Key words: procalcitonin, systemic inflammatory response syndrome (SIRS), infection, sepsis
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1 Key words: procalcitonin, systemic inflammatory response syndrome (SIRS), infection, sepsis
2
3 Procalcitonin and CRP levels in patients with systemic inflammatory response sundrome (SIRS). group A: normal volunteers, group B : patients with trauma, group C: patients with sepsis, group D: patients with severe sepsis or septic shock. Horizontal bars donate mean values. TNF-a and IL-6 levels in patients with systemic inflammatory response syndrome (SIRS). group A: normal volunteers, group B : patients with trauma, group C: patients with sepsis, group D : patients with severe sepsis or septic shock. Horizontal bars donate mean values.
4 Case1: Kinetics of procalcitinin, cytokine, CRP and endotoxin levels in39- year-old man with rupture of the pancreas and duodenum. MODS: multiple organ dysfunction syndrome Case2: Case of a33-year-old woman with burns (90% of total body surface area) from admission to outcome. MODS: multiple organ dysfunction syndrome
5 Case3: Case of 76-year-old man with general periotonitis associated with perforation of the large intestine, followed by septic shock MODS: multiple organ dysfunction syndrome
6 1) Members of the American College of Chest Phy-
7 10) Gendrel D, Assicot M, Raymond J et al.: Procalcitonin as a marker for the early diagnosis of neo- sicians/society of Critical Care Medicine Consensus Conference Committee: Definitions for sep- 11) Nylen ES, Snider RH, Thompson KA, Rohatgi P, natal infection. J Pediatr1996; 128: sis and organ failure and guidelines for the use of Becker KL: Pneumonitis-associated hyperprocalcitonemia. Am J Med Sci1996; 312: innovative therapies in sepsis. Chest199; 101: /Crit Care Med1992;20: ) Werra I, Jaccard C, Corradin SB et al.: Cytokine, nitrite/nitrate, soluble tomor necxrosis factor receptors, and procalcitonin concentrations: com- 3) Takakuwa T, Endo S, Inada K, Kasai T, Yamada Y, Ogawa M: Assessment of inflammatory cytokines, nitrite/nitrate, type II phospholipase A2, and souble adhesion molecules in systemic inflammatory response syndrome. Res Commun Molecul Pathol Pharamacol1997; 98: ) Zajac JD, Martin TJ, Hudson P, Niall H, Jacobs JW: Biosynthesis of calcitonin by human lung cancer cells. Endocrinol1985; 116: ) Assicot M, Gendrel D, Carsin H. Raymond J, Guibaud J, Bohuin C: High serum procalcitonin concentrations in patients with sepsis and infection. Lancet1993; 341: ) Davis TME, Assicot M, Bohuon C, John AS, Li GQ, Anh TK: Serum procalcitonin concentrations in acute malaria. Trans R Soc Med Hyg 1994; 88: ) Smith MD, Suputtamongkol Y, Chaowagul W et al.: Elevated serum procalcitonon levels in patients with melioidosis. Clin Infect Dis1995; 20: ) Reith HB, Lehmkuhl R, Beier W, Hogy B, die Stuidiengruppe Pritonitis: Procalcitonin-ein prognostischer Infektionsparameter bei der Perionitis. Chir Gastroenterol1995; 7 (Suppl2): ) Gramm H-J, Dollinger P, Beier W: Procalcitoninein neuer Marker der inflammatorischen Wirtsantwort Longitudinalstudien bei Patienten mit Sepsis and Peritonitis. Chir Gastroenterol1995; 11 (Suppl2): parison in patients with septic shock, cardiogenic shock, and bacterial pneumonia, Crit Care Med 1997; 25: ) Inada K, Endo S, Takahashi K et al.: Establishment of a new perchroric acid treatment method to allow determination of the total evdotoxin in human plasma by the limulus test and clinical application. Microbiol Immunol1991; 35: ) Obayashi T, Tamura H, Tanaka S et al.: New chromogenic endotoxin-specific assay recombined limulus coagulation enzymes and its clinical application. Clin Chim Acta1985; 149: ) Knaus WA, Draper EA, Wagner DP, Zimmerman JE: APACHE II: A severity of disease classification system. Crit Care Med1985; 13: ) Kimberly JV, Laura ED, Lyle LM et al.: IL-8 in septic shock, endotoxin, and after IL-1 administration. J Immunol1199; 46: ) Nylen ES, O'neill W, Jordan MH et al.: Serum procalcitonin as an index of inhalation injury in burns. Horm Metab Res1992; 24: ) Carsin H. Assicot M, Feger F et al.: Evolution and significance of circulating procalcitonin levels compared with IL-6, TNF-ƒ and endotoxin levels early after thermal injury. Burns1997; 23: ) Gerard Y, Hober D, Petitjean S et al.: High serum procalcitonin level in a4-year-old liver transplant recipient with a disseminated candidiasis. Infection1995; 23:
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