544( 56 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. 25 2003 2. * *
Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 545( 57 ) 9 5 2003 8 2004 714 565 719 50 20 39 0 9 70 79 44.4 91.7% Escherichia coli Pseudomonas aeruginosa Enterococcus faecalis E. coli P. aeruginosa E. faecalis E. coli 40% E. coli E. coli P. aeruginosa E. faecalis P. aeruginosa E. coli P. aeruginosa E. faecalis
546( 58 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. 1 23) 2003 8 2004 714 565 719 1 3 I. 1. Fig. 1 41.8% (236/565) 58.2% (329/565) 50 12.7% (30/236) 26.7% (8/30) 60.0% (18/30) 13.3% (4/30) 50 70 79 35.6% (84/236) 10 19 60 79 48.0% (158/329) 0 9 70 79 44.4 91.7% 2. Fig. 2 Escherichia coli 51.7% 23.5% 13.6% Pseudomonas aeruginosa 2.9% 7.9% 13.6% Enterococcus faecalis 8.8% 12.6% 21.5% 3. Fig. 3 Fig. 3 1 E. coli 20 41.2%, 20 49 61.1% 50 69 48.7%, 7048.0% E. faecalis 20 5.9%, 20 49 4.2%, 50 69 10.5%, 70 12.0% Fig. 3 2 E. coli 2036.4%, 20 49 27.6%, 50 69 25.5%, 7020.5% E. faecalis 20 27.3%, 20 49 10.3%, 50 69 8.5%, 70 14.7% E. coli P. aeruginosa Fig. 3 3 50 69 70 E. faecalis 50 69 22.5%, 70 18.5% E. coli, P. aeruginosa, S. aureus
Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 547( 59 ) Fig. 1. 2003
548( 60 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. Fig. 2. 2003
Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 549( 61 ) Fig. 3. 2003
550( 62 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. 4. 1 Fig. 4 153 87 E. coli 50.3%54.0% P. aeruginosa 2.0% 4.6% E. faecalis 9.2% 8.0% 249 53 E. coli E. faecalis 25.7%, 12.4% 13.2% E. coli P. aeruginosa S. aureus 6.4%, 6.4% 15.1%, 7.5% 107 70 P. aeruginosa 10.3% 18.6% E. coli S. aureus 16.8%, 11.2%, 8.6%, 7.1% E. faecalis 20.6% 22.9% 5. Fig. 5 54186 E. coli E. faecalis 33.3% 14.8% E. coli 57.0% 6 Klebsiella spp., Proteus spp., Enterobacter spp., P. aeruginosa, S. aureus, E. faecalis 166136 E. coli, E. faecalis, P. aeruginosa 22.3%, 13.9%, 11.4% E. coli, E. faecalis, S. aureus 25.0%, 11.0%, 7.4% 12453 E. faecalis 25.0% P. aeruginosa 14.5% E. coli 17.0% E. faecalis 13.2% II. 1 23) 2003 8 2004 714 565719 50 12.7%, 20 5.2% 20 29 10 19 E. coli
Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 551( 63 ) Fig. 4. 2003
552( 64 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. Fig. 5. 2003
Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 553( 65 ) P. aeruginosa E. faecalis P. aeruginosa E. coli 20 49 61.1% E. faecalis E. coli E. faecalis 50 69 E. coli P. aeruginosa E. faecalis 20 49 E. faecalis 55.6% E. coli P. aeruginosa E. coli P. aeruginosa E. coli Klebsiella spp., P. aeruginosa, E. faecalis E. coli, E. faecalis P. aeruginosa E. coli, E. faecalis E. coli P. aeruginosa P. aeruginosa E. faecalis E. coli, P. aeruginosa, E. faecalis 1) E.coli, Klebsiella, Citrobacter Proteus Jpn. J. Antibiotics 34: 959 975, 1981 2) Escherichia coli, Klebsiella, Citrobacter Proteus 3 1981 3. Jpn. J. Antibiotics 36: 1521 1543, 1983 3) 4 1982 2. Jpn. J. Antibiotics 37: 723 733, 1984 4) 5 1983 2. Jpn. J. Antibiotics 38: 2230 2241, 1985 5) 6 1984 2. Jpn. J. Antibiotics 39: 3007 3018, 1986 6) 7 1985 2. Jpn. J. Antibiotics 40: 2013 2025, 1987 7) 8 1986 2. Jpn. J. Antibiotics 42: 2175 2188, 1989 8) 9 1987 2. Jpn. J. Antibiotics 43: 954 967, 1990 9) 10 1988 2. Jpn. J. Antibiotics 45: 1103 1111, 1992 10) 11 1989 2. Jpn. J. Antibiotics 48: 1161 1173, 1995 11) 12 1990 2. Jpn. J. Antibiotics 48: 1317 1328, 1995 12) 13 1991 2. Jpn. J. Antibiotics
554( 66 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. 48: 1422 1435, 1995 13) 14 1992 2. Jpn. J. Antibiotics 48: 1658 1670, 1995 14) 15 1993 2. Jpn. J. Antibiotics 48: 1788 1801, 1995 15) 16 1994 2. Jpn. J. Antibiotics 49: 494 508, 1996 16) 17 1995 2. Jpn. J. Antibiotics 50: 251 264, 1997 17) 18 1996 2. Jpn. J. Antibiotics 51: 112 129, 1998 18) 19 1997 2. Jpn. J. Antibiotics 52: 130 145, 1999 19) 20 1998 2. Jpn. J. Antibiotics 53: 234 248, 2000 20) 21 1999 2. Jpn. J. Antibiotics 54: 217 299, 2001 21) 22 2000 2. Jpn. J. Antibiotics 55: 399 411, 2002 22) 23 2001 2. Jpn. J. Antibiotics 56: 396 423, 2003 23) 24 2002 2. Jpn. J. Antibiotics 57: 275 287, 2004 COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM PATIENTS WITH URINARY TRACT INFECTIONS (2003) II. BACKGROUND OF PATIENTS YOSHIAKI KUMAMOTO*, TAIJI TSUKAMOTO, MASANORI MATSUKAWA and YASUHARU KUNISHIMA Department of Urology, Sapporo Medical University School of Medicine (*: a honorary professor at present) TAKAOKI HIROSE Department of Urology, Hokkaido Social Insurance Hospital OSAMU YAMAGUTI and KEI ISHIBASHI Department of Urology, Fukushima Medical University TATSUO SUZUTANI Department of Microbiology, Fukushima Medical University SHIRO SHIGETA Division, Bureau of Hospital Administration, Fukushima Prefectural Goverment HIROSHI YOSHIDA and YUUJI IMAFUKU Department of Clinical Laboratory Medicine, Fukushima Medical University
Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 555( 67 ) MASARU MURAI Department of Urology, Keio University School of Medicine KIYOAKI WATANABE, YOSHIO KOBAYASHI and HIROSHI UCHIDA Central Clinical Laboratories, Keio University School of Medicine SEIJI MATSUDA Department of Gynecology, Koto Hospital SHINICHI SATO Department of Clinical Laboratories, Koto Hospital TOSHITSUGU OKA and MASAYA KITAMURA Department of Urology Osaka National Hospital YOSHINORI FUKUHARA Department of Clinical Laboratories, Osaka National Hospital SADAO KAMIDONO Division of Urology, Kobe University Graduate School of Medicine SOICHI ARAKAWA Department of Surgical Operation, Kobe University Hospital MAKOTO FUJIME and KAZUHIKO FUJITA Department of Urology, Juntendo University School of Medicine HIROMI KUMON and KOICHI MONDEN Department of Urology, Okayama University Graduate School of Medicine and Dentistry JUN IGARI Urayasu Hospital, Juntendo University School of Medicine TOYOKO OGURI Department of Clinical Laboratories, Juntendo University Hospital KEIZO YAMAGUCHI and NOBUHIKO FURUYA Department of Microbiology, Toho University School of Medicine TAKASHI DEGUCHI and SATOSHI ISHIHARA Urological Devision, Disease Control Course, Gifu University Graduate School of Medicine HIROSHI OOE Department of Urology, Kyoto Second Red Cross Hospital TETSURO MATSUMOTO and KOICHI TAKAHASHI Department of Urology, School of Medicine, University of Occupational and Environmental Health SEIJI NAITO, TOSHIHISA EGASHIRA, and TAKATOSHI KONISHI Department of Urology, Kyushu University Graduate School of Medicine SHIGERU KOHNO Second Department of Internal Medicine, Nagasaki University School of Medicine YOICHI HIRAKATA, AKIRA KONDO, JUNICHI MATSUDA and MICHIKO NAKANO Department of Laboratory Medicine, Nagasaki University Hospital of Medicine and Dentistry MINEKO NISHIKAWA Department of Clinical Laboratory, Kyoto Second Red Cross Hospital YUMIKO SUZUKI Department of Laboratory, Yamada Evidence Research
556( 68 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. Seven hundred and nineteen bacterial strains isolated from 565 patients diagnosed as having urinary tract infections (UTIs) in 14 institutions in Japan were collected between August 2002 and July 2003. The frequency of bacteria isolation divided with patient clinical background was compared. The clinical background investigated included sex, age, type of infections, timing of antibiotics administration, and presence or absence of surgery affecting a decrease in defense against infection. The bacterial strains were divided with the age and sex of the patients and the types of infections. In males, the number of patients aged less than 50 years was few and the complicated UTIs without indwelling catheter was observed most frequently. Number of patients aged 20 39 years was greater in female than male. In all of ages except 0 9 and 70 79 years, the ratio of the uncomplicated UTIs was high, accounting for 44.4 91.7% of all types of infections. In the present time, the bacteria most frequently isolated were Escherichia coli, Pseudomonas aeruginosa and Enterococcus faecalis also were relatively frequently isolated. E. coli was most frequently isolated from the uncomplicated UTIs, and P. aeruginosa and E. faecalis were frequently isolated from the complicated UTIs with indwelling catheter. With respect to the relation of these results to the age of the patients, in the uncomplicated UTIs, the isolation frequency of E. coli was the highest in all age groups, accounting for 40% or higher. In the complicated UTIs without indwelling catheter, the isolation frequency of E. coli decreased with aging of the patients but still was the highest in all age groups. In the complicated UTIs with indwelling catheter, the isolation frequency of E. coli was lower than in the uncomplicated UTIs in all age groups and P. aeruginosa and E. faecalis were more frequently isolated. In comparison of causative bacteria in UTIs between before and after the administration of antibiotics, P. aeruginosa increased after the administration in any types of UTIs. In comparison of causative bacteria in UTIs with or without surgery, E. coli was more frequently isolated in the patients without surgery, while P. aeruginosa and E. faecalis were more frequently isolated in the patients with surgery in any UTIs.