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1 Short Review kuwata@cc.gifu-u.ac.jp Structural medicine and structure-based drug design for prion diseases
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6 2) Anfinsen, C. B.: Harvey Lect., 61, (1967) 3) Carrel, R. W., Lomas, D. A. : Lancet, 350, (1997) 4) James, T. L. et al. : Proc. Natl. Acad. Sci. USA, 94, (1997) 11) Wildegger, G., Liemann, S., Glockshuber, R. : Nature Struct. Biol., 6, (1999) 12) Kuwata, K., Shastry, M., Cheng, H., Hoshino, M., Batt, C. A., Goto, Y., Roder, H. : Nature Struct. Biol., 8, (2001) 1) Prusiner, S. B.: Science, 216, (1982) 5) Riek, R., Horneman, S., Wider, G., Billeter, M., Glockshuber, R., Wbthrich, K.: Nature, 382, (1996) 6) Lopez-Garcia, F., Zahn, R., Riek, R., W6thrich, K. : Proc. Natl. Acad. Sci. USA, 97, (2000) 7) Zahn, R. et al. : Proc. Natl. Acad. Sci. USA, 97, (2000) 8) Swietnicki, W., Petersen, R., Gambetti, P., Surewicz, W.K. : J. Biol. Chem., 272, (1997) 9) Hornemann, S., Glockshuber. R.: Proc. Natl. Acad. Sci. USA, 95, (1998) 10) Zhang, H., Stockel, J., Mehlhorn, I., Groth, D., Baldwin, M. A., Prusiner, S. B., James, T. L., Cohen, F. E.: Biochemistry, 36, (1997) 13) Akke, M., Bruschweiler, R., Palmer, A. G.: J. Am. Chem. Soc., 115, (1993) 14) Mulder, F. A. A., Mittermaier, A., Hon, B., Dahlquist, F. W., Kay, L. E. : Nature Struct. Biol., 8, (2001) 15) Akasaka, K., Yamada, H. : in Methods in Enzymology (ed. James, T. L., Dotsch, V., Schmitz, U.), pp , Academic Press, San Diego (2001) 16) Akasaka, K., Li, H. : Biochemistry, 40, (2001) 17) Fandrich, M., Fletcher, M. A., Dobson, C. M. : Nature, 410, (2001) 18) Goldberg, M. S., Lansbury, P. T. Jr. : Nature Cell Biol., 2, E115-E119(2000) 19) Prusiner, S. B. : in Prion Biology and Diseases(ed. Prusiner, S. B.), pp , Cold Spring Harbor Press, New York (1999) Laboratory 20) Telling, G. C., Scott, M., Mastrianni, J., Gabizon, R., Torchia, M., Cohen, F. E., DeArmond, S. J., Prusiner, S. B.: Cell, 83, 79-90(1995) 21) Kaneko, K., Zulianello, L., Scott, M., Cooper, C. M., Wallace, A. C., James, T. L., Cohen, F. E., Prusiner, S. B. : Proc. Natl. Acad. Sci. USA, 94, (1997) 22) Prusiner, S. B. : in Prion Biology and Diseases (ed. Prusiner, S. B.), pp , Cold Spring Harbor Laboratory Press, New York (1999) 23) Wiithrich, K., Riek, R. : Adv. Protein Chem., 57,55-82 (2001)
7 24) Farrow, N. A., Muhandiram, R., Singer, A. U., Pascal, S. M.. Kay, C. M., Gish, G., Shoelson, S. E., Pawson. T., Forman- Kay, J. D., Kay, L. E. : Biochemistry, 33, (1994) 25) Viles, J. H.. Donne, D.. Kroon, G., Prusiner, S. B., Cohen. F. E.. Dyson, H. J., Wright, P. E. : Biochemistry, 40, (2001) 26) Kitahara, R.. Sareth, S., Yamada, H., Ohmae, E., Gekko, K., Akasaka, K. : Biochemistry, 39, (2000) 27) Stahl, N., Prusiner, S. B. : FASEB J., 5, (1991) 28) Prusiner, S. B., Groth, D., Serban, A., Stahl, N., Gabizon, R. : Proc. Natl. Acad. Sci. USA. 90, (1993) 29) Turk, E., Teplow, D. B., Hood, L. E., Prusiner, S. B. : Eur. J. Biochem,, 176, (1988) 30) Knaus, K. J., Morillas, M., Swietnick, W., Malone, M., Surewicz, W. K., Yee, V. C.: Nature Struct. Biol., 8, (2001) 31) Liemann, S., Glockshuber, R.: Biochemistry, 38, (1999) 32) Schapira, M., Raaka, B. M., Samuels, H. H., Abagyan, R. : Proc. Natl. Acad. Sci. USA (2000) (http : // P/-idenshi/ 33) Perrier, V., Wallace, A. C., Kaneko, K.. Sajar, J., Prusiner, S. B., Cohen. F. E.: Proc. Natl. Acad. Sci. USA, 97, (2000) 34) Doh-ura. K.. Iwaki, T., Caughey, B.: J. Virol.. 74, (2000) 35) Perez, D. et al. : Nature. 412, (2001) Tel FAX seijitcmcdmbox.nc.kyushu-u.ac.jp Tel FAX nagasakicabioa.eng.osaka-cu.ac.jp
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Database Center for Life Science Online Service Miho Shimizu, [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sap
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The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Database Center for Life Science Online Service Key words Shigey
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drug development Toshimi Michigami, E-mail : michigami@mch.pref.osaka.jp Keiichi Ozono, E-mail : keioz@ped.med.osaka-u.ac.jp The progress in the research on vitamin D 1) McCollum, E. V. et al.:
Novel chemical mediators in the resolution of inflammation Charles N. Serhan Key words E-mail : marita@nih.go.jp Charles N. Serhan Brigham & Women's Hospital/Harvard Medical School 1) Serhan, C. N.,
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Various function and toxicity of iron Key words 1) Hentze, M. W. et al: Cell, 117, 285-297 (2004) 2) Ganz, T.: Blood, 102, 783-788 (2003) 3) Nemeth, E. et al.: Science, 306, 2090-2093 (2004) 4) Hentze,
1) van Meer, G., Op den Kamp, J. A.: J. Cell. Biochem., 19, 193-2040982) 2) Gaffet, P., Bettache, N., Bienvenue, A.: Biochemistry, 34, 6762-6769(1995) 3) Sims, P. J., Wiedmer, T.: Thromb. Haemost., 86,
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Database Center for Life Science Online Service archlaboratories, 4-1-1 Miyazaki, Miyamae-ku, Kawasaki-shi, Kanagawa 213, Japan] Developmental Genetics of Caenorhabditis elegans Database Center for
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Structure and function of nitric oxide synthases 3) Furchgott, R. F., Zawadzki, J. V. : Nature, 288,373-376 (1980) 4) Palmer, R. M., Ferrige, A. G., Moncada, S.: Nature, 327,524-5260987) 5) Alderton,
Review Fumio Imamoto1, Takefumi Sone1, Kazuhide Yahata1, Yukari Sasaki1, Masatoshi Takagi2, Kazuhiro Maeshima2, Naoko 25) Dong, W. K. et al.: Gene, 91, 217-223 (1990) 26) Masatsugu, T. et al.:
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Review Database Center for Life Science Online Service Masanori Mishima, p Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
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Database Center for Life Science Online Service [Department of Molecular Physiology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome,
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Database Center for Life Science Online Service Matthias P. Mayer*, Toshifumi Tomoyasu* *, Bernd Bukau*, Institut fiir Biochemie and Molekularbiologie
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E-mail : tmatsumo@house.rbc.kyoto-u.ac.jp htm Spindle checkpoint : Cell cycle regulation by a signal emitted from kinetochores http://www.rbc.kyoto-u.ac.jp/radiation_system/m-index. 19) Yao, X., Abrieu,
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1) Araki, T.: Curr. Opin. Plant Biol., 4, 63-68 (2001) 2) Boss, P. K., Bastow, R. M., Mylne, J. S., Dean, C.: Plant Cell, 16, S18-S31(2004) 3) Simpson, G. G., Dean, C. : Science, 296, 285-289 (2002) 4)
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E-mail: khatano@fms.saitama-u.ac.jp Tel & Fax: 048-858-3535 Toxin Virus Bacterium Glycolipid Glycoprotein Vero toxin (Stx1 and Stx2) Side view Bottom view H H H H N H Grobotriaosyl Ceramide (Gb 3 : Galα1-4Galβ1-4Glcβ-Cer)
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Short Review Mycoplasma mobile Mycoplasma mobile http : //www. geocities.co.j p/technopolis/1721/myco.htm Makoto Miyata, E-mail : miyata(sci.osaka-cu.ac.jp http://www.geocities.co.jp/technopolis/1721/myco.htm
Database Center for Life Science Online Service Vol.48 No.16 (2003)
Database Center for Life Science Online Service Key words Kikuya Kato, E-mail : kkato@bs.aist-nara. ac.jp http://love2.aist-nara.ac.jp Shin Ishii, E-mail : ishii@is.aist-nara.ac.jp http://hawaii.aist-nara.
Molecular bases for plant circadian clock and flowering : How does the quintet tell the time? Cell, 101, 319-329(2000) 8) Schultz, T. F., Kiyosue, T., Yanovsky, M., Wada, M., Kay, S. 9) A. : Plant
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特集生体機能の多階層的理解と創薬研究への応用 Folia Pharmacol. Jpn. 147 要約 :Pi 3 CKD CKD FGF Nampt 1. はじめに chronic kidney disease CKD CKD CKD FGF,, CKD 辰巳佐和子, 宮本賢一 2. リントランスポーターとリン恒常性維持機構 Pi ph mm Pi - - E-mail: tatsumi@tokushima-u.ac.jp
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D., Nicola, N. A., Hilton, D. J.: Nature, 387, 917-921 (1997) 12) Alexander, W. S. : Nat. Rev. Immunol., 2,410-416 (2002) 13) Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., Shuai, K. : Science,
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Database Center for Life Science Online Service Signal transduction of growth factor mediated by heparin heparan sulfate
Signal transduction of growth factor mediated by heparin heparan sulfate 1) Zhu. X.. Komiya, H., Chirino, A.. Faham. S.. Fox, G. M., Arakawa, T., Hsu, B.T., Rees, D. C.: Science. 251, 90-93 (1991)
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CLINICIAN 11 NO. 602 16 Chemical Exchange Saturation Transfer Forsen Hoffman Balaban Exchange Magnetization Transfer CEST agent -NH -OH CEST agent CEST agent 17 CLINICIAN 11 NO. 602 A B Z- CEST CLINICIAN
1) Y. Hatefi: Annu. Rev. Biochem., 54, 1015 (1985). 2) H. Weiss, T. Friedrich, G. Hofhaus & D. Preis: Eur. 4) M. Yamaguchi & Y. Hatefi: Biochemistry, 32, 1935 (1993). 5) K. Leonard, H. Haiker & H. Weiss:
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1) Ogawa, H., Lazarus, G. S., Hopsu-Havu, K.: The Biological Role of Proteinases and their Inhibitors in Skin, Univ. Tokyo Press (1985) 2) Sottrup-Jensen, L., Stepanik, T. M., Kristen sen,t., Wierzbicki,
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最前線 免疫疾患における創薬標的としてのカリウムチャネル 大矢 進 Susumu OHYA 京都薬科大学薬理学分野教授 異なる経路を辿る １つは マイトジェンシグナル 1 はじめに を活性化し 細胞増殖が促進されるシグナル伝達経 路 図１A 右 であり もう１つはカスパーゼやエ 神 経 筋 の よ う な 興 奮 性 細 胞 で は カ リ ウ ム ンドヌクレアーゼ活性を上昇させ アポトーシスが K
Teru Ogura, Tomoko Yamada-Inagawa, E-mail : ogura@gpo.kumamotou.ac.jp AAA family ATPases : ring-shaped chaperones which catalyze energy-dependent conformational changes of proteins 29) Braun, S.,
Stress-responsive MAP kinases 15) Lu, H. T., Yang, D. D., Wysk, M., Gatti, E., Mellman, I., Davis, R. J., Flavell, R. A. : EMBO J., 18,1845-1857 (1999) 16) Lu, B., Yu, H., Chow, C., Li, B., Zheng,
(1982) 4) Bennett, J. W. : in The 10th International Congress for Culture Collections. (Okuda, T., Bennett, J. W. ed.), pp. 54-57(2004) 5) Machida, M.: Adv. Appl. Microbiol. 51, 81-106 (2002) 6) Florea,
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20) Unwin, N.: Nature, 373, 37-43 (1995) 22) Berridge, M.: Nature, 361, 315-325 (1993) 1) Johnson, L. N., Cell, 85, 149-158 2) Hanks, S. K., (1995) Noble, M. E. M Owen, (1996) Hunter, T. : FASEB J., D.
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5200) [Department of Biochemistry, Miyazaki Medical College, Kihara, Kiyotake-cho, Miyazaki 889-16, Japan] Natriuretic Peptide Family: ANP and BNP 1) de Bold, A. J.: Science, 230, 767-770 (1985)
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