植込型補助人工心臓がもたらす経済効果
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1 特集 植込型補助人工心臓の時代を迎えて Tomoyuki TAKURA, Shunei KYO, Yoshiki SAWA 1. はじめに value well-being socio economics 2. 医療技術の臨床経済的評価の概念 1) 医療技術の臨床経済価値の基本的な考え方 function cost performance value outcome utility 1 outcome cost performance value 1) 2) 医療技術の臨床経済的な価値評価の方法論 2 著者連絡先 takura@heip.med.osaka-u.ac.jp 1 効用 utility
2 utility 1.0 utility year Qalys Cost (-) Therapy(+) Doubtful Dominant base Therapy(-) Survival time (quantitative profit), Quality of life (qualitative profit) Utility (-) Utility (+) 0.0 Inferior Effective pre treatment post time 図 1 in press 2) utility 1 Qaly: quality adjusted life years 図 1 2) / 1 1 incremental cost utility ratio: ICUR ICUR / 図 2 図 2 3) 3) 医療技術が有する価値を貨幣換算する議論 ICUR WTP: Cost ( + ) willingness to pay 2 1 Qaly 3 5 US$ 4) Qaly 1 Qaly 5),6) 600 benefit consideration ICUR Performances are compared between medical technology Value of medicine is discussed with acceptance of public health insurance 図 2 2 Incremental Cost Utility Ratio ICUR 1340: 16-7, ) 2 支払意思額 stated preference
3 表 1 US$/Qaly Therapy Range of Cost-Utility Performance: US$/Qaly Notes Reference Usual clinical ventricular assist system 78, ,100 BTT/LTCS 7) 11) Implantable clinical ventricular assist 198, ,200 HeartMate, BTT/DT, 13),14) system second-generation significantly increases survival and QOL but high cost Transplantation 29,000 57,000 12) BTT: bridge to transplantation, LTCS: long-term chronic support, DT: destination therapy, QOL: quality of life. Qaly Qaly prospective health rule Qaly fair inning rule rule of rescue 3. 植込型補助人工心臓の経済評価の試行 1) 植込型補助人工心臓の費用効用分析 2. ventricular assist system: VAS 表 1 7) 11) bridge to transplantation: BTT 78, ,100 US$/Qaly quality of life: QOL QOL 29,000 57,000 US$/Qaly 12) DuraHeart EVAHEAR T ml ),14) BTT destination therapy: DT HeartMate Qaly QOL 198, ,200 US$/Qaly DT 2) 技術イノベーションの社会経済的評価の概念 value value of medicine 1 3 図
4 To urge technological innovation 3 index of socioeconomics Improvement of burden OS, QOL, etc. Evaluation of medical technology Reduction of social cost Budget impact, etc. Growth of economic condition GDP, trade balance, etc. discusses technology as economical value 図 : 16-7, ) Improvement of burden Reduction of social cost Growth of economic condition 15) 3 3) 植込型補助人工心臓の社会経済的な効果 2 表 2 3 7) 33) / ,166 5,402 2, Qaly Qaly 881 /3 3,326 /3 VAS 70 /3 207 /3 3,027 /3 1 1, おわりに
5 表 2 Improvement of burden Reduction of social cost Growth of economic condition Total socioeconomics A B C Labor productivity-national contribution C : impact Medical cost Public sector, etc. B : imapct Utility-Benefit Spirit of cooperation, etc. A : impact Therapy Model Model Model , ,820.0 i 36 ƒ i I, Ur, Br, Sr, S, A, N i i 36 ƒi C, Sr, S, A i 1 Conservative Treatment Medicine i 36 ƒ i W, Rr, Sr, S, A i 1 4, , ,020.0 I : Annual income, Ur: Unemployment rate, Br: Comeback ratio to work, Sr: Survival rate, S: Sex, A: Age, N: National contribution rate, i: time of post treatment monthly C: surgery, hospital, outpatient, Sr: Survival rate, S: Sex, A: Age, i: time of post treatment monthly W: WTP-Qaly, Rr: Return ratio to society, Sr: Survival rate, S: Sex, A: Age, i: time of post treatment monthly Usual Clinical Ventricular Assist System 8, , ,744.8 Implantable Clinical Ventricular Assist System secondgeneration , ,440.0 vs. Conservative Treatment Medicine 8,660.9 vs. Conservative Treatment Medicine vs. Conservative Treatment Medicine , ,454.0 vs. Usual Clinical Ventricular Assist System 4,117.6 vs. Usual Clinical Ventricular Assist System vs. Usual Clinical Ventricular Assist System Socioeconomic gain of Implantable Clinical Ventricular Assist System The labor production is not converted into the tax and insurance fee. WTP: willingness to pay, QALY: quality adjusted life year. 18 7) 25) 7 26) 33) 文献 1) 77: , ) in press 3) 1340: 16-7, ) Guidelines Manual-Appraising Orphan Drugs, NICE, Available from: 5) 40(Suppl : S-107, ) 1QALY 16: , ) Hutchinson J, Scott DA, Clegg AJ, et al: Cost-effectiveness of left ventricular-assist devices in end-stage heart failure. Expert Rev Cardiovasc Ther 6: , ) Sharples LD, Dyer M, Cafferty F, et al: Cost-effectiveness of ventricular assist device use in the United Kingdom: results from the evaluation of ventricular assist device programme in the UK (EVAD-UK). J Hear t Lung Transplant 25: , ) Mahle WT, Ianucci G, Vincent RN, et al: Costs associated with ventricular assist device use in children. Ann Thorac Surg 86: , ) Sharples L, Buxton M, Caine N, et al: Evaluation of the ventricular assist device programme in the UK. Health Technol Assess 10: 1-119, iii-iv, ) Clegg AJ, Scott DA, Loveman E, et al: The clinical and costeffectiveness of left ventricular assist devices for end-stage heart failure: a systematic review and economic evaluation. Health Technol Assess 9: 1-132, iii-iv, ) 44: 60-8, ) Rogers JG, Bostic RR, Tong KB, et al: Cost-effectiveness analysis of continuous-flow left ventricular assist devices as destination therapy. Circ Heart Fail 5: 10-6, ) Moreno SG, Novielli N, Cooper NJ: Cost-effectiveness of the implantable HeartMate II left ventricular assist device for patients awaiting heart transplantation. J Heart Lung Transplant, 2011 [Epub ahead of print] 15) 1338: 14-5,
6 16) 218: , ) 37: , ) 15: 246, ) 239: 193-8, ) 62: 67-73, ) 36: 244-7, ) Hear t View 12: , ) 44: 10-7, ) Stevenson LW: Clinical use of inotropic therapy for heart failure: looking backward or forward?. Circulation 108: 492-7, ) Slaughter MS, Rogers JG, Milano CA, et al: Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med 361: , ) ) ) ) ) ) ) )
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