Key words: procalcitonin, systemic inflammatory response syndrome (SIRS), infection, sepsis

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1 Key words: procalcitonin, systemic inflammatory response syndrome (SIRS), infection, sepsis

2

3 Procalcitonin and CRP levels in patients with systemic inflammatory response sundrome (SIRS). group A: normal volunteers, group B : patients with trauma, group C: patients with sepsis, group D: patients with severe sepsis or septic shock. Horizontal bars donate mean values. TNF-a and IL-6 levels in patients with systemic inflammatory response syndrome (SIRS). group A: normal volunteers, group B : patients with trauma, group C: patients with sepsis, group D : patients with severe sepsis or septic shock. Horizontal bars donate mean values.

4 Case1: Kinetics of procalcitinin, cytokine, CRP and endotoxin levels in39- year-old man with rupture of the pancreas and duodenum. MODS: multiple organ dysfunction syndrome Case2: Case of a33-year-old woman with burns (90% of total body surface area) from admission to outcome. MODS: multiple organ dysfunction syndrome

5 Case3: Case of 76-year-old man with general periotonitis associated with perforation of the large intestine, followed by septic shock MODS: multiple organ dysfunction syndrome

6 1) Members of the American College of Chest Phy-

7 10) Gendrel D, Assicot M, Raymond J et al.: Procalcitonin as a marker for the early diagnosis of neo- sicians/society of Critical Care Medicine Consensus Conference Committee: Definitions for sep- 11) Nylen ES, Snider RH, Thompson KA, Rohatgi P, natal infection. J Pediatr1996; 128: sis and organ failure and guidelines for the use of Becker KL: Pneumonitis-associated hyperprocalcitonemia. Am J Med Sci1996; 312: innovative therapies in sepsis. Chest199; 101: /Crit Care Med1992;20: ) Werra I, Jaccard C, Corradin SB et al.: Cytokine, nitrite/nitrate, soluble tomor necxrosis factor receptors, and procalcitonin concentrations: com- 3) Takakuwa T, Endo S, Inada K, Kasai T, Yamada Y, Ogawa M: Assessment of inflammatory cytokines, nitrite/nitrate, type II phospholipase A2, and souble adhesion molecules in systemic inflammatory response syndrome. Res Commun Molecul Pathol Pharamacol1997; 98: ) Zajac JD, Martin TJ, Hudson P, Niall H, Jacobs JW: Biosynthesis of calcitonin by human lung cancer cells. Endocrinol1985; 116: ) Assicot M, Gendrel D, Carsin H. Raymond J, Guibaud J, Bohuin C: High serum procalcitonin concentrations in patients with sepsis and infection. Lancet1993; 341: ) Davis TME, Assicot M, Bohuon C, John AS, Li GQ, Anh TK: Serum procalcitonin concentrations in acute malaria. Trans R Soc Med Hyg 1994; 88: ) Smith MD, Suputtamongkol Y, Chaowagul W et al.: Elevated serum procalcitonon levels in patients with melioidosis. Clin Infect Dis1995; 20: ) Reith HB, Lehmkuhl R, Beier W, Hogy B, die Stuidiengruppe Pritonitis: Procalcitonin-ein prognostischer Infektionsparameter bei der Perionitis. Chir Gastroenterol1995; 7 (Suppl2): ) Gramm H-J, Dollinger P, Beier W: Procalcitoninein neuer Marker der inflammatorischen Wirtsantwort Longitudinalstudien bei Patienten mit Sepsis and Peritonitis. Chir Gastroenterol1995; 11 (Suppl2): parison in patients with septic shock, cardiogenic shock, and bacterial pneumonia, Crit Care Med 1997; 25: ) Inada K, Endo S, Takahashi K et al.: Establishment of a new perchroric acid treatment method to allow determination of the total evdotoxin in human plasma by the limulus test and clinical application. Microbiol Immunol1991; 35: ) Obayashi T, Tamura H, Tanaka S et al.: New chromogenic endotoxin-specific assay recombined limulus coagulation enzymes and its clinical application. Clin Chim Acta1985; 149: ) Knaus WA, Draper EA, Wagner DP, Zimmerman JE: APACHE II: A severity of disease classification system. Crit Care Med1985; 13: ) Kimberly JV, Laura ED, Lyle LM et al.: IL-8 in septic shock, endotoxin, and after IL-1 administration. J Immunol1199; 46: ) Nylen ES, O'neill W, Jordan MH et al.: Serum procalcitonin as an index of inhalation injury in burns. Horm Metab Res1992; 24: ) Carsin H. Assicot M, Feger F et al.: Evolution and significance of circulating procalcitonin levels compared with IL-6, TNF-ƒ and endotoxin levels early after thermal injury. Burns1997; 23: ) Gerard Y, Hober D, Petitjean S et al.: High serum procalcitonin level in a4-year-old liver transplant recipient with a disseminated candidiasis. Infection1995; 23:

8 Evaluation of Procalcitonin Levels in Patients with Systemic Inflammatory Response Syndrome as the Diagnosis of Infection and the Severity of Illness Shigeatsu ENDO1), Takeshi KASAI & Katsuya INADA2) To understand the presence or absence of bacterial infection in patients with systemic inflammatory response syndrome (SIRS), the level of procalcitonin (PCT), a precursor of calcitonin, was determined. Subjects consisted of14sirs patients without complication by bacterial infection, 14SIRS patients complicated by sepsis, and14sirs patients complicated by severe sepsis and septic shock. PCT levels in SIRS patients with sepsis (2.9 }2.3ng/m Œ) were significantly higher than those in SIRS patients without complication by infection (0.7 }1.1neml). However, there wrer no significant differences in the levels of C-reactive protein (CRP), interleukin6 (I-6) or tumor necrosis factor-a (TNF- and TNF-a were also significantly higher in the patients with sepsis compared to those in patients with local infection. Significant correlations were observed between the levels of PCT and those of CRP, IL-6and TNF-a in SIRS patients. It was suggsted that to measure the levels of procalcitonin in patients with SIRS is useful to diagnose the infection and severity of illness.

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Title 歯性病巣の関連する皮膚疾患におけるビオチンの効用 Author(s) 高橋, 愼一 ; 川島, 淳子 ; 森本, 光明 ; 山根, 源之 Journal, (): - URL   Right Posted at the Inst Title 歯性病巣の関連する皮膚疾患におけるビオチンの効用 Author(s) 高橋, 愼一 ; 川島, 淳子 ; 森本, 光明 ; 山根, 源之 Journal, (): - URL http://hdl.handle.net/10130/526 Right Posted at the Institutional Resources for Unique Colle Available from

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