136ｾ46ﾑ8096ﾒ26ﾑ8090806ｦﾐ ﾌ6ｾ4 2007 6ﾒ20308apple08apple086ｧ9090409 020ｷ307 09 03 09fi07020ｷ307 ﾒ0607 6ｦ007080ｸ7 0400 ﾞ04030007006ｧ90ｹ0 0000 0900030608000306026ｧ8 ﾞ030209030608apple07030006 01 030703 00apple080ｹ0 090903060607090ｹ0*, 6ﾑ8apple6ｧ902080ｸ703080ｹ0 ﾒ 03090909026ｧ80ｹ0 09 03080308096ｧ9 0ｹ0, ｦﾐ 020306026ｧ8 6ｾ40408036ｧ8 09 0700apple06040209006ｧ9080ｸ7 ｦﾐ0ｷ3 07076ｧ9070ｷ307 090603020607 090ｹ0 09 0204070902 0ｹ0, 6ﾑ8apple6ｧ902080ｸ703080ｹ0 ﾒ 03090909026ｧ80ｹ0 ﾞ090900060804000603080ｸ7030906026ｧ80ｹ0, ｦﾐ 020306026ｧ8 6ｾ40408036ｧ8 09 0700apple06040209006ｧ9080ｸ7 ｦﾐ0ｷ3 07076ｧ9070ｷ307 22 0900 020807 fi0308 apple00030608000306026ｧ8 030209030608apple07030006 6ｧ8 apple00030608000306026ｧ8 0302090306 026ｧ8 07fi04080ｹ0 (09 ﾞ03) 07 080003fi00 040200 04020907 0309030804020309030ｷ30206026ｧ80ｹ0 06020608-0308096ｧ9 0ｹ0 ｮ apple080803 020206026ｧ8 ｯ 07fi0408 020ｷ307 03020903060607 020ｷ307 0207020ｷ3 0702030ｷ307 02 06 02090ｹ0 0208060306 026ｧ80ｹ0 0803026ｧ80ｹ0. ﾌ 000202060006-000007080ｹ0 00apple06apple0803 0400fi0ｹ0 02090ｹ0 07fi04080ｸ7 0001 03020702 06 applefi 0900080903 080602086ｦ00ｹ0 apple 030709080702000ｹ0 020ｷ307 0ｸ7applefi 000003 閨0209 apple0309030ｸ704000607, 02 03060ｹ0 02 06 applefi 02060ｹ0 000003fi 080ｸ70ｹ0 02090ｹ0 060709070ｷ304090ｹ0. 縺06 apple 0307 00060900, 08 00apple06apple0803 0400fi0ｹ0 02090ｹ0 09 ﾞ03 006ｧ907 06 06apple03070406080ｹ0 0402080ｸ70ｹ0 ﾞ08030602 0706026ｧ80ｹ0 02 02 090ｷ3096ｧ80ｹ0 ﾞ00000306-02 07086ｦ00ｹ0 0400 046ｦ0090203060409 0000 02080ｸ70ｹ0 0009 0604apple 07fi080ｷ307080ｸ70ｹ0 03000ｸ702086ｦ00ｹ0, 09000908-07fi0ｹ0 apple080ｸ7 00apple0803006ｧ9 07 000109090903006ｧ9 0000-030602060ｹ0 applefi 020907 000009 036ｦ002000309 00apple6ｧ9- apple020ｷ30409 apple 03 09fi07020ｷ307 020607 6ｦ007080ｸ7 02 03 06 09090006 026ｧ80ｹ0 07fi04080ｸ7 ( ﾒ ﾞ03), fiapple0ｷ30ｹ0 08 04 0204 0306 090ｹ0 06 6 56ｧ802090ｹ0, 09 0ｸ7apple 閨0302 0409 02 06 09 apple 040ｸ704 03026ｧ9. [1] 縺0007060207, 09 040ｸ70407fi020902 02090ｹ0 07fi04080ｸ7 006ｧ907 06 000009 036ｦ002000309 0402080ｸ70ｹ0 0707 03000ｹ0 02 06 0ｸ70107070002 06 0000 020907 090306026ｧ9. [1] ﾇ 09 ﾞ03 03000ｷ303006ｧ902 06 0ｷ30ｹ0 0002 6ｧ8030ｷ30409 02090ｹ0 040ｸ704020900 0206026ｧ80ｹ0 0309030804020309-030ｸ7070206026ｧ80ｹ0 07fi04080ｸ7 apple080ｸ7 閨040006 0001000306-6ﾑ809020008 0308 09090006 026ｧ8 07fi04080ｹ0 0403006ｧ9 040209 060703020006 030200020607 0403fi- 070ｷ307. ﾌ 04080ｸ703086 503 0406fi0706080ｹ0 006ｧ9-0202090ｹ0 ( ﾞ08ｦﾐ, ankle-brachial index) 閨040006 0106080308090903006ｧ9 0ｷ30ｹ0 06 06 6ｧ9020003 000ｸ7 6ｧ90403090209 02 06 0006 06026ｧ8 00 閨0308 080ｹ0 0906 0209 060709070ｷ30409 02090ｹ0 09 ﾞ03 02 06 0300-0ｷ303006ｧ902 06 006ｧ90202090ｹ0 0900070602000ｸ700 閨07090ｹ0 0309030ｷ30007020ｷ304090ｹ0. [2] 0903fi0408 02 00-0800 閨07 applefi 020907 00apple06 0900060803080906026ｧ8 02 02 0903 086ｧ8 REACH 00apple06040900 6ｧ9-07080ｸ707 fi0206 apple0003060404fi0200030806 applefi 0208 60% 020ｷ307 040300070607 0000 09 ﾞ03 006ｧ904 07 020306070602 閨0ｹ0 0007 006ｧ90100060ｹ0 04020008 0706 6ｧ9 0ｹ0 6ｧ8 0009020008 0308 09090006 026ｧ80ｹ0 07fi04080ｸ7[3] (6ｾ4046ｧ8-00 1). 6ｾ40900 07020602fi0ｹ0 03060300fi0ｹ0 020ｷ307 040300070607 0000 09 ﾞ03 apple 03 00 閨07080ｸ707 060709070ｷ304020806 [4], 000706 040900 07020602fi apple0804080402fi 040300070607 0000 020002000903060ｷ3-00 閨0709 09 ﾞ03 0007 03 006 507070006 02 020703-03090309 030003 apple000ｸ70206026ｧ8 090ｷ3096ｧ8 0000 apple - 030709080702000ｹ0 apple080ｸ7 0000060607080ｸ707 020807 026ｧ907-0ｸ70708 00000807070604090ｹ0 02 03 06 09090006 020607 040ｸ7006 5 0007020ｷ307 [5, 6]. 1. 020ｸ70406026ｧ8 06040208036ｧ9 040300070607 0000 09 ﾞ03 (6ｾ4046ｧ800 2) 6ｾ4020907 apple0300060807fi02090207 02080ｸ70ｹ0 0806 040300-07006ｧ90ｹ0 0000 09 ﾞ03 006ｧ907 06 040ｸ700apple020ｷ300 0206-02086ｧ9. 090003 閨02000ｹ0 陦000601 07 fi0206 0402060ｹ0 apple0003060404fi020003000ｹ0 apple000306apple02060400060ｹ0 6ｾ4020008 0706 6ｧ9 07fi04080ｹ0 040300070607 0000 06 03006ｧ9apple080ｸ704 040ｷ303fi020902 09 apple08-03006ｧ9 006ｧ907 06 0402-0300036ｧ8 02 06 00fi0708 閨07 00060203fi apple08-04080402fi 000008 076ｧ9- ｨB0006 00apple06 006ｧ9070ｷ30409 02090ｹ0 040ｸ700apple020ｷ300-02080308096ｧ9 0ｹ0 020ｷ307 0207020ｷ3 0702030ｷ307 [5, 6]. 0903fi02000602 06 0906 0006 0001000306020206026ｧ8 06 0602 046ｧ9 apple080ｸ7 0900030608000306026ｧ8 030209030608apple07030006 6ｾ4046ｧ800 1. 6ｾ40ｸ7076ｦ0apple 030109 020ｷ307 0002 09030604000ｷ307 02090ｹ0 03090308-020309030ｷ30206026ｧ80ｹ0 060206080308096ｧ9 0ｹ0 02 03 06 09090006 026ｧ80ｹ0 07fi04080ｸ7[3]. 00apple066 50703030006 020907 apple 03 閨006 5 0409 apple030607 applefi 020907 0000080707060409 040ｸ7-00apple020ｷ30007020ｷ307 02 06 040900006ｧ90ｷ307 02036ｧ90406-00090ｹ0 060404 06006ｧ9 0ｹ0 02080ｸ7 0402 閨03080ｸ70ｹ0. 2. ﾇ 09 ﾞ03 0ｷ30ｹ0 060408 6ｦ007 0008 04020008 0706 6ｧ9080ｸ7 020607 6ｦ007080ｸ7 ﾇ apple0603 07fi020902 0002 6ｧ8030ｷ304090ｹ0 0309-030804020309030ｷ30206020607 00apple06apple0308020607 006ｧ907 06 0ｸ7010900 閨0709 0402080ｸ70ｹ0 04030007006ｧ90ｹ0 0000 09 ﾞ03. ﾌ 026ｧ907 0ｸ707080ｹ0 00000807070604090ｹ0 0000-0803070900 02080ｹ0 02080ｸ7 000ｸ70802 03 6ｧ9080ｸ7 006ｧ9-07 06 02000203 apple03070406080ｹ0, 000706 08 026ｧ907 0ｸ7-07080ｹ0 09090006 02086ｦ0 0009020008 030602086ｦ0 00apple0006-0408 6ｧ9080ｸ7 2-3 080803 閨0ｹ0 000009 036ｦ0020003080ｹ0 0400 046ｦ0090203060409 0000 07020800 apple080ｸ7 0007 閨04080ｸ707 apple00030608000306026ｧ8 030209030608apple07-030006. ﾌ06 04030007006ｧ90ｹ0 0000 09 ﾞ03 06-0203 閨04080ｸ707 2-4 080803 閨0ｹ0 000009 036ｦ002000308 026ｧ907 0ｸ70708 040ｸ707080306026ｧ80ｹ0 030709040600fi020902 0ｹ0 02 06 3-6 080803 閨0ｹ0 apple0608 0ｸ7010900 閨0708 026ｧ907-0ｸ70708 03070902fi020902 0ｹ0 0001 06026ｧ9 0ｹ0 02 03-06 09090006 020607 040ｸ7006 5 0007020ｷ307 0400 046ｦ0-090203060409 0000 04030007006ｧ90ｹ0 apple080ｸ7 0007 閨04080ｸ707 09 ﾞ03 [1, 2, 9]. ﾌ 026ｧ907 0ｸ707080ｹ0 00006ｧ9ｨB0807080ｹ0 02 03 06 09090006-02086ｦ0 040ｸ7006 50700 02080ｹ0 006ｧ907 06 0700010703-020902080ｹ0 applefi 020907 apple 03080ｸ7046ｧ9 6ｧ8 fi0406 040ｸ700apple020ｷ30007020ｷ307 06 03006ｧ9apple080ｸ704 0ｹ0 040ｷ3-03fi020902 0ｹ0 02 06 006ｧ907 06 0ｸ7010900 閨07080ｹ0 02fi0009 02 06 0402060ｹ0 apple000306apple02060400060ｹ0 040300070607 040ｷ3036ｧ90ｹ0 040ｸ700apple020600 02 apple080ｸ7 06 09060907060402080702 06 0000 6 5070409 0209 00-0203090409 02080ｸ7 ﾞ08ｦﾐ. ﾒ 0207 040ｸ707 鐶pple0006, 0806 04030007006ｧ90ｹ0 0000 09 ﾞ03 apple03 鐶pple0006 07 0702060000020ｷ3apple6ｧ9ｨB080702 06 0ｷ30ｹ0 04030007006ｧ90ｹ0 02090ｹ0 000ｸ702000308090007086ｦ00ｹ0 apple03fi03096 7090ｹ0, fiapple0ｷ30ｹ0 02 06 0806 04030007006ｧ90ｹ0 0000 0200020009-03060ｷ300 閨0709 04020008 0706 6ｧ9 07fi0408 [10]. 3. 050003 apple000ｸ70206026ｧ8 apple030804 閨0909060409 040300070607 0000 09 ﾞ03 6ﾑ80202fi0ｹ0 applefi 02060ｹ0 apple000306apple02060400060ｹ0 020ｷ307 040300070607 apple080ｸ7 apple03 鐶pple0006 07 0702060000-020ｷ3apple060403086ｦ007 00apple000609fi07020ｷ30ｹ0 applefi 020807 090900060804000603080ｸ70309fi, 08 06 0203fi0ｹ0 02090ｹ0 apple030ｷ30208090007086ｦ00ｹ0 08030807026ｧ9 0ｹ0 0808006ｧ9030006 07 apple 03 apple 閨00apple0006 04020807 0006 0602fi 09-0900060804000603080ｸ70309fi 02070300 apple00036ｧ9apple020ｷ30409 04030007086ｦ00ｹ0 0000 00000008076ｧ8 020ｷ307 040ｸ7-00apple020ｷ30007020ｷ307 apple 0307 020907 02 02070303090309 030003 apple006ｧ9, 040300070607 apple080ｸ7 000008 076ｧ9-
136ｾ408 縺0106 ﾌ036ﾑ86ｾ4 ﾌ04 ﾇ 罔ﾐ6ﾑ86ｾ4 ｨB080ｸ707 00006ｧ90ｷ30409 6ｧ8 apple080ｸ7046ｧ9 04086ｦ001000ｷ307 0402060ｹ0 00090306 6ｧ9000ｹ0 030209036ｧ9000ｹ0, 02 03060ｹ0 02 06 fi03080ｸ70ｹ0 02080ｸ70ｹ0 04030007006ｧ90ｹ0 0000 04 02-04 0306 09 06 6 56ｧ80209 [11] (096ｧ907 02 0ｹ0 1). ﾇ 00apple0603000206026ｧ8 apple 03 閨006 5 0409 0000 020308apple08apple086ｧ9090409 020ｷ307 apple 03 09fi07020ｷ307 02 03-06 09090006 02086ｦ0 020607 6ｦ007080ｸ7 apple080ｸ7 020002-000903060ｷ300 閨07 0ｸ7010707080ｸ707 020807 026ｧ907 0ｸ7-0708 09 ﾞ03 006ｧ907 06 00apple066 5006 5030900 閨0709 02 06 9] 0007 00apple06 閨040002 06 04030807080203066 56ｧ80ｹ0[2, (6ｾ4046ｧ800 3). 3.1. 0406 0208apple6ｧ8 02080ｸ7 02 apple076ｧ90400 02080ｹ0 6ﾒ208 0207apple07060400 06apple03 040607ｨB0006 020807 026ｧ907-0ｸ70708 00000807070604090ｹ0 09 ﾞ03, 000706 09 00apple06-0008076ｧ8 020ｷ307 040300070607 0400 0ｸ7026ｧ8 020907 00apple06ｨB6ｧ80006 040ｸ7076ｧ8030006 0ｸ7apple0003020306apple03-040607ｨB0006 0208 026ｧ907 0ｸ70708 00apple06 006ｧ9070ｷ304090ｹ0 02090ｹ0 6ｧ8 09 0ｸ7apple070304080ｸ704 0ｹ0 030209030608apple07030006 0ｹ0[13] 0ｸ7010707080702 0ｹ0 020807 026ｧ907-0ｸ70708 0002 6ｧ8030ｷ304090ｹ0 0203060206026ｧ80ｹ0 060404 06-006ｧ9 0ｹ0 02080ｸ7 0402 閨03080ｸ70ｹ0 6ｧ8/02 06 02030ｷ30209-0306 0400086ｦ0. 6ｾ400 0006 000003 閨0209 apple 03 026ｧ8-030904090ｹ0 6 503 閨03090200 0006 080408-0001 03-020600000709 040ｸ70404 閨02060409 02080ｸ7 02 apple076ｧ9-0400 02080ｹ0 02 06 020ｷ307 02030ｷ302090306 04000607 0400 04030007006ｧ90ｹ0 0000 09 ﾞ03 [14]. ﾞ07026ｧ9030002, 09 06 0208apple6ｧ8 02080ｸ7 02 apple076ｧ90400 02080ｹ0 0ｸ7-0107070006 020907 00apple066 56ｧ90ｷ30409 [15]. 縺06 0209 06 0208apple6ｧ8 02080ｸ7 02 apple076ｧ90400-02080ｹ0 040ｸ7070604020702 06 09 040ｸ70000000208046ｧ8 020ｷ307 040300070607 0400 040ｸ7006 5080ｸ703000ｸ702060207 apple03080903070000 02 6 5086ｧ8030006 0ｹ0 6ｧ8/02 06 04036ｧ80409 08 0300 02000ｸ70206020607 apple 03 09fi- 07020ｷ307, fiapple0ｷ30ｹ0 0208 6 5080ｸ7apple03fiapple0608, 02 0ｸ7apple0802 02070402 02 07060208026ｧ907090ｹ0, 02 03060ｹ0 02 06 0700fi020003 08070300 02 fiapple0ｷ30ｹ0 09 6 5 0300070602036ｧ90709 [16]. 3.2. 090402090409 ﾞapplefi 02 0009 08 0300 02000ｸ702060207 00 閨0203, 09 6ｦ001090409 02090ｹ0 040ｷ300 0206026ｧ80ｹ0 03-0402090306fi020902 0ｹ0 閨040006 apple08 00060403006ｧ9 fi0206 6 50003020606070006 0209 040ｸ700apple020ｷ300 02080308096ｧ9 020ｷ307 040300070607, apple0603 07fi07 06 00 閨04080ｸ7 09030ｷ302080900076ｧ80ｹ0 08030807026ｧ9 - ｮ ﾞ 0ｸ707 006ｧ9 ｯ 060709070ｷ304090ｹ0-040ｸ70404 閨030006 04020907 apple 03 020803086ｦ003090409-6ﾑ8000008076ｧ8 040ｸ700apple020ｷ30007020ｷ307 apple 0307 0209 030003 apple006ｧ9-09006ｧ90ｷ30409 6ｧ8 apple080ｸ7046ｧ9 04086ｦ001000ｷ307 0402060ｹ0 00090306 6ｧ9000ｹ0 030209036ｧ9000ｹ0-6ｾ4 0204 0306 090ｹ0 06 6 56ｧ802090ｹ0 6ﾑ8apple006ｧ909080ｸ704 : - ﾒ036ｧ904060009 060404 06006ｧ9 / 09fi07080ｹ0 04020907 0707apple 0ｸ70409-030302080ｹ0 6ｧ8 縺07090903 0607-08apple086 76ｧ9 ﾞ ﾒ ﾞ / 6ﾒ2ｦﾐ ﾞ / Amaurosis Fugax 096ｧ907 02 0ｹ0 1. ﾞ0707090209 ﾞ090900060804000603080ｸ7030906026ｧ80ｹ0 6ﾑ802026ｧ9000904090ｹ0 ﾞ040300070607 0000 0900030608000306026ｧ8 ﾞ030209030608apple07030006 [2,9]. 02090ｹ0 6 50003026ｧ90ｷ304090ｹ0 02090ｹ0 03000602080ｸ703090602fi- 020902 0ｹ0 02080ｸ7 0007 080309036ｧ9080ｸ7, 02090ｹ0 00006ｧ90ｷ3-04090ｹ0 02090ｹ0 0803000900080706 080ｸ70ｹ0 06000309-046ｧ9 0ｹ0, 02090ｹ0 000ｸ707080ｸ8026ｧ80ｹ0 00apple6ｧ9 03 04090ｹ0 040208 000002 6 50803060400fi 020ｷ307 000ｸ70607 02 06 0402080ｸ70ｹ0 060008030300080308090602086ｦ00ｹ0 apple 0307-09080702000ｹ0[17]. 6ｾ402060ｹ0 046ｦ00904030807000ｹ0 040ｸ7040207-0400060ｹ0 07020600000206apple0604090ｹ0 020ｷ307 040300070607 0000 09 ﾞ03 09 070402090409 apple08020003006ｧ9 apple030ｷ3-02 03040602fi 00 閨020308 apple 03 閨006 5 04090ｹ0[2, 9]. 6ｾ402060ｹ0 02 02000ｸ7030ｸ707026ｧ80306000ｹ0 08 09096ｧ9000ｹ0 040ｸ7-04026ｧ8070002 06 006ｧ90200 閨07 apple03fi0903 0000 0704020904090ｹ0 0ｸ7applefi 00apple6ｧ96 503006 709 0003070406-0402090ｹ0 060703020006 0ｹ0 30-45 min, 02080ｸ7-0307040604020807 3 080803 閨0ｹ0 020907 006 5 080007 0906 apple0003060404fi020003000ｹ0 applefi 12 006 5 08-0007 000ｹ0 006ｧ90200 0208000602fi apple03fi0903 0000 0704020904090ｹ0 (6 507 060400 ) 040ｷ3036ｧ90ｹ0 00apple6ｧ9-6 503006 709 02080ｸ70307040604020807 3 080803 閨0ｹ0 020907 006 5 080007. 6ｾ400 0006 020ｸ704 0608apple08060900 閨0709 000003 閨0209 04020907 08apple086ｧ9 040ｸ700000002006ｧ904 07 882 0707-03000ｹ0 04030007006ｧ90ｹ0 0000 040ｸ700apple020ｷ300 0206-026ｧ8 09 ﾞ03, 00 閨04090ｹ0 090306026ｧ9 0ｹ0 73 00020607, 0008 0300fi0402090200 006ｧ90200 閨07 08000900 閨0708 apple03fi0903 0000 06 0208apple6ｧ80ｹ0 02080ｸ7 02 apple076ｧ9-0400 02080ｹ0 0400 040ｸ707 0ｸ7 0400fi 0000 020907 6ｦ001090409 040ｷ300 0206026ｧ80ｹ0 03 0402090306fi- 020902 0ｹ0 (080007 apple 03 閨006 5 04090ｹ0, n=441) 006ｧ90200 0806 04030007006ｧ90ｹ0 08 閨0309-02 07 04020907 02 030600030ｷ300 閨0709 08030807026ｧ9 02080ｸ7 080602080900070006 02086ｦ0 0906 0203086ｦ0 (080007-0003 閨0904080ｸ7, n=441). 6ｾ46ｦ000080ｷ307 0000 02 apple08020003 閨0400 02 02090ｹ0 000003-02090ｹ0, 04020907 080007 02090ｹ0 apple 03 閨006 5-04090ｹ0 apple 03 0209036ｧ8030902 07 000009 036ｦ00200-03 apple080408040207 6 50003026ｧ90ｷ304090ｹ0 02090ｹ0 00 閨0906-0402090ｹ0 06 070ｸ7fi000007090ｹ0 applefi0402 04090ｹ0 (maximum walking distance, apple08-04080402fi 6 50003026ｧ90ｷ304090ｹ0 0400 046ｦ0090203060409 0000 020907 080007 0003 閨0904080ｸ7 (23% vs 15%; P=0.008). ﾞ0ｸ702fi apple08 fi0309-0200 020ｸ7036ｧ90ｷ30ｹ0 04020907 6ｦ001090409 02090ｹ0 040ｷ3-00 0206026ｧ80ｹ0 03 0402090306fi020902 0ｹ0 [34% 020ｷ307 040300070607 04020907 080007 02090ｹ0 apple 03 閨006 5 04090ｹ0 apple0003apple 02086ｦ004 07 apple00-03060404fi020003000ｹ0 applefi 3 080803 閨0ｹ0 020907 006 5-080007 vs 25% 04020907 080007 0003-0904080ｸ7 (P=0.01)]. ﾞ016ｧ9ｨB0006 07 04090000060ｷ303006ｧ9 fi0206 04020907 080007-02090ｹ0 apple 03 閨006 5-04090ｹ0 12% 020ｷ307 02 - apple070604020607 02 02fi03030ｷ30400 07 06 02fi- 6 70006 0208 0207apple07060400 閨07 070206 8% 04020907 080007 0003 閨0904080ｸ7 (P=0.43) 3.3. ﾞ070206 060008apple0002 0306 026ｧ8 090ｷ3096ｧ8 0900090703080ｹ0 03060300fi0ｹ0 00000300020607 陦0006-0100 fi0206 09 0408036ｧ809090409 070206 060008apple0002-0306 026ｧ80ｹ0 090ｷ3096ｧ80ｹ0 (020ｸ7apple060207 0000 04apple06-036ｧ90709) 00000606070006 0209 030709040600fi020902 02 06 02 02 03 06 09090006 0207 040ｸ7006 50700 02 0400 0ｸ76 70903086ｦ0 020607 6ｦ007080ｸ7 04030007006ｧ90ｹ0 0000 09 ﾞ03. 6ｾ400 0006 000002-0707030ｸ70409 42 020ｸ704 0608apple08060900 閨070ｷ307 00000300020607, apple080ｸ7 040ｸ700apple000306 閨03 6 5 07 040ｸ7070803060207 9700 04030007006ｧ90ｹ0 0000 040ｸ700apple020ｷ300 0206026ｧ8 09 ﾞ03, 09 0408036ｧ809090409 070206 060008apple0002 0306 026ｧ80ｹ0 090ｷ3096ｧ80ｹ0 040ｸ7040400026ｧ9ｨB080702 07 0000 00006ｧ90ｷ3-0409 02 0207 23% 02080ｸ7 020607 6ｦ007080ｸ7 0000-6ｧ8 02 03 06 09090006 026ｧ80ｹ0 030709040600fi020902 0ｹ0 0400 046ｦ0090203060409 0000 0209 036ｧ86 709 000602080706-02086ｦ0 08 03000702080ｸ7[19]. 6ｾ40209 000003 閨0209 CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events), 000002 016ｦ0 020ｷ307 19185 040300070607 040ｸ700apple000306036ｧ8080309-02 07 02 06 6400 04030007006ｧ90ｹ0 0000 09 ﾞ03, 0806 08apple086ｧ90806 020ｸ704 0608apple08066ｧ8030902 07 006ｧ90200 0400 04apple06036ｧ90709 (325 mg/0900 閨03 ) 006ｧ90200 0400 020308apple06 080903 閨0309 ( 0702 090ｷ3070604026ｧ8 020ｷ307 0ｸ7apple08 0804 閨0ｷ307 02090ｹ0 06080804080ｷ30306026ｧ80ｹ0 000708046ｧ907090ｹ0, 75 mg/0900 閨03 ). ﾇ post-hoc 0707030ｸ70409 020ｷ307 040300070607 0000 09 ﾞ03 陦00060100 fi0206 0400 046ｦ0090203060409 0000 020907 04apple06036ｧ90709 0402080ｸ70ｹ0 04030007006ｧ90ｹ0 apple080ｸ7 apple6ｧ803 07 020308apple06 080903 閨0309 apple 03-0209036ｧ803090200 00006ｧ90ｷ30409 02 0207 23.8% 02080ｸ7 040400020602086ｦ0 020607 6ｦ007080ｸ7 000008070706-04090ｹ0 00000803070900 02080ｹ0 02080ｸ7 000ｸ70802 03 6ｧ9-080ｸ7, 060404 06000602086ｦ0 09090006 02086ｦ0 00090200-08 030602086ｦ0 00apple00060408 6ｧ9080ｸ7 6ｧ8 03 07 020908fi- 030ｷ307 040ｸ7006 5 0007020ｷ307 09090006 026ｧ80ｹ0 06-0206080308096ｧ9 0ｹ0 (P=0.0028). ﾇ 040ｸ7090408-036ｧ809090409 04apple06036ｧ907090ｹ0 0000 020308apple06 08-0903 閨0309 0400 09090006 02086ｦ00ｹ0 04030007006ｧ90ｹ0 0000 apple080303 apple03086ｦ00ｹ0 apple 030709080702000ｹ0 020607-6ｦ007080ｸ7 0007 6 503 閨03090200 fi0206 0ｸ7apple0003 閨040006 040209 00006ｧ90ｷ30409 020ｷ307 040ｸ7006 5 0007020ｷ307, 000706 0ｸ70107070006 0208 apple0804080402fi 020ｷ307 06-00080303 0906020607 00apple06apple0308020607 [21]. ﾇ 0408-036ｧ809090409 070206 060008apple0002 0306 020607 0400 04030007006ｧ90ｹ0 0000 09 ﾞ03 閨040006 000ｸ707080ｸ8026ｧ8 00apple6ｧ9 03 0409 040209 6 5 02fi020902 020ｷ307 09-090006 020607 00080404000ｸ70007020ｷ307, 020ｷ307 0007-09090006 020607 apple030803 閨04000ｷ307 02 06 02090ｹ0 0909000608apple03 040206026ｧ80ｹ0[22]. 6ｾ402080ｸ70ｹ0 04030007006ｧ90ｹ0 0000 09 ﾞ03 apple030802006ｧ9-070002 06 09 0408036ｧ809090409 04apple06036ｧ907090ｹ0 75 mg-325 mg/0900 閨03 6ｧ8 0007 0303 020206-0207 020308apple06 080903 閨03090ｹ0 75 mg/0900 閨03. ﾇ 00apple060308096ｧ8 02080ｸ7 08 03000702080ｸ7 apple03 鐶pple0006 07 096ｧ9070002 06 0001 0208000602000ｸ700 閨07 0000 6 5070409 040ｸ700apple 030800 0302086ｦ004000ｹ0 02 02-23
13046ﾑ8 ﾒ6ﾑ8090806ｦﾐ ﾌ6ｾ4 2007 06 03006ｧ9apple080ｸ704 0ｹ0 040ｷ303fi020902 0ｹ0 02 0207 0ｸ7fi00060406 080803 閨0ｹ0 apple0003060404fi02000308 0402080ｸ70ｹ0 0707 03000ｹ0 02 06 02 0207 4 080803 閨0ｹ0 apple0003060404fi02000308 0402060ｹ0 090ｸ707 6ｧ902000ｹ0 0400 046ｦ0090203060409 0000 02080ｸ70ｹ0 070803000802 0406-02086ｦ00ｹ0 04030007006ｧ90ｹ0[30]. 0300fi020003 00apple06-09000608030809060207 00 0800 閨07 00apple066 5006 5 06-0607080ｸ707 fi0206 0806 0ｸ7apple000302 040602086ｧ9 閨04080ｸ707 06apple03070406 apple0603 07fi020902 00000807070604090ｹ0 09 ﾞ03 [12]. 6ｾ4046ｧ800 2. 020ｸ70406026ｧ8 06040208036ｧ9 02090ｹ0 apple00030608000306026ｧ80ｹ0 0302090306 026ｧ80ｹ0 07fi04080ｸ7[2,9]. 0402070400060ｹ0, 020907 0708046ｧ8 02080ｸ7 040300-07086ｦ00ｹ0 02 06 0208 02fi0402080ｹ0[2, 9]. 3.4. 08apple080306apple06 060006026ｧ8 090ｷ3096ｧ8 6ﾑ8apple06 090006080308090602 閨0ｹ0 000003 閨02000ｹ0 陦000601 07 fi0206 0ｸ7apple0703040006 03000206026ｧ8 040ｸ70404 閨02060409 0000-02 016ｦ0 02080ｸ7 020607 6ｦ007080ｸ7 09 ﾞ03 02 06 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 080306026ｧ80ｹ0, 02090ｹ0 LDL- 0408030904020003fi03090ｹ0, 02 06 020ｷ307 02030609030ｸ70200-0306 6ｧ90ｷ307 02 06 0307090206026ｧ8 000002 016ｦ0 09 ﾞ03 02 06 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 HDL-04080309-04020003fi03090ｹ0. 0903070900 0206 0906 02070300 6ｦ0-01090409 02090ｹ0 080306026ｧ80ｹ0 0408030904020003fi03090ｹ0 02 0207 10 mg/dl 08 026ｧ907 0ｸ707080ｹ0 00000807-070604090ｹ0 09 ﾞ03 0ｸ70107070002 06 02 0207 5% - 10% [23], 000706 0906 02070300 00080707 6ｦ0-010904090ｹ0 02080ｸ7 apple09036ｧ902080ｸ7 080306026ｧ8/ HDL- 0408030904020003fi0309 08 040400020602fi0ｹ0 026ｧ907 0ｸ7-07080ｹ0 09 ﾞ03 0ｸ70107070002 06 02 0207 35% [13]. 70 09 apple030607 applefi 020907 0000080707060409 020ｷ307 0402 0206070607, 09 00006ｧ90ｷ30409 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 0408030904020003fi03090ｹ0 0000 0ｸ7apple080306apple06 06-00060207 08070300 02 6ｧ8 0000 0209 04000603080ｸ7030906-026ｧ8 00000306026ｧ8 apple 030702 006 709 02080ｸ7 00060300086ｦ0 006ｧ90400 apple08 00060403006ｧ9 fi0206 00000606070006 6ｧ8 00apple06-6 503 6ｦ0070006 020907 0001 閨03060109 020ｷ307 03090308-04020309030ｷ30206020607 6 503 6 50607 0402060ｹ0 00090306-6ｧ9000ｹ0 030209036ｧ9000ｹ0[24]. 0906 post-hoc 0707030ｸ70409 020ｷ307 apple0802000300040007020ｷ307 02090ｹ0 000003 閨02090ｹ0 4S (Simvastatin Scandinavian Survival Study) 陦00060100 fi0206 09 0408036ｧ809090409 0406006 5 0402 026ｧ907090ｹ0 0400 04020008 0706 6ｧ9080ｸ70ｹ0 04030007006ｧ90ｹ0 0000 0ｸ7apple0003-04080309040200030803 06006ｧ9 00006ｧ90ｷ30400 02 0207 38% 020907 0000080707060409 07 陦 0ｹ0 6ｧ8 020907 00apple06 006ｧ9070ｷ30409 apple030800apple070304080ｸ704 0ｹ0 06-03006ｧ9apple080ｸ704 0ｹ0 040ｷ303fi020902 0ｹ0[25]. 0400 08-00 閨07 applefi 0209 000003 閨0209 Heart Protection Study 陦000601 07 fi0206 0806 04030007006ｧ90ｹ0 0000 09 ﾞN 0ｷ3080003086ｦ00702 06 04020807 6ｧ9 0608 6 5 0300fi 0000 02080ｸ70ｹ0 040300-07006ｧ90ｹ0 apple080ｸ7 閨04080ｸ707 070303080ｸ7 006ｧ9 080ｸ70ｹ0 09-090006 026ｧ8 07fi0408 (00006ｧ90ｷ30409 02 0207 24% 020ｷ307 000006ｨBfi070ｷ307 09090006 020607 040ｸ7006 5-0007020ｷ307), 0700010703020902 applefi 02 00apple6ｧ9- apple00 020ｷ307 0306apple06 6ｧ90ｷ307 02 06 07000107030209-02 applefi 020907 apple 03080ｸ7046ｧ9 04 0204 0306-09 06 6 56ｧ80209 [26]. 6ｾ4040002060207 apple03fi0408 02000ｹ0 000003 閨02000ｹ0 閨04080ｸ707 00apple066 5006 5 0606040006 0209 040900 070206026ｧ8 03 閨0409 02090ｹ0 030003 apple006ｧ9 0ｹ0 0000 0402 026ｧ907000ｹ0 04020907 07020600000206apple060409 040300070607 0000 09 ﾞ03 02 06 0ｸ7apple000304080309040200030803 06006ｧ9 02fi0408 0906 0209 6 50003026ｧ90ｷ30409 020ｷ307 040ｸ700apple020ｷ30007-020ｷ307 [27] fi0408 02 06 0906 020907 6ｦ001090409 02090ｹ0 040ｸ707080306026ｧ80ｹ0 00apple066 56ｧ90ｷ304090ｹ0[28]. ﾞ016ｧ9ｨB0006 07 04090000060ｷ303006ｧ9 fi0206 09 030003 - apple006ｧ9 0000 0209 0408036ｧ809090409 0402 0206070607 0402080ｸ70ｹ0 04030007006ｧ90ｹ0 0000 09 ﾞ03 閨040006 000ｸ7-07080ｸ8026ｧ8 00apple6ｧ9 03 0409 0402080ｸ70ｹ0 006ｧ90202000ｹ0 02090ｹ0 080300090008076ｧ80ｹ0, 02 06 06 06 6ｧ9020003 0402060ｹ0 040ｸ7090200070203060400060ｹ0 02090ｹ0 C- 070206 0306-04 0ｹ0 apple030ｷ302000ｹ107090ｹ0 (CRP). ﾞ0ｸ7026ｧ8 09 0702060803000900080706 090ｹ0 03070409 020ｷ307 0402 0206070607 閨040006 6 5030003006ｧ9 fi0206 040ｸ7040400026ｧ9- ｨB0002 06 0000 00006ｧ90ｷ30409 02090ｹ0 040ｸ707080306026ｧ80ｹ0 030709040600fi020902 0ｹ0 02 06 020907 6ｦ001090409 02090ｹ0 0003006ｦ0030003090ｹ0 040ｸ700apple020ｷ30007020ｷ307 00apple066 56ｧ90ｷ3-04090ｹ0 0ｸ7020607 020ｷ307 040300070607 [28]. 00apple0ｷ30ｹ0 02 06 0402080ｸ70ｹ0 04030007006ｧ90ｹ0 0000 040200-08 0706 6ｧ9 07fi0408, 026ｦ00306080ｹ0 0402fi04080ｹ0 02090ｹ0 0ｸ7apple080306apple06 060006026ｧ80ｹ0 090ｷ3096ｧ80ｹ0 006ｧ907 06 09 00006ｧ90ｷ30409 020ｷ307 00apple06apple 陦0ｷ307 02090ｹ0 LDL-0408-030904020003fi03090ｹ0 0207020ｷ3 applefi 100 mg/dl 6ｧ8 02 06 0207020ｷ3 applefi 70 mg/dl 0400 04030007006ｧ90ｹ0 0000 apple08036ｦ0 0ｸ7010900 閨0708 02 03-06 09090006 02fi 026ｧ907 0ｸ70708 [29]. 3.5. 0303000904080ｹ0 02090ｹ0 0ｸ7apple 閨0302 04090ｹ0 ﾇ 040ｸ70404 閨02060409 0ｸ7apple 閨0302 04090ｹ0 02 06 09 ﾞ03 03000ｷ303006ｧ902 06 030609fi02000308 0604040ｸ7036ｧ8 0400 046ｦ0090203060409 0000 0209 040ｸ70404 閨02060409 09 ﾞ03 02 06 02 03 06 09090006 026ｧ80ｹ0 6ｧ8 04020008 0706 6ｧ9-0ｹ0 07fi04080ｸ7. 6ｾ40209 000003 閨0209 02080ｸ7 Framingham, 09 0ｸ7apple 閨0302 0409 apple08-006ｧ90403090200 fi0206 0ｸ70107070006 020807 026ｧ907 0ｸ70708 00030806 0806 0702060ｸ7apple000302 040602086ｧ9 apple 0307-09080702000ｹ0 00apple0803086ｦ007 07 04030904060008apple0806-0903086ｦ007 0402080ｸ70ｹ0 04030007006ｧ90ｹ0 0000 09 ﾞ03. 09 0307 020907 0709040ｸ7046ｧ9 04040002060207 0000 0209 0ｸ7040000076ｧ8 00apple6ｧ9 03 0409 020ｷ307 6 5- apple08-0203000604020607, 040900 07020602fi0ｹ0 03060300fi0ｹ0 00000300020607 02 06 000002-07 036ｦ004000ｷ307 閨040006 apple0802 02 04026ｧ8040006 0209 03 閨0409 02080ｸ70ｹ0 02 06 04020907 07020600000206apple060409 0ｸ7apple000302 0406020607 040300070607 0000 09 ﾞ03 [31]. 6ｾ40209 000003 閨0209 ﾇ ﾌ066ﾑ8 (Heart Outcomes Prevention Evaluation), 0208 00apple06apple03fi0403000208 fi080003080ｹ0 040209 00006ｧ90ｷ30409 020ｷ307 02 03 06 09090006 020607 040ｸ7006 5 0007-020ｷ307 applefi 0209 0408036ｧ809090409 0007fi0ｹ0 0702-090ｷ3070604026ｧ8 02080ｸ7 000002 020300apple020602086ｦ0 0007ｨB6ｦ0-00080ｸ7 02090ｹ0 0909000608020007046ｧ907090ｹ0 ( -096ﾑ8 ﾞ), 02090ｹ0 03 0006apple036ｧ903090ｹ0, 6ｧ802 07 0208 6ｧ9 0608 0409-00 07020602fi 02fi0408 0402080ｸ70ｹ0 04030007006ｧ90ｹ0 0000 09 ﾞ03 fi0408 02 06 0402080ｸ70ｹ0 04030007006ｧ90ｹ0 0000 070303000ｹ0 0002 0903060400060ｹ0 09090006 026ｧ80ｹ0 07fi- 04080ｸ7[32]. 6ｾ40209 000003 閨0209 0ｸ7026ｧ8 020ｸ704 0608apple08066ｧ8030902 07 4051 04030007006ｧ90ｹ0 0000 09 ﾞ03, 0402080ｸ70ｹ0 08apple086ｧ9080ｸ70ｹ0 09 0408036ｧ809090409 03 0006apple036ｧ903090ｹ0 00006ｧ90ｷ30400 02 0207 22% 0208 040400020602fi 026ｧ907 0ｸ70708 00000807070604090ｹ0 0000-6ｧ8 02090ｹ0 03070902fi020902 0ｹ0 applefi 02 03 06 09-090006 026ｧ8 07fi0408 [32]. ﾌ06 0402fi040806 02090ｹ0 0702060ｸ7apple000302 0406026ｧ80ｹ0 090ｷ3096ｧ80ｹ0 02 0308036ｧ9ｨB080702 06 04020907 00apple6ｧ9-02000ｸ70109 00apple06apple 陦0ｷ307 04 000903fi0200030ｷ307 applefi 140/90 mmhg 6ｧ8 04 000903fi0200-030ｷ307 applefi 130/80 mmhg 0400 040300-07006ｧ90ｹ0 0000 04 0204 0306 09 06 6 56ｧ80209 02 06 0403fi0706 0700080306026ｧ8 07fi0408 [2, 9]. ﾇ 000003-0209 ABCD (Appropriate Blood Pressure Control in Diabetics) 陦00060100 fi0206 09 0408036ｧ809090409 00apple0603000206-026ｧ80ｹ0 030003 apple006ｧ9 0ｹ0 (0000 閨07 07-096ﾑ8 ﾞ, 020907 0007 03 apple036ｧ90309, 6ｧ8 0000 閨07 07 0702-090ｷ3070604026ｧ8 020ｷ307 06 6ｦ0030ｷ307 046 50004026ｧ9080ｸ7, 020907 0706040803 06apple6ｧ90709) 0906 020907 00apple6ｧ902000ｸ70109 020ｷ307 0402fi040ｷ307 02090ｹ0 0702060ｸ7apple000302 0406-026ｧ80ｹ0 090ｷ3096ｧ80ｹ0 02 02 0309006ｧ9 020907 030709-0206026ｧ8 040ｸ70404 閨02060409 000002 016ｦ0 02080ｸ7 ﾞ08ｦﾐ 02 06 02080ｸ7 020607 6ｦ007080ｸ7 00000807070604090ｹ0 0000-6ｧ8 02090ｹ0 03070902fi020902 0ｹ0 applefi 02 03 06 09-24
136ｾ408 縺0106 ﾌ036ﾑ86ｾ4 ﾌ04 ﾇ 罔ﾐ6ﾑ86ｾ4 6ｾ40400020602fi0ｹ0 ﾒ6ｧ907 0ｸ707080ｹ0 (RR) 6ｾ4046ｧ800 3. 09 030709080702000ｹ0 020607 6ｦ007080ｸ7 0900030608000306026ｧ80ｹ0 ﾞ030209030608apple07030006 0ｹ0 ｨC 0400 0800 閨07 6ﾑ8apple06 0900060803080906-020607 09000300020607 [5]. 090006 026ｧ8 07fi0408 0402080ｸ70ｹ0 04030007006ｧ90ｹ0 0000 09 ﾞ03 [33]. 3.6. 0303000904080ｹ0 02090ｹ0 09030ｸ704 06006ｧ9 0ｹ0 0400 0800 閨07 00000300020607 apple 03 026ｧ80309-04090ｹ0 陦000601 07 fi0206 09 apple 03080ｸ7046ｧ9 04 02-04 0306 09 06 6 56ｧ80209 0ｸ70107070006 040900-0702060207 020807 026ｧ907 0ｸ70708 00000807070604090ｹ0 09 ﾞ03 06 06 6ｧ9020003 0400 09030602060ｷ300 閨07080ｸ70ｹ0 (07070ｷ3 020ｷ307 60 0403fi070ｷ307) 02 apple07060402 閨0ｹ0 0000 0ｸ7apple 閨0302 0409 02 06 0ｸ7apple000304080309040200-030803 06006ｧ9 [12, 23]. 040007 閨040006 apple08 00060403006ｧ9 0000 04 086ｧ8-070006 fi0206 09 00apple0603000206026ｧ8 07020600000206apple06-0409 02080ｸ7 04 0204 0306 09 06 6 56ｧ80209 026ｦ0- apple080ｸ7 1 02 06 026ｦ0apple080ｸ7 2 00000606070006 020807 026ｧ907 0ｸ70708 02 03 06 09090006 020607 040ｸ7006 5-0007020ｷ307 0400 04030007006ｧ90ｹ0 09 ﾞ03 [34, 35]. 030402fi0408, 0400 fi03080ｸ70ｹ0 02080ｸ70ｹ0 06 6 5090206-02086ｦ00ｹ0 04030007006ｧ90ｹ0 040ｸ7070604020702 06 09 06-026ｧ803090409 02090ｹ0 09030ｸ70208ｨB0ｸ703060ｷ300 閨07090ｹ0 0600080408 06036ｧ907090ｹ0 (HbA1C) 0400 00apple6ｧ9- apple00 00060203fi020003 applefi 7%, 02 03060ｹ0 02 06 09 04040803 040206026ｧ8 08030807026ｧ9 020ｷ307 0702030ｷ307 apple08 060607 0906 0209 00006ｧ90ｷ30409 02080ｸ7 020607 6ｦ007080ｸ7 00000807070604090ｹ0 0003020607, 0907090903 0607 0ｹ0 02 06 02090ｹ0 07 0902 06fi020902 0ｹ0 02030ｷ3-02090306 0400086ｦ0 [2, 9]. 3.7. 090303 030003 apple000ｸ7-02060207 00 閨0203 6ｾ400 fi03080ｸ70ｹ0 02080ｸ70ｹ0 0ｸ7apple 閨03-6 5 03080ｸ70ｹ0 6ｧ8 apple 046ｦ004 03-02080ｸ70ｹ0 04030007006ｧ90ｹ0 0000 09 ﾞ03 6ｧ907080702 06 040ｸ7006 5080ｸ703 閨0ｹ0 0906 020807 閨0300090408 02080ｸ7 040ｷ300 020602086ｦ0 6 50703080ｸ70ｹ0. ﾞ070206apple09020206026ｧ8 090ｷ3096ｧ8 applefi 02080ｸ7 0402fi00 02080ｹ0 040ｸ7-070604020702 06 00fi0708 0402060ｹ0 apple00-0306apple02060400060ｹ0 040300070607 0000 020803apple06026ｧ8 00 0300 030ｸ7096ｧ8, 6 5 036 506 08apple07030006, 0007 020ｷ3 6 507030006 0803006 5080303fi006 50ｷ30409, 02-03060ｹ0 02 06 0400 04030007006ｧ90ｹ0 0ｸ76 70903086ｦ0 020607-6ｦ007080ｸ7 applefi0803 01090ｹ0 020ｷ307 0302090306-020607 00080404000ｸ70007020ｷ307. 040007 0ｸ7apple070304080ｸ707 apple030808apple020602 閨0ｹ0, 020ｸ7-04 0608apple08060900 閨07000ｹ0 000003 閨02090ｹ0 0002026ｧ90009-04090ｹ0 02080ｸ7 0808 閨03080ｸ70ｹ0 0408036ｧ8090904090ｹ0 6 506-02 0006070607, fiapple0ｷ30ｹ0 0208 080ｸ703030602fi 08016ｦ0 02 06 09 6 50602 006ｧ90709 0812 apple080ｸ7 0000060607080ｸ707 02 00apple6ｧ9apple00 02090ｹ0 080008020ｸ70402000ｹ107090ｹ0 04020807 0803fi, 0400 04030007006ｧ90ｹ0 0000 09 ﾞ03. 6ｾ400 0006 0007 06 08 閨03080ｸ704 000003 閨0209 0000 020907 08070800 046ｧ9 Health Professionals Follow-up Study, 040ｸ700000002006ｧ9-04 07 46036 0707 03000ｹ0 040ｷ3036ｧ90ｹ0 09 ﾞ03, 02 03 06 09090006 026ｧ8 07fi0408 6ｧ8 04 0204 0306-09 06 6 56ｧ80209 02 06 apple 03 020803080ｸ7036ｧ80309-02 07 0906 12 0403fi0706 040209 060703020006 020ｷ307 08apple086ｧ90ｷ307 02 02 090307080902 07 308 apple000306apple02060400060ｹ0 09 ﾞ03. 6ｾ40209 000003 閨0209 0ｸ7026ｧ8 06 apple0604020603090200 0006 07026ｧ9-040203080809 040ｸ70404 閨02060409 000002 016ｦ0 02090ｹ0 02 030900000306076ｧ80ｹ0 apple03fi0403096 7090ｹ0 080ｸ7030306-02086ｦ0 0801 閨080ｹ0 (400 mg/0900 閨03 ) 02 06 02080ｸ7 020607 6ｦ007080ｸ7 00000807070604090ｹ0 09 ﾞ03 (00006ｧ90ｷ30409 02 0207 21%) [36]. 4. 09006ｧ90ｷ30409 02080ｸ7 02 03 06 09090006 02086ｦ0 020607 6ｦ007080ｸ7 0400 04030007006ｧ90ｹ0 0000 09 ﾞ03: 0002026ｧ900090409 02080ｸ7 040ｸ70708030602086ｦ0 020607 6ｦ007080ｸ7 02 06 00apple0603000206026ｧ8 0008 030008096ｧ8 030003 apple000ｸ70206020607 00 閨02030ｷ307 0906 apple08020003000400 0206026ｧ8 040203 02090906026ｧ8 04020907 07020600000206apple060409 040300070607 0000 09 ﾞ03 00apple066 50703030006 020907 閨0902 060309 0607-09070ｷ30409, 020907 0002026ｧ900090409 02080ｸ7 040ｸ707080306-02086ｦ0 020607 6ｦ007080ｸ7 02 06 020907 00apple0603000206026ｧ8 apple 03 閨006 5 0409 0906 020907 020308apple08apple086ｧ909-0409 020ｷ307 apple 03 09fi07020ｷ307 020607 6ｦ007080ｸ7[2, 9]. 08apple070304080ｸ707 0007 006ｧ90100060ｹ0 fi0206 09 00apple060300-0206026ｧ8 020308apple08apple086ｧ9090409 020ｷ307 apple 03 09fi- 07020ｷ307 020607 6ｦ007080ｸ7 0400 04030007006ｧ90ｹ0 0000 09 ﾞ03 apple030803 006 507070006 020907 0000080707060409 00000803070900 02080ｹ0, 09090006 02086ｦ0 00090200-08 030602086ｦ0 00apple00060408 6ｧ9080ｸ7 02 06 00000606070006 020807 026ｧ907 0ｸ70708 03 07 020908fi030ｷ307 040ｸ700-6 5 0007020ｷ307. 6ｾ400 0006 apple03fi0408 0209 0000-03 閨0209 2420 040300070607 0000 09 ﾞ03, 060703020006 0ｹ0 8 00020607, 6 503 閨03090200 fi0206 09 030003 apple006ｧ9 0000 04apple06036ｧ90709, 0402 026ｧ907000ｹ0, 6 5- apple08020300060402 閨0ｹ0 02 06-096ﾑ8 ﾞ 040ｸ7040400-026ｧ9ｨB080702 07 0700010703020902 0000 6ｦ001090409 02090ｹ0 00apple066 56ｧ90ｷ304090ｹ0[37]. 6ﾒ2 000ｸ7036ｧ800 02 0ｸ70207 040ｸ70709090803086ｦ007 040208 fi0206 0006 apple08030ｸ7 06070402 0209 030003 apple006ｧ9 0400 040ｸ707-0ｸ7 0400fi 0000 020907 0008 030008096ｧ8 0ｸ709060006-0708 06 0602090206020607 0009 08 0300 02000ｸ70206-020607 00 閨02030ｷ307 (070402090409, 06 0208apple6ｧ8 02080ｸ7 02 apple076ｧ90400 02080ｹ0, 00006ｧ90ｷ30409 02080ｸ7 040ｷ300 020602086ｦ0 6 50703080ｸ70ｹ0) 閨040006 03030806-04020602fi fi080003080ｹ0 040209 00006ｧ90ｷ30409 02080ｸ7 02 03 06 09090006 02086ｦ0 020607 6ｦ007080ｸ7 02 06 040209 030709040600fi020902 020ｷ307 040300070607 0000 09 ﾞ03. 08066 50306080903 086ｧ9 [1] Selvin E, Erlinger TP. 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