untitled

Size: px

Start display at page:

Download "untitled"

あいとやすこ
4 years ago
Views:

1 Traber MG. Vitamin E. Modern nutrition in health and disease, 9th edition. Baltimore, MD: Williams & Wilkins. (1999) : E Tomassi G, Silano V. An assessment of the safety of tocopherols as food additives. Food and chemical toxicology. (1986) 24(10-11): in vitro D K Bendich A, Machlin L J. Safety of oral intake of Vitamin E. Am J Clin Nutr. (1988) 48 : E 3,200 mg/ E E K E K E Kappus H, Diplock A T. Tolerance and Safety of Vitamin E : A Toxicological Position Report. Free Radical Biology & Medicine (1992) 13 : E mg/ 1

2 3200 IU/ E E E E 2

3 - Blomstrand R, Forsgren L. Labelled tocopherols in man. Internat. Z. Vit. forschung (1968) 38 : dl-α % dl-α- 28.5% E Bioavailability dl- d-α- d-α- E d-α- - Kiyose C, Muramatsu R, Kameyama Y, Ueda T, Igarashi O. Biodiscrimination of α-tocopherol stereoisomers in humans after oral administration. Am J Clin Nutr. (1997) 65 : (21 37 ) RRR-α- all-rac- α- α RRR-α- 100 mg/ all-rac- α- 100 mg/ all-rac- α- 300 mg/ α- RRR-α- all-rac- 3

4 α- RRR or all-racα- 100 mg/ RRR-α 300 mg/ all-rac- α- R S all-rac- α- - Burton GW, Traber MG, Acuff RV, Walters DN, Kayden H, Hughes L, Ingold KU. Human plasma and tissue α-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. Am J Clin Nutr (1998) 67 : E E RRR- α- all-rac- α- E mg mg mg/ 22 α- 30 mg/ ± mg/ ±0.17 E Traber MG, Burton GW, Ingold KU, Kayden HJ, RRR- and SRR-α-tocopherols are secreted without discrimination in human chylomicrons, but RRR-α-tocopherol is preferentially secreted in very low density lipoproteins. J.Lipid.Res (1990) 31 : d 6 -RRR-α- d 3 -SRR-α- 50 mg d 6 d d 3 d 6 d 6 /d 3 4

5 d 6 RRR-α- SRR-α- RRR-α- SRR-α-VLDL - Taraber MG, Burton GW, Hughes L, Ingold KU, Hidaka H, Malloy M, Kane J, Hyams J, Kayden HJ. Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. J.Lipid Res. (1992) 33 : E B d 6 -RRR-α d 3 -SRR-α d 2 -RRR-γ 3 d 2 -RRR-γ d 3 -SRR-α d 6 -RRR-α RRR-α VLDL VLDL RRR-α - Cheesman KH, Holley AE, Kelly FJ, Wasil M, Hughes L, Burton G. Biokinetics in human of RRR-alpha-tocopherol: the free phenol, acetate ester, and succinate ester forms of vitamine. Free Radical Biology & Medicine. (1995) 19(5) : RRR-α 51 RRR-α 12 RRR-α 1.0 RRR-α 27 5

6 - Kelleher J, Losowsky MS. The absorption of α-tocopherol in man. Br J Nutr. (1970) 24 : dl-α- 70% α- α % - Macmahon MT, Neale G. The absorption of α-tocopherol in control subjects and in patients with intestinal malabsorption. Clinical Science. (1970) 38 : α % α % - Traber MG, Ramakrishnan R, Kayden HJ. Human plasma vitamin E kinetics demonstrate rapid recycling of plasma RRR-α-tocopherol. Proc Nat.Acad Sci USA (1994) 91 : E α- RRR- SRR- α- 24 RRR- RRR- VLDL E 3 RRR- SRR-α- SRR-α- 6 RRR-α- 0.4±0.1 pool/day SRR-α- (1.2±0.6 pool/day) 2 0.8±0.6 RRR-α- 6

7 RRR-α- RRR-α- SRR-α- VLDL RRR-α- RRR-α- α- 1 pool - Traber MG, Elsner A, Brigelius-Flohe R. Synthetic as compared with natural vitamin E is preferentially excreted as α-cehc in human urine: studies using deuterated α-tocopheryl acetates. FEBS letter (1998). α-cehc 2,5,7,8-tetramethyl-2(2 carboxyethyl)-6-hydroxychroman E E α-cehc mg RRR- all-rac- α- d 3 RRR-α- d 6 all-rac-α α-cehc E α-cehc - Eichhorn J, Lee R, Dunster C, Basu S, Kelly FJ. Alpha- and gamma-tocopherol plasma and urinary biokinetics following alpha-tocopherol supplementation. Annals of the New York Academy of Science (2004)1031: , 100, 200, 400 mg CEHC -QL -CEHC 15 mg - - in vivo CEHC - -CEHC -CEHC - - 7

8 - Schultz M, Leist M, Petrzika M, Gassmann B, Brigelius-Flohe R. Novel urinary metabolite of α-tocopherol, 2,5,7,8-tetramethyl-2(2 carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply? Am J Clin Nutr (1995) 62 : E α- α-cehc α- α- α-cehc RRR-α mg/ HPMC GC-MS α- 7 9 µ mol /g α-cehc α mg α-cehc E E 8

9 CRN( ) UL Gillilan RE, Mondell B, Warbasse JR. Quantitative evaluation of vitamin E in the treatment of angina pectoris. Am Heart J. (1977) 93 : d-α- 1,600 IU/ E SCF(EU) UL Meydani SN, Meydani M, Blumberg JB, Leka LS, Pedrosa M, Diamond R, Schaefer EJ. Assessment of the safety of supplementation with different amounts of vitamin E in healthy older adults. Am J Clin Nutr. (1998) 68 : all-rac-α IU/ mg/ 4 Candida albicans E E EVM( ) UL Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet. (1996) Mar 23;347(9004) : E LDL α- CHAOS 2002 α IU/ E ( ) UL Morinobu T, Ban R, Yoshikawa S, Murata T and Tamai H. The safety of high-dose vitamin E supplementation in healthy Japanese male adults. J Nutr Sci Vitaminol. (2002) 9

10 48: 6-9. E d-α IU 800 mg d-α α- α- 28 d-α IU Cohen HM. Fatigue caused by vitamin E? Calif. Med. (1973) 119 : IU E E Briggs MH, Briggs M. Are vitamin E supplements beneficial? Med J Aust. (1974) 1: E 1) 2) 3) 4) E E Vitamin E supplements and fatigue. N Engl J Med. (1974) 290 : Cohen HM Letter Fatigue caused by vitamin E? Calif. Med. (1973) 119 : 72. (1) Briggs M. 8 d-α- 800 IU/ 3 10

11 (2) Ayres S, Mihan R. 10 E IU E E 400 1,600 IU/ E Farrell PM, Bieri JG. Megavitamin E supplementation in man. American Journal of Clinical Nutrition. (1975) 28 : E IU/ 3 Tsai AC, Kelley JJ, Peng B, Cook N. Study on the effect of megavitamin E supplementation in man. The American Journal of clinical Nutrition. (1978) 31 : dl-α- 600 mg/ 600 IU/ 4 Stampher MJ, Willett W, Castelli WP, Taylor JO, Fine J, Hennekens CH. Effect of vitamin E on lipids. Am J Clin Pathol. (1983) 79 : E HDL-C HDL-C 30 E 800 IU/ 16 E 11

12 Ernst E, Matrai A. Einflub von alpha-tocopherol (Vitamin E) auf die fliebeigenschaften des blutes. Therapiewoche (1985) 35 : α- E 10 α- 800 mg/ 4 α- Hale WE, Perkins LL, May FE, Marks RG, Stewart RB. Vitamin E effect on symptoms and laboratory values in the elderly. J Am Diet Assoc. (1986) 86 : E E 369 1,861 E E SGOT Kitagawa K, Mino M. Effect of Elevated d-alpha(rrr)-tocopherol Dosage in Man. J Nutr Sci Vitaminol (1989) 35 : mg 900IU RRR-α RBC α γ- RBC Taylor HR, Tikellis G, Robman LD, MaCarty CA, McNeil JJ. Vitamin E supplementation and macular degeneration: randomized controlled trial. BMJ (2002) 325 : E AMD IU/ 335 mg/ 12

13 d-α- 4 E AMD 2 Moharana S, Moharana DN. Letter to Editor:Hypervitaminosis E. Indian journal of physiology and pharmacology. (1999) 43 (3) : ( ) E mg/kg/ mg/kg/ E GISSI Prevention Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto miocardico. Lancet (1999) Aug 7 ; 354 (9177) : GISSI 2,830 E(300 mg/ ) 3 Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. (2000) Jan 20 ; 342(3) : E E 400 IU/ Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS, Thal LJ. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med. (1997) Apr 24 ; 336(17) :

14 mg/ α- 2,000 IU/ 2 + Mortality in DATATOP: a multicenter trial in early Parkinson's disease. Parkinson Study Group. Ann Neurol. (1998) Mar;43(3) : dl-α- 2,000 IU/ Miller ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality. Annals of Internal Medicine 142(1): (Epub 2004 Nov 10.) E E E Pub Med E ,967 E ,000 IU 400 IU IU/ E 150 IU/ 400 IU/ E Effect of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer. Journal of the American Medical Association (2005) 293(11):

15 Heart Outcome Prevention Evaluation-The Ongoing Outcomes HOPE-TOO 55 9, HOPE E 400 IU/ E E Bairati I, Meyer F, Gelinas M, Fortin A, Nabid A, Brochet F, Mercier JP, Tetu B, Harel F, Masse B, Vigneault E, Vass S, del Vecchio P, Roy J. A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer patients. Journal of the National Cancer Institute (2005) 97(7): α βfirst phase Second phase phase First phase E Second phase α 15

<4D F736F F D E8D8297EE8ED E837E AAE90AC2E646F63>

<4D F736F F D E8D8297EE8ED E837E AAE90AC2E646F63> 平成 19 年度厚生労働科学研究費補助金 ( 循環器疾患等生活習慣病対策総合研究事業 ) 日本人の食事摂取基準を改定するためのエビデンスの構築に関する研究 - 微量栄養素と多量栄養素摂取量のバランスの解明 - 主任研究者柴田克己滋賀県立大学教授 Ⅱ. 主任研究者の報告書 7. 高齢者における尿中トコフェロール代謝産物排泄量主任研究者柴田克己滋賀県立大学教授研究要旨わが国における高齢者のビタミン