patent foramen ovale PFO 15 25 PFO 1990 PFO PFO 2015 6 Amplatzer PFO 2016 10 2016 11 2017 5 1 2
CQ 1 50 B patent foramen ovale PFO migraine with aura MA PFO 40 60 migraine without aura MO 20 2,444 PFO 2016 MA 16 90 MO 11 34 1 10 MA PFO 50 MA PFO 2008 Schwedt PFO OR 1.87 5.88 OR 2.54 95 CI 2.01 3.08 2 112 PFO MA 54.8 MO 30.0 p 0.008 3 1,101 PFO 14.6 vs 15MA MO 19 vs 11 4 61 PFO PFO 5, 6 CQ 1 3
1 Tariq N, Tepper SJ, Kriegler JS : Patent foramen ovale and migraine : closing the debate A review. Headache 2016 ; 56 3 : 462 478. 2 Schwedt TJ, Demaerschalk BM, Dodick DW : Patent foramen ovale and migraine : a quantitative systematic review. Cephalalgia 2008 ; 28 5 : 531 540. 3 Iwasaki A, Suzuki K, Takekawa H, Takashima R, Suzuki A, Suzuki S, Hirata K : Prevalence of right to left shunts in Japanese patients with migraine : a single center study. Intern Med 2017 ; 56 12 : 1491 1495 4 Rundek T, Elkind MS, Di Tullio MR, Carrera E, Jin Z, Sacco RL, Homma S : Patent foramen ovale and migraine : a cross sectional study from the Northern Manhattan Study NOMAS. Circulation 2008 ; 118 14 : 1419 1424. 5 Anzola GP, Morandi E, Casilli F, Onorato E : Different degrees of right to left shunting predict migraine and stroke : data from 420 patients. Neurology 2006 ; 66 5 : 765 767. 6 Schwerzmann M, Nedeltchev K, Lagger F, Mattle HP, Windecker S, Meier B, Seiler C : Prevalence and size of directly detected patent foramen ovale in migraine with aura. Neurology 2005 ; 65 9 :1415 1418. DB Pubmed 2016/2/6 Migraine patent foramen ovale 465 4
CQ 2 OR 3.21 95 CI 2.38 4.17 B CQ1 patent foramen ovale PFO PFO migraine with aura MA 14 2,602 PFO 2016 16 64 MA 10 50 3 25 1 2008 Schwedt PFO OR 1.82 5.88 OR 5.13 95 CI 4.67 5.59 PFO MA OR 3.21 95 CI 2.38 4.17 2 OR 1 Tariq N, Tepper SJ, Kriegler JS : Patent foramen ovale and migraine : closing the debate A review. Headache 2016 ; 56 3 : 462 478. 2 Schwedt TJ, Demaerschalk BM, Dodick DW : Patent foramen ovale and migraine : a quantitative systematic review. Cephalalgia 2008 ; 28 5 : 531 540. CQ 2 5
DB Pubmed 2016/2/6 Migraine patent foramen ovale 465 6
CQ 3 B patent foramen ovale PFO migraine with aura MA PFO PFO 20 1,194 PFO PFO 2016 3 50 10 83 14 83 1 54 4 8 8 1 PFO 19 Amplatzer 3 9 2 3 RCT PFO 1 MIST 2 PFO MA STARFlex 74 sham 73 3 6 50 4.1 P 0.51 CQ 3 7
2 PRIMA MA Amplatzer PFO 40 43 4 9 12 2.9 8.0 1.7 8.3 P 0.17 50 38 15P 0.0189 3 PREMIUM 6 14 3 Amplatzer PFO 107 sham 123 5 2/3 MA 10 12 50 38 32P 0.3 3.4 2.0 P 0.03 3 RCT PFO 1 Tariq N, Tepper SJ, Kriegler JS : Patent foramen ovale and migraine : closing the debate A review. Headache 2016 ; 56 3 : 462 478. 2 Takaya Y, Akagi T, Kijima Y, Nakagawa K, Kono S, Deguchi K, Sano S, Ito H : Influence of transcatheter closure of atrial communication on migraine headache in patients with ischemic stroke. Cardiovasc Interv Ther 2016 31 4 263 268. 3 Dowson A, Mullen MJ, Peatfield R, Muir K, Khan AA, Wells C, Lipscombe SL, Rees T, De Giovanni JV, Morrison WL, Hildick Smith D, Elrington G, Hillis WS, Malik IS, Rickards A : Migraine Intervention With STARFlex Technology MIST trial : a prospective, multicenter, double blind, sham controlled trial to evaluate the effectiveness of patent foramen ovale closure with STARFlex septal repair implant to resolve refractory migraine headache. Circulation 2008 ; 117 11 : 1397 1404. 4 Mattle HP, Evers S, Hildick Smith D, Becker WJ, Baumgartner H, Chataway J, Gawel M, Göbel H, Heinze A, Horlick E, Malik I, Ray S, Zermansky A, Findling O, Windecker S, Meier B : Percutaneous closure of patent foramen ovale in migraine with aura, a randomized controlled trial. Eur Heart J 2016 ; 37 26 : 2029 2036. 5 Charles A, Silberstein S, Sorensen S, Maini B, Horwitz P, Gurley J, Tobis J. Results of the PREMIUM trial : patent foramen ovale closure with the AMPLATZER TM PFO occlude for the prevention of migraine. Headache 2015 ; 55 S5 : 251. DB Pubmed 2016/2/6 Migraine patent foramen ovale closure 250 8
CQ 4 A patent foramen ovale PFO 2016 PFO Amplatzer PFO FDA PFO MIST STARFlex 17.5 1 Amplatzer PFO FDA 0.8 0.40.60.2 0.2 0.2 2 1 Dowson A, Mullen MJ, Peatfield R, Muir K, Khan AA, Wells C, Lipscombe SL, Rees T, De Giovanni JV, Morrison WL, Hildick Smith D, Elrington G, Hillis WS, Malik IS, Rickards A : Migraine Intervention With STARFlex Technology MIST trial: a prospective, multicenter, double blind, sham controlled trial to evaluate the effectiveness of patent foramen ovale closure with STARFlex septal repair implant to resolve refractory migraine headache. Circulation 2008 ; 117 11 : 1397 1404. 2 http://www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials/medicaldevices/ MedicalDevicesAdvisoryCommittee/CirculatorySystemDevicesPanel/UCM502195.pdf#search=%27amplatzer+PFO+occlu der%27 CQ 4 9
DB Pubmed 2016/2/6 1. patent foramen ovale clsore adverse events 110 2. Amplatzer PFO occlude adverse events 21 10
CQ 5 6 12 3 2 B patent foramen ovale PFO 4 8 1 PFO atrial septal defect ASD 10 2, 3 PFO ASD 2, 3 2015 ASD 171 CANOA 3 9.5 vs 21.8 3 3 6 PFO RCT 2 CANOA 4, 5 2, 3 CQ 5 11
1 Tariq N, Tepper SJ, Kriegler JS. Patent foramen ovale and migraine : closing the debate A review. Headache 2016 ; 56 3 : 462 478. 2 Kato Y, Kobayashi T, Ishido H, Hayashi T, Furuya D, Tanahashi N : Migraine attacks after transcatheter closure of atrial septal defect. Cephalalgia 2013 ; 33 15 : 1229 1237. 3 Rodés Cabau J, Horlick E, Ibrahim R, Cheema AN, Labinaz M, Nadeem N, Osten M, Côté M, Marsal JR, Rivest D, Marrero A, Houde C : Effect of Clopidogrel and Aspirin vs Aspirin Alone on Migraine Headaches After Transcatheter Atrial Septal Defect Closure : The CANOA Randomized Clinical Trial. JAMA 2015 ; 314 20 : 2147 2154. 4 Dowson A, Mullen MJ, Peatfield R, Muir K, Khan AA, Wells C, Lipscombe SL, Rees T, De Giovanni JV, Morrison WL, Hildick Smith D, Elrington G, Hillis WS, Malik IS, Rickards A : Migraine Intervention With STARFlex Technology MIST trial : a prospective, multicenter, double blind, sham controlled trial to evaluate the effectiveness of patent foramen ovale closure with STARFlex septal repair implant to resolve refractory migraine headache. Circulation 2008 ; 117 11 : 1397 1404. 5 Charles A, Silberstein S, Sorensen S, Maini B, Horwitz P, Gurley J, Tobis J : Results of the PREMIUM trial: patent foramen ovale closure with the AMPLATZER TM PFO occlude for the prevention of migraine. Headache 2015 ; 55 S5 : 251. DB Pubmed 2016/2/6 1. patent foramen ovale clsore clopidogrel 25 2. atrial septal defect clopidogrel 11 12