B UEDA 6 TEL FAX
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1 B UEDA 6 TEL FAX symposium@kuba.jp
2 10:00 10:03 開会挨拶 10:03 10:13 文部科学省挨拶 10:13 10:30 タンパク質の構造研究のいま 10:30 10:40 招待講演者紹介 解説 10:40 11:40 招待講演 RESISTANCE TO RIBOSOMAL ANTIBIOTICS REVEALED BY HIGH BRILLIANCE SYNCHROTRON RADIATION Ada E. Yonath Weizmann Institute, Rehovot, Israel 11:40 13:00 ポスターセッション (1) 13:00 13:30 植物はいかにしてストレス環境に適応するかアブシジン酸シグナリングの構造基盤 13:30 14:00 植物の生長に関わるシグナル受容因子の構造と機能 14:00 14:30 核酸およびレドックス調節パスウェイを標的とする抗トリパノソーマ薬の開発 14:30 15:00 情報プラットフォーム : プログラムにおける情報共有と情報発信ターゲットタンパク研究の最新動向を知るには 15:00 16:30 ポスターセッション (2) 16:30 17:00 ギャップ結合チャネルの構造とチャネル作動機構 17:00 17:30 直鎖状ポリユビキチン化 : NF-κB 活性化に必須な新たなユビキチン修飾系 17:30 18:00 小胞輸送における膜のリモデリング 18:30 20:00 交流会 4,000
3 10:40 11:40 招待講演 RESISTANCE TO RIBOSOMAL ANTIBIOTICS REVEALED BY HIGH BRILLIANCE SYNCHROTRON RADIATION 13:00 13:30 Weizmann Institute, Rehovot, Israel Ada E. Yonath Ribosomes are the universal cellular machines that translate the genetic code into proteins in all organisms with high efficiency. Because of the fundamental tasks of the ribosomes in life cycle, many antibiotics hamper specific ribosomal functions. Based on the crystal structures of complexes of ribosomal antibiotics with ribosomal particles from a pathogen model (the eubacterium Deinococcus radiodurans), obtained by synchrotron radiation, we found that the distinction Ada E. Yonath between the eubacterial and eukaryotic ribosomes is hinged on subtle differences between them. We also identified parameters that can lead to resistance to antibiotics, a major problem in modern medicine. Future promising candidates are two-components antibiotics, each of which can be rather weak, but acting synergistically they become powerful drugs. Recent findings in this frontier will be shown Hebrew RSGI SSBC ABA ABA ABA PYR/PYL/RCAR ABA Protein phosphatase 2C PP2C SnRK2 1 ABA PYL1 ABA PP2C ABI1 2 ABA ABA PYL1 ABA ABA PYL1 ABA ABA ABA ABA PYL1 ABA PYL1 ABI1 ABI1 ABA PYL1 PYL1 ABA ABI1 Trp PYL1 ABI1 PP2C 3 ABA ABA 2 3
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9 A description of the structural determination procedures of a gap junction channel at 3.5 Å resolution. Suga M, Maeda S, Nakagawa S, Yamashita E, Tsukihara T. Acta Crystallogr D Biol Crystallogr. D65, Structure of the connexin 26 gap junction channel at 3.5 Å resolution. Maeda S, Nakagawa S, Suga M, Yamashita E, Oshima A, Fujiyoshi Y, Tsukihara T. Nature 458, Protein Society Amgen
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