1135 特集認知症 (AD,DLB) およびパーキンソン病における認知障害と抑うつ症状 1 2 QOL 1030 SHAPS SHAPS 索引用語 SnaithHamilton Pleasure Scale SHAPS はじめに QOL 1 Syndrome Subtype Prevalence Depression Major depression 1030 Minor depression 1020 Anxiety All 3040 Panic 430 Psychosis Hallucinations 4050 Delusions 510 Apathy 1770 Fatigue 3258 1 Ⅰ. うつの頻度 Aarsland 1 10 30 1020 1 1 DSM ICD10 Montgomery A sberg Depression Rating Scale Beck 1 2
1136 2013115 11 1SHAPS YJEXPANDS 2SHAPS YJEXPANDS 2 3SHAPS YJEXPANDS 2 Depression Inventory DSM DSMR 235 18 7.7 13 Montgomery Åsberg Depression Rating Scale 12 5.1 106 45.5 13 Beck Depression Inventory 18 49203 24.1 11100 11 4100 4 13 MMSE 20 3.67194 20 25.61143 13 Ⅱ. アンヘドニア Chapman Scales for Physical and Social Anhedonia SnaithHamilton Pleasure ScaleSHAPS 2 SHAPSJ The Young Japanese Expert Group for Parkinsons D i s e a s e a n d M o v e m e n t D i s o r d e r sy J
1137 2SnaithHamilton Pleasure ScaleSHAPS 23 1 8 2 9 3 10 4 11 5 12 6 13 7 14 EXPANDS SHAPSJ 9 225 95 130 68.88.4 61.110.1 SHAPS 14 0 1 3 38 16.9 0.049 SHAPS SHAPS Hohen Yahr stage SHAPS A10SHAPS
1138 2013115 11 3SHAPSJ p 187 38 79108 1622 0.99NS SHAPSJ 0.50.7 5.22.5 0.0001 68.88.6 69.47.6 0.82NS 61.49.9 59.411.6 0.28NS 88.562.3 121.982.1 0.018 HoehnYahr stage 2.80.9 3.10.9 0.025 YJEXPANDS 4 10 odds 2,4,68,11,1416 odds 95 Ⅲ. うつはパーキンソン病の前駆症状か?
1139 4 odds 95 p Behari 2 Taylor 14 McCann 8 Hubble 4 PD 9.98 2.6337.7 0.001 20 0.19 0.080.47 0.001 20 0.74 0.461.19 0.125 10 0.65 0.192.20 0.491 10 1.94 1.332.80 0.080 10 0.78 0.331.84 0.570 10 0.50 0.340.74 0.001 10 1.54 1.062.23 0.024 10 1.51 0.542.50 0.707 5.09 2.3311.09 0.0001 PD 3.94 1.748.94 0.001 2.46 1.254.85 0.01 0.87 0.800.96 0.003 0.96 0.930.99 0.02 0.99 0.980.998 0.02 PD 3.7 1.96.0 0.001 1.8 1.72.5 0.001 1.2 0.72.2 0.6 0.7 0.41.0 0.03 0.2 0.10.5 0.001 0.2 0.10.4 0.001 3.15 1.306.63 0.0084 PD 2.84 1.127.21 0.0238 2.95 1.088.01 0.0284 2,4,8,14 1.53.4 4 10 4 10 10 PD 45 peak 10 5 12 5hydroxyindoleacetic acid 5 3 おわりに QOL
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Powered by TCPDF (www.tcpdf.org) 1141 Depression in Parkinson s Disease Shin KITAMURA 1, Hiroshi NAGAYAMA 2 1Department of Neurology, Nippon Medical School Musashikosugi Hospital 2Department of Neurology, Nippon Medical School Depression affects Parkinsons diseasepdpatients QOL. Although it changes with the diagnostic criteria used, the frequency of depression in PD is approximately 1030. Anhedonia is characteristic in PD. According to research on anhedonia in PD using the SnaithHamilton Pleasure ScaleSHAPS, the positive ratio of anhedonia is high in PD. The SHAPS score significantly correlates with the severity of PD and duration of the disease. An examination of the literature on depression before the development of motor symptoms of PD revealed that the risk of PD is high in patients with a history of depression. Pathologically, the substantia nigra is affected in the later stages and raphe nuclei are affected in the early stages. This suggests that depression is a prodromal symptom of PD. Authors abstract Keywords Parkinsons disease, depression, anhedonia, SnaithHamilton Pleasure Scale SHAPS