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1 The Japanese Association for Laboratory Animal Science Experimental Animals Clostridium piliforme...26 T simian T-cell leukemia virus: STLV...30 Experimental Animals 65(2) i... ii...iv Vol. 65 No. 2 / April 2016
2 Vol. 65 No :30 15:
3 14 Vol. 65 No :00 12: The 2nd Round Table Discussion of JALAS-KALAS
4 Vol. 65 No WG WG WG WG WG WG ARRIVE NC3Rs The 2nd Round Table Discussion of JALAS-KALAS
5 16 Vol. 65 No ,000 ICLAS
6 Vol. 65 No ,000 5,000 6,
7 18 Vol. 65 No Experimental Animals 2015 Experimental Animals Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/ Cas9 CRiSPR/Cas9 Experimental Animals Vol. 64, No. 1, 31 37, , 2) 2) 3) 3) 1) 1) 4) 5) 2) 1) 2) 3) 4) ir 5) Experimental Animals
8 Vol. 65 No The 63rd Annual Meeting of the Japanese Association for Laboratory Animal Science Bench to Bedside :00 17:00 1 JALAS :00 17: IBD 1 JALAS :30 11:00 3Rs
9 20 Vol. 65 No :00 12:30 / ips 3 in vivo :15 10:45 in vivo 1. in vivo 2. MRI 3. MRI in vivo :45 12: DDS mrna :15 10:45
10 Vol. 65 No ips 6 JALAS :45 12: :50 17: Yuanwu Ma 2. Heng-Yi Chen ) 3. Seonggon Kim 4. Devi Kartika :30 12:10 14:00 15:30 2 9:30 12:40 14:00 18: :15 12: :15 12: F LAS LAS :30 17:
11 22 Vol. 65 No. 2 LAS ES ips / :00 11: ES ips LAS :00 11: ARRIVE : :00 16: JALAS-KALAS Round Table Discussion :00 13:00 Lee Cheol-Seung KFDA Lee Yong-Soon Hyun Byung-Hwa ICLAS Kim Chuel-Kyu Lee Beum-Jun
12 Vol. 65 No F :30 14: :00 13: :30 14: :00 19:30 2F :30 20:30 8,000 4,000 10,000 9,000 10,000 5,000 12,000 11,000 NPO 8,000 6,000 10,000 8, TEL: FAX: jalas63@ciea.or.jp URL:
13 24 Vol. 65 No ,000 25,000 URL 33.html TEL: FAX: jaca@jaca-1963.or.jp
14 Vol. 65 No ,000 8,000 1,500 8,000 10,000 2, URL TEL: FAX: jbf@ipec-pub.co.jp ,000 12,000 14,000 13,000 14,000 16, URL TEL: FAX: jsot43@senkyo.co.jp
15 26 Vol. 65 No. 2 Clostridium piliforme Clostridium piliforme C. piliforme PCR C. piliforme C. piliforme 1 Tyzzer s disease Clostridium piliforme 1917 [14] C. piliforme [3] Tyzzer s organism Bacillus piliformis S rrna Clostridium Clostridium piliforme [2] 3T3 BRL3A [10] 4 1 [14] % 4% 100 1% 0.015% 1
![piliforme 1 Tyzzer s disease Clostridium piliforme 1917 [14] C.](/docs-images/42/22889011/images/page_15.jpg "piliforme [3] Tyzzer s organism Bacillus piliformis 1993 16S rrna Clostridium")
16 Vol. 65 No [11] DBA/2 C57BL/6 [15] 3 40 [8] HIV-1 1 [13] % 0.97 [7] [1, 6, 12] PCR ELISA MFIA IFA [9, 16] Clostriduim [4, 9] PCR [5] PCR PCR PCR PCR [9] PCR PCR PCR PCR 16S rrna
![[13] 2011 0% 0.97 [7] 16.7 10.](/docs-images/42/22889011/images/page_16.jpg "7 [1, 6, 12] PCR ELISA MFIA IFA [9, 16]")
17 28 Vol. 65 No. 2 16S rrna 3 5 PCR 16S PCR [4] PCR HE Warthin- Starry C. piliforme 1 1. Dammann, P., Hilken, G., Hueber, B., Köhl, W., Bappert, M.T., and Mähler, M Infectious microorganisms in mice (Mus musculus) purchased from commercial pet shops in Germany. Lab. Anim. 45: Duncan, A.L., Carman, R.J., Olsen, G.J., and Wilson, K.H Assignment of the agent of Tyzzer s disease to Clostridium piliforme comb. nov. on the basis of 16S rrna sequence analysis. Int. J. Syst. Bacteriol. 43: Franklin, C.L., Motzel, S.L., Besch-Williford, C.L., Hood, R.R., and Riley, L.K Tyzzer s infection: host specificity of Clostridium piliforme isolates. Lab. Anim. Sci. 44: Feldman, S.H., Kiavand, A., Seidlelin, M., and Reiske, H.R Ribosomal RNA sequences of Clostridium piliforme isolated from rodent and rabbit: reexamining the phylogeny of the Tyzzer s disease agent and development of a diagnostic polymerase chain reaction assay. J. Am. Assoc. Lab. Anim. Sci. 45: Furukawa, T., Furumoto, K., Fujieda, M., and Okada, E Detection by PCR of the Tyzzer s disease organism (Clostridium piliforme) in feces. Exp. Anim. 51: Hayashimoto, N., Morita, H., Ishida, T., Uchida, R., Tanaka, M., Ozawa, M., Yasuda, M., and Itoh, T Microbiological survey of mice (Mus musculus) purchased from commercial pet shops in Kanagawa and Tokyo, Japan. Exp. Anim. 64: Hayashimoto, N., Morita, H., Ishida, T., Yasuda, M., Kameda, S., Uchida, R., Tanaka, M., Ozawa, M., Sato, A., Takakura, A., Itoh, T., and Kagiyama, N Current microbiological status of laboratory mice and rats in experimental facilities in Japan. Exp. Anim. 62: Livingston RS, Franklin CL, Besch-Williford CL, Hook RR and Riley LK A novel presentation of Clostridium piliforme infection (Tyzzer s disease) in nude mice. Lab Anim Sci; 46:
18 Vol. 65 No Pritt, S., Henderson, K.S., and Shek, W.R Evaluation of available diagnostic methods for Clostridium piliforme in laboratory rabbits (Oryctolagus cuniculus). Lab. Anim. 44: Riley, L.K., Besch-Williford, C., and Waggie, K.S Protein and antigenic heterogeneity among isolates of Bacillus piliformis. Infect. Immun. 58: Riley, L.K., Caffrey, C.J., Musille, V.S., and Meyer, J.K Cytotoxicity of Bacillus piliformis. J. Med. Microbiol. 37: Roble, G.S., Gillespie, V., and Lipman, N.S Infectious disease survey of Mus musculus from pet stores in New York City. J. Am. Assoc. Lab. Anim. Sci. 51: Smith, K.J., Skelton, H.G., Hilyard, E.J., Hadfield, T., Moeller, R.S., Tuur, S., Decker, C., Wagner, K.F., and Angritt, P Bacillus piliformis infection (Tyzzer s disease) in a patient infected with HIV-1: confirmation with 16S ribosomal RNA sequence analysis. J. Am. Acad. Dermatol. 34: Tyzzer, E.E A fatal disease of the Japanese waltzing mouse caused by a spore-bearing bacillus (Bacillus piliformis, N. sp.). J. Med. Res. 37: Waggie, K.S., Hansen, C.T., Ganaway, J.R., and Spencer, T.S A study of mouse strains susceptibility to Bacillus piliformis (Tyzzer s disease): the association of B-cell function and resistance. Lab. Anim. Sci. 31: Waggie, K.S., Spencer, T.H., and Ganaway, J.R An enzyme-linked immunosorbent assay for detection of anti-bacillus piliformis serum antibody in rabbits. Lab. Anim. Sci. 37:
19 30 Vol. 65 No. 2 T simian T-cell leukemia virus: STLV T T T STLV RNA T HTLV BLV RNA DNA HTLV STLV HTLV STLV BSL2 HTLV 100 STLV STLV [3, 5, 10, 14] 50 [2, 4, 9] STLV STLV STLV HTLV [6, 7] HTLV STLV STLV [13] HTLV 1 STLV HTLV HTLV T adult T-cell leukemia:
20 Vol. 65 No ATL HTLV-1 HTLV-1 associated myelopathy: HAM HTLV-1 HTLV-1 tax T Tax T ATL Tax HTLV HTLV-1 bzip factor hbz ATL [11] HBZ T HBZ Foxp3 T [12] STLV STLV HTLV 90 Tax SBZ HBZ STLV HTLV-1 [9] T [1, 15, 16] HAM HTLV ATL 67 ATL STLV PA DNA STLV PA ATL CCR4 CC 4 ATL 2012 ATL HAM STLV STLV HTLV STLV DNA [9]ATL HAM STLV HTLV T T [18]STLV ATL HAM HTLV PA EIA CLEIA STLV PCR STLV DNA 1. Akari, H., Ono, F., Sakakibara, I., Takahashi, H., Murayama, Y., Hiyaoka, A., Terao, K., Otani, I., Mukai, R., Adachi, A., and Yoshikawa, Y Simian T cell leukemia virus type I-induced malignant adult T cell leukemia-like disease in a naturally infected African green monkey: implication of CD8+ T cell leukemia. AI DS Res Hum Retroviruses 14:
![[9] T [1, 15, 16] HAM HTLV ATL 67 ATL STLV PA DNA STLV PA ATL CCR4 CC 4 ATL 2012 ATL HAM STLV STLV HTLV STLV DNA [9]ATL HAM STLV HTLV T T [18]STLV ATL HAM HTLV PA EIA CLEIA STLV PCR STLV](/docs-images/42/22889011/images/page_20.jpg "DNA 1. Akari, H., Ono, F., Sakakibara, I., Takahashi, H., Murayama, Y., Hiyaoka, A., Terao, K., Otani, I., Mukai, R., Adachi, A., and Yoshikawa, Y. 1998.")
21 32 Vol. 65 No Eguchi, K., Ohsawa, K., Fuse, Kiyono, M., Suzuki, J., Kurokawa, K., and Yamamoto, T Short communication: epidemiological evidence that simian T-lymphotropic virus type 1 in Macaca fuscata has an alternative transmission route to maternal infection. AIDS Res. Hum. Retroviruses 27: Giri, A., Markham, P., Digilio, L., Hurteau, G., Gallo, R.C., and Franchini, G Isolation of a novel simian T-cell lymphotropic virus from Pan paniscus that is distantly related to the human T-cell leukemia/ lymphotropic virus types I and II. J. Virol. 68: Hayami, M., Komuro, A., Nozawa, K., Shotake, T., Ishikawa, K., Yamamoto, K., Ishida, T., Honjo, S., and Hinuma, Y Prevalence of antibody to adult T-cell leukemia virus-associated antigens (ATLA) in Japanese monkeys and other non-human primates. Int. J. Cancer 33: Ishikawa, K., Fukasawa, M., Tsujimoto, H., Else, J.G., Isahakia, M., Ubhi, N.K., Ishida, T., Takenaka, O., Kawamoto, Y., and Shotake, T Serological survey and virus isolation of simian T-cell leukemia/ T-lymphotropic virus type I (STLV-I) in non-human primates in their native countries. Int. J. Cancer 40: Kazanji, M., Mouinga-Ondeme, A., Lekana-Douki- Etenna, S., Caron, M., Makuwa, M., Mahieux, R., and Gessain, A Origin of HTLV-1 in hunters of nonhuman primates in Central Africa. J. Infect. Dis. 211: Locatelli, S. and Peeters, M Cross-species transmission of simian retroviruses: how and why they could lead to the emergence of new diseases in the human population. AIDS 26: Ma, G., Yasunaga, J., Akari, H., and Matsuoka, M TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax. Proc. Natl. Acad. Sci. U S A 112: Miura, M., Yasunaga, J., Tanabe, J., Sugata, K., Zhao, T., Ma, G., Miyazato, P., Ohshima, K., Kaneko, A., Watanabe, A., Saito, A., Akari, H., and Matsuoka, M Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection. Retrovirology 10: Saksena, N.K, Herve, V., Durand, J.P., Leguenno, B., Diop, O.M., Digouette, J.P., Mathiot, C., Muller, M.C., Love, J.L., Dube, S., Sherman, M.P., Benz, P.M., Erensoy, S.,Galat-Luong, A.,Galat, G., Paul, B.,Dube,D.K., Sinoussi, F.B., and Poiesz, B.J Seroepidemiologic, molecular, and phylogenetic analyses of simian T-cell leukemia viruses (STLV-I) from various naturally infected monkey species from central and western Africa. Virology 198: Satou, Y., Yasunaga, J., Yoshida, M., and Matsuoka, M HTLV-I basic leucine zipper factor gene mrna supports proliferation of adult T cell leukemia cells. Proc. Natl. Acad. Sci. U S A 103: Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P.L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., and Matsuoka, M HTLV-1 bzip factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog 7: e Song, K.J., Nerurkar, V.R., Saitou, N., Lazo, A., Blakeslee, J.R., Miyoshi, I., and Yanagihara, R Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus type I: evidence for independent virus evolution in Asia and Africa. Virology 199: Takemura, T., Yamashita, M., Shimada, M.K., Ohkura, S., Shotake, T., Ikeda, M., Miura, T., and Hayami, M High Prevalence of Simian T-Lymphotropic Virus Type L in Wild Ethiopian Baboons. J. Virol. 76: Tsujimoto, H., Noda, Y., Ishikawa, K., Nakamura, H., Fukasawa, M., Sakakibara, I., Sasagawa, A., Honjo, S., and Hayami, M Development of adult T- cell leukemia-like disease in African green monkey associated with clonal integration of simian T-cell leukemia virus type I. Cancer. Res. 47: Voevodin, A., Samilchuk, E., Schatzl, H., Boeri, E., and Franchini, G Interspecies transmission of macaque simian T-cell leukemia/lymphoma virus type 1 in baboons resulted in an outbreak of malignant lymphoma. J. Vir ol. 70:
22 Vol. 65 No Experimental Animals Vol. 65, No. April 2016 Histomorphometry of the tibia and mandible of healthy female Wistar rats at different stages of growth María M. NENDA, Marianela LEWICKI, and Patricia M. MANDALUNIS Department of Histology and Embryology, School of Dentistry, University of Buenos Aires, Marcelo T de Alvear C1122, Buenos Aires, Argentina Female Wistar rats are frequently used in experimental models to study hormone and bone pathologies and treatments. Most experimental studies involving histomorphometric evaluation assessed long bones, and few reports also studied mandibular bone. The aim of this work was to clarify and distinguish the age-related histomorphometric changes that occur in the tibia (subchondral bone) and in the mandible (interradicular bone), and thus obtain reference histomorphometric data of healthy female Wistar rats at different growth stages. Three groups of 8 healthy female Wistar rats were euthanized at 6 (GI), 10 (GII), and 14 (GIII) weeks. The tibiae and mandible were resected and histologically processed to obtain H&E stained sections of the tibia and the lower first molar to analyze the following histomorphometric parameters: Bone volume, trabecular width, trabecular number (Th.N)(1/mm), growth cartilage width, hypertrophic cartilage width and number of osteoclasts per area in the tibiae, and bone volume and number of osteoclasts per area N.Oc/mm 2 in the interradicular bone of the first lower molar. A significant decrease in subchondral bone volume as a result of a decrease in trabecular number and growth cartilage width was observed in 14-weekold rats. Conversely, interradicular bone volume was found to increase with age. The results highlight the importance of analyzing both types of bone to better understand the response of two different trabecular bones, contributing in turn to decision making regarding treatment strategies and disease management.
23 34 Vol. 65 No. 2 Detection and analysis of tupaia hepatocytes via mabs against tupaia serum albumin Xuan LIU 1), Lunzhi YUAN 1), Quan YUAN 1), Yali ZHANG 2), Kun WU 1), Tianying ZHANG 1), Yong WU 1), Wangheng HOU 1), Tengyun WANG 1), Pingguo LIU 3), James Wai Kuo SHIH 1), Tong CHENG 1), and Ningshao XIA 1) 1) State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, , P.R. China, 2) Blood Center of Xiamen, Xiamen, , P.R. China, 3) Department of Hepatobiliary Surgery, Zhongshan Hospital of Xiamen University, Xiamen , P.R. China On the basis of its close phylogenetic relationship with primates, the development of Tupaia belangeri as an infection animal model and drug metabolism model could provide a new option for preclinical studies, especially in hepatitis virus research. As a replacement for primary human hepatocytes (PHHs), primary tupaia hepatocytes (PTHs) have been widely used. Similar to human serum albumin, tupaia serum albumin (TSA) is the most common liver synthesis protein and is an important biomarker for PTHs and liver function. However, no detection or quantitative method for TSA has been reported. In this study, mouse monoclonal antibodies (mabs) 4G5 and 9H3 against TSA were developed to recognize PTHs, and they did not show cross-reactivity with serum albumin from common experimental animals, such as the mouse, rat, cow, rabbit, goat, monkey, and chicken. The two mabs also exhibited good performance in fluorescence activated cell sorting (FACS) analysis and immunofluorescence (IF) detection of PTHs. A chemiluminescent enzyme immune assay method using the two mabs, with a linear range from pg/ml to 49, pg/ml, was developed for the quantitative detection of TSA. The mabs and the CLEIA method provide useful tools for research on TSA and PTHs. Isolation and morphological characterization of ovine amniotic fluid mesenchymal stem cells Yunyun TIAN 1), Li TAO 1), Siriguleng ZHAO 1), Dapeng TAI 2), Dongjun LIU 2), and Pengxia LIU 1) 1) College of Life Sciences, Inner Mongolia University, Inner Mongolia, Hohhot , P.R.China, 2) Key Laboratory of Mammalian Reproductive Biology and Biotechnology Ministry of Education, Inner Mongolia University, Inner Mongolia, Hohhot , P.R.China Mesenchymal stem cells (MSCs) are one of the most promising cell populations for tissue engineering and regenerative medicine. Of utmost importance to MSC research is identification of MSC sources that are easily obtainable and stable. Several studies have shown that MSCs can be isolated from amniotic fluid. The sheep is one of the main types of farm animal, and it has many biophysical and biochemical similarities to humans. Here, we obtained MSCs from ovine amniotic fluid and determined the expansion capacity, surface and intracellular marker expression, karyotype, and multilineage differentiation ability of these ovine amniotic fluid mesenchymal stem cells (oaf-mscs). Moreover, expression levels of differentiation markers were measured using reverse transcription-qpcr (RT-qPCR). Our phenotypic analysis shows that the isolated oaf-mscs are indeed MSCs.
24 Vol. 65 No RT-PCR PCNA Ki67 topoisomerase IIα H3 S M S Spp1 osteopontin Epcam Hnf1b mrna Spp1 mrna Pharmacokinetics of 1-methyl-L-tryptophan after single and repeated subcutaneous application in a porcine model Elisa WIRTHGEN 1,2), Ellen KANITZ 1), Margret TUCHSCHERER 1), Armin TUCHSCHERER 3), Grazyna DOMANSKA 4), Werner WEITSCHIES 5), Anne SEIDLITZ 5), Eberhard SCHEUCH 6), and Winfried OTTEN 1) 1) Institute of Behavioural Physiology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany, 2) Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany, 3) Institute of Genetics and Biometry, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany, 4) Institute of Immunology and Transfusion Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany, 5) Institute of Pharmacy, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany, 6) Institute of Pharmacology, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany Increased activity of the tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO) is associated with immunological and neurological disorders, and inhibition of its enzyme activity could be a therapeutic approach for treatment of these disorders. The aim of the present study was to establish a large animal model to study the accumulation of the potential IDO inhibitor 1-methyltryptophan (1-MT) in blood and different organs of domestic pigs (Sus scrofa domestica). Because 1-MT has not been previously evaluated in pigs, the pharmacokinetics of a single subcutaneous 1-MT application was investigated. Based on this kinetic study, a profile for repeated 1-MT applications over a period of five days was simulated and tested. The results show that a single administration of 1-MT increases its concentrations in blood, with the maximum concentration being obtained at 12 h. Repeated daily injections of 1-MT generated increasing plasma concentrations followed by a steady-state after two days. Twelve hours after the final application, accumulation of 1-MT was observed in the brain and other organs, with a substantial variability among various tissues. The concentrations of 1-MT measured in plasma and tissues were similar to,
25 36 Vol. 65 No. 2 or even higher, than those of tryptophan. Our data indicate that repeated subcutaneous injections of 1-MT provide a suitable model for accumulation of 1-MT in plasma and tissues of domestic pigs. These findings provide a basis for further research on the immunoregulatory functions of IDO in a large animal model. Noni (Morinda citrifolia L.) fruit extract attenuates the rewarding effect of heroin in conditioned place preference but not withdrawal in rodents Megala NARASINGAM, Vijayapandi PANDY, and Zahurin MOHAMED Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia The present study was designed to investigate the effect of a methanolic extract of Morinda citrifolia Linn. fruit (MMC) on the rewarding effect of heroin in the rat conditioned place preference (CPP) paradigm and naloxone-precipitated withdrawal in mice. In the first experiment, following a baseline preference test (preconditioning score), the rats were subjected to conditioning trials with five counterbalanced escalating doses of heroin versus saline followed by a preference test conducted under drug-free conditions (post-conditioning score) using the CPP test. Meanwhile, in the second experiment, withdrawal jumping was precipitated by naloxone administration after heroin dependence was induced by escalating doses for 6 days (3 / day). The CPP test results revealed that acute administration of MMC (1, 3, and 5 g/kg body weight (bw), p.o.), 1 h prior to the CPP test on the 12th day significantly reversed the heroin-seeking behavior in a dose-dependent manner, which was similar to the results observed with a reference drug, methadone (3 mg/kg bw, p.o.). On the other hand, MMC (0.5, 1, and 3 g/kg bw, p.o.) did not attenuate the heroin withdrawal jumps precipitated by naloxone. These findings suggest that the mechanism by which MMC inhibits the rewarding effect of heroin is distinct from naloxone-precipitated heroin withdrawal. Establishment of a novel rat model of different degrees of portal vein stenosis following 70% partial hepatectomy Lulu YANG 1), Yan LUO 1), Lin MA 1), Hong WANG 1), Wenwu LING 1), Jiawu LI 1), Xiaoying QI 1), Qiang LU 1), and Kefei CHEN 2) 1) Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, P.R. China, 2) Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, P.R. China Liver transplantation may fail due to complications of insufficient portal vein (PV) flow such as portal vein stenosis (PVS). Therefore, establishing a model to explore the effect of PV flow on liver regeneration is crucial and essential. Rats were randomly divided into 6 groups: sham operation rats group; 70% partial hepatectomy (PH) group (group A); PVS groups with mild, moderate, or severe stenosis (group B D) and portal vein ligation (PVL) group. PVS was produced by ligating PV with parallelly placed needles of different gauges. Ultrasound was performed to validate the stenosis ratio (SR) and velocity ratio (VR) at the prestenotic and stenotic site. Rats were sacrificed on day 1,3,7, and 14 after surgery, and liver regeneration rate (LRR) was calculated. We successfully established rat models of different degrees of PVS following 70%PH in 72 rats. The SRs of each PVS group were 44.8 ± 5.23%, 59.3 ± 4.07% and 69.5 ± 2.17%, which showed no statistical differences compared with those measured by stenosis ratio measured by ultrasound. The survival rate in groups A-D were
26 Vol. 65 No %, 83.3%, 66.7% and 50% respectively. Differences were demonstrated between groups A and C, as well as groups A and D (both P<0.05). Moreover, LRR negatively correlated with SR u and VR, and the correlation coefficients were and 0.522, respectively. The rat model we established has the potential to be applied in most conditions of liver regeneration with reduced PV inflow, and it provides a foundation for further exploring the relationship between PV hemodynamic changes and liver regeneration. JAXA ) 1,2,4) 1,2,4) 1 3) 2,5) 2,5) 1,2) 2,6) 4,7) 1,4,7) 8,9) 8,9) 1,8) 1,10,11) 10,11) 11) 10) 6) 1,10,11) 1,12) 1,12) 1,13) 1,14) 1,14) 1,15) 15) 16) 1,16) 17,18) 17) 10,17) 10,17) 10,17) 17) 1,10,17) 1,19) 1,19) 1,19) 20) 20) 1,2,4) 1) Mouse epigenetics project, ISS/Kibo experiment, JAXA 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) 13) 14) 15) 16) 17) 18) Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Sichuan Medical University, Luzhou, Sichuan, P.R. China 19) (JAXA) 20) JAXA the mouse Habitat Cage Unit; HCU HCU CBEF 1 g HCU HCU C57BL/6J HCU 32 HCU HCU 11 HCU HCU
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11-19 2012 1 2 3 30 2 Key words acupuncture insulated needle cervical sympathetick trunk thermography blood flow of the nasal skin Received September 12, 2011; Accepted November 1, 2011 I 1 2 1954 3 564-0034
日本消化器外科学会雑誌第31巻第7号
Key words: obstructive jaundice, biliary drainage, bile refeeding, hepatectomy Fig. 1 Animal models a: experiment I b: experiment 2 silicon tube Fig. 2 Experimantal design Sham Ope J - l r bile duct Zweeks
840 Geographical Review of Japan 73A-12 835-854 2000 The Mechanism of Household Reproduction in the Fishing Community on Oro Island Masakazu YAMAUCHI (Graduate Student, Tokyo University) This
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2011 Vol.60 No.4 p.332 338 Usefulness of regional education program for dietary salt reduction: Self-monitoring of urinary salt excretion Kenichiro YASUTAKE[1] Kayoko SAWANO[1] Shoko YAMAGUCHI[1] Hiroko
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2) Goetz, A., Tsuneishi, N.: Application of molecular filter membranes to the bacteriological analysis of water, J. Am. Water Works Assn., 43 (12): 943-969,1951. 3) Clark, H.F. et al.: The membrane filter
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Review The Secret to Healthy Long Life Decrease in Oxidative and Mental Stress My motto is Health is not all. But nothing can be done without health. Health is the most important requisite for all human
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55 1 18 Bull. Nara Univ. Educ., Vol. 55, No.1 (Cult. & Soc.), 2006 165 2002 * 18 Collaboration Between a School Athletic Club and a Community Sports Club A Case Study of SOLESTRELLA NARA 2002 Rie TAKAMURA
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"G um exp." in the table means before the gum chewing experiment, and "Cont exp." in the table means Table 1. Rest values of heart rate (HR), coefficient of variation in RR (CVRR), wave height of plethysmogram
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\ (1963): Recent Trends of Urban Geography in Japan A, A, A, G, 53 93^ 102 Yamaga S, & Y, Masai (1966) : Japanese Urban Geography-General View Japanese Geography 1966; Spec, Publ, No,1 Ass, Jap, Geogrs,
1) Barat, I. u. Wagner, R.: Brauer, Beitrage Zur Klinik der Tub., Bd. 71 (1929) 2) Warnecke, F.: Zeitschr. f. Tbk. Bd. 54 (1929) 3) Leoni, Alfonso: Zbl. f. g. Tbk. Forsch. Bd. 33 (1930) 4) Jalavisto, Eva
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This report shows innovation of competency of our faculty of social welfare. The aim of evaluation competency is improvement in the Social welfare education effects, by understanding of studentʼs development
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Title 社 会 化 教 育 における 公 民 的 資 質 : 法 教 育 における 憲 法 的 価 値 原 理 ( fulltext ) Author(s) 中 平, 一 義 Citation 学 校 教 育 学 研 究 論 集 (21): 113-126 Issue Date 2010-03 URL http://hdl.handle.net/2309/107543 Publisher 東 京
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semen quality or those without WBC in semen. In the patients with azoospermia and normal FSH levels (normogonadotropic azzospermia), the antibody (IgG
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ORYZA POLYAMINE ORYZA POLYAMINE -P -PC -LC 1. Ver.1.0 MM ver. 1.0MM 1) Roseeuw D.I. et al., Epidermal keratinocytes actively maintain their intracellular polyamine levels. Cell Tissue Kinet. 16, 493-504
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201 Presenteeism 202 203 204 Table 1. Name Elements of Work Productivity Targeted Populations Measurement items of Presenteeism (Number of Items) Reliability Validity α α 205 α ä 206 Table 2. Factors of
1) Garner J. S.: The Hospital Infection Control Practices Advisory Committee, CDC, Guidelines for Isolation Precautions in Hospitals, 1996. http://wonder.cdc.gov/wonder/prevguid/ p0000419/p0000419.asp.
1 Department of Legal Medicine, Toyama University School of Medicine 2 3 4 5 6 7 8 Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama VEGF Key words
明海大学歯学雑誌 ３７‐２／１．秦泉寺
J Meikai Dent Med 37, 153 158, 8 153 1 7 5ml /1 min Wong-Baker Face Rating Scale FS 5 1 9. g 3 5ml /1 min, FS 1 66 6ml /1 min FS 5 1 9. g 3 6ml /1 min, FS 3 Two Cases of Xerostomia that Showed an Improvement
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Yamagata Journal of Health Science, Vol. 6, 23 Kyoko SUGAWARA, Junko GOTO, Mutuko WATARAI Asako HIRATUKA, Reiko ICHIKAWA Recently in Japan, there has been a gradual decrease in the practice of community
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1) University Group Diabetes Program: A study of hypoglycemic agents on vascular complica- in patients with adult-onset tions diabetes. I. Design, methods and baseline results. Diabetes 19 (suppl. 2):
Breastfeedin g among Mothers at One Month Postpartum: Structure of Intentions Department of Maternal and Child Health Nursing, Midwifery, School of Nursing, Faculty of Medical Sciences, University of Fukui
千葉県における温泉地の地域的展開
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1) Lysozyme and Viral Infections, 2nd Intern- Symposium on Fleming's Lysozyme, ational Milano, Apr. 1961. 2) Ermol'eva, Z.V. et al.: Experimental study and clinical application of lysozyme. Fed. Proc.
研究成果報告書(基金分)
The most remarkable characteristic of the mammalian neocortex is its layered structure. Because all, but only the mammalian species, have this layered structure in the telencephalon, it has been accepted
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1988 2000 2002 2004 2006 2008 IFN Lamivudine Adefovir Entecavir 1 Total number 560 Sex (male/female) 424/136 Age (years)* 38 (15-68) Duration of treatment (weeks)* 26 (1-592) Follow-up time (years) 75(05-21
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JAIS 1 2 1 2 In this paper, we focus on the pauses that partly characterize the utterances of simultaneous interpreters, and attempt to analyze the results of experiments conducted using human subjects
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b) Gram-negative bacteria Fig. 2 Sensitivity distribution of clinical isolates : E. coli Fig. 3 Sensitivity distribution of clinical isolates : Pseudomonas Fig. 1 Sensitivity distribution of clinical isolates
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8 The Bulletin of Meiji University of Integrative Medicine API II 61 ASO X 11 7 X-4 6 X m 5 X-2 4 X 3 9 X 11 7 API 0.84 ASO X 1 1 MR-angio
7-14 2010 1 1 1 2 1 1 1 2 Fontaine II ASO61 3 API ASO ASO ASO API API KKKKKKKKKK ASO Fontaine II API Received April 14, 2009; Accepted July 16, 2009 I arteriosclerosis obliterans: ASO ASO 50 70 1,2 Fontaine
rectomy as the subjects of study, urinary steroid hormones were measured, and simultaneously the enzyme work and enzyme pattern related to the steroid metabolism, as proposed by Yoshida of our laboratory,
44 2012 2013 3 35 48 法人化後の国立大学の収入変動 37 法人化後の国立大学の収入変動 2009 2005 2010 2012 2012 2008 2009a 2010 16 18 17 20 2 4 2012 38 44 2012 17 22 (1) (2) 2012 5 GP COE 30 WPI 1 2012 17 22 16 17 22 17 17 19 2012 2012
2001 Received November 28, 2014 Current status and long-term changes of the physique and physical fitness of female university students Shiho Hiraku Y
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coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, F
VOL.43 S-1 coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, Flavobacter- Table 1. Concentration of grepafloxacin