狂牛病調査第２巻1章，２章.doc

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こうざぶろうさわい
5 years ago
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40 2.1 A LD50/30mg () 10 ND ND ND ND 11 ND ND ND 11 ND ND ND 13 ND ND ND ND ND

41 B LD50/30mg () ND ND ND ND ND ND ND ND NT ND C () LD50/30mg ND

42 Hadlow, W., Kennedy, R. and Race, R. (1982) Naural infection of Suffolk Sheep with Scrapie Virus, Journal of Infectious Diseases, 146, ND= 2NT= 62

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45 2.2 / ( 1 ) Pro-Leu 102 Met 129 GSS( ) Hsiao, K.K. et al. (1989) 6 Met 129, Lys Furukawa, H. et al PrP (1995) al Telling, G.C. et al. Pro-Leu 102, Met 129 (1995) 12 Young, K. et al. (1997) Pro-Leu 105 al Kitamoto, T. et al. (1993) Ala-Val 117 Val 129 Hsaio, K.K. et al PrP (1991b) Tyr-Stop 145 Met 129 PrP Kitamoto, T. et al 1 PrP (1993a) As-Asn 178 Val 129 CJD CJD Goldfarb, L.G. et al. Met FFI (Val 129 Met (1991) 129) Lugaresi, E. et al. (1986) Val-Ile 180 Met 129 Farlow, M.R. et al. (1989) Tateishi, J. et al. (1995) Thr-Ala 183 Met Nitrimi, R. et al. (1997) 4 Phe-Ser 198 Val 129 GSS PrP Farlow, M.R. et al. (1989) Ghetti, B. et al. (1989) Glu-Lys 200 Met 129 CJD12 Goldfarb, L.G. et al. 55 (1990) Goldfarb, L.G. et al (1990a) Goldfarb, L.G. et al (1991b) Collinge, J. et al. (1993) Hsiao, K.K. et al. (1991) Korczyn, A.D. et al 65

46 (1991) Brown, P. et al. (1992) Neufeld, M.Y. et al. (1992) Chapman, J. et al. (1994) Arg-His 208 Met 129 CJD CJD Mastrianni, J.A. et al. (1995) 2 Val-Ile 210 Met 129 Davies, P.T.G. et al. (1993) Gln-Pro 212 Met Young, K. et al. (1998) 8 Gln-Arg 217 Val Hsiao, K.K. et al. (1992) Met-Arg 232 Met Kitamoto, T. et al. 3 (1993) 24 bp Met 129 Laplanche, J. et al. (1 ) 1 4 (1995) 48 bp Met CJD EEG Goldfarb, L.G. et al. (2 ) 58 (1993) 96 bp Met 129/ Met CJD GSS Goldfarb, L.G. et al. (4 ) Val 129 Val (1991) Laplanche, J. et al. (1995) 120 bp Met Goldfarb, L.G. et al. (5 ) (1991) 144 bp Met 129 CJD Owen, F. et al. (1989) (6 ) Nicholl, D. et al. (1995) Oda, T. et al. (1995) 168 bp Met Goldfarb, L.G. et al. (7 ) (1991) 192 bp Val Goldfarb, L.G. et al. (8 ) (1991) Guiroy, D.C. et al. (1993) 216 bp Met 129 (9 ) PrP Owen, F. et al. (1989) Tagliavini, F. et al. (1993) Krasemann, S. et al. (1995) 1 PrP Met-Val 129 Goldfarb, L.G. et al. (1989) Palmer, M.S. et al. (1991) GGC-GGG Hsiao, K. K. et al. (1992) GCA-GCG Wu, Y. et al. (1987) CAC-CAT Ripoll, L. et al. (1993) Glu-Lys 219 Furukawa, H. et al. (1995) 24 bp 1 Laplanche, J. et al. ( ) (1990) Palmer, M.S. et al. (1993) 1 66

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48 2.3CJD 129 / / 38% 11% 51% CJD 68% 15% 17% CJD 11% 67% 22% CJD 100% 68

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™·”õ/sec3_p63_84/fiü“eflÅ

™·”õ/sec3_p63_84/fiü“eflÅ Section3 64 1 65 Section 3 1 2 3 4 5 6 7 8 9 10 11 12 13 14 1 Babara E. Ainsworth et al. Med. Sci. Sports. Exevc.1993 66 67 Section 3 1 10 9 8 1 2 3 4 7 6 5 6 7 5 1 2 3 4 68 69 Section 3 2 70 Section 3