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5 乳幼児のスギ花粉症の現状と治療の展望 表２ 表３ スギ花粉飛散数の特徴 表４ スギ花粉数の回避 重症度に応じた花粉症の治療 鼻アレルギー診療ガイドラインを一部改変 221
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7 223 NO Th ECP Lactobacillus Bifidobacterium Bifidobacterium BB IgE 17 Rautava 22 Lactobacillus GG TGF Okuda M. Epidemiology of Japanese cedar pollinosis throughout Japan. Annals of Allergy, Athma Immunology 2003; 9: : EBM Roman M, Martin-Orozco E. Goodman JS, Nguyen MD, Sato Y, Ronaghy A, Koenbluth RS, Richman DD, Carson DA, Raz E. Immunositmulatory DNA sequences function as T helper-1promoting adjuvants.nat Med 1997; 3: DNA Cretics PS, Schroeder JT, Hamilton RG, Bacler- Whaley SL, Khattignavong AP, Lindblad R, Li H, Coffman R, Seyfert V, Eiden JJ, Broide D, Immune Tolerance Network Group Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis N Engl J Med2006; 356: Tulic MK, Fiset PO, christodoulopoulos P, Vaillancourt P, Desrosiers M, Lavigne F, Eiden J, Hamid Q J Allergy Clic Immunol 2004; 113: Cox LS, Linnemann DL, Nolte H, Wedon D, Finegold I, Nelson HS Sublingual immunotherapy: a comprehensive review J Allergy Clic Immunol Burastero SE. Sublingual immunotherapy for allergic rhinitis: an update. Curr Opin Otolaryngol Head Neck Surg 2006; 14: Larsen TH, Poulsen LK, Melac M, Combebias A, Andre C, MallingHJ Safety and tolerability of grass pollen tablets in sublingual immunotherapya phase-1 study Allergy 2006; 61: Dahl R, Kapp A, Colombo G, de Monchy JG, Rak S, Emminger W, Rivas MF, Ribel M, Durham SR.Efficacy and safety of sublingual immunotherapy with grass allergen tablets for
8 224 seasonal allergic rhinoconjunctivitis. J Allergy Clic Immunol 2006; 118: Enomoto T, Nakasako-Akazone Y, Kanda T, Ikeda M, Dake Y. Clinical Effects of apple polyphenols on persistent allergic rhinitis: A randomized double-blind placebo-controlled parallel arm study. J Investig Allergol Clin Immunol 2006; 16: Xiao JZ, Kondo S, Yanagisawa N, Takahashi N, Odamaki T, Iwabuchi N, Miyaji K, Iwatsuki K, Togashi H, Enomoto K, Enomoto T. Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial. Clin Exp Allergy 2006; 36: Higa S, Hirano T, Kotani M, Matsumoto M, Fuita A, Suemura M, Kawase T, Tanaka T. Fisetin, a flavonol, Inhibits Th2-type cytokine production by activated human basophils. J allergy Clin Immunol 2003; 111: Hirano T, Higa S, Arimitsu J, Shima Y, Ohshima S, Fujimoto M, Yamadori T, Kawase I, Tanaka T. Flavonoids such as lutelion, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils Int Arch Allergy Immunol 2004; 134: Kotani M, Matsumoto M, Fujita A, Higa S, Wang W, Suemura M, Kishimoto T, Tanaka T. Persimmon leaf extract and astragalin inhibit development of drmataitis and IgE elevation in NC/Nga mice. J Allergy Clin Immunol 2000: 106; Rautava, S, Kalliomaki, M, Isolauri E. Probiotics during pregnancy and brest-feeding might confer immunomodulatory protection against atopic disease in the infant J allergy clin immunol 2002; 109: Itsuo Suzuki Sanno Hospital International University of Health and Welfare In recent year, the number of patients with Japanese cedar pollinosis has been increasing because infantile and elderly patients are elevating. Whereas, various investigations and researches are performed for pollinosis as a subject of public concern. The clinical guideline for allergic rhinitis was created due to elucidation of the mechanism of pollinosis and selection of drugs was defined. Furthermore, more safety and effective treatments are investigated and exploited. The Japanese government build panel for pollinosis. They develop specialized Japanese cedars that are diminished pollen and also convert Japanese cedar to needle-leaved trees. And some functional diets that inhibit allergic reaction are now investigated. The author believes that the Japanese cedar pollinosis will be overcome in the future. Japanese cedar pollinosis, infant, atmospheric pollen counts, new countermeasure for pollen
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