Hb Fluctuation NIRS Hb 1 Hb BOLD fmri arteriole oxy-hb Hb oxy-hb, deoxy-hb, t-hb Hb fluctuation 24 fluctuation Hb fluctuation
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1 1. P. Born, E. Rostrup, H. Leth, et al. Lancet, 347 (1996) N. Fujiwara, K. Sakatani, Y. Katayama, et al. Neuroimage, 21 (2004) J.H. Meek, M. Firbank, C.E. Elwell, et al. Pediatr Res, 43 (1998) Y. Murata, K. Sakatani, Y. Katayama, et al. J Neurol Neurosurg Psychiatry, 73 (2002) Y. Murata, K. Sakatani, Y. Katayama, et al. AJNR, 25 (2004) K. Sakatani, Y. Xie, W. Lichty, et al. Stroke, 29 (1998) K. Sakatani, C. Saying, L. Wemara, et al. Early Hum Devel, 55 (1999)
2 Hb Fluctuation NIRS Hb 1 Hb BOLD fmri arteriole oxy-hb Hb oxy-hb, deoxy-hb, t-hb Hb fluctuation 24 fluctuation Hb fluctuation
3 NIRS-Imaging NIRS-Imaging
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6 : NIRS-Imaging., 46: 20-32, Kato T. Principle and technique of NIRS-Imaging for human brain FORCE: fast-oxygen response in capillary event. International Congress Series. Frontiers in Human Brain Topology. The Proceeding of ISBET Edited by M. Nakagawa, K. Hirata, Y. Koga and K Nagata. Vol.1270C, pp88-99, 2004, 6:. Brain Medical 12 (in press) 2004.
7 Yamamoto T, Kato T. Paradoxical correlation between signal in functional magnetic resonance imaging and deoxygenated haemoglobin content in capillaries: a new theoretical explanation. Phys. Med. Biol. 47: , 2002
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11 NIRS effect sizelaterality index 1. Miyai I, Tanabe HC, Sase I, et al. Cortical mapping of gait in humans: a near-infrared spectroscopic topography study. Neuroimage 2001; 14: Miyai I, Yagura H, Oda I, et al. Premotor cortex is involved in restoration of gait in stroke. Ann Neurol 2002; 52: Miyai I, Yagura H, Hatakenaka M, et al K. Longitudinal Optical Imaging Study for Locomotor Recovery After Stroke. Stroke 2003; 34: Suzuki M, Miyai I, Ono T, et al. Prefrontal and premotor cortices are involved in adapting walking and running speed on the treadmill: an optical imaging study. Neuroimage 2004;23:
12 NIRS [Hb] 2 [Hb] [Hb] [Hb] S/N 5 NIRS 0.1 PETSPECT fmri Anatural design NIRS [Hb] (1) (2) Bblock design 2 Cevent-related design 2 NIRS PET NIRS 33:787, 2004 NIRS 14:155, 2003 NIRS Hb
13 near-infrared spectroscopy (NIRS) functiona1 MRIfMRI PET 5 5 ( ) non-rem 8Hz 24ch 3cm cm OMM , 804, 828nm oxyhb deoxyhb 5 4 oxyhb total Hb deoxyhb
14 10 12ch cm oxyhb 3 3 oxyhb Pena 2 5 backward 4 rcbf ±3.1 ml/100g/min PET rcbf 24.1 ml/100g/min 7.0 ml/100g/min MRI SPECT SPECT PETMRISPECT 133 Xe NIRS 1Isobe K, Kusaka T, Nagano K, et al. Functional imaging of the brain in sedated newborn infants using near-infrared topography during passive knee movement. Neurosci Lett 2001; 299: Nagano K, Kusaka T, Okubo K, et al : Functional imaging of the brain in infant under sedated sleep using near infrared topography. Excerpta Medica International Congress Series 2001; 1232 : Kusaka T, Isobe K, Nagano K, et al: Estimation of regional cerebral blood flow distribution in infants by multichannel near-infrared spectroscopy with indocyanine green. Proc SPIE 2001; 4250: Kusaka K, Isobe K, Nagano K, et al: Estimation of regional cerebral blood flow distribution in infants by near-infrared topography using indocyanine green. NeuroImage 2001; 13: Pena M, Maki A, Kovacic D, et al: Sounds and silence: an optical topography study of language recognition at birth. Proc Natl Acad Sci U S A. 2003; 100: Kusaka T, Kawada K, Okubo K, et al: Noninvasive optical imaging in the visual cortex in young infants. Hum Brain Mapp 2004; 22:
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16 NIRS NIRS (1) PET fmri NIRS NIRS NIRS NIRS NIRS NIRS MNIMontreal Neurological Institute Talairach fmri PET MEGERPEEG NIRS MNITalairach 1) ) MRI 2,3) D 10-20
17 NIRS MRI 4) MNI MRI ) NIRS MNI NIRS Matlab MNI ) Okamoto, M. et al. Three-dimensional probabilistic anatomical cranio-cerebral correlation via the international system oriented for transcranial functional brain mapping. NeuroImage (2004) 2) Okamoto, M. et al. Multimodal assessment of cortical activation during apple peeling by NIRS and fmri. NeuroImage 21, , Front cover (2004) 3) Okamoto, M. and Dan, I. Automated cortical projection of head-surface locations for transcranial functional brain mapping. NeuroImage, 26, (2005). 4) Singh, A. et al. Spatial Registration of multichannel multi-subject fnirs data to MNI space without MRI. NeuroImage, in press (2005). 5) Jurcak, J. et al. Virtual measurement on MR images to facilitate inter-modal trends in functional brain imaging. NeuroImage, in press (2005)
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