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4 1) Y. Okano, Y. Abe, H. Masaki, U. Santhanam, M. Ichihashi, Y. Funasaka, Exp. Dermatol., Suppl 2, S57-S63 (2003) 2) E. F. Bernstein, C. B. Underhill, J. Lakkakorpi, C. M. Ditre, J. Uitto, R. J. Yu, E. V. Scott, Dermatol. Surg., 23, (1997) 3) C. M. Ditre, T. D. Griffin, G. F. Murphy, H. Sueki, B. Telegan, W. C. Johnson, R. J. Yu, E. J. Van Scott, J. Am. Acad. Dermatol., 34, (1996) 4) E. F. Bernstein, J. Lee, D. B. Brown, R. Yu, E. Van Scott, Dermatol. Surg., 27, (2001) 5) S. J. Kim, J. H. Park, D. H. Kim, Y. H. Won, H. I. Maibach, Dermatol. Surg., 24, (1998) 6) Y. Funasaka, H. Sato, A. Usuki, A. Ohashi, H. Kotoya, K. Miyamoto, G. Hillebrand, M. Ichihashi, J. Dermatol. Sci., Suppl 1, (2001) 8) A. Usuki, A. Ohashi, H. Sato, N. Ochiai, M. Ichihashi, Y. Funasaka, Exp. Dermatol., Suppl 2, S43-S50 (2003) 9) S. Ando, O. Ando, Y. Suemoto, Y. Mishima, J. Invest. Der matol., 100 (Suppl), 150S-155S (1993) 10) V. B. Swope, Z. Abdel-Malek, L. M. Kassem, J. J. Nordlund, J. Invest. Dermatol., 96, (1991) 11) T. Horikoshi, M. Matsumoto, A. Usuki, S. Igarashi, R. Hikima, H. Uchiwa, S. Hayashi, M. M. Brysk, M. Ichihashi, Y. Funasaka, Exp. Dermatol., 14, (2005) 12) I. Effendy, C. Kwangsukstith, J. Y. Lee, H. I. Maibach, Acta Derm. Venereol., 75, (1995) 13) A. V. Rawlings, A. Davies, M. Carlomusto, S. Pillai, K. Zhang, R. Kosturko, P. Verdejo, C. Feinberg, L. Nguyen, P. Chandar, Arch. Dermatol. Res., 288, (1996) 14) M. Fartasch, J. Teal, G. K. Menon, Arch. Dermatol. Res., 289, (1997) 15) Y. Yamamoto, K. Obayashi, Y. Okano, Y. Satoh, H. Masaki, Y. Funasaka, J. Dermatol. Sci., Suppl 2, S39-S49 (2006) 16) P. Brenneisen, R. Blaudschun, M. Bernards, J. Wenk, M. Wlaschek, W. Meyer-Ingold, M. Schauen, T. Krieg, K. Scharffetter-Kochanek, Br. J. Dermatol., 139, (1998) 17) P. Verbeke, J. Fonager, B. F. C. Clark, S. I. S. Rattan, Cell Biol. Int., 25, (2001) 18) P. J. Neafsey, Mech. Ageing Dev., 51, 1-31 (1990) 19) M. Pollycove, Eur. J. Nucl. Med., 22, (1995) 20) E. J. Calabrese, L. A. Baldwin, Hum. Exp. Toxicol., 19, 2-31 (2000) 21) N. Minois, Biogerontology, 1, (2000) 22) S. I. Rattan, Indian J. Exp. Biol., 38, 1-5 (2000) 23) P. Verbeke, B. F. Clark, S. I. Rattan, Free Radic. Biol. Med., 31, (2001) 24) S. I. Rattan, Biochem. Mol. Biol. Int., 45, (1998) 25) R. Singh, A. Barden, T. Mori, L. Beillin, Diabetologia, 44, (2001) 26) S. Dukic-Stefanovic, R. Schnizel, P. Riederer, G. Munch, Biogerontology, 2, (2001) 27) T. Miyata, K. Kurokawa, C. Van Ypersele De Strihou, J. Am. Soc. Nephrol., 11, (2000) 28) T. Finkel, N. J. Holbrook, Nature, 408, (2000) 29) B. S. Berlett, E. Stadtman, J. Biol. Chem., 272, (1997) 30) J. W. Baynes, Biogerontology, 1, (2000) 31) P. Verbeke, B. F. Clark, S. I. Rattan, Exp. Gerontol., 35, (2000) 32) S. I. Rattan, Exp. Gerontol., 31, (1996) 33) K. Mizutari, T. Ono, K. Ikeda, K. Kayashima, S. Horiuchi, J. Invest. Dermatol., 108, (1997) 34) P. Boukamp, S. Popp, K. Bleuel, E. Tomakidi, A. Brkle, N. E. Fusenig, Oncogene, 18, (1999) 35) M. McVean, D. C. Liebler, Carcinogenesis, 18, (1997) 36) T. R. Berton, C. J. Conti, D. L. Mitchell, C. M. Aldaz, R. A. Lubet, S. M. Fischer, Mol. Carcinog., 23, (1998) 37) M. S. Stewart, G. S. Cameron, B. C. Pence, J. Invest. Der matol., 106, (1996)
5 Overview of Cosmetic Dermatological Approach for Photoaging* Yoko Funasaka Division of Dermatology, Kobe University Graduate School of Medicine** Photoaging could be induced by accumulated DNA damage on skin cells. Photoaged skin has such characteristics as a nodular leathery surface with fine and coarse wrinkles, blotches and yellowing, dryness, and teleangiectasia, and finally skin cancer formation. For this condition, chemical peeling, iontophoresis, laser and phototherapy are used with some improvement, especially in wrinkles and pigmentary uniformity. Now the mechanisms of these treatments on Photoaging have been studied. Glycolic acid may act on skin cells via keratinocytes and activate the cytokine network, which results in the remodeling of tissue construct and elimination of pigment. Heat generated by non-ablative laser or phototherapy might induce heat shock proteins which induce new collagen formation, and eliminate oxidized abnormal materials. This type of research is expected to disclose the cellular and molecular mechanisms of photoaging, and to lead to the establishment of further effective photoaging treatment. Key words: photoaging, cosmetic dermatology, chemical peeling, glycolic acid, skin rejuve nation, non-ablative laser, Intense pulsed light (IPL), heat shock protein (hsp), matrix metallo proteinase (MMP), thermal stimulation, advanced glycation end products (AGE), oxidative stress
日本皮膚科学会第121巻第9号
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Br J Dermatol NEnglJ Med 尋常性白斑診療ガイドライン 図 1 先天性白斑 白皮症の病型分類 図 2 後天性白斑 白皮症の病型分類 の尋常性白斑患者で家系内発症がみられることより 3 5 れらの合併が染色体 17p13 における一塩基多型に起 非分節 因し その候補遺伝子の一つが自然免疫に重要とされ 型に含まれる汎発型には甲状腺に対する抗サイログロ る NALP1 遺伝子であると報告している6
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Current Therapy of Skin Laser Surgery Takeshi SHIMBASHI * (Received July 15, 1996) It has been remarkably progressed in cutaneous laser surgery. Anderson elucidated the theory of selected photothermolysis
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1 Department of Legal Medicine, Toyama University School of Medicine 2 3 4 5 6 7 8 Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama VEGF Key words
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肺癌第50巻第4号
1 Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan; 2 Department of Thoracic Surgery, Aichi Cancer Center, Japan;
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RYZA IL & FAT CHEMICAL C., LTD. SAKURA EXTRACT Ver.1.4MK Ver. 1.4MK 1) 1300 1929 1 Ver. 1.4MK Sakura 1-caffeoyl---D-glucopyranoside quercetin 3---D-glucopyranoside 1) :, 4, 11-22 (1995). 2 Ver. 1.4MK 3
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