Clinical studies on Cef triaxone in the field of oral surgery JIRO SASAKI,*1 MASATAKA UEMATSU,*l AKIHIRO KANEKO,*1 YOSHIHIDE OHTA,*1 KAZUO SHIIKI,*2 T

Similar documents
VOL.42 S-1

Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (45)

VOL.35 S-2 CHEMOTHERAPY Table 1 Sex and age distribution Table 2 Applications of treatment with carumonam Table 3 Concentration of carumonam in human

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study

988 CHEMOTHERAPY NOV. 1971

VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains )

coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, F




CHEMOTHERAPY

Fig. 1 Chemical structure of DL-8280

VOL. 40 S- 1 Table 1. Susceptibility of methicillin-resistant Staphylococcus aureus to meropenem Table 2. Coagulase typing of methicillin-resistant St

CHEMOTHERAPY Table 1 Urinary excretion of mezlocillin Fig. 4 Urinary excretion of mezlocillin Fig. 3 Blood levels of mezlocillin

THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec LVFX 100 mg 3 / mg 2 / LVFX PK PD mg mg 1 1 AUC/MIC

CHEMOTHERAPY JUN Citrobacter freundii 27, Enterobacter aerogenes 26, Enterobacter cloacae 27, Proteus rettgeri 7, Proteus inconstans 20, Proteus

CHEMOTHERAPY APR Fig. 2 The inactivation of aminoglycoside antibiotics by PC-904 Fig. 3 Serum concentration of PC-904 (1) Fig. 4 Urinary recover

CHEMOTHERAPY FEB Table 1 Background of volunteers

CHEMOTHERAPY NOV S. aureus, S. epidermidis, E. coli, K. pgeumoniae, E. cloacae, S. marcescens, P. mirabilis, Proteus, P. aeruginosa Inoculum siz

Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S.

CHEMOTHERAPY MAY. 1988

VOL. 34 S-2 CHEMOTH8RAPY 913

Fig. 1 Chemical structure of KW-1070

epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia




VOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity of gram nega

Table 1. Antibacterial spectrum SBT ABPC ABPC CPZ : sulbactamiampicillin : ampicillin : cefoperazone

CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX

Fig. 1 Chemical structure of TE-031 Code number: TE-031 Chemical name: (-) (3R, 4S, 5S, 6R, 7R, 9R, 11R, 12R, 13S, 14R)-4-[(2, 6-dideoxy-3-C-methyl-3-

Changes in Electrodermal Activity Associated with Candies and Chewing Gum Chewing Satoshi Beppu, Takeshi Morita*, Susumu Igarashi **, Kanichi Seto* an

Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates

Staphylococcus sp. K.pneumoniae P.mirabilis C.freundii E. cloacae Serratia sp. P. aeruginosa ml, Enterococcus avium >100ƒÊg/ml

CHEMOTHERAPY FEB Table 1. Activity of cefpirome and others against clinical isolates


Table 1. Concentration of ritipenem in plasma, gallbladder tissue and bile after ritipenem acoxil administration (200 mg t.i.d., 3 days) N.D.: not det

Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile


Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection

Hisao Takayasu Department of Urology, Faculty of Medicine, University of Tokyo Masaaki Ohkoshi Department of Urology, Tokai University School of Medic

Fig.2. Sensitivity distribution of clinical isolates of S. epidermidis (24 strains, 106 CFU/ml) Staphylococcus aureus Staphylococcus epider- midis Ent

日本化学療法学会雑誌第51巻第2号

Postoperative Assessment by Using a Torque Machine (BIODEX) and MRIs in Patients treated for a Recurrent Anterior Dislocation or Subluxation of the Sh

日本化学療法学会雑誌第53巻第S-3号

VOL.39 S-3

CHEMOTHERAPY


VOL.30 S-1 CHEMOTHERAPY Table 1 Antibacterial activity of CTT against standard strains Table 2 Antibacterial activity of CTT against standard strains

THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec DNA 2, , % 1.65% 1.17% 90% 9 Escherichia coli -

CHEMOTHERAPY SEPT. 1991




Feb. 2001

_’£”R‡Ù‡©


CHEMOTHERAPY JUNE 1986


VOL. 36 S-3 CHEMOTHERAPY 437

Experimental and Clinical Studies of Pregnant Hypertension Takashi SHIMAZU Department of Obstetrics and Gynecology, Osaka City University Medical Scho


日本消化器病学会雑誌第102巻第8号

Jan THE JAPANESE JOURNAL OF ANTIBIOTICS XL-1 Table 1. Outline of administering doses, routes and sampling times *: 4 ml/hr/kg Bacillus subtilis

Fig.1 Chemical structure of BAY o 9867

Fig. 1 Chemical structure of norfioxacin (AM-715)

特殊病態下感染症における抗菌薬治験の手引き作成委員会報告書（案）

明海大学歯学雑誌　３７‐２／１．秦泉寺

CHEMOTHERAPY aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Prote

STUDIES ON THE RELATION BETWEEN LATE DUMPING SYNDROME AND GLUCAGON RESPONCES TO GLUCOSE Taisuke MATSUI The First Department of Surgery, Nara Medical U

1272 CHEMOTHERAPY MAR. 1975

Endocrinological and statistical analysis of ovarian function in hysterectomized patients Masaya HAYAFUJI, Kazuaki KATAYAMA and Matsuto MOCHIZUKI Depa

VOL.27 S-5 CHEMOTHERAPY Table 1 Clinical evaluations of cefamandole on UTI (1) Benign prostatic hypertrophy (2) Transurethral resection of bladder tum

Table 1 Classification of female patients with vesical irritating symptom by their signs : Urinary pain with or without other vesical irritability. s



pneumoniae 30, C. freundii 32, E. aerogenes 27, E. cloacae 32, P. mirabilis 31, P. vulgaris 34, M. morganii 32, S. marcescens 31, H. influenzae 27, P.


VOL. 23 NO. 3 CHEMOTHERAPY 1379 Table 1 Susceptibility of clinical isolated strains to Tobramycin

Table1MIC of BAY o 9867 against standard strains

VOL.27 CHEMOT S-1 HERAPY 185 に感 性 を示 して い たが,臨 床 的 に は無 効 で あ った 本 症 る 細 菌学 的 に も検 討 した が,起 炎菌 と考 え られ る細 菌 を 例 で は 基礎 疾 患 と して縦 隔 洞腫 瘍 が あ り,既 に 副 腎

Effect of Sympathetic and parasympathetic agents on cholesterol metabolism in mice salivary glands. Eriko, NEZU and Haruo, NAKAMURA (Department of Ora

Key words : Adverse reactions, Egg allergy, IgG antibody, Mills allergy, FAST




Title 歯性病巣の関連する皮膚疾患におけるビオチンの効用 Author(s) 高橋, 愼一 ; 川島, 淳子 ; 森本, 光明 ; 山根, 源之 Journal, (): - URL Right Posted at the Inst

CHEMOTHERAPY Table 1 Clinical effect of Sultamicillin



A sensory testing of mental nerve by Semmes-Weinstein monofilaments standard value from 19 -A to 29 years old- The objective of the present study was




VOL. 20 NO. 5 CHEMOTHERAPY Methoxy-4-sulfanilamidopyrimidine (OS-3376) Sulfadimethoxine (SDM) Table 1. In vitro antibacterial activities of OS-3




8 The Bulletin of Meiji University of Integrative Medicine API II 61 ASO X 11 7 X-4 6 X m 5 X-2 4 X 3 9 X 11 7 API 0.84 ASO X 1 1 MR-angio

Effect of Trimoprostil on Gastric Secretion Takeshi KAWAMURA * Hiroko EBINA * Fumiaki KOIZUMI * and Akira ISHIMORI * *Department of Clinical and Labor

Transcription:

Clinical studies on Cef triaxone in the field of oral surgery JIRO SASAKI,*1 MASATAKA UEMATSU,*l AKIHIRO KANEKO,*1 YOSHIHIDE OHTA,*1 KAZUO SHIIKI,*2 TAKEFUMI MORIHANA,*3 FUMISADA TOMITA,*3 KEN-ICHI MICHI,*4 HIROSHI YOSHIDA,*4 MASAO NAGUMO,*5 YUKARI GOGUN,*5 KAN-ICHI SETO,*6 TORU MAKI,*6 KATSUNORI ISHIBASHI,*7 TORU SATOH,*7 MASAHIKO FUKAYA,*8 YOSHIKI TAKAI,*8 KOU-ICHI DEGUCHI*9 1) Following 1-h i.v, drip infusion with Ceftriaxone (CTRX) at 33 mg/kg into NZW rabbits, the serum level remained high for a long period of time : The Cmax was 67.761 mcg/ ml and the T1/2 4.189 h. The proportion of oral tissue level to serum level was 41 to 95% at the peak and 42 to 119% 10 h post-dose. 2) With administration of CTRX at 1 or 2 g once daily into 96 patients with osteitis or cellulitis of the jaw, both acute suppurative infections in the oral surgery field, the clinical efficacy rate was 86.8% (91/96) by judging the numerical rating on the 3rd day and 84.4% according to the evaluation by the doctor in charge. 3) Adverse reactions were observed in 3 patients (3%). Drug administration was dis- Department of Oral Surgery, School of Medicine, Tokai University (Chief : Prof. JIRO SASAKI) Department of Dentistry and Oral Surgery, Iwaki Kyoritsu General Hospital (Chief : Dr, KAZUO SlinKI) Department of Dentistry and Oral Surgery, Ashikaga Seki ju ji Hospital (Chief: Dr. TAKEFUMI MORIHANA) First Department of Oral and Maxillofacial Surgery, School of Dentistry Showa University (Chief : Prof. KEN-ICHI MICHI) Second Department of Oral and Maxillofacial Surgery, School of Dentistry Showa University (Chief Prof. MASAO NAGUMO) First Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University (Chief: Prof. KAN-ICHI SETO) Second Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University (Chief ; Prof. KATSUNORI ISHIBASHI) First Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University (Chief: Prof. MASAHIKO FUKAYA) Laboratory Section, Tokyo Clinical Research Center 1987 9ŒŽ25 úžó t

continued in 1 of the 3 due to nausea and fever which appeared immediately after the i.v. injection. In the other 2, natural remission was observed during the course of continued administration. 4) In clinical laboratory tests, abnormal parameter values were detected in 16% (12 patients) ; liver dysfunction suggested by an increase in transaminase, etc. in 10, an increase in BUN in 1 and an increase in eosinophils in 1. 5) CTRX is characterized by a broad antibacterial spectrum, long half-life, favourable tissue transfer and enough clinical efficacy with once-a-day dosing to enable outpatient treatment. When treating with the drug, however, patients should be carefully observed for liver function.

a ) Coagulase Negative Staphylococci.

pentration after single and multiple dose of ceftriaxone. Antimicrob Agents Chemother 1985 28 : 123 `127. 3) Hayton, W.L., et al: Age associated changes 1) Stoeckel, K., et al : Effect of concentrationdependent plasma protein binding on ceftriaxone kinetics. Clin Pharmacol Ther 1981 29 : 650 `657. 2) LeBel, M., et al : Difference in blister fluid in ceftriaxone pharmacokinetics. Clin Pharmacokinet 1986 11:76 `78. 4) Fass, R.J.: Comparative in vitro activities of third-generation cephalosporins. Arch Intern Med 1983 143: 1743 `1745. 5) Pollock, H.M., et al : Comparison of susceptibilities of anaerobic bacteria to cefmenoxime, ceftriaxone, and other antimicrobial compounds. Antimicrob Agents Chemother 1983 23 : 780 `783. 6) Emmerson, A.M., et al: The in vitro antibacterial activity of ceftriaxone in comparison with nine other antibiotics. Curr Med Res Opin 1985 9:480 `493.

2024 © docsplayer.net プライバシー | 利用規約 | フィードバック