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1 AB

2 nm 830nm 380nm 780nm 540nm 580nm 660nm 540nm 660nm Log relative corneal sensitivity nm 1.2 retina5 rod cone2 3 SML visual pigment SShort 419nmMMiddle 531nmLLong 558nm

3 735 X Xq28 n 72 n primary colors 3 3 trichromacy opsin A retinal rhodopsin blue, green, red opsin ) X Xq ) nm277 9nm285 15nm 2)3) nm 4)6) )3) )4

4 Thr 180 Ser 230 Ile 233 Ala 277 Tyr 285 Thr 309 Tyr Ile 116 Ser 153 Leu 236 Met 274 ILe 275 Phe 279 Val 298 Ala Ile 180 Ala 230 Thr 233 Ser 277 Phe 285 Ala 309 Phe Val 116 Tyr 153 Met 236 Val 274 Val 275 Leu 279 Phe 298 Pro Ser Ala Ser Ala nm X , ) nm 625nm 95nm 9) 531nm 558nm 27nm 2 X 1 X X 2

5 ) 2 10) color blindness, color vision defects 2 dichromacy 3 anomalous trichromacy 5 1 protan protanopes 2 deutan deuteranopes 3 tritan tritanopes red-green color blindness 3 yellow-blue color blindness ) X )16) 4 3 4A 2 X X2 2

6 738 A 1 2 B C )17) B B 2 1 4C 53

7 X PCR 2 PCR 3 3, X carrier X X

8 740 X 2 X inactivationdeactivation, lyonization 7 X X X X X 1 6A yellow spot 6B 2 3 6C ) 2 X D ) E )

9 741 X X X X A B C X 1 1 X E F X X 1 X X X X 2 X 1 X 9 X X X 1 1 7A X 1 2 6F7B X 1 2

10 742 A 1 Y X 1 1 X X 1 B 1 Y X 2 X X PCR 10 pseudoisochromatic plates pseudoisocolor confusion color Ishihara Plates

11 A 8B negative result positive result D-15 anomaloscope 9 589nm 546nm 671nm D-15 2 cm

12 D-15 D ) ) 4) 1) Nathans J, et al: Science (1986) 232: ) Merbs SL, et al: Science (1992) 258: ) Asenjo AB, et al: Neuron (1994) 12: ) Winderrickx J, et al: Nature (1992) 356: ) Deeb SS, et al: Proc Natl Acad Sci USA (1994) 91: ) : (1998) 102: ) Jocobs, GH: Biol Rev (1993) 68: ) : (1999) 53: ) : (1999) 53: ) Onishi A, et al: Nature (1999) 402: ) : 12) Dalton J: Mem Literary Philos Soc Manchester (1798) 5: ) Hunt DM, et al: Science (1995) 267: ) Nathans J, et al: Science (1986) 232: ) Smallwood PM, et al: Proc Natl Acad Sci USA (2002) 99: ) Hayashi T, et al: Nat Genet (1999) 22: ) Jφrgensen AL, et al: Proc Natl Acad Sci USA (1990) 87: ) Kremers J, et al: J Opt Soc Am A (2000) 17: ) Miyahara E, et al: Vision Res (1998) 38: ) Jordan G, et al: Vision Res (1993) 33: ) : (1999) 41: ) : VISION (1999) 11:

13 maokabe@lab.nig.ac.jp CREST Cold Spring Harbor Meeting 1 itokei@nibb.ac.jp ERATO phph rosy white CCD 2 2

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