Do probiotic bacteria improve human oral microbiota? NOBUKO MAEDA, TOMOKO OHSHIMA, KENICHI HOJO and NAOKI TAKETOMO The term eprobiotics f is defined a

Size: px
Start display at page:

Download "Do probiotic bacteria improve human oral microbiota? NOBUKO MAEDA, TOMOKO OHSHIMA, KENICHI HOJO and NAOKI TAKETOMO The term eprobiotics f is defined a"

Transcription

1 Do probiotic bacteria improve human oral microbiota? NOBUKO MAEDA, TOMOKO OHSHIMA, KENICHI HOJO and NAOKI TAKETOMO The term eprobiotics f is defined as eliving microorganisms that exhibit beneficial effects for health based on improvement of balance of indigenous microbiota. f Several strains of Lactobacillus and Bifidobacterium, and a certain yogurt are included in this definition. Probiotics have been developed for use in the prevention of intestinal infections, and the treatment of antibiotic-associated diarrhea and intestinal malfunction. Recently, the use of probiotics has come to exert a wide range of different effects such as the suppression of Helicobacter pylori, and the prevention of allergic disease. Moreover, evidence for the clinical effectiveness of probiotics has been reported in their use for the prevention and treatment of dental caries and periodontal diseases. For example, the administration of a dairy product containing L. rhamnosus appeared to reduce the risk of dental caries in a randomized, double-blind, placebo-controlled trial. This trial demonstrated reduced levels of dental caries and lower mutans streptococcal counts in probiotics patients after seven months of administration. From the viewpoint of periodontal diseases, it has been suggested that L. salivarius decrease the risk of periodontal disease by eliminating black-pigmented anaerobic rods (BPARs) which have been suspected of playing a role in periodontal disease. Yogurt may suppress the number of mutans streptococci in saliva and improve halitosis. However, there is little available information about the use of probiotics in dentistry. In addition, the role of indigenous Lactobacillus and Bifidobacterium on oral health, the adhesion of probiotics in the human oral cavity, and the mechanisms of probiotics against cariogenic and periodontopathogenic bacteria have not been clarified. In this review, the authors would like to address the possible use and problem of probiotics in dentistry. Key words : Probiotics (ƒvƒ ƒoƒcƒiƒeƒbƒnƒx), Lactobacillus ( ûž_ž Û), Bifidobacterium (ƒrƒtƒc ƒyƒx Û ), Dental caries ( I), Periodontal diseases (Ž Žü a) 1 Department of Oral Bacteriology, School of Dentistry, Tsurumi University (Chief: Prof. NOBUKO MAEDA) 2 Food Science Institute, Meiji Dairies Corporation

2

3

4

5

6

7 1) Seminario, A., et al: Mutans streptococci and the development of dental plaque. Prague Med Rep : 349 `358. 2) Socransky, S. S., et al: Subgingival microbial profiles in refractory periodontal disease. J Clin Periodontol : 260 `268. 3) Socransky, S. S., et al: Microbial complexes in subgingival plaque. J Clin Periodontol : 134 `144. 4) Kumar, P. S., et al: Identification of candidate periodontal pathogens and beneficial species by quantitative 16S clonal analysis. J Clin Microbiol : 3944 ` ) Meurman, J. H., et al: Effect of Lactobacillus rhamnosus strain GG (ATCC 53103) on the growth of Streptococcus sobrinus in vitro. Eur J Oral Sci : 253 `258. 6) Nase, L., et al: Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res : 412 `420. 7) Nikawa, H., et al: Lactobacillus reuteri in bovine milk fermented decreases the oral carriage of mutans streptococci. Int J Food Microbiol : 219 `223. 8) Ishikawa, H., et al: Suppression of periodontal pathogenic bacteria in the saliva of human by the administration of Lactobacillus salivarius T J Jap Soc Periodontol : 105 `112. 9) Grudianov, A. I., et al: Use of probiotics Bifidumbacterin and Acilact in tablets in therapy of periodontal inflammations. Stomatologiia : 39 `43. 10) Petti, S., et al: A randomized clinical trial of the effect of yoghurt on the human salivary microflora. Arch Oral Biol : 705 ` ) Caglar, E., et al: Effect of yogurt with Bifidobacterium DN on salivary mutans streptococci and lactobacilli in young adults. Acta Odontol Scand : 317 ` ) Ahola, A. J., et al: Short-term consumption of probiotic-containing cheese and its effect on dental caries risk factors. Arch Oral Biol : 799 ` ) Comelli, E. M., et al: selection of dairy bacterial strains as probiotics for oral health. Eur J Oral Sci 16) Sakamoto, I., et al: Suppressinve effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. J Antimicrob Chemother : 709 ` ) Falagas, M. E., et al: Probiotics for prevention of recurrent vulvovaginal candidiasis. J Antimicrob Chemother : 266 ` ) Abe, F., et al: Effect of administration of bifidobacteria and lactic acid bacteria to newborn calves and piglets. J Dairy Sci : 2838 ` ) Adami, A., et al: Occurrence of selected bacterial groups in the faeces of piglets fed with Bacillus coagulans as probiotic. J Basic Microbiol : 3 `9. 21) Ogata, T., et al: Effect of Bifidobacterium longum BB536 Administration on the Intestinal Environment, Defecation Frequency and Fecal Characteristics of Human Volunteers. Bioscience Microflora : 53 `58. 26) Aiba, Y., et al: Lactic acid-mediated suppression of Helicobacter pylori by the oral administration of Lactobacillus salivarius as a probiotic in a gnotobiotic murine model. Am J Gastroenterol : 2097 ` ) Kabir, A. M., et al: Prevention of Helicobacter pylori infection by lactobacilli in a gnotobiotic murine model. Gut : 49 `55. 28) Bjorksten, B., et al: The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy : 342 ` ) Bjorksten, B., et al: Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol : 516 ` : 218 ` ) Fuller, R.: Probiotics in man and animals. J Appl 30) Kalliomaki, M., et al: Probiotics in primary prevention of atopic disease : a randomised placebocontrolled trial. Lancet : 1076 ` ) Rosenfeldt, V., et al: Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis. J Pediatr : 612 `616. Bacteriol : 365 ` ) Rosenfeldt, V., et al: Effect of probiotic Lactobacil-

8 Vol. 25 No lus strains in children with atopic dermatitis. J Allergy Clin Immunol : 389 ` ) Kalliomaki, M., et al: Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet : 1869 ` ) Isolauri, E., et al: Probiotics in the management of atopic eczema. Clin Exp Allergy : 1604 ` ) Ishida, Y., et al: Effect of milk fermented with Lactobacillus acidophilus strain L-92 on symptoms of Japanese cedar pollen allergy: a randomized placebo-controlled trial. Biosci Biotechnol Biochem : 1652 ` ) Ishida, Y., et al: Clinical effects of Lactobacillus acidophilus strain L-92 on perennial allergic rhinitis: a double-blind, placebo-controlled study. J Dairy Sci : 527 ` ) Byun, R., et al: Quantitative analysis of diverse Lactobacillus species present in advanced dental caries. J Clin Microbiol : 3128 ` ) Becker, M. R., et al: Molecular analysis of bacterial species associated with childhood caries. J Clin Microbiol : 1001 ` ) Munson, M. A., et al: Molecular analysis of the microflora associated with dental caries. J Clin Microbiol : 3023 ` ) Haffajee, A. D., et al: Subgingival microbiota in healthy, well-maintained elder and periodontitis subjects. J Clin Periodontol : 346 ` ) Tanner, A., et al: Microbiota of health, gingivitis, and initial periodontitis. J Clin Periodontol : 85 `98. 42) Hillman, J. D., et al: The relationships between streptococcal species and periodontopathic bacteria in human dental plaque. Arch Oral Biol : 791 ` ) Morita, E., et al: Molecular analysis of age-related changes of Streptococcus anginosus group and Streptococcus mitis in saliva. Oral Microbiol Immunol : 386 ` ) Hojo, K., et al: Distribution of Salivary Lactobacillus and Bifidobacterium Species in Periodontal Health and Disease. Biosci Biotechnol Biochem 2006 (in press). 46) Koll-Klais, P., et al: Oral lactobacilli in chronic periodontitis and periodontal health: species composition and antimicrobial activity. Oral Microbiol Immunol : 354 ` ) Vacca-Smith, A. M., and Bowen, W. H.: The effect of milk and kappa casein on streptococcal glucosyltransferase. Caries Res : 498 `506.

Key words : Adverse reactions, Egg allergy, IgG antibody, Mills allergy, FAST

Key words : Adverse reactions, Egg allergy, IgG antibody, Mills allergy, FAST Key words : Adverse reactions, Egg allergy, IgG antibody, Mills allergy, FAST 13) Danaeus, A., Johansson, S. G. O., Foucard, T. & Ohman, S.: Clinical and immunogical aspects of food allergy in childhood.

More information

Microflora in Patients Treated with Fixed Prosthetic Appliances Supragingival Plaque Formed on the Full Cast Crown - Fabricated with Platinum Gold Cas

Microflora in Patients Treated with Fixed Prosthetic Appliances Supragingival Plaque Formed on the Full Cast Crown - Fabricated with Platinum Gold Cas Microflora in Patients Treated with Fixed Prosthetic Appliances Supragingival Plaque Formed on the Full Cast Crown - Fabricated with Platinum Gold Cast Alloy- Junichi Mega, Yosizumi Murata, Masatomo Hirasawa*

More information

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study VOL. 41 S 1 Table 2. Levels (Đg/ml or Đg/g) of S-1006 in serum, bile, and tissue (gallbladder) after oral administration

More information

To establish a local therapy of periodontitis by using minocycline HCl, a series of studies has been conducted. The present study was to re-confirm th

To establish a local therapy of periodontitis by using minocycline HCl, a series of studies has been conducted. The present study was to re-confirm th Local Administration of Minocycline for Periodontitis Double Blind Comparative Study of LS-007 Yoji MURAYAMA1), Yoshio NOMURA1), Akira YAMAOKA2), Masatoshi UEDA2), Toshio HORP), Masato MINABE3), Toshio

More information

Key words : R-plasmid, Urinary tract infection, E. coli Fig. 1. MIC distribution against E. coli isolated from urinary tract (366 strains) and isolation - frequencies of drug-resistant strains Table 1.

More information

Changes in Electrodermal Activity Associated with Candies and Chewing Gum Chewing Satoshi Beppu, Takeshi Morita*, Susumu Igarashi **, Kanichi Seto* an

Changes in Electrodermal Activity Associated with Candies and Chewing Gum Chewing Satoshi Beppu, Takeshi Morita*, Susumu Igarashi **, Kanichi Seto* an Changes in Electrodermal Activity Associated with Candies and Chewing Gum Chewing Satoshi Beppu, Takeshi Morita*, Susumu Igarashi **, Kanichi Seto* and Yosihiro Amemiya Abstract: This study was designed

More information

ESTIMATION OF THE SALIVARY ANTIBACTERIAL ACTIVITY IN TRYPTICASE SOY AGAR BY CUP PLATE METHOD BY Hajime TAKAHATA, Toshio MORIOKA and Toshiharu MATSUMURA The peroxidase antibacterial action in human saliva

More information

Cephaloridine Conc. 125mcg/m/+ DC 10mg/ml Cephaloridine Conc. 125mcg/ml C- adap+ E. coli Ampicillin Conc. 125mcg/ml+C 10mg/ml Cephaloridine Conc. 12.5mcg/ml D-adap+E.coil JORGENSEN : Alteration of bile

More information

1) i) Barber, M. et al.: Brit. Med J, 2, 565, 19'49. ii) Barber, M.F.G. J. Hayhoe and J. E. M. Whithead: Lancet, 1120 `1125, 1949.-2) Bergey: Bergey's Manual of Determinative Bacteriology 7 th Ed: (1958).-3)

More information

抗アレルギー効果のあるKW乳酸菌の発見と活用

抗アレルギー効果のあるKW乳酸菌の発見と活用 KW3110 3 1 90 1983 6 1998 20 1989 Strachan BCG Lactobacillus Lactococcus Streptococcus Lactobacillus casei brevis johnsonii Th2 Th2 IL 4 B IgE IgE IgE IL-12 IL-12 Th1 Th1 Th2 Th2 Th1 Th2 KW 101 Th1/Th2

More information

Table 1 Survival rates of infected mice given antibiotic doses producing peak serum a) S. aurcus Smith Challenge dose :7 ~10 (5% mucin) CFU/mouse. LD50: 1 ~103 (5% mucin) CFU/mouse. Table 2 Survival rates

More information

1272 CHEMOTHERAPY MAR. 1975

1272 CHEMOTHERAPY MAR. 1975 1272 CHEMOTHERAPY MAR. 1975 VOL. 23 NO. 3 CHEMOTHERAPY 1273 Fig. 2 Minimal inhibitory concentration of aminoglycosides against 50 strains of Klebsiella Fig. 1 Minimal inhibitory concentration of aminoglycosides

More information

Fig. 1 Chemical structure of DL-8280

Fig. 1 Chemical structure of DL-8280 Fig. 1 Chemical structure of DL-8280 Fig. 2 Susceptibility of cl in ical isolates to DL4280 Fig. 5 Susceptibility of clinical isolates to DL-8280 Fig. 3 Susceptibility of clinical isolates to DL-8280 Fig.

More information

先端社会研究 ★5★号/4.山崎

先端社会研究 ★5★号/4.山崎 71 72 5 1 2005 7 8 47 14 2,379 2,440 1 2 3 2 73 4 3 1 4 1 5 1 5 8 3 2002 79 232 2 1999 249 265 74 5 3 5. 1 1 3. 1 1 2004 4. 1 23 2 75 52 5,000 2 500 250 250 125 3 1995 1998 76 5 1 2 1 100 2004 4 100 200

More information

Effects of Isomaltooligosaccharides Intake on Defecation and Intestinal Environment in Healthy Volunteers Toshiyuki KANEKO, Takanobu KOHMOTO, Hiroe KI

Effects of Isomaltooligosaccharides Intake on Defecation and Intestinal Environment in Healthy Volunteers Toshiyuki KANEKO, Takanobu KOHMOTO, Hiroe KI Effects of Isomaltooligosaccharides Intake on Defecation and Intestinal Environment in Healthy Volunteers Toshiyuki KANEKO, Takanobu KOHMOTO, Hiroe KIKUCHI, Masao SHIOTA*, Tsuneya YATAKE*, Hisakazu IINO**

More information

The Japanese Journal of Experimental Social Psychology. 2003, Vol. 42, No. 2, 146-165 Discoursive Strategy for the Commitment to Adoption with Infants Who Had Been Reared at Residential

More information

名称未設定-1

名称未設定-1 Study on Clinical Factors Affecting the Fungal Culture Test - Relevance of Dry Mouth - Yoshiko YAMAMURA, Yukihiro MOMOTA, Hideyuki TAKANO, Koichi KANI, Katsumi MOTEGI, Fumihiro MATSUMOTO, Masayuki AZUMA

More information

untitled

untitled Vol. 19 No. 1 2009 13 23 Λ1 Λ2 2 1) 10 1 Infertility 1785 1978 1980 1983 IVF-ET 2) 1 1 1 6 65% 1 80% Λ1 Λ2 701-0193 288 E-Mail: hiro210691@yahoo.co.jp 13 14 2 90% 3 93% 2 10% 40% 40% 15% 5% 3) 2 4) 5)

More information

特集-角田.indd

特集-角田.indd 飲み込んでも安全な乳酸菌抗菌ペプチドの効果と臨床応用 角田愛美永利浩平善藤威史 1. はじめに 1 1 2 3 1 4 5 6 7 8 9 10 12 13 24 FRAGRANCE JOURNAL 2016-3 オーラルヘルスケア 2. 乳酸菌バクテリオシンの医療用途へ の有効性 A 1 1 A 34 1 2 MRSA VRE 3 4 5 ph 6 7 8 9 14 16 17 3. 乳酸菌バクテリオシンの代表,

More information

E Societe de Pathologie Infectieuse de Langue Francaise (, 1991) E Spanish Thoracic Society (1992) E American Thoracic Society (ATS : 1993. ü ù2001 ) E British Thoracic Society (1993, ü è2001 ) E Canadian

More information

HPV HPV HPV HPV 7 HPV 8 9 HPV 3 HPV HPV HPV , Becker Ajzen H

HPV HPV HPV HPV 7 HPV 8 9 HPV 3 HPV HPV HPV , Becker Ajzen H 3 26 3 Journal of Junshin Gakuen University, HPV Faculty of Health Sciences Vol.3, March 2014 99 HPV Knowledge of and attitudes towards human papillomavirus vaccinations among mothers who have daughters

More information

2) Goetz, A., Tsuneishi, N.: Application of molecular filter membranes to the bacteriological analysis of water, J. Am. Water Works Assn., 43 (12): 943-969,1951. 3) Clark, H.F. et al.: The membrane filter

More information

東洋医学雑誌

東洋医学雑誌 Vol.67 No.2 123-130, 2016 Akiyo GUSHI a Chihaya KORIYAMA b Ryo YOSHINAGA c Hiromi YANO c Junichi TSUMAGARI d Eiichi TAHARA c a Gushi Dermatological Clinic, 45-3 Higashiohsyoji, Satsumasendai city, Kagoshima

More information

IR0036_62-3.indb

IR0036_62-3.indb 62 3 2016 253 272 1921 25 : 27 8 19 : 28 6 3 1921 25 1921 25 1952 27 1954 291960 35 1921 25 Ⅰ 0 5 1 5 10 14 21 25 34 36 59 61 6 8 9 11 12 16 1921 25 4 8 1 5 254 62 3 2016 1 1938.8 1926 30 1938.6.23 1939.9

More information

CHEMOTHERAPY JUNE 1986

CHEMOTHERAPY JUNE 1986 VOL. 34 S-3 CHEMOTHERAPY Fig. 1 Structural formula of L-105 CHEMOTHERAPY JUNE 1986 VOL. 34 S-3 CHEMOTHERAPY Table 1 Antibacterial spectra of L-105 against gram negative anaerobic rods Inoculum 106 cells/ml

More information

Juntendo Medical Journal

Juntendo Medical Journal * Department of Health Science Health Sociology Section, Juntendo University School of Health and Sports Science, Chiba, Japan (WHO: Ottawa Charter for Health promotion, 1986.) (WHO: Bangkok Charter

More information

特殊病態下感染症における抗菌薬治験の手引き作成委員会報告書(案)

特殊病態下感染症における抗菌薬治験の手引き作成委員会報告書(案) VOL.51 NO.6 JUNE 2003 JUNE 2003 9) Niederman MS et al: Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy and prevention.

More information

CHEMOTHERAPY FEB Table 1. Activity of cefpirome and others against clinical isolates

CHEMOTHERAPY FEB Table 1. Activity of cefpirome and others against clinical isolates VOL.39 S-1 CHEMOTHERAPY FEB. 1981 Table 1. Activity of cefpirome and others against clinical isolates VOL.39 S-1 CHEMOTHERAPY FEB. 1991 72 M, 55.5 kg 66 F, 53 kg Chronic bronchitis Bronchopneumonia Peak

More information

Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection

Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection Table 1. Bacterial cell counts in feces of mice infected with Esclwrichia coli O 157: H7 NK2 before and during oral dosing with fosfomycin

More information

CHEMOTHERAPY Table 1 Clinical effect of Sultamicillin

CHEMOTHERAPY Table 1 Clinical effect of Sultamicillin CHEMOTHERAPY CHEMOTHERAPY Table 1 Clinical effect of Sultamicillin CHEMOTHERAPY Fig. 1 MICs of sultamicillin against respiratory pathogenic Branhamella catarrhalis 62 strains, inoculum size 106CFU/m1 Fig.

More information

;~ (Summary) The Study on the Effects of Foot Bathing on Urination Kumiko Toyoda School of Human Nursing, University of Shiga Prefecture Background Foot bathing is one of the important nursing care for

More information

™…

™… Review The Secret to Healthy Long Life Decrease in Oxidative and Mental Stress My motto is Health is not all. But nothing can be done without health. Health is the most important requisite for all human

More information

24) Bergeron M.G., Menard C. et al: Rapid Detection 19) Aber R. C., Allen N., Howell J. T. et al.: Nosocomial Transmission of Group B Streptococci, Pediatrics, 58(3), 346-359, 1976. 20) Baker C.J., Barrett

More information

Perspective-Taking Perspective-Taking.... Vol. No.

Perspective-Taking Perspective-Taking.... Vol. No. Nurses Thinking Process in Understanding Patients Unconscious Denial Tomoko Hayashi Key Words putting oneself in the patient s place, perspective-taking, misunderstand patient s perspective, modifying

More information

A Study on Life-Table based on the Death Rate from a Specific Disease by Fumio Nakamura, M. D. Department of Hygiene Okayama University Medical School (Director: Professor Masahiko O. D., M. P. H.) In

More information

9 WHO 89,, TD 8, km Beth Damgkor Beth Meas Samrong Angkor Wat Svay Chra Mok Chrouk Wat Svay Wat Chak 7,7 8 7,7 8 9 χ

9 WHO 89,, TD 8, km Beth Damgkor Beth Meas Samrong Angkor Wat Svay Chra Mok Chrouk Wat Svay Wat Chak 7,7 8 7,7 8 9 χ 8 : 8 8, 7 9. 99. 97.dft DMFT dft 9., dft., DMFT.8 Key words 97 979 99 99 ODA NGO 78 78 78 9 98 98, 7 7 Auxiliary Dentist 99 7 7 Traditional Dentist TD TD, 8, 9 8 9 WHO 89,, TD 8, km Beth Damgkor Beth

More information

1 Department of Legal Medicine, Toyama University School of Medicine 2 3 4 5 6 7 8 Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama VEGF Key words

More information

5) Kawada T, Hagihara K, Iwai K (1986) Effects of capsaicin on lipid metabolism in rats fed a high fat diet. J Nutr 116 : 1272-8. 6) Kawada T, Watanabe T, Takaishi T, Tanaka T, Iwai K (1986) Capsaicin-induced

More information

Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates

Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates Table 2-1. Summary of patients treated with grepafloxacin for respiratory infection 1) Out: outpatient,

More information

VOL.42 S-1

VOL.42 S-1 CHEMOTHERAPY APR. 1994 VOL.42 S-1 CHEMOTHERAPY APR. 1994 Table 1. Criteria for evaluation of clinical efficacy by the Japanese Society of Oral and Maxillo-Facial Surgeons Grades of symptoms and numerical

More information

Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile

Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile Key words: temafloxacin, TA-167, Bacteroides fragilis,

More information

\ (1963): Recent Trends of Urban Geography in Japan A, A, A, G, 53 93^ 102 Yamaga S, & Y, Masai (1966) : Japanese Urban Geography-General View Japanese Geography 1966; Spec, Publ, No,1 Ass, Jap, Geogrs,

More information

Effect of Trimoprostil on Gastric Secretion Takeshi KAWAMURA * Hiroko EBINA * Fumiaki KOIZUMI * and Akira ISHIMORI * *Department of Clinical and Labor

Effect of Trimoprostil on Gastric Secretion Takeshi KAWAMURA * Hiroko EBINA * Fumiaki KOIZUMI * and Akira ISHIMORI * *Department of Clinical and Labor Effect of Trimoprostil on Gastric Secretion Takeshi KAWAMURA * Hiroko EBINA * Fumiaki KOIZUMI * and Akira ISHIMORI * *Department of Clinical and Laboratory Medicine University School of Medicine, Tohoku

More information

-

- - disembodyment personal meaninglessness champ - - - No. No. No. No. No. No. No. END - New - - - - Giddens, A., The Consequences of Modernity, Polity,, p.. - Ibid.,., p.. Giddens, A., Modernity

More information

縺サ繧

縺サ繧 380 513: 380 389 2013 2 1 129 1 1 1 1 16.5 1 29.5 Key words 1 14 14 1 2 3 23 2-1-1 2013 3 21 2013 6 3 4 1 5 1 1 22 9 23 5 A A 129 513 2013 381 1 5 2 3 2 1.63 4 1 0.8 1 0.8 5 25 16.5 5 15 33 14.4 16 25

More information

東洋医学雑誌

東洋医学雑誌 Vol.61 No.7 924-929, 2010 a b c d Naoki OKADA ad Masaru NATSUAKI b Takashi NISHIMOTO ac Nishimoto Clinic, 2-8-31 Koshienguchi, Nishinomiya, Hyogo 663-8113, Japan Department of Dermatology, Hyogo College

More information

VOL. 17 NO. 7 CHEMOTHERAPY 1305 1) W. BRumFirr et al. : Clinical and laboratory studies with carbenicillin. Lancet 1: 1289~ 1293, 1967 2) E. T. KNUDSEN et al. : A new semisynthetic penicillin active against

More information

CHEMOTHERAPY

CHEMOTHERAPY CHEMOTHERAPY VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin CHEMOTHERAPY AUG. 1993 VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin Table 1. Comparative in vitro activity of teicoplanin

More information

慢性膵炎

慢性膵炎 - - 121 , g CCK g g - kgkcal kgkcal - g,,, - G.I.Res ; 10 : - ; 13 : - ; 22 : - Meier RF, Beglinger C. Nutrition in pancreatic diseases. Best Pract Res Clin Gastroenterol ; 20 : - Pfutzer RH, Schneider

More information

Therapy for Asthenopia in Cases of Convergence Insufficiency Hiroko TAKASAKI, C.O.J., Nobuko INAGAMI, C.O.J., and Kayoko TAKENAWA, C.O.J.. Orthoptic c

Therapy for Asthenopia in Cases of Convergence Insufficiency Hiroko TAKASAKI, C.O.J., Nobuko INAGAMI, C.O.J., and Kayoko TAKENAWA, C.O.J.. Orthoptic c Therapy for Asthenopia in Cases of Convergence Insufficiency Hiroko TAKASAKI, C.O.J., Nobuko INAGAMI, C.O.J., and Kayoko TAKENAWA, C.O.J.. Orthoptic clinic, Department of Ophthalmology, (Director: Prof

More information

_’£”R‡Ù‡©

_’£”R‡Ù‡© 29 31 38 2008 31 1) 2) 2) 3) 2) 1) 2008 302008 12 Activities of Daily Living ADL ADL 42 ADL ADL 1990 QOL Quality of Life QOL 1 QOL // 2 Activity of Daily Living ADL Performance Status PS ADL 3 1) 2) 3)

More information

1) University Group Diabetes Program: A study of hypoglycemic agents on vascular complica- in patients with adult-onset tions diabetes. I. Design, methods and baseline results. Diabetes 19 (suppl. 2):

More information

Validation of a Food Frequency Questionnaire Based on Food Groups for Estimating Individual Nutrient Intake Keiko Takahashi *', Yukio Yoshimura *', Ta

Validation of a Food Frequency Questionnaire Based on Food Groups for Estimating Individual Nutrient Intake Keiko Takahashi *', Yukio Yoshimura *', Ta Validation of a Food Frequency Questionnaire Based on Food Groups for Estimating Individual Nutrient Intake Keiko Takahashi *', Yukio Yoshimura *', Tae Kaimoto *', Daisuke Kunii *', Tatsushi Komatsu *2

More information

202

202 201 Presenteeism 202 203 204 Table 1. Name Elements of Work Productivity Targeted Populations Measurement items of Presenteeism (Number of Items) Reliability Validity α α 205 α ä 206 Table 2. Factors of

More information

15) Egawa, R., Sawai, T. and Mit.uhashi, S.: Jap. J. Microbiol., 11 : 173-178, 1967. 16) Tanaka, T. and Hashimoto, H., Nagai, Y. and Mitsuhashi, S.: Jap. J. Microbiol., 11: 155-162, 1967. 17) Mitsuhashi,

More information

Effects of Diet Class on Overweight Middle-aged Women Analysis of Nutritional Intake Pattern YAMAGUCHI Shizue*, MATSUMOTO Tomoko**, MIMURA Kan-ichi***, ASAI Hitoshi****, OKUDA Toyoko***** * O saka Shin-ai

More information

37, 9-14, 2017 : cefcapene piperacillin 3 CT Clostridium difficile CD vancomycin CD 7 Clostridium difficile CD CD associate

37, 9-14, 2017 : cefcapene piperacillin 3 CT Clostridium difficile CD vancomycin CD 7 Clostridium difficile CD CD associate 37, 9-14, 2017 : 36 2015 8 6 cefcapene piperacillin 3 CT Clostridium difficile CD vancomycin 20 1983 2016 3 CD 7 Clostridium difficile CD CD associated diarrhea : CDAD CD 1,2 PPI 3 1 36 33 2015 8 6 5 5

More information

STUDIES ON THE RELATION BETWEEN LATE DUMPING SYNDROME AND GLUCAGON RESPONCES TO GLUCOSE Taisuke MATSUI The First Department of Surgery, Nara Medical U

STUDIES ON THE RELATION BETWEEN LATE DUMPING SYNDROME AND GLUCAGON RESPONCES TO GLUCOSE Taisuke MATSUI The First Department of Surgery, Nara Medical U STUDIES ON THE RELATION BETWEEN LATE DUMPING SYNDROME AND GLUCAGON RESPONCES TO GLUCOSE Taisuke MATSUI The First Department of Surgery, Nara Medical University, Kashihara (Director: Prof. H. Nakano) This

More information

The positive correlation between bad breath and subgigival microflora OTakafumi Department of Periodontics, Tokyo Dental College MORIYAMA, Masatake TS

The positive correlation between bad breath and subgigival microflora OTakafumi Department of Periodontics, Tokyo Dental College MORIYAMA, Masatake TS A study of ultrasonic scaling with regard to the changes of bacterial phase in the periodontal pocket Department of Periodontology, *Preventive Dentistry, **Bacteriology, Osaka Dental University Masatoshi

More information

Clinical Factors which Affect the Shortend Life Span of Abutment Teeth in Removable Partial Denture Mitsuhiro Yoshida Abstract: In order to establish diagnostic parameters for the estimation of prognosis

More information

第58巻6号/投稿規定・目次・表2・奥付・背

第58巻6号/投稿規定・目次・表2・奥付・背 Feature articles 1Why is it that allergic diseases have been increasing? Feature articles 2Space medicine and medicine for the future Review γ ε γ γ γγ α αβ et al et al et al et al et al et al Is nutritional

More information

untitled

untitled 2010 58 1 39 59 c 2010 20 2009 11 30 2010 6 24 6 25 1 1953 12 2008 III 1. 5, 1961, 1970, 1975, 1982, 1992 12 2008 2008 226 0015 32 40 58 1 2010 III 2., 2009 3 #3.xx #3.1 #3.2 1 1953 2 1958 12 2008 1 2

More information

Osamu NEMOTO, M.D. Clinical and Bacteriological Research of Sucrose/ Povidone-Iodine Ointment (U-PASTA kowa) for Pressure Sores and Skin Ulcers Osamu Nemoto Department of Dermatology,Tonan Hosptal

More information

Fig.1 MICs of penicillins against 24 strains of B. pertussis Fig.2 MICs of cepherns against 24 strains of B. pertussis Fig.3 MICs of macrolides against 24 strains of B. pertussis Fig.4 MICs of nalidixic

More information

大学論集第42号本文.indb

大学論集第42号本文.indb 42 2010 2011 3 279 295 COSO 281 COSO 1990 1 internal control 1 19962007, Internal Control Integrated Framework COSO COSO 282 42 2 2) the Committee of Sponsoring Organizations of the Treadway committee

More information

Table 1.Resistance criteria Fig.1.The resistance rates of piperacillin,ceftazidime, cefsulodin,imipenem,aztreonam,gentamicin,tobramycin,amikacin,isepamicin,fosfomycin and ofloxacin against 2,793 strains

More information

Studies of Foot Form for Footwear Design (Part 9) : Characteristics of the Foot Form of Young and Elder Women Based on their Sizes of Ball Joint Girth

Studies of Foot Form for Footwear Design (Part 9) : Characteristics of the Foot Form of Young and Elder Women Based on their Sizes of Ball Joint Girth Studies of Foot Form for Footwear Design (Part 9) : Characteristics of the Foot Form of Young and Elder Women Based on their Sizes of Ball Joint Girth and Foot Breadth Akiko Yamamoto Fukuoka Women's University,

More information

_念3)医療2009_夏.indd

_念3)医療2009_夏.indd Evaluation of the Social Benefits of the Regional Medical System Based on Land Price Information -A Hedonic Valuation of the Sense of Relief Provided by Health Care Facilities- Takuma Sugahara Ph.D. Abstract

More information

164 SDD & SOD SDD E100 mg 80 mg B500 mg 2 E 2 B 48 /59 81 SDD SOD 10 /63 16 RCT RCT 1992 Gastinne 15 ICU 445 SDD E100 mg 80 mg B 10

164 SDD & SOD SDD E100 mg 80 mg B500 mg 2 E 2 B 48 /59 81 SDD SOD 10 /63 16 RCT RCT 1992 Gastinne 15 ICU 445 SDD E100 mg 80 mg B 10 163 特 集 SDD & SOD SDD(Selective digestive decontamination),sod(selective oropharynx decontamination), 腸内細菌叢, 耐性菌 Ⅰ はじめに SDD Selective digestive decontamination SOD Selective oropharynx decontamination

More information

Repatriation and International Development Assistance: Is the Relief-Development Continuum Becoming in the Chronic Political Emergencies? KOIZUMI Koichi In the 1990's the main focus of the global refugee

More information

Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with blad

Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with blad Key words: Female with bladder irritability, Subjective symptoms, Pyuria, Bacteriuria Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution

More information

Vol. No. Honda, et al.,

Vol. No. Honda, et al., A Study of Effects of Foot Bath before Exercise on Fall Prevention Yoko Honda Yoko Aso Aki Ibe Megumi Katayama Tomoko Tamaru Key Words fall prevention, foot bath, elderly, fall prevention programs Honda,

More information

Key words: Neonate, Intestinal flora, Infection, Bifidobacterium

Key words: Neonate, Intestinal flora, Infection, Bifidobacterium Key words: Neonate, Intestinal flora, Infection, Bifidobacterium Table 1 Media of aerobic culture (37 Ž 24 hrs) Table 2 Media of anaerobic culture (37 Ž 48 hrs ) Table 3 Methods for analysis of fecal flora

More information

<95DB8C9288E397C389C88A E696E6462>

<95DB8C9288E397C389C88A E696E6462> 2011 Vol.60 No.2 p.138 147 Performance of the Japanese long-term care benefit: An International comparison based on OECD health data Mie MORIKAWA[1] Takako TSUTSUI[2] [1]National Institute of Public Health,

More information

総研大文化科学研究第 11 号 (2015)

総研大文化科学研究第 11 号 (2015) 栄 元 総研大文化科学研究第 11 号 (2015) 45 ..... 46 総研大文化科学研究第 11 号 (2015) 栄 租借地都市大連における 満洲日日新聞 の役割に関する一考察 総研大文化科学研究第 11 号 (2015) 47 48 総研大文化科学研究第 11 号 (2015) 栄 租借地都市大連における 満洲日日新聞 の役割に関する一考察 総研大文化科学研究第 11 号 (2015)

More information

40B: 43-54 2010 43 2010 1 27 Satoshi Shimai 1 and Shigehiro Fujimoto 2 1 Center for Liberal Arts and Education, Minami-Kyushu University, Miyakonojo,

40B: 43-54 2010 43 2010 1 27 Satoshi Shimai 1 and Shigehiro Fujimoto 2 1 Center for Liberal Arts and Education, Minami-Kyushu University, Miyakonojo, 40B: 43-54 2010 2010 1 27 Satoshi Shimai 1 and Shigehiro Fujimoto 2 1 Center for Liberal Arts and Education, Minami-Kyushu University, Miyakonojo, Miyazaki 885-0035, Japan; 2 Miyakonojo Public Health Institute,

More information

DISTRIBUTION OF NEUROPEPTIDES IN THE INFERIOR NASAL TURBINATE MUCOSA OF PATIENTS WITH ALLERGIC RHINITIS KAZUHIRO YAMAMOTO. M.D. Department of Otolaryngology, School of Medicine, Kitasato University, Sagamihara

More information

/‚“1/ŒxŒ{‚×›î’æ’¶

/‚“1/ŒxŒ{‚×›î’æ’¶ 60 1 pp.3-8 2010 1. H1N1 1) 2) 3) 4) ERATO 2009 H1N1 21 H1N1 HA PB2 2009 3 Pandemic H1N1 2009 WHO 6 11 21 2009 11 2010 4 21 H1N1 H1N1 2009 4 15 CDC 108-8639 4-6-1 TEL: 03-5449-5281 FAX: 03-5449-5408 E-mail:

More information

8 The Bulletin of Meiji University of Integrative Medicine API II 61 ASO X 11 7 X-4 6 X m 5 X-2 4 X 3 9 X 11 7 API 0.84 ASO X 1 1 MR-angio

8 The Bulletin of Meiji University of Integrative Medicine API II 61 ASO X 11 7 X-4 6 X m 5 X-2 4 X 3 9 X 11 7 API 0.84 ASO X 1 1 MR-angio 7-14 2010 1 1 1 2 1 1 1 2 Fontaine II ASO61 3 API ASO ASO ASO API API KKKKKKKKKK ASO Fontaine II API Received April 14, 2009; Accepted July 16, 2009 I arteriosclerosis obliterans: ASO ASO 50 70 1,2 Fontaine

More information

越智59.qxd

越智59.qxd Social Skills Training; SST SST Social Skills, SST, ;, SST, SST SST, ;, ; DeRosier & Marcus,, ;, a b SST Ladd & Mize, ; Hansen, Nagle, & Meyer,,, A BC SST SST SST SST SST SST, SST Goldstein & McGinnis,

More information

CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX

CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX Fig. 1 Chemical structure of CXM-AX NOV. 1986 Fig. 2 Sensitivity distribution of clinical isolates organisms (106 cells/ml) a Smurcus 27 strains d) P.m irabilis 15 strains b Ecol i 27 strains 111.morganii

More information

CHEMOTHERAPY APRIL 1992 Table 2. Concentration of meropenem in human prostatic fluid Table 1. Background of 21 chronic complicated UTI cases * NB + BPH, NB + Kidney tumor, NB + Kidney tuberculosis Table

More information

untitled

untitled ORYZA POLYAMINE ORYZA POLYAMINE -P -PC -LC 1. Ver.1.0 MM ver. 1.0MM 1) Roseeuw D.I. et al., Epidermal keratinocytes actively maintain their intracellular polyamine levels. Cell Tissue Kinet. 16, 493-504

More information

untitled

untitled Quantitative Risk Assessment on the Public Health Impact of Pathogenic Vibrio parahaemolyticus in Raw Oyster 1 15 5 23 48 2 21 1 16 1 16 1 11 3 1 3 4 23 1 2 16 12 16 5 6 Hazard IdentificationExposure

More information

The Nutrient Intake of Young Women With Special Attention on the Trace Nutrients Including Folate SUZUKI Kazu', HIGASHINE Yuuko", ITOU Ryoko YAMADA Yukiko', KOSEKI Sakiyo*, OKUDA Toyoko"" Seibo Jogakuin

More information

learning of life long , Community Centers and Lifelong Learning: Contemporary Challenges in Lifelong Education and Learning IIDA Tetsuya : In Japan, great importance is being placed on

More information

Hirosaki University Repository 妊 娠 可 能 てんかん 女 性 の 治 療 管 理 基 準 設 定 に 関 する 研 Title 究 Author(s) 兼 子, 直 Citation てんかん 治 療 研 究 振 興 財 団 研 究 年 報. 4, 1992, p.24-35 Issue Date 1992 URL http://hdl.handle.net/10129/1905

More information

16_.....E...._.I.v2006

16_.....E...._.I.v2006 55 1 18 Bull. Nara Univ. Educ., Vol. 55, No.1 (Cult. & Soc.), 2006 165 2002 * 18 Collaboration Between a School Athletic Club and a Community Sports Club A Case Study of SOLESTRELLA NARA 2002 Rie TAKAMURA

More information

Title 社 会 化 教 育 における 公 民 的 資 質 : 法 教 育 における 憲 法 的 価 値 原 理 ( fulltext ) Author(s) 中 平, 一 義 Citation 学 校 教 育 学 研 究 論 集 (21): 113-126 Issue Date 2010-03 URL http://hdl.handle.net/2309/107543 Publisher 東 京

More information

Web Stamps 96 KJ Stamps Web Vol 8, No 1, 2004

Web Stamps 96 KJ Stamps Web Vol 8, No 1, 2004 The Journal of the Japan Academy of Nursing Administration and Policies Vol 8, No 1, pp 43 _ 57, 2004 The Literature Review of the Japanese Nurses Job Satisfaction Research Which the Stamps-Ozaki Scale

More information

Core Ethics Vol. -

Core Ethics Vol. - Core Ethics Vol. - Core Ethics Vol. - Core Ethics Vol. % NICU - Core Ethics Vol. - - - - Core Ethics Vol. - NICU NICU NICU NICU http://www.arsvi.com/d/i.htm -. http://www.normanet.ne.jp/~ww/,,.,,, -.

More information

小児感染免疫第27巻第4号

小児感染免疫第27巻第4号 364 2015 C 1 2 3 4 5 6 7 8 urinary tract infection UTI 2 1 UTI 1 3 5 2,3 4 1 UTI Escherichia coli E. coli 80 5 Enterococcus 1 UTI 83 78 53 98 5 WBCs HPF 73 81 81 83 or 93 72 ororor 99.8 70 4 Key words

More information

「リストラ中高年」の行方

「リストラ中高年」の行方 ESRI Discussion Paper Series No.10 by February 2002 Economic and Social Research Institute Cabinet Office Tokyo, Japan 1 ESRI 2 ABSTRACT * In this paper, based on the Employment Trend Survey in 2000 and

More information

Microsoft Word - 「黄砂とその健康影響について」小冊子180323版

Microsoft Word - 「黄砂とその健康影響について」小冊子180323版 ...1...1...1...2...4...4...4...6...7...7...7...7...8...8...9...9...10... 11... 11... 11... 11...12...12...13...16...18...20 1 1-1 1-2 1 1 km 24.5 m/s 10 50 m 1 1-3 μm 1-4 1-5 2 8 http://www.jma-net.go.jp/sat/himawari/obsimg/image_dust.html

More information

I

I 九州大学学術情報リポジトリ Kyushu University Institutional Repository 熊本県水俣市の限界集落における耕作放棄地の拡大とその要因 寺床, 幸雄九州大学大学院人文科学府 : 博士後期課程 : 農村 農業地理学 Teratoko, Yukio http://hdl.handle.net/2324/20036 出版情報 : 地理学評論. 82 (6), pp.588-603,

More information

環境影響評価制度をめぐる法的諸問題(4) : 米国の環境影響評価制度について

環境影響評価制度をめぐる法的諸問題(4) : 米国の環境影響評価制度について Kwansei Gakuin University Rep Title Author(s) 環 境 影 響 評 価 制 度 をめぐる 法 的 諸 問 題 (4) : 米 国 の 環 境 影 響 評 価 制 度 について Sekine, Takamichi, 関 根, 孝 道 Citation 総 合 政 策 研 究, 33: 73-103 Issue Date 2010-02-20 URL http://hdl.handle.net/10236/3583

More information

日本看護管理学会誌15-2

日本看護管理学会誌15-2 The Journal of the Japan Academy of Nursing Administration and Policies Vol. 15, No. 2, PP 135-146, 2011 Differences between Expectations and Experiences of Experienced Nurses Entering a New Work Environment

More information

A Study on Throw Simulation for Baseball Pitching Machine with Rollers and Its Optimization Shinobu SAKAI*5, Yuichiro KITAGAWA, Ryo KANAI and Juhachi

A Study on Throw Simulation for Baseball Pitching Machine with Rollers and Its Optimization Shinobu SAKAI*5, Yuichiro KITAGAWA, Ryo KANAI and Juhachi A Study on Throw Simulation for Baseball Pitching Machine with Rollers and Its Optimization Shinobu SAKAI*5, Yuichiro KITAGAWA, Ryo KANAI and Juhachi ODA Department of Human and Mechanical Systems Engineering,

More information

CHEMOTHERAPY FEB Table 1 Background of volunteers

CHEMOTHERAPY FEB Table 1 Background of volunteers CHEMOTHERAPY FEB. 1985 Table 1 Background of volunteers Table 3 Reproducibility of saisomicln In the EIA and the RIA Fig.1 Comparison of the EIA with the RIA or bioassay of sisomicin Table 4 Blood levels

More information

untitled

untitled SATO Kentaro Milk and its by-products are naturally nutritious food, and people in ancient Japan enjoyed tasting them as foods, drinks, or medicines. On the other hand, milk and its by-products were closely

More information