*Criteria 1) B-marker positive 2) Variability in nuclear size and shape 3) Giant cells and multinucleated cells

*Criteria 1) B-marker positive 2) Variability in nuclear size and shape 3) Giant cells and multinucleated cells

Abbreviation: LC=large cleaved nuclei, LNC=large non-cleaved nuclei, IMBL=immunoblastic nuclei, F=follicular, F/D=follicular and diffuse, L=Logrank, W=Wilcoxon } 5

Variables in histochemical categories (diffuse large cell lymphomas) Abbreviation: LC=large cleaved, LNC=large non-cleaved, IMB=immunoblastic, PLO=pleomorphic, EN=extranodal, N=nodal.

1) T and B cell Malignancy Study Group: Statistical analysis of immunological, clinical and histological data on lymphoid malignancies in Japan. Jpn J Clin Oncol 11: 15-37 1981 2) Shimoyama, M: Celluar origin, differentiation and classification of leukemia and lymphoma cells, based on surface marker analysis. Acta Harmatol Jpn 42: 897-917 1979 13) Lennert, K.: Malignant lymphomas other than Hodgkin's disease. Springer-Verlag, N.Y. Heiderberg Berlin 1978 14) Strauchen, J.A. Young, R.C. DeVita, V.T. et al: Clinical relevance of the histopathological subclassification of diffuse ghistiocytic h lymphoma. New Eng J Med 299: 1382-1387 1978 15) Nathwani, B.N. Kim, H. Rappaport, H. et al: Non-Hodgkin's lymphomas. A clincopathologic study comparing two classifications. Cancer 41 4) Mikata, A. Harigaya, K. Suzuki, H et al: Enzyme histochemistry of non-hodgkin's lymphomas. Acta Pathol Jpn 29: 739-753 1979 6) Cox, D.R.: Regression models and life tables. J Roy Stat Soc Ser B 34: 187-202 1972 of histologic classification of advanced diffuse al: Subcategories of hostiocytic lymphoma. Association with survival and reproducibility 8) Suchi, T. Tajima, K. Namba, K. et al: Some problems on the histopathological diagnosis of non-hodgkin's lymphoma. A proposal for a new type. Acta Pathol Jpn 29: 755-776 1979 19) Rappaport, H.: Follicular lymphoma, a re- evaluation of its position in the schema of 10) Jones, S.E. Fuks, Z. Bull, M et al: Non- Hodgkin's lymphomas. IV. Clinicopathologic correlations in 405 cases. Cancer 31: 806-823 1973 11) Rosenberg, S.A. Berard, C.W. Browm, B.W. et al: National Cancer Institute sponcered study of classification of non-hodgkin's lymphomas. Summary and description of a working formulation for clinical usage. Cancer 49: 2112-2135 1982 12) Lukes, R.J. and Collins, R.D.: The Lukes- Collins classification and its significance. Cancer Treat Rep 61: 1-9 1977 : 303-325 1978 16) Armitage, J.O. Dick, F.R. Platz, C.E. et al: Clinical usefulness and reproducibility histiocytic lymphoma. Am J Med 67: 929-934 1979 17) Whitcomb, C.C. Cousar, J.B. Flint, A. et of classification. South-eastern Cancer Study Group experience. Cancer 48: 2464-2474 1981 malignant lymphoma based on a survey of 253 cases. Cancer 9: 792-821 1956 20) Rappaport, H.: Tumors of the hematopoietic tissue. F 8-160, AFIP Atlas of Tumor 1966 Pathology 23) Parfrey, N.A. Mann R.B. Delnonick, S.E. and Beschorner, W.E.: Malignant large cell lymphoma of B-cell type with multilobulated nuclei. Cancer 55: 1913-1917 1985

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