Yozu Ryohei, Inoue T, Shimomitsu T, Morilnoto T, Sugita Y, Watanabe T, Ishikawa M, Stacy G, Jacobs G, Harasaki H, Nose Y. EXERCISE RESPONSE IN CHRONIC NONPULSATILE (NPBVB) AND PULSATILE TAH ANIMALS. Treadmill s were done (NPBVB=6 times, TAH=4) on 5 chronic NPBVB (34-99 days) and 4 pusher-plate type TAH (45-206 days) calves comparing ir hemodynamic and metabolic responses. No adjustments of driving conditions were done se tests (1.5 mph 15 min, pre- CO;NPBVB=95 }11 ml/kg/min, TAH=90 }8). In both groups AoP, PAP, PVR, blood ph, and lactate values showed no changes. Norepinephrine increased from 395 }204 PG/ml to 1571 }565 (P<0.05) in NP and from 441 }138 to 595 }237 in TAH group. These data suggest that 1) increased O2 demand was met by augmented O2 extraction NP, and by increased CO and increased O2 extraction TAH recipients, and 2) NPBVB group has a higher adrenergic response tests than TAH group. Key words:tah, test,, pulsatile flow, nonpulsatile flow Jpn. J. Artif. Organs 18(2), 619-623 (1989)
TABLE 1. CHANGES IN HEMODYNAMIC PARAMETERS DURING EXERCISE Figure 1. Hemodynamic changes in right atrial pressure (RAP) bee, and after. Figure 2. Hemodynamic changes in left atrial pressure (LAP) bee, and after.
Figure 5. Changes in systemic vascular resistance (SVR) bee, and after. Figure 3. Changes in left pump flow bee, and after. Figure 4. Changes in right pump flow bee, and after. TABLE II. CHANGES IN METABOLIC PARAMETERS DURING EXERCISE
Figure 6. Changes in oxygen consumption bee, and after. Figure 7. Plasma catecholamine levels bee and.
V. 結 論 ピ ネ フ リ ンの 反 応 が み られ た 1. 拍 動 流AHと 無 拍 動 流AHの 仔 牛 は と も に, 1.5MPHの 運 動 負 荷 に 対 し 良 好 な 耐 容 能 を 示 し た 2.無 仔 牛 は, 運 動 中 動 静 脈O2較 on る うえ で, 差 を よ り増 大 す る 事 で, O2 デ マ ン ド を 代 償 し て い た 3.無 Pulsatile 以 上 よ り機 械 的 駆 動 に よ る 完 全 埋 め 込 み 型AHを 拍 動 群 の chamberの 拍 動 群 は よ り高 い ノル エ 無 拍 動 流 ポ ン プ は 小 型, 効 率, 考 え Compliance 不 要 な 点 な ど の 利 点 を 有 し, 考 慮 さ れ る べ き ポ ン プ 型 式 と考 え る test Non-pulsatile on test REFERENCES 1. Kasai S, et al:survival 145 days a total. J Thorac Cardiovasc Surg 73:637, 1976. 2. Takatani mode. S, et al:pusher-plate Artif Organs type 5:132, 3. Yozu R, et al:experimental 9:116. results and future Y. et al:hemodynamic prossis. J Surg JK, TH, and after Res studies 23:75, et al:effects 6. Stanley in left and rightfree-running variable rate prospects a nonpulsatile cardiac prossis. on a in World J Surg of implantation. on cardiovascular 22:315, 1976. et al:comparison a total cardiac 1977. of cardiovascular implantation. 7. Kito Y, et al:hemodynamic studies 667, operated 1985. 4. Mitamura 5. Lunn TAH system 1981. Surgery responses 83:542, and respiratory and left ventricular dynamics work bee and after bee 1978. in calves totol s. 20: 1974. 8. Chiang BY, et al:evaluation of on total recipients. 30:514, pulseless orterial 1984, 9. Sheer flow. PM, et al:hemodynamic 10. Joyce. 26:1, LD, et al:response 29:81, 11. Yozu R, et al:a Cleveland 12. Beregard ISAO BS, response to in of human body to first unanestized 1980. new control Press, Shepard permanent implant of Jarvik-7 total 1980. No.204, method 1984, JT.:Regulation a ventricular assist device. Progress in Artificial Organs-1983. pp98-106. of circulation in man. Physiol Rey 47:178, 1967. 人 工 臓 器18巻2号 1989年 623