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なぎさわしあし
5 years ago
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1 pp. Perspective of prevention and treatment for allergic diseases Yasuyuki Ishii Laboratory for Vaccine Design, RIKEN Research Institute for Allergy and Immunology,, Suehiro-chou, Tsurumi, Yokohama, Kanagawa, Japan IgE I T Th Th IL - B B IgE B IgE IgE IgE

2 IgE I IgE Omalizumab XolairIgE IgE IgE IgE IgE IgE IgE IgE IgE B T T B IgE IgE B B IgE IgE IgG B IgE B IL- B germline Cε IL- IgE IgE IL- B B BCG IgE T invariant Vα -NKT inkt IL- inkt IL- IgE T Th IL- B IgE Th IL- IgE Th Th Toll TLR TLR- LPS monophosphoryl lipid A MPL Th IgG IgE TLR- DNA CpG immunostimulatory sequence ISS DNA DNA ODN Krieg CpG CpG dendritic cell DC Th IL- IL- IL- TNF-α Th Tighe ragweed Amb a ISS Amb a IgG a IgE Shirota

3 OVA CpGODN Dynavax Technologies ISS Amb a TOLAMBA TLR- myeloid DCTh IL- plasmacytoid DC ISS IL- TOLAMBA Amb a ISS IgE CpGODN Th TOLAMBA IgE IgG IgE ThTh IgE Th T IgE T Treg Treg Tr IL- IL- CD T OVA Tr OVA IgG IgE heat-killed Listeria monocytogenes HKL OVA OVA IgE IL- IFN-γ Treg Treg IgE Treg T B PEG T IgE Treg IL- TGF-β T Treg IgE T AIT allergen immunotherapy Cry j Cry j Cry j Cry j Cry j Cry j IgE IgE Treg IgE T CD T MHC CD T T in vitro in vivo T BALB c T Cry j Cry j Cry j Cry j T T T Cry j Cry j

4 T T T Cry j Cry j IgE Cry j Cry j T Th B T T Th T T T sublingual immunotherapy: SLIT SLIT SLIT IL- T Treg FcεRI IgE SLIT IgE FcεRI IL-TGF-β idioleamine dioxygenase IDO Treg SLIT AIT IgE SLIT Cry j Cry j T IgE T Cry j Cry j T Cry j Cry j Cry j Cry j PEG Cry j PEG IgE PEG Cry j IgE IgE ELISA Cry j IgE Cry j PEG Cry j C BL DBA F BDF Cry j Cry j PEG Cry jg g Cry j Cry j

5 PEG Cry j Cry j IgE IgG PEG Cry j IgE IgG PEG Cry j IgE PEG Cry j Cry j IgE IgE PEG Cry j Treg Treg Treg DC Treg GM-CSF CD c DC LPS DC T DC D DC DC DC CD T Tr Treg in vivo IL- CD c low CD RB high DC in vitro in vivo IL- IFN-γ CD T DC DC IL- Treg CD c low CD RB high DC IL- inkt α- α-galcer α-galcer IFN-γ α-galcer IFN-γ IL- α-galcer α-galcer α-galcer DC CD c CD RB α-galcer CD c low CD RB high α-galcer Treg CD c low CD RB high OVA OVA DO - CD T CD T CD Treg fork-

head box P Foxp IL- IFN-γ BALB c OVA IgE IgG IgG a IgE α-galcer

α-galcer α-galcer CD c DC B B CD b inkt in vitro α-galcer B B IFN-γ

α-galcer B B mariginal zone B; MZB CD high CD low inkt IL- MZB

high B α-galcer MZB CD d high B MZB α-galcer CD c low CD RB high

6 head box P Foxp IL- IFN-γ BALB c OVA IgE IgG IgG a IgE α-galcer Foxp CD CD T CD c low CD RB high α-galcer CD c low CD RB high α-galcer α-galcer CD c DC B B CD b inkt in vitro α-galcer B B IFN-γ IL- IL- α-galcer B B IFN-γ α-galcer DC IL- IL- B α-galcer inkt IL- α-galcer B B mariginal zone B; MZB CD high CD low inkt IL- MZB α-galcer CD d α-galcer MZB α-galcer inkt IL- GFP α-galcer MZB CD d high B α-galcer MZB CD d high B MZB α-galcer CD c low CD RB high α-galcer MZB CD c low CD RB high IL- α-galcer α-galcer MZB inkt α-galcer B inkt IL-

7 IL- IL- Treg CD c low CD RB high α-galcer in vivo IgE α-galcer Treg IgE α-galcer OVA CD T OVA CD CDFoxp OVA CD T CD CD high T Foxp IL- IFN-γ CD T DNP OVA BDFDNP-OVA IgE IgG IgG a OVA α-galcer CD CD Foxp α-galcer CD T

8 α-galcer α-galcer BDF OVA OVA α-galcer OVA OVA OVA IgE OVA α-galcer IgE PEG Cry j α-galcer IgE I Cry j Cry j Mirkina, I., Schweighoffer, T., & Kricek, F.Immunol. Lett.,,. Sedivá, A., Kayserová, J., Vernerová, E., Poloucková, A., Capková, S., Spísek, R., & Bartu nková, J.J. Allergy Clin. Immunol.,,. Suto, A., Nakajima, H., Hirose, K., Suzuki, K., Kagami, S., Seto, Y,, Hoshimoto, A., Saito, Y., Foster, D.C., & Iwamoto, I. Blood,,. Harada, M., Magara-Koyanagi, K., Watarai, H., Nagata, Y., Ishii, Y., Kojo, S., Horiguchi, S., Okamoto, Y., Nakayama, T., Suzuki, N., Yeh, W.C., Akira, S., Kitamura, H., Ohara, O., Seino, K., & Taniguchi, M.J. Exp. Med.,,. Mothes, N., Heinzkill, M., Drachenberg, K.J., Sperr, W.R., Krauth, M.T., Majlesi, Y., Semper, H., Valent, P., Niederberger, V., Kraft, D., Valenta, R.Clin. Exp. Allergy,,. Wheeler, A.W., Marshall, J.S., Ulrich, J.T.Int. Arch. Allergy Immunol.,,. Krieg, A.M.Trends Microbiol.,,. Tighe, H., Takabayashi, K., Schwartz, D., Van Nest, G., Tuck, S., Eiden, J.J., Kagey-Sobotka, A., Creticos, P.S., Lichtenstein, L.M., Spiegelberg, H.L., & Raz, E.J. Allergy Clin. Immunol.,,. Shirota, H., Sano, K., Kikuchi, T., Tamura, G., & Shirato, K. Am.J.Respir.CellMol.Biol.,,. Creticos, P.S., Schroeder, J.T., Hamilton, R.G., Balcer-Whaley, S.L., Khattignavong, A.P., Lindblad, R., Li, H., Coffman, R., Seyfert, V., Eiden, J.J., & Broide, D.N.Engl.J.Med.,,. Cottrez, F., Hurst, S.D., Coffman, R.L., & Groux, H.J. Immunol.,,. Stock, P., Akbari, O., Berry, G., Freeman, G.J., Dekruyff, R.H.,

9 Umetsu, D.T.Nat. Immunol.,,. Takatsu, K. & Ishizaka, K.J. Immunol.,,. Lee, W.Y., Sehon, A.H., & Akerblom, E.Int. Arch. Allergy Appl. Immunol.,,. Harding, F.A., McArthur, J.G., Gross, J.A., Raulet, D.H., & Allison, J.P.Nature,,. Moingeon, P., Batard, T., Fadel, R., Sieber, J., & Van Overtvelt, L.Allergy,,. Vieira, P.L., Christensen, J.R., Minaee, S., O Neill, E.J., Barrat, F.J., Boonstra, A., Barthlott, T., Stockinger, B., Wraith, D.C., &O Garra, A.J. Immunol.,,. Wakkach, A., Fournier, N., Brun, V., Breittmayer, J.P., Cottrez, F., & Groux, H.Immunity,,. Ishii, Y., Nozawa, R., Takamoto-Matsui, Y., Teng, A., Katagiri-Matsumura, H., Nishikawa, H., Fujita, H., & Tamura, Y.Front. Biosci.,,. Kojo, S., Seino, K., Harada, M., Watarai, H, Wakao, H., Uchida, T., Nakayama, T., & Taniguchi, M.J. Immunol.,,.

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