本文／ＹＡ１１７４Ｃ

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1 RecF DNA RecA DNA RecA RecF Steve Kowalczykowski Susan Lovett RecJ Mimitou, E.P. & Symington, L.S.Nature,,. Zhu, Z., Chung, W.H., Shim, E.Y., Lee, S.E., & Ira, G. Cell,,. Gravel, S., Chapman, J.R., Magill, C., & Jackson, S.P. Genes Dev.,,. Hopkins, B.B. & Paull, T.T.Cell,,. Nimonkar, A.V., Ozsoy, A.Z., Genschel, J., Modrich, P., & Kowalczykowski, S.C.Proc. Natl. Acad. Sci. USA,,. Handa, N., Morimatsu, K., Lovett, S.T., & Kowalczykowski, S. C.Genes Dev.,,. Kuzminov, A.Microbiol. Mol. Biol. Rev.,,. Corrette-Bennett, S.E. & Lovett, S.T.J. Biol. Chem.,,. Sung, P. & Klein, H.Nat. Rev. Mol. Cell Biol.,,. Sung, P., Krejci, L., Van Komen, S., & Sehorn, M.G. J. Biol. Chem.,,. Kantake, N., Madiraju, M.V., Sugiyama, T., & Kowalczykowski, S.C.Proc. Natl. Acad. Sci. USA,,. Koroleva, O., Makharashvili, N., Courcelle, C.T., Courcelle, J., & Korolev, S.EMBO J.,,. Rocha, E.P., Cornet, E., & Michel, B.PLoS Genet.,, e. Resection, as an important step of homologous recombination Naofumi Handa Laboratory of Social Genome Sciences, Department of Medical Genome Sciences, University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan QOL A B B B B

2 A NSG B NTGNSG IMCVCL TJ Na β SGA M α - C -IP Ca Cl Na B α Ca Ca β IPR camp IPR camp GTP

3 camp PKA PKA PKA C PKC cgmp PKA camp Epac camp Epac SNARE SNARE soluble N -ethylmaleimide-sensitive fusion protein attachment protein SNAP receptor SNARE t- SNARE SNAP- v-snare VAMP vesicleassociated membrane protein - VAMP- VAMP- SNAP- SNAP- SNARE VAMP- SNARE VAMP- SNAP- MuncSec Munc-Muncc Munc- SNARE Munc-Munca Sec Ca Munc- SNAP- VAMP- SNARE Munc- Munc- Munc- PKC SNARE Munc Slp -a granuphilin-a Munc Munc-Muncb GTP Rab Slp synaptotagmin-like protein-a granuphilin-a COS- Slp -a Slp -a Munc- Munc- Slp a A Slp -a SHD Slp homologue domain C linker Munc- GST GST-Slp -a-linker O β B Munc-Slp -a A SNARE GST-Slp -a-linker Rab GTP Rab Rab Rab D RabRabRabA B Rab Rab Rab

4 Slp -a Slac -c Rab A Slp -a Slac -c Slp -a SHD GTP GDP Rab C B Munc- linker Slac -c SHD GTP Rab Slac -c B GST-Slp -a-linker n p C Rab Slac -c n p Rab SlacSlp homologue lacking C domains -c Slp -a Nocno C domainmunc- Rab Slac -c IPR C Rab Slac -c A Rab Slac -c Slp -a β IPR Slp -a Slac -c Ca Rab Slp -a Slac -c Noc

5 Rab IPR Rab Rabmin min min Rab IPR IPR GTP Rab GTP GDP GDI GDP Noc Rab Noc Noc -RBD Rab binding domain QOL RNAi

6 Gorr, S.-U., Venkatesh, S.G., & Darling, D.S.J. Dent. Res.,,. Ishikawa, Y., Cho, G., Yuan, Z., Skowronski, M.T., Pan, Y., & Ishida, H.J. Pharmacol. Sci.,,. Seino, S. & Shibasaki, T.Physiol. Rev.,.. Takuma, T. & Ichida, T.J. Biol. Chem.,,. Shimomura, H., Imai, A., & Nashida, T.Arch. Biochem. Biophys.,,. Fujita-Yoshigaki, J.Cell Signal.,,. Imai, A., Nashida, T., Yoshie, S., & Shimomura, H. Arch. Oral. Biol.,,. Imai, A., Nashida, T., & Shimomura, H.Arch. Biochem. Biophys.,,. Fukuda, M., Imai, A., Nashida, T., & Shimomura, H.J. Biol. Chem.,,. Fukuda, M.Cell. Mol. Life Sci.,,. Imai, A., Yoshie, S., Nashida, T., Shimomura, H., & Fukuda, M.J. Cell Sci.,,. Imai, A., Yoshie, S., Nashida, T., Fukuda, M., & Shimomura, H.Eur. J. Oral Sci.,,. Fujita-Yoshigaki, J., Matsuki-Fukushima, M., & Sugiya, H. Am. J. Physiol. Cell Physiol.,, C C. Mechanisms of salivary secretion from parotid acinar cells Akane Imai Department of Biochemistry, School of Life Dentistry at Niigata, The Nippon Dental University, Hamaura-cho, Chuo-ku, Niigata, Japan α- DNA ATP RNA Toll TLR- TLR RNA TLR- IRF- NF-κB IFN-α IFN-β TLR-

10中西_他.indd

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