲ0030900 02090ケ0 0000-03 閨02090ケ0 0ク7026ァ80ケ0 6ァ802 07 fi0206 09 090キ3096ァ8 0000 PRRB 0007 00006ァ90キ3-0400 0209 040ク70902 閨0702030キ30409 02090ケ0 0909000608020007046ァ907090ケ0 040208 06070000-0408 060402fi 000706 09 6 5 0304 0302070709 020907 6ヲ001090400 fiapple0キ30ケ0 6ァ802 07 07 000007fi00000708. ヲ apple 03 apple07070キ3 000ク7036ァ800 02 0ク7apple08 090306-07080ク707 fi0206 040209 06 6 5090206026ァ8 0700080308apple07030006, 09 02000306026ァ8 06026ァ9 6 503076 5090ケ0 02080ク7 07000803086ヲ0 006ァ907 06 09 0ク7apple0003apple 03 090キ3096ァ8 080300090008-070キ3 0607 020ク70202 03080206070607 apple080ク7 000202036ァ907080702 06 fi0406 00fi0708 applefi 0209 03070409 02090ケ0 0909000608020007046ァ907090ケ0 ヲミヲミ, 030307 02 06 applefi 0209 046ヲ007 000409 02080ク7 PRR 0000 020907 apple03080300076ァ90709 00 閨040キ3 02090ケ0 0006 06-026ァ80ケ0 040900 0208 080206026ァ80ケ0 08 086ヲ0 02080ク7 PRR 0700010703020902 applefi 0209 03070409 02090ケ0 apple030602090ケ0. 03040006 00060403006ァ9 fi000キ30ケ0 fi0206 02 HRP 0007 閨04080ク707 0700080308apple03080402 02000ク70206026ァ8 03070409 040209 07000803 09090006 026ァ8 0ク7apple 閨0302 0409 (Goldblatt hypertension) 19 0キ30ケ0 09 03070409 02080ク70ケ0 07 08080307 0006 060207 0209 06 6 509-0206026ァ8 0700080308apple07030006. 縺0007060207 00 閨040306 046ァ8000003, 08 000904 07060400fi0ケ0 02090ケ0 0700-080308apple03080402 02000ク70206026ァ80ケ0 030704090ケ0 020キ307 apple00apple0206 6ァ90キ307 HRP 閨040006 apple 03 00006ァ9070006 06000ク702036ァ907060402080ケ0. ヌ 02080106026ァ8 00apple6ァ9 03 0409 02090ケ0 apple03080300076ァ907090ケ0 ヲ 08 2008 0806 Peters 02 06 040ク707 20 apple030804apple07030904 07 07 00apple066 5006 5 060604080ク707 020907 apple 0308090007000206026ァ8 040900 046ァ9 02090ケ0 apple03080300076ァ907090ケ0. 縺06 0208 040208applefi 0ク702fi 04030904060008apple086ァ90904 07 06 09080706 06 02086ヲ00ケ0 03080ク703 6ァ9080ク70ケ0 0000 閨020803 0409 040208 6ァ8apple 03 0000apple 09fi000007080ク7 apple0308 090キ309 陦 03 (inducible promoter) 02080ク7 09080706 6ァ9080ク7 02090ケ0 0300076ァ907090ケ0 apple08070206020607 Ren-2. 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O 0ク7apple08 0804 陦 0ケ0 02090ケ0 apple03080300076ァ907090ケ0 09 046ヲ007 00-0409 02090ケ0 apple03080300076ァ907090ケ0, 02090ケ0 0300076ァ907090ケ0 02 06 09 0006 06026ァ8 040900 0208 080206026ァ8 08 fi0ケ0 00apple0キ30ケ0 6ァ8 09 07 08 閨0303090200 0400 apple03fi0408 0209 07-0402fiapple09046ァ8 00 0ケ0 08 PRR apple 03080ク7040607ィB0006 020907 6ァ9 06 0400060307 0006070801 閨0キ307 (coding sequence) 0000 020907 ATP6AP2, 0903 6ァ8 020907 apple030キ302000ケ10709-00010703020900 (accessory protein) 02090ケ0 020ク7040206 06 026ァ80ケ0 H + -ATP0704090ケ0 (vacuolar proton-transporting ATPase, v-h + -ATPase) 24. ヌ 080ク7-04060803080906026ァ8 apple08040208036ァ8 02090ケ0 ゙ヲ 060704090ケ0 0ク7026ァ80ケ0 006ァ907 06 07 0801060708apple0806006ァ9 0208 apple0003060004fi00000708 020キ307 020ク7040206020607 020ク70202 0308apple03 0400 0206020607 04040900 020604000607, fiapple0キ30ケ0 006ァ907 06 02 030ク70408-040600 02 02 06 02 03066 508040600 02, 02 06 07 0801060708apple0806006ァ9 02 086ヲ003 04020907 apple00030608046ァ8 020キ307 03030806040206020607 applefi030キ307. 090003-02000ケ0 陦000601 07 fi0206 08 PRR 040208 07000803fi 00070208apple6ァ9ィB0002 06 020ク7-036ァ90キ30ケ0 0402 07apple0キ3 030308060402060207 02 06 0402080ク70ケ0 0303080604020602086ヲ00ケ0 applefi03080ク70ケ0 fiapple080ク7 006ァ907 06 02 06 0806 040ク7076ァ80300060ケ0 03 閨0400060ケ0 閨020803-04090ケ0 02090ケ0 0702036ァ9 0ケ0 apple030キ30208076ァ90キ307 (06fi07020キ307 0ク7 030809fi07080ク7). 01 03 02020903060402060207 08 0ク7apple08 0804 陦 0ケ0 00 ィB6ァ9 0000 020907 020003000ク7-02 6ァ9, 02090ケ0 08apple086ァ9 apple08020003006ァ9 apple030キ302000ケ10709-00010703020900, 0002-080307ィB0002 06 0402060ケ0 6 709020203080006 006ァ90ケ0 apple03080400026 50803 閨0ケ0 02090ケ0 0208-030ク708 6ァ9 0ケ0 (apical) 0000006 5030707090ケ0 020キ307 apple 03 閨070300020キ307 00- apple0603090306 020607 020ク7020207030キ307 026ヲ0apple080ク7 ゙ (intercalated A) 020キ307 03030806040206020607 applefi030キ307 25. ヌ 閨020803 0409 02080ク7 0ク7apple08 0804 陦 006ァ907 06 06 00 0800 閨0709, 0400 fi03080ク70ケ0 040400 fi07 02080ク70ケ0 060402086ヲ00ケ0, 0900090807fi0ケ0 apple080ク7 0ク7apple08 090306070006 fi0206 09 046ヲ007 00046ァ8 02080ク7 0000 020907 apple03080300076ァ90709 02 06 0209 0300076ァ90709 apple08020003006ァ9 閨07 00060203fi 00fi0708 00 閨03080ケ0 020キ307 03000602080ク70309060607 02080ク7. 0903070900 0206, 09 apple00070003-0908apple086ァ9090409 02080ク7 09080706 6ァ9080ク7 02080ク7 PRR 02 02 036ァ8090006 0400 0307-07 0208 02080ク7 00006 5036ヲ0080ク7 apple030607 020907 0000086ヲ002000ク70409 040208 0007 08006ァ8-02030608. 6セ4020807 070703030キ3apple08 0006 000002070303 0109 040208 0908076ァ9 0608 02080ク7 PRR (exonic splice enhancer mutation) 040ク707 0ク707ィB00-02 06 0000 01-080ク70308046ヲ007 000209 080602080900076ァ8 0708090206026ァ8 0ク70402 閨03090409 02 06 00apple0603096 76ァ9 26. 6セ46ァ8000003 0ク7apple0703040006 09 07apple086 709 fi0206 08 PRR 02 06 09 ゙ヲ 066 ゙062 02090ケ0 020ク7040206 06 026ァ80ケ0 0702036ァ9 0ケ0 apple030キ30208076ァ90キ307 006ァ907 06 02 0ク702fi040900 00fi0306 02 06 09 閨020803 0409 04020907 020ク70202 0306026ァ8 0000006 503070709 02080ク7 0ク7apple08 0804 陦 apple08020003006ァ9 閨07 02006ァ800 00fi0708 02080ク7 040ク70708030602086ヲ0 00080803026ァ9080ク703 PRR/ ゙ヲ 066 ゙062 02080ク7 020ク702-020703080ク7. 0903080ケ0 0ク7026ァ8 020907 02 02006ヲ0030ク7070409 040ク70709090803006ァ9 09 apple03fi- 0408 0209 07 0207030ク76 709 fi0206 閨07 02006ァ800 02090ケ0 ゙ヲ 066 ゙062 02080ク7 020ク7040206 06 02086ヲ0 060402086ヲ0 (030ク70408040600 02, 03066 508040600 02 ) - 020803080ク703060702 0ケ0 020907 00 apple00020203060206026ァ8 08 fi 02080ク7 020ク702020703080ク703 (secretary pathway) apple08 6ァ9 0002 06 0003006ヲ003000308 04020907 020ク7-18

136ム80303090706026ァ8 03000803080308096ァ9 23, 2011 036ム86ム86セ4 04ヲミ ゙6セ4ヲ ゙6セ46ム8ヲミ6セ4 6ム8ヲミヲ O0806 罔ミ ゙6セ4 066ム803ヲミ03 ヌ6セ4- ゙ 罍縺6ム8ヲミOヲ 6ム8036セ4ヲミ03 ヌ6セ4- ゙ 04O6セ4ヲ 6ム806O03 ヌ6セ4 0203080808036ァ9 02 06 040ク707 閨0002 06 0000 0209 0300076ァ90709 27. 09 閨040306 046ァ8-000003 0007 006ァ907 06 09070キ304026ァ8 09 040900 046ァ9 02080ク7 00 06 030ク702086ヲ003 0ク702086ヲ0 PRR. ゙0700010703020902 0ク702086ヲ0 fi000キ30ケ0 09 apple 03 08046ァ8 02090ケ0 02 0ク702fi020902 0ケ0 02080ク7 PRR 0000 020907 ゙ヲ 066 ゙062 040ク70700apple07-090002 06 080308020309030キ30206026ァ8 07 020308apple6ァ8 020キ307 00 閨040306 046ァ8000003 00 0800 閨070キ307, 0906 026ァ9 086ヲ00200 09 ゙ヲ 066 ゙062, 086ヲ00200 09 v-h + - ATP070409, 006ァ907 06 040900 0208 08020602086ァ9 0ク7apple08 0804006ァ90ケ0, 08applefi0200 apple 0602006ァ902 06 06000ク702036ァ907060409 02080ク7 000904 07060400086ヲ0 020607090208apple086ァ909-04090ケ0 02090ケ0 040900 0208 080206026ァ80ケ0 08 086ヲ0 020キ307 MAPK 020607 040607. 6ム8apple6ァ904090ケ0, 00 閨040306 046ァ8000003 0007 閨040006 000109090903006ァ9 0ク7applefi apple0806 閨0ケ0 040ク707036ァ802000ケ0 0400 040ク709020002030600 閨07080ク70ケ0 060402086ヲ00ケ0, fiapple0キ30ケ0 0806 0700-0803086ァ9, 09 040ク70902 閨0702030キ30409 02090ケ0 apple03080300076ァ907090ケ0 02 06 02090ケ0 0300076ァ9-07090ケ0, apple080ク7 080ク7040608030809060207 006ァ907 06 02090ケ0 020701090ケ0 020キ307 picomol, 08030707080ク707 0400 00apple6ァ9apple00 08 nanomol apple080ク7 006ァ907 06 0208 0003070406040208 apple 03 6ァ902090208 fi030608 0906 020907 046ヲ007 00046ァ8 02080ク70ケ0 0000 020807 P06R. 0906 00apple6ァ904090ケ0 0700016ァ809090209 apple 03 026ァ803090409 07 閨0203006 700 02 00 閨040306 046ァ8000003 00apple060203 02086ヲ00702 0906 0209 040ク70909 閨070006 020キ307 HRP 0000 020807 PRR. 09 閨040306 046ァ8000003 apple060402000ク7fi02 07 fi0206 09 03070409 020キ307 HRP 040ク7076ァ90402 02 06 04020907 07020602 02070402 0409 02090ケ0 apple03080300076ァ907090ケ0 02 06 02090ケ0 0300076ァ907090ケ0 applefi 020907 03 閨0409 046ヲ007-0004090ケ0 0000 020807 PRR, 03fi090キ3 000009 036ヲ0020003090ケ0 040ク70909 閨070006 0ケ0 HRP-PRR 28. 0903fi0408 02 000702086ヲ00208060ケ0 0400 0604020802 030306 閨03-090006000ケ0 0007 02 02 閨040209 0ク707 02fi07 07 apple08 00060403006ァ9 09 07020602-02070402 0409 02090ケ0 apple03080300076ァ907090ケ0 0000 02 HRP applefi 0209 03 閨0409 046ヲ007 00046ァ80ケ0 02080ク70ケ0 0000 020807 0ク7apple08 0804 陦 02 06 09 07 040208036ァ8 02090ケ0 000700030908apple086ァ90904090ケ0 02090ケ0 040900 0208 080206026ァ80ケ0 08 086ヲ0 020キ307 MAPK 020607 040607 29. ヲ 08 006ヲ0030900 0ク702fi 02 0306040207 02fi00 apple00030604-04fi02000308 00apple0602 020206026ァ8 020907 0707090209 00016ァ8090904090ケ0 02080ク7 0203fiapple080ク7 030704090ケ0 020キ307 HRP, 06 6ァ90キ30ケ0 04020907 apple00036ァ9apple020キ30409 02080ク7 0702-090キ307060400086ヲ0 02090ケ0 0300076ァ907090ケ0, 0906 026ァ9 0208 00fi030608 02090ケ0 0007000309086ヲ0 0300076ァ907090ケ0 04020003006ァ902 06 apple0308apple00apple0206 6ァ9080ク7 0000 0208 08apple086ァ908 02 HRP 閨04080ク707 070703080909 08006ァ8 27. 6ム80707 030806applefi07 02 apple080200-03 閨0400 02 020キ307 00000300020607 0400 020ク70202 030802 030306 閨03090006000ケ0 00apple06-6 5006 5 060キ303086ヲ007, 03 apple03 鐶pple0006 07 096ァ9070006 apple08 000202fi fi0206 08 PRR 00 06 03 閨020006 0006 020806076ァ8 03 閨0409 046ヲ007 0004090ケ0 0906 020907 apple03080300076ァ90709 02 06 020907 0300076ァ90709 030307 6ヲ008 0100040キ303060402 閨0ケ0 03-0400060ケ0 0906 02 03 閨07 applefi 02 00fi0306 0ク70207 27. ヌ 036ヲ00300060409 02090ケ0 03000602080ク703096ァ9 0ケ0 020キ307 0ク7apple08 08-04 閨0キ307 02090ケ0 0909000608020007046ァ907090ケ0 ゙applefi 02 02 閨04040003 00 閨0309 02090ケ0 0806020809 閨070006 0ケ0 020キ307 09070キ304020607 0ク7apple08 0804 閨0キ307 02090ケ0 0909000608020007046ァ907090ケ0 ヲミヲミ 09 閨03000ク7-07 閨040006 040408030903006ァ9 020ク7036ァ90キ30ケ0 0000 02080ク70ケ0 ゙ヲ 1, 00apple0006 6ァ8 0806 020ク70306fi020003000ケ0 03070400060ケ0 02090ケ0 0909000608020007046ァ907090ケ0 ヲミヲミ 0402086ヲ0-0702 06 00 閨040キ3 0ク7020607. ヌ 080007 020キ307 ゙ヲ 2 070304060400 07 0000-0300020702 06 apple08036ヲ0 apple03fi0408 02, 000706 0906 02060ケ0 070303000ケ0 6ヲ008 080007 000ケ0 0806 0907060400060ケ0 00 0ケ0 apple 03 00 閨07080ク707 0ク7apple08020ク7apple06 00060ケ0. 00030806 0806 0ク7apple08 0804006ァ90ケ0 0ク702086ァ9 076ァ802080ク707 04020907 0806020809 閨070006 020キ307 0ク7apple08 0804 閨0キ307 apple080ク7 0906 07 03000602080ク703096ァ804080ク707 0キ30ケ0 apple0ク7-0308 fi02000ケ0 02090ケ0 040900 0208 080206026ァ80ケ0 06000309 046ァ9 0ケ0 006ァ907 06 apple - 03 6ァ902090208 07 00070キ303086ヲ007 0000 0006 000602036ァ8 G-apple030キ302000ケ10709 (Gprotein-coupled-receptors, GPCRs). 040007 0ク7apple0703040006 000009070309 08000806fi020902 040209 0400060307 020キ307 0006070801 閨0キ307 (homology) 02080ク7 0008036ァ9080ク7 02080ク70ケ0, 030307 fi030806 閨04080ク707 7 06-0000006 503 07060207 02006ァ800 02 0002 020キ307 08apple086ァ90キ307 0208 02036ァ90208 (IC3) 閨040006 020807 02000702030602fi 03fi0308 040209 040900 0208 080206026ァ8 06000309-046ァ9. 09036ァ803080ケ0 apple000603 00 0206020607, 020ク7036ァ90キ30ケ0, 00 0800 閨070キ307 0ク7apple0804026ァ803060100 020907 07apple086 709 080206 09 03070409 020キ307 ゙ヲ 1 02 06 ゙ヲ 2 006ァ907 06 0702 090キ30706040206026ァ8. 6ム80ク708 080206026ァ8 02090ケ0 046ヲ004apple - 04090ケ0 02 06 02090ケ0 0ク7apple0003020308086ァ9 0ケ0-0ク7apple0003apple03 046ァ9 0ケ0 0806 apple0306020806 02 06 0909000608 06 0402 03020602086ァ9 02 06 000ク70708086ヲ00702000ケ0 020907 applefiapple020キ30409 0806 006ヲ00200030806. ヌ 06 08080307 0ク7026ァ8 apple08 6ァ9 0002 06 0203066 5060ケ0 040208 02006ァ800 IC3 0208 08apple086ァ908 閨040006 02 0308030604020602fi 03fi0308 0906 020907 00apple060308096ァ8 02080ク7 006ヲ0020003080ク7 040ク704026ァ800 02080ケ0 06 6 56ァ96 5 04090ケ0 (second messenger) 30. 09 0307 0209 040900-046ァ9 02080ク7 IC3 0906 020907 030406026ァ8, 02 06 02 03080306040206026ァ80ケ0 0409-00 046ァ9 0ケ0 閨070キ30409 0000 02060ケ0 G-apple030キ302000ケ107000ケ0, 00 閨040306 046ァ8000003 0007 閨040006 06 apple0604020キ303006ァ9 09 6ヲ0apple 030109 apple030キ302000ク8070607 apple080ク7 07 070206 03086ヲ007 0000 0208 02006ァ800 0ク702fi, 000706 閨040006 apple08 00060403006ァ9 fi0206 0006 0400060307 0008036ァ90キ307 070206 03086ヲ007 0000 0607080803 02006ァ8-00 02 020キ307 0ク7apple08 0804 閨0キ307 02090ケ0 0909000608020007046ァ907090ケ0 020308apple08apple0806060702 0ケ0 0209 03000602080ク703096ァ9 02080ク70ケ0. O06 apple030キ302000ケ107000ケ0 0ク702 閨0ケ0 07 08 閨03080702 06 0000 0208 0900070602fi fi070800 00apple030キ302000ケ107000ケ0 apple080ク7 070206 03086ヲ007 0000 02080ク70ケ0 GPCRs03 (GPCR interacting proteins, GIPs), 0402060ケ0 08apple086ァ9000ケ0 apple08 6ァ9 0002 06 09 06 08080307 00apple06apple 陦080ク7 030704090ケ0 02080ク7 6セ406 ゙ ゙, 0402080ク70ケ0 0607080803080ク70ケ0 060402086ヲ00ケ0 6ァ8 0400 0607080803 02006ァ800 02 02080ク7 6ァ9 06080ク7 060402086ヲ0 00apple6ァ9 060009 閨0304000キ30ケ0 02080ク7 040ク704026ァ800 02080ケ0 applefi 02090ケ0 6ァ9 06 0ケ0 閨0702 04090ケ0 0003 閨03060400. 09 閨040306 apple03fi0408 02 006ァ904 07 02 0ク70208apple08060903006ァ9 apple00-036ァ9 02060ケ0 50 apple030キ302000ケ107000ケ0 GIPs apple080ク7 040ク707 閨080702 06 040208 02 03-6 508010ク7030602fi 0007 08020ク7020207030608 02006ァ800 02080ク7 0008036ァ9080ク7 02080ク7 0ク7apple08-0804 陦 02 06 閨04080ク707 040900 070206026ァ8 00apple6ァ9 03 0409 040208 08 0607fi0000-0708 02090ケ0 apple000ク7 060403090208apple086ァ90904090ケ0 (desensitization), 02080ク7 04040900 02060400086ヲ0 080008-02 06 0002000308-060000030607 020キ307 0ク7apple08 0804-0キ307, 020907 000700030908apple086ァ909046ァ8 02080ク70ケ0 applefi 000904 07060207 000300036ァ9-0400 02 02.03.apple. O0ク70406 0402060207, 0903 6ァ8, 020308apple08apple0806086ヲ007 0209 03000602080ク703096ァ9 02080ク70ケ031. ヌ 0300apple02080000036ァ80ケ0 0707apple020ク70109 020キ307 0009-04 070604000607 apple000ク7 060403090208apple086ァ90904090ケ0 020キ307 0ク7apple08 0804 閨0キ307 0100-08006ヲ0090006 applefi 0208 040208applefi 02090ケ0 apple 03086ヲ004 0ケ0 07 0402fiapple0904090ケ0, fiapple080ク7 fi000キ30ケ0 02036ァ9070002 06 apple 03 6ァ902090208 03 07 08 閨03080702 06 02 040900 0702060207 0906 020907 02 02 07fi090409 040900006ァ9. ヌ 0806020809 閨070006 020キ307 GPCR apple08020003006ァ9 020907 000009-036ヲ002000309 0806020809 閨070006 0ク7apple08 0804 閨0キ307, 02 00 閨0309 02090ケ0 08apple086ァ9 0ケ0 0ク7apple080308096ァ9ィB080702 06 0400 0406030607 000ケ0. ヲ 00fi0306 apple080ク7 02080ク70ケ0 00-0700030908apple0806086ヲ007 006ァ907 06 apple0806026ァ903 fiapple0キ30ケ0 080300fi07000ケ0, 07000ク70308-06 6 5066 5 0402 閨0ケ0, apple 03 02030607006ァ90ケ0 apple 030709080702000ケ0, 06fi0702, 020ク7-0203060207 07080ク702030008026ァ9 06, apple030キ302000704000ケ0 02.03.apple. ヌ 040900 0208- fi02090409 06 020キ307 0ク7apple08 0804 閨0キ307 0ク7020607 03046ァ9ィB0006 0000 020907 000700030908apple086ァ9090409 020キ307 G-apple030キ302000ク8070607 0806 08apple086ァ9000ケ0 006ァ907 06 00020003080203060000036ァ8 apple08020003086ヲ0000007 applefi 0203006ァ90ケ0 0ク7apple08080007 000ケ0 020907,6 5, 02 06 09-0ク7apple08080007. 0900 020907 000700030908apple086ァ909046ァ8 19

136セ4. ニヲミ ゙ メ メ ゙, 03. 09 ゙09 ゙ 罍゙ ゙03 ヌ6セ4 6ム80303090706026ァ8 03000803o03o096ァ9 23, 2011 02080ク70ケ0 0208 00fi030608 040キ3036ァ9ィB0006 0402 00fi0306 02 06 6 509, 02 03 閨07 applefi 02 08apple086ァ9 000700030908apple0806006ァ9 06 0808030002060207 00fi0306 02 08apple086ァ9 020308apple08apple0806086ヲ007 020907 03000602080ク703096ァ9 0703030キ307 apple030キ302000ク8-070607 (effectors), fiapple0キ30ケ0 0007ィB6ヲ0000キ307 (020ク7036ァ90キ30ケ0 02090ケ0 00070ク703-020ク702030704090ケ0 02 06 020キ307 080キ30408080306apple 040607) 02 06 06 6ヲ003080ク70ケ0 06fi- 07020キ307 (ion channels) 32. 6セ400 07026ァ903000409 0000 02080ク70ケ0 GPCR 08 03060300fi0ケ0 020キ307 apple 03 apple07070キ3 apple030キ302000ク8070607 006ァ907 06 apple000306080306-0400 閨07080ケ0 02 06 閨020406, 09 040900 0208 080206026ァ8 03000602080ク703096ァ9 apple0803030607 0ク7apple08 0804 閨0キ307 00010ク7apple09030002006ァ902 06 applefi 02080607 閨0ケ0 apple030キ302000ケ107000ケ0. ゙0ク702fi 040ク70700apple07090002 06 閨07 040ク707020807060400fi 020キ307 03000602080ク7030906-0607 0400 00 0800 閨0709 04020609006ァ8 060009000300 閨070キ307 0ク7apple08 0804 閨0キ307 08 08apple086ァ9080ケ0 0002080307ィB0002 06 0000 00030702020キ30409 02090ケ0 040900 0208 080206-026ァ80ケ0 03000602080ク703096ァ9 0ケ0 0207apple0806080ク7 0ク7apple08 0804 陦 applefi 0209 06 閨090003-0409 0207apple0806080ク7 070303080ク7 040キ3036ァ90ケ0 07 閨040006 0003 02020キ303006ァ9 09 040ク7-0902 閨0702030キ30409 02090ケ0 080ク7046ァ9 0ケ0 apple080ク7 020907 060009006ァ9030006 (desensitization) 6ァ8 02 06 0208 07026ァ903000208, 000700030908apple086ァ9090409 02090ケ0 040900-0208 080206026ァ80ケ0 08 086ヲ0 0007fi0ケ0 0ク7apple08 0804 陦 applefi 020907 06 閨0900030409 0207apple0806080ク7 070303080ク7 0ク7apple08 0804 陦 (sensitization). ヌ 06000309 046ァ9 02090ケ0 apple 03 apple07070キ3 apple000ク7 060403090208apple086ァ9-0904090ケ0 006ァ907 06 閨07 apple08036ヲ0apple03080208 6 506080308090602fi 08 0607fi00000708 030307 06 06 6ァ9020003 040900 07020602fi, 0906 026ァ9 02 0308036ァ9ィB0006 0209 06-0703020006 030704090ケ0 02090ケ0 03000602080ク703096ァ9 0ケ0 02080ク7 0ク7apple08 0804 陦 33-35 02 06 06 02036ァ9070002 06 0400 0800fi03080909 02 06 00020003fi03080909. 6セ4020907 apple03060209 08 6ァ9 06080ケ0 08 0ク7apple08 0804 陦 0ケ0 apple080ク7 閨040006 060009000303006ァ9 applefi 0207apple080608 040ク707 閨0209 020607090208apple0806006ァ9 000904 07060400086ヲ00ケ0 apple080ク7 07-0402 閨0303080ク707 0209 06 閨090003046ァ8 02080ク7, 000706 04020907 00020003fi03080909 09 06 閨0900030409 0207apple0806080ク7 0ク7apple08 0804 陦 020803080ク703006ァ902 06 applefi 020907 apple000ク7 060403090208apple086ァ9090409 0207apple0806080ク7 070303080ク7 08 08apple086ァ9080ケ0 00 060009006ァ9030002 06 applefi 020807 6ァ9 0608. O06 0ク7apple08 0804006ァ90ケ0 0000 0209 046ヲ007 00046ァ8 02080ク70ケ0 0000 020807 090キ3-070604026ァ8 0ク7086ァ90402 0702 06 080キ3040808030ク7036ァ90キ30409, 09 08apple086ァ9 apple080200-03006ァ9 020807 026ヲ0030608 02 06 0700000408 000904 07060400fi 000800fi030809090ケ0 - apple000ク7 060403090208apple086ァ90904090ケ003. 6ム8apple06apple03 閨0807 fi000キ30ケ0 09 080キ3040808030ク7-036ァ90キ30409 0ク7026ァ8 020803080ク703006ァ902 06 applefi 0209 06000309 046ァ9 02090ケ0 0007-08026ヲ002020キ304090ケ0 02080ク7 0ク7apple08 0804 陦 (receptor internalization), 09 08apple086ァ9 apple08020003006ァ9 02 06 026ヲ0030608 000904 07060400fi 02090ケ0 08-00fi030809090ケ0 apple000ク7 060403090208apple086ァ90904090ケ0. 6セ40208 080キ3040808030ク703060キ3-00 閨0708 0ク7apple08 0804 陦 apple03080402080303060702 06 apple030804 0300080402060207 00fi- 0306 (adapter molecules), apple.04. 0208 046ヲ000apple03000900 2 ( - adaptin, 6 5 2 adaptin, 002-chain, 042-chain), 02 08apple086ァ9 0000 020907 0400060307 02080ク70ケ0 apple030802 03086ヲ007 020907 apple03080402fi0303090409 020キ307 0006-06020607 0008036ァ90キ307 0203 03036ァ90709 (clathrin) 6ァ8 0ク707 006ァ90709 (dynamin). ヌ 06000309 046ァ9 02 02 036ァ8090006 040209 090006080ク703096ァ9 0006 0ケ0 apple03080ケ0 02 閨040キ3 026ヲ003 0704090ケ0 02090ケ0 020ク70202 0306026ァ80ケ0 0000006 5030707090ケ0 (membrane invagination) 09 08apple086ァ9 apple000306 閨040006 0208 046ヲ0-00apple03000900 0ク7apple08 0804 陦 - 090キ3070604026ァ8, apple0003066 5 0303fi00000708 applefi 00fi0306 0203 03036ァ907090ケ0, apple080ク7 apple0804apple0702 06 applefi 020907 00apple060807-070006 02080ク7 020ク702020703080ク7 04040900 026ァ9ィB080702 0ケ0 0700010703020902 020ク7-04026ァ9 06 00apple0602 030ク70000 閨07 0000 0203 03036ァ90709, (clarthrin-coated vesicles). 6ム80702fi0ケ0 020キ307 04040900 020604000607 0ク7020607 06 040キ3-036ァ9ィB0002 06 08 090キ3070604026ァ80ケ0 applefi 020807 0ク7apple08 0804 陦 08 08apple086ァ9080ケ0 040209 040ク707 閨040006 00apple 070002080307ィB0002 06 04020907 020ク70202 0306026ァ8 0000006 50307-0709 6ァ8 apple08 0800006ァ902 06 0402 03066 508040600 02. 09030キ302000ケ107000ケ0 apple080ク7 070206 03086ヲ007 0000 02080ク70ケ0 ゙ヲ 1 0ク7apple08 0804006ァ90ケ0 ATRAP (AT1-receptor-associated protein) ヲ 08 1999 0806 Daviet 02 06 040ク707. 36 07 02086ァ9070キ304 07 0209 08006ァ8 02090ケ0 ATRAP apple030キ302000ケ107090ケ0 (apple030キ302000ケ10709 0404000206ィBfi0000-0709 0000 020807 ゙ヲ 1 0ク7apple08 0804 陦, AT1, receptor-associated protein). ヌ apple 03 apple07070キ3 apple030キ302000ケ10709 apple08020003006ァ902 06 applefi 020300060ケ0 06 0000006 503 070602 閨0ケ0 036ヲ004080ク70ケ0 02 06 040ク707 閨0002 06 0402080ク70ケ0 000400086ヲ00ケ0 339 02 06 359 02080ク7 02 036 508010ク7030602086ヲ0 (0007 08020ク7020207-0306080ク7) 070203080ク7 02080ク7 0ク7apple08 0804 陦 ゙ヲ 1, 030307 fi0406 02080ク7 ゙ヲ 2. 040007 070206 0307 00apple6ァ904090ケ0 0000 02 07 閨07 07030308 0ク7apple08 0804 陦 00-0202fi0ケ0 0002006ァ9070キ307 02090ケ0 0909000608020007046ァ907090ケ0 (00080ク70402 03060706020607, 0007 080309036ァ907090ケ0, 2-0300070003090602086ヲ00ケ0). H ATRAP 0002-080307ィB0002 06 0400 apple080303086ヲ00ケ0 060402086ヲ00ケ0, fiapple0キ30ケ0 0208 0803020602fi 02086ァ9-040キ300, 0208 000ク708020703 0608, 0806 apple07006ヲ0000807000ケ0 02 06 020ク7036ァ90キ30ケ0 02 0700-0803060207 040キ3030907070306, 0402 08apple086ァ9 040ク7070002080307ィB0002 06 0000 02080ク70ケ0 ゙ヲ 1 0ク7apple08 0804006ァ90ケ037. ヌ 046ヲ007 000409 02090ケ0 ATRAP 0000 020807 ゙ヲ 1 040ク70700apple07-090002 06 00030702020キ30409 02090ケ0 0ク7apple0003apple03 040206026ァ80ケ0 02 06 0ク7apple00030203080806-026ァ80ケ0 030704090ケ0 02080ク7 0ク7apple08 0804 陦 0402 03006ァ9 000ク70ク80207 026ヲ00202 03 02080ク7 09090006 02086ヲ0 020806040600 02080ケ0 03fi090キ3 00apple6ァ902 04090ケ0 02080ク7 08 06-070800 閨07080ク7 02090ケ0 000007 08026ヲ002020キ304090ケ003 (internalization) 38. 03040006 00apple6ァ904090ケ0 06 apple0604020キ303006ァ9 fi0206 09 0ク7apple0003 閨020803 0409 02090ケ0 ATRAP apple030802 03006ァ9 000009070309 00030702020キ30409 02080ク7 03060300086ヲ0 020キ307 ゙ヲ 1 04020907 00apple060807070006 020キ307 000ク70802 03 06 020607 020ク702-0207030キ307 (downregulation), 09 08apple086ァ9 040ク70708 006ヲ00002 06 applefi 06 06 6ァ9020003 000008 076ァ8 00030702020キ30409 02090ケ0 apple030キ302000ク80708046ヲ0070300-04090ケ039. 090003 閨0209 陦00060100 fi0206 06 09080706 06 02086ァ9 apple0807020602086ァ9 0000 0ク7apple0003 閨020803 0409 02090ケ0 ATRAP apple 03080ク7040607ィB080ク707 04 03-0202090306040206026ァ8 0ク707 006ァ9 0803000900080706 080ク70ケ0 07026ァ9 03 04090ケ0, 02 06 000009070309 00030702020キ30409 02080ク7 04040900 02060400086ヲ0 07 閨080ク7 閨040キ3 0406-020607 00000207 applefi 02 030002090306 0400fi 02 06 02 02 04020308086ァ8 02080ク7 0007 080309036ァ9080ク7. ヲ apple0807026ァ90206 0ク70207, 00000207 applefi 04000603060400086ヲ00ケ0 apple080ク7 apple03080207030004 07 0ク7apple0003020308086ァ9 02090ケ0 030604020003070ケ0 020806036ァ9 0ケ0 (0408036ァ809090409 0909000608020007046ァ907090ケ0 ヲミヲミ 00apple6ァ9 14 0900 閨03000ケ0 6ァ8 apple00036ァ9-000409 02090ケ0 0803026ァ80ケ0), 07 閨02020904 07 040900 0702060207 00060203fi02000309 0ク7apple0003020308086ァ9 0400 046ヲ0090203060409 0000 02 080ク7040608030809060207 (wildtype) apple0807026ァ90206. O06 0002 0903060400060ケ0 0ク702 閨0ケ0 040ク707 0ク707ィB080702 07 0000 000009070309 00030702020キ30409 02090ケ0 03 0402090306fi020902 0ケ0 02090ケ0 0001 03-0206000007090ケ0 applefi 02 07060208020607 006ァ9 06 08010006 0704090ケ0, apple080ク7 04-03 020209036ァ9ィB0002 06 applefi 020907 apple 03080ク7046ァ9 02090ケ0 0ク7apple08080007 0ケ0 p22 phox (p22 phox - NADPH oxidase). 6ム8apple0006 6ァ8 00 09 apple - 03 apple07070キ3 08010006 070409 apple08020003006ァ9 0402fi0408 02090ケ0 Ang II, 02 000ク7-036ァ800 02 0ク70207 0ク7apple08 09030607080ク707 00030702020キ30409 02090ケ0 030704090ケ0 020キ307 ゙ヲ 1 37. 6ム8apple06apple03 閨0807 fi000キ30ケ0 09 ATRAP 08 6ァ9070002 06 fi0206 20

136ム80303090706026ァ8 03000803080308096ァ9 23, 2011 036ム86ム86セ4 04ヲミ ゙6セ4ヲ ゙6セ46ム8ヲミ6セ4 6ム8ヲミヲ O0806 罔ミ ゙6セ4 066ム803ヲミ03 ヌ6セ4- ゙ 罍縺6ム8ヲミOヲ 6ム8036セ4ヲミ03 ヌ6セ4- ゙ 04O6セ4ヲ 6ム806O03 ヌ6セ4 apple 0300006 5 6ァ9070006 02 06 040208 03000000030606 09 0906 020907 0ク7apple0003020308086ァ9 000904 07060400fi 02 03040607000ク7036ァ907090ケ0-apple0ク70309070602086ヲ0 apple 030709080702 000700030908apple08060900 閨070キ307 ヲ -0300000808020ク7020207030キ307 (nuclear factor of acivated T-cells-NFAT) 03fi090キ3 02090ケ0 06 閨09000304090ケ0 02080ク7 00apple 030709080702 036ヲ003000604090ケ0 020キ307 00apple06apple 陦0キ307 02080ク7 0007 08020ク7020207-0306080ク7 046 50004026ァ9080ク703 (calcium-modulating cyclophilin ligand, CALM) 40. O apple 03 apple07070キ3 apple 030709080702 0ケ0 006ァ90400 0304060207 07 09070キ303060403006ァ9 0キ30ケ0 080ク70406 04020602fi0ケ0 040ク7070200030004026ァ80ケ0 02090ケ0 040900 0208 080206026ァ80ケ0 08 086ヲ0 02080ク7 0ク7apple08 0804 陦 020キ307 000700030908apple08060900 閨070キ307 0300000808020ク7020207030キ307 41, 026ヲ00306 00apple6ァ9 03 0409 02080ク7 08apple086ァ9080ク7 6ァ802 07 09 6ヲ001090409 02080ク7 0007 08020ク70202070306080ク7 046 50004026ァ9-080ク7, apple 03 6ァ902090209 0906 020907 000700030908apple086ァ9090409 02090ケ0 02 03040607000ク7-036ァ907090ケ0 (080キ30408 020704090ケ0) 09 08apple086ァ9 0000 0209 0400060307 02090ケ0 apple08-080キ3040808030ク7030606070006 020807 NFAT (000002 0903 080602fi apple 03070908-0702 -02030006 6ァ9 0906 020907 0ク7apple0003020308086ァ9 ) 40. 6ム80202fi0ケ0 applefi 020907 08 fi 0ク7026ァ8 08 CALM 000700030908apple0806006ァ9 020807 NFAT 00 閨040キ3 02080ク7 TACI (transmembrane activator and CAML interactor). O 020003000ク702 6ァ9080ケ0 apple08020003006ァ9 00 閨03080ケ0 02090ケ0 0806020809 閨070006 0ケ0 02080ク7 apple 030709080702 07 閨02030キ304090ケ0 020キ307 fi09020キ307 08 08apple086ァ9080ケ0 000202fi0ケ0 02080ク7 NFAT 006ァ907 06 0ク7apple006ヲ0030ク707080ケ0 02 06 0906 020907 000700030908apple086ァ909-0409 02 06 6ヲ008 0703030キ307 apple08036ヲ0 040900 070206020607 apple 03 09fi07020キ307 000002 0903 086ァ80ケ0 apple080ク7 apple030802 03086ヲ007 020607090208apple086ァ9090409 020キ307 06070キ3-0206020607 020ク70202 03080206070607 02 06 06 08080308apple086ァ9090409 02080ク7 0304-090807080ク7 0000040009040ク700 020602086ヲ0 020ク702020703080ク7 0400 0607086 50307040209: 02080ク7 AP-1 02 06 02080ク7 NF-02B 42. 0903fi0408 02 6 503 閨03090200 fi0206 0806 apple0807020602086ァ9 0000 閨0303006 709 ATRAP (ATRAP-deficient a- trap-/-) 0400 046ヲ0090203060409 0000 02080ク70ケ0 080ク70406080308090602086ヲ00ケ0 (atrap +/+) apple 03080ク7040607ィB080ク707 0ク7010900 閨0708 fi090208 6ァ900 02080ケ0 02 06 0ク7010900 閨0709 ゙09, 000706 09 apple 03 090キ3096ァ8 0300076ァ907090ケ0 apple 03 00 閨070006 080ク704060803080906026ァ8. ヲ 08 006ヲ0030900 0ク702fi 0ク7apple08 6ァ8030キ30700 000009070309 6ヲ001090409 02090ケ0 00apple 07 0303fi080904090ケ0 07 02036ァ9080ク7 02 06 6ヲ0 02080ケ0 0キ30ケ0 040ク707 鐶pple0006 0ク7apple0003 閨020803 04090ケ0 020キ307 ゙ヲ 1 0ク7apple08 0804 閨0キ307 04020907 6 709020203080006 6ァ8 apple 030ク7086ァ8 020キ307 0009096ヲ00ケ0 0004apple000603 00 閨070キ307 040キ3-030907 036ァ90キ307. ゙0ケ0 04090000060キ303006ァ9 fi0206 0402 080ク7040608030809060207 apple0807026ァ9-0206 02090ケ0 apple 03 apple07070キ3 000003 閨02090ケ0 00 06 apple0604020603090200 閨02-0803 0409 02090ケ0 ATRAP 086ヲ00200 040208 09090006 02fi 02086ァ9040キ300 020キ307 0700080306020607 0909006ァ90キ307, 086ヲ00200 0402 00apple0603090306080006 6ァ8 (030007060708apple 03 090キ30907) 026ヲ00202 03 02080ク7 apple030804 090キ309086ヲ0 43. 6セ40ク7070803060207 030806applefi07 08 6ァ9070002 06 fi0206 09 ATRAP apple08020003006ァ9 07 0402 030206-02fi apple 030709080702 020キ307 0402080ク700 閨070キ307 030704000キ307 00 閨040キ3 020キ307 ゙ヲ 1 0ク7apple08 0804 閨0キ307 02090ケ0 0909000608020007046ァ907090ケ0 ヲミヲミ (negative regulatory effect), fi0406 03fi090キ3 0702 090キ307060400086ヲ0 02090ケ0 030704090ケ0 0400 0207apple080608 00apple6ァ9apple00 08 02090ケ0 040900 0208 080206026ァ80ケ0 06000309 046ァ9 0ケ0, 030307 03fi090キ3 00030702020キ304090ケ0 02090ケ0 閨020803 046ァ80ケ0 02080ク70ケ0. ARAP1 (AT1a receptor associated protein-1) 046ヲ008 0403fi0706 00000207 020907 07 02086ァ9070キ30409 02090ケ0 08006ァ80ケ0 02090ケ0 ATRAP, 0806 Guo 02 06 040ク707. 44 07 02086ァ9070キ304 07 0209 08006ァ8 0006 0ケ0 070303090ケ0 GIP (GPCR interacting protein, GIP) 0000 020306apple0307040608 09ヲフ (57,2 kda 閨07 070206 17,8 kda 02090ケ0 ATRAP), 09 08apple086ァ9 00apple6ァ904090ケ0 040ク707 閨0002 06 0000 0208 02 03-6 508010ク7030602fi 07020308 02080ク7 ゙ヲ 1a 0ク7apple08 0804 陦 apple08036ヲ0 0208070207 040208 040900006ァ908 046ヲ007 0004090ケ0 02090ケ0 ATRAP ( 000400086ァ9 318 02 06 359), 030307 閨040006 07026ァ903000209 03000602080ク703096ァ9. 6ム8apple0602 046ヲ0070006 020907 00apple - 07 閨020803 0409 02080ク7 0ク7apple08 0804 陦 04020907 020ク70202 0306026ァ8 0000006 503070709 00000207 020907 0007 08026ヲ002020キ30409 02080ク7 040ク700apple03 閨0900 02080ケ0 0ク7apple08 08-04 陦 - 090キ3070604026ァ8 (receptor recycling). 0400 0800 閨07080ク7 fi0206 0806 GPCR 0007 08020ク702020607080702 06 apple08036ヲ0 09036ァ8090803 00000207 0209 046ヲ007 00046ァ8 02080ク70ケ0 0000 020807 090キ3070604026ァ8, 09 03000602080ク703096ァ9 0ク7026ァ8 02090ケ0 ARAP1 08 0909006ァ9 0400 apple 030702 0409 02090ケ0 040900 0208 080206026ァ80ケ0 06000309 046ァ9 0ケ0 apple00030608036ァ9ィb080702 0ケ0 020907 閨0202 0409 02090ケ0 00006ァ90キ304090ケ0 020キ307 0ク7apple08 0804 閨0キ307 45. 6ム8apple 02fi03080ク703, apple0807026ァ90206 0000 0ク7apple00-03 閨020803 0409 02090ケ0 ARAP1 apple 03080ク7040607ィB080ク707 6ヲ001090409 02080ク7 03060300086ヲ0 (upregulation) 020キ307 ゙ヲ 1 0ク7apple08 0804 閨0キ307. 6セ400 apple00-036ァ9apple020キ30409 00 apple080ク7 09 0ク7apple0003 閨020803 0409 0ク7026ァ8 08080307 0006 060207 02080ク70ケ0 07000803086ヲ00ケ0 02fi0200 02 apple000603 00 02fiィB0キ3 apple 03080ク7040607ィB080ク707 6ヲ001090409 02080ク7 fi0902080ク7 02080ク7 6ァ900 02080ケ0 02 06 0ク7apple 閨0302 0409 43 fiapple0キ30ケ0 0203066 5060ケ0 02 atrap-/- apple0807026ァ90206, 040209 000003 閨0209 apple080ク7 07-08 閨0303090200 apple 03 apple07070キ3. 09030キ302000ケ107000ケ0 apple080ク7 070206 03086ヲ007 0000 02080ク70ケ0 ゙ヲ 2 0ク7apple08 0804006ァ90ケ0 0900 00 0800 閨0708 fi0206 09 040900 046ァ9 020キ307 ゙ヲ 2 0ク7apple08 08-04 閨0キ307 0906 0209 00 080006026ァ8 07 06 00fi03080キ3040903 (remodeling) 02080ク7 02 03 06 09090006 02086ヲ0 040ク704026ァ800 02080ケ0 apple 03 00 閨070006 00 閨040306 046ァ8000003 04 086ァ80ケ0, 09 06000ク702036ァ907060409 020キ307 apple 03 09fi- 07020キ307 apple080ク7 02 0308036ァ9ィB080ク707 0208 00apple6ァ9apple00 08 02090ケ0 03 04020602fi0209-02070ケ0 02080ク70ケ0 閨040006 06 06 6ァ902000309 040900 046ァ9. 6ム86ァ907 06 09070キ30402fi fi0206 09 000203 0406026ァ803 07apple086 709 0906 0209 040900 046ァ9 020キ307 ゙ヲ 2 0ク7apple08 0804 閨0キ307 006ァ907 06 fi0206 0702 090キ3076ァ9- ィB080702 06 0209 00 06000900030206026ァ803 00apple6ァ9 03 0409 020キ307 ゙ヲ 1 04020907 0ク7- apple0003020308086ァ9 02 06 0ク7apple0003apple03 046ァ9 020キ307 0604020607, apple0802000306-0702 0ケ0 閨07 applefi 02 0203 040602fi020003 apple 03 006ァ90900 02 02080ク7 0ク70ク80400086ヲ0 apple080ク7 apple08020003006ァ9 0208 0ク7applefi6 5 030308 02090ケ0 00 0ク707 0006-026ァ80ケ0 060408030308apple6ァ9 0ケ003 020キ307 03000602080ク70309060607 02080ク7 07030306apple0607080ク7 080309 07060400086ヲ0. 0903070900 0206 0400 020306070602fi 00apple6ァ9apple00 08, apple080303 閨0ケ0 000003 閨02000ケ0 陦000601 07 fi0206 0208 0200030602fi apple0802 閨03000400 02090ケ0 0307-04090ケ0 02090ケ0 0909000608020007046ァ907090ケ0 ヲミヲミ 04020907 ゙09, 04020907 02 03 06 026ァ8 0ク7apple0003020308086ァ9, 04020907 0ク7apple0003020308086ァ9 020キ307 03006ァ90キ307 000ク70ク8020607 06070607 02080ク7 09090006 02086ヲ0 020806040600 02080ケ0 02 06 04020907 06040206026ァ8 0707apple03 0409-04040900 02060400fi 07 閨080ク7 閨040キ3 0406020607 (neointimal formation) 46-50 apple08020003006ァ9 0208 040ク709020003 0400fi 02090ケ0 000ク708 080206026ァ80ケ0 030704090ケ0 02090ケ0 040900 0208 080206026ァ80ケ0 08 086ヲ0 020キ307 ゙ヲ 1 02 06 02090ケ0 07 0402 030206026ァ80ケ0 030704090ケ0 02090ケ0 040900 0208 080206-026ァ80ケ0 08 086ヲ0 020キ307 ゙ヲ 2. ゙02fi0009, 閨040006 00060403006ァ9 fi0206 09 06-0900030409 6ァ8 09 0ク7apple0003 閨020803 0409 020キ307 ゙ヲ 2 0ク7apple08 0804 閨0キ307 0400 apple080303 閨0ケ0 020ク70202 030602 閨0ケ0 04000603 閨0ケ0 07 0402 閨03030006 020907 0ク7apple0003020308-086ァ9 apple080ク7 apple030802 03086ヲ007 0806 0ク70109020602086ァ9 apple 030709080702000ケ0 (growth factors) 51-53, 02 06 apple030807090006 020907 applefiapple020キ30409. ヌ 00 0702060ク7apple0003apple03 040206026ァ803 0ク7026ァ8 03070409 閨040006 040ク704040002060403006ァ9, 21