資料1－3－8放射線医学総合研究所
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9 QOL H18 H19 H20 H21 H22 1 5,388 5,418 5,690 5,237 5, ,065 1,154 1,076 1,024 1,038 S H18 H19 H20 H21 S S H18 H19 H20 H21 S S S S B 1111C H18 H19 H20 H S S
10 CT 9 X FPD QOL 5 TMS 6 7 TMS Q CT GTV 9HIMC X FPD 67 CXDI FPD 1
11 10 in vivo 11 RCR MKM Invivo RCR
12 1 E H18 H19 H20 H21 H ( IF Σ(IFxHL) IF Σ(IF ) B. : 3,964 5,620 6,902 7,536 7,428 2,108 1,852 1,744 1,636 1, ,450 8, HeadFirst uthorcorresponding uthor 2IF HL 1HIMC E 430MeVn E IHEHL7 CT TMS 4 3 HIMC MeVn H18 H19 H20 H21 S S S
13 MRI CT 4 CT 147 5KEK CT X DFDP 4 CT DFPD H18 H19 H20 H21 H IF Σ(IFxHL) IF Σ(IF ) B Head First uthor Corresponding uthor 2IF HL 1 H18 H1 H20 21 MRI CT 4 CT
14 4 CT 2 PET 62 CuTSM 3 PET 4 FNC IE 5 6 X CT 4 CT 2 PET 62CuTSM METPET 1 23 FDGPETCT MRI 4 FNC 3 FNC IE ICRP 6 X CT 1
15 IE 9 H18 H19 H20 H21 H IF Σ(IFxHL IF Σ(IF B Head First uthor Corresponding uthor 2IF HL S H18 H19 H20 H21
16 HIMT OpenSourceSoftware DU IRSN S S HIMT
17 NIRS International Symposium on Radiation Life Sciences S. S 24 S S S HIMT S S 3 2 S
18 1111 B B H18 H19 H20 H21 H H FGF2 CD44 FGF2 42 CDKN1BX p53 p53 1 CDKN H18 H19 H20 H B 1111C H18 H19 H20 H21 SNP FGF2 SNP
19 21 2 SNPs X X RN NKT 2 SNP SNPs SNP CD44 4 SNP 208 SNP SNP2 (NPT TM URK) MIPaCa-2 MMP-2 X MMP-2 ROCK Panc-1 X MMP 549 X 2Gy 1Gy 1 RN C3H/HeSlc NR-S1 C57BL/6JNrs Lewis lung carcinoma (LLC)
20 NKT NKT NKT LLC H18 H19 H20 H21 H ) IF Σ(IFxHL) 2) IF Σ(IF ) 2) B Head First uthor Corresponding uthor 2IF HL 1 SOBP SOBP 2 2 SOBP RBE 15 3CD133CD44ES X 172 invitro X DN 4 p53 p53 H18 H19 H20 H21
21 RN HIMC E 6 CNO HIMC 7 SPM RN DNPK SPM DN SPM 8 γtdmg E X X 17G invivo X 9X X 10 ph 11 X H18 H19 H20 H21 H (
22 1 ips ipsc ipsc 10 DN 2 HiCEP 3 HiCEP HiCEP 1 IF Σ(IFxHL) IF Σ(IF ) HeadFirst) uthorcorresponding uthor 2IF HL 1 ips ipsc ips ips ipsc ipscpreconversionstage cmyc ips 2 HiCEP HiCEP JST ES H18 H19 H20 H21 B B HiCEP 22 ips HiCEP HiCEP ips H18 H19 H20 H21 H
23 RBE IF Σ(IF B HeadFirst uthorcorresponding uthor 2IF HL H19 H21 RBE RBE HSG ICRU RBE H18 H19 H20 H21 B RBE
24 C S PET H18 H19 S H20 S H21 S H18 H19 H20 H21 H ,819 1,700 1,631 1,516 1, PET FLT PET PET PET 1 PET 18 FFLT 18 FFLT B 1111C H18 H19 H20 H21
25 FLT FZCuTSM 2 18 FFLTPET 18 FFLT 18 FFZ FFZPET 18 FFZPET MRI 4 62 CuTSM C4DST CuTSM 24 PET 11 CIB PET NaI NIS 99m TcO 4 SPECT NIS HIMC
26 3 4 invivo 3 EGFRIgG scfvclegfr scfvcl invivo ckit Y90IgG HER2 V H PET Cu64 RGD v3 PET v3 NaI NIS HRE 38 mrn m TcO 4 4
27 MnSOD MRI MnSOD MRI H18 H19 H20 H21 H ) IF Σ(IFxHL) 2) PET 18 FFEPE2I 2 D 2 11 CMNP 11 Craclopride D 2 IF Σ(IF ) 2) HeadFirst uthorcorresponding uthor 2IF HL 1PET 18 FFEPE2I PET sulpiride 11 Csulpiride 11 CZD CMNP 11 Craclopride D 2 D 2 D 2 S H18 H19 H20 H21 S S S PET
28 D CDOP 11 CMNP D CDOP 1 18 FTHK930 strazeneca 3 11 CMNP PET 18 FFCT 11 CPIB 4 18 FFMeNERD 2 11 CMNP 1 1 Craclopride D 2 D 2 11 CDOP 1 18 F 18 FTHK930 PET PET 11 CZD2184
29 glutaminyl cyclase PET RI p62 PBR 2 PBR PBR PET PBR PBR PBR 3 D 2 1 β βn3pe MCP1 QC QC PET 11 CPBD CPBB3 PET p62 p62 P2Y12 CB2 PET 2 PBR PBR MCP1 MCP1 3 D 2 PET NMD D 2 D 2 D2 NMD D 2 1
30 PET 2 PET PET 3 PET 2 SSRI 2 C1 D 2 3 PET D1 D2 H18 H19 H20 H21 H ) IF Σ(IFxHL) 2) IF Σ(IF ) 2) B Head First uthor Corresponding uthor 2IF HL
31 1 2 Glutathione GST Ciμmol 11 C 18 F in vivo 6 11 C 11 C 18 F 7 PET 1 MRP4 OT3 2 GlutathioneGST 18 F PET Inoxine 99m TcHMPO 4 11 C 5 I 2 PET 11 CFTIMD PET 100Ciμmol 11 CFTIMD PET 2Ciμmol 11 CFTIMD PET I C 11 C 11 C C 11 C 11 C 11 CPET 7 1 PET invivo invitro invivo PET PET H18 H19 H20 H21 S Mo99Tc99m
32 8 Zr89 PET 9 Br DDS 2 MRI 8Zr89 99m Tc 9Br H18 H19 H20 H21 H ) IF Σ(IFxHL) 2) IF Σ(IF ) 2) B Head First uthor Corresponding uthor 2IF HL 1DDS 2MRI S H18 H19 H20 H21 S S 1 PET OpenPET
33 3 MRI MRI PETMRI PET PET 3MRIMRI 4 19 F 1 2 PET MRI MRI PET 3PP 4 60μm 1 2PET
34 3 PET PET 4 MP PET 1 PET OpenPET 2 3 DOI 3mm 3 DOI 3PET PET 4MP PET MPmaximumaposteriori 1 PET OpenPET 8 4 DOI 2 42mm HIMC DOI 2mm 3DOI DOI PET PET jpet DOI NEDO PET DOI
35 1 2 3 OpenPET PET DOI 3 H18 H19 H20 H21 H IF Σ(IFxHL) IF Σ(IF ) B HeadFirst uthorcorresponding uthor 2IF HL WorldMolecularImagingCongress2010 JMP RI H18 H19 H20 H21
36 PET MRI 1 PET MRI PET PET MRI 1PET MRI
37 CRC PET CRC CRC CRC
38 S C Mo-99Tc-99m 21 OpenPET S S C PET S S C 22 OpenPET OpenPET S
39 H18 H19 H20 H21 H18 H19 H20 H21 H B 1111C
40 H
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43 H18 H19 H20 H21 H22 1 1,173 1,089 1, H18 H19 H20 H ICRP UNSCER 1 NORM 1 H18 H19 H20 H21 UNSCER 22
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45 UNSCER UNSCER 5 21 UNSCER UNSCER IE RC 5 21 Referral guidelines H18 H19 H20 H21 H IF Σ(IFxHL IF Σ(IF B HeadFirst uthorcorresponding uthor 2IF HL kevum H18 H19 H20 21
46 1 1 B6C3F1 B6C3F1 C57BL C3H F MeV 2300 RBE RBE SD SD Gy Gy Gy SD Gy 300 WM WM Min Mlh1 Min pc Mlh1 2 Mlh Gy 17 2 Gy B T C3H C3H Ptch1 Ptch1 05Gy 1
47 2 DN DN Gy 3Gy T 2 LOH 1 DN DN Ptch mgy DN Pax6 p16 SD 7 amphiregulin 3 EGF HBEGF 3 B6C3F1 T 1 T Ikaros p53 DN 3 1 Pten 50 Mlh1 T Ikaros p53 Min pc SDxCOP F DN 10q23
48 3 4 prt X gptdelta invivo i ii prt 1 prt 7 2 gptdelta 4 Gy Schofield Tapio InstituteofRadiationBiology H18 H19 H20 H21 H ) IF Σ(IFxHL) 2) IF Σ(IF ) 2) B
49 1 scid T Head First uthor Corresponding uthor 2IF HL 1 scid scid T Notch1 H18 19 H20 H21 2DN PCR MDC1 21 MDC1-/- Ku70 Ku70 DN 2DN DN MDC1 DN 9 DN MDC1 DN MDC1 DN HCT MDC1 NHEJ DN NHEJ Ku70 Ku70 NHEJ Ku80 Ku80 Ku γ 3 60 Coγ 9 C57BL/10J 0.1 Gy
50 RBE γ γ 4 Tead3Csf1 Cacna1a PI3 RBESi 2.3r 3.1Fe 4.5 γ 0.1 Gy Gy γ γ LET 4 Cacna1a Tead3 Csf1 MCF7 Pi3 M2 H18 H19 H20 H2 1 H ( IF Σ(IFxHL IF Σ(IF B
51 1 2 NORM NORM 1 1 HeadFirst uthorcorresponding uthor 2IF HL LN HIMC H18 H19 H20 H21
52 3 m241 3 m241 H18 H19 H20 H21 H IF ΣIFxHL IF ΣIF B * HeadFirst uthorcorresponding uthor 2IF HL *
53 B H18 H19 H20 H21 H H18 H19 H20 H21 B B 11121B FGF TT 1Gy mrn 3 Gy DECOR U 2 CBMID
54 1FGF 2 TT PIDD IPs 3IP 4 5 RN DECOR 1FGF1 FGF 24 FGF1 FGFC FGFC FGFC 2 TT XIP cip2 3 XIPcIP cip2 XIP 3 9 Bir2 Bir3 416GyX 54mRN mrn 0110Gy H18 H19 H20 H21 H IF ΣIFxHL IF ΣIF H18 H19 H20 H21 B
55 1 2 B HeadFirst uthorcorresponding uthor 2IF HL Gy 0.02 Gy 10 Gy PCCring 110 Gy NIRSXmanP DECOR 100 kev DECOR NIRSXmanV CT JE OTOKO NIRSXmanP OTOKO 2 H18 H19 H20 H21 B B
56 3 ICRP Publ103 60Co 16 ICPMS 4 22 S1S2 3 CFD DCFPG 3 30 MD m 1.0 Bqcc90Sr90Y 26Bqcc ICRP Publ103
57 H18 H19 H20 H21 H IF ΣIFxHL IF ΣIF B HeadFirst uthorcorresponding uthor 2IF HL
58 1122 H18 H19 H20 H21 H18 H19 H20 H21 H ,173 1,089 1, B C NORM NORM UNSCER UNSCER NORM ICRP2007
59 H18 H19 H20 H21 H H18 H19 H20 H CR bacillus 2 Clostridiumdifficile 3 DB2XCF1 XCF1 DB2 CF1 CF1 DB2XddY 1 1 CR bacillus 2 Clostridiumdifficile Clostridiumdifficile DN 50 3 CF1 5 D5Mit135 kit CF CROSSII
60 XddYDB2 ddy ddy 1 2 CROSSII SPICE invivo ddy CROSS 3 2 HIMC C8 30MeV 3 Funneling 9G2000Hz 4 HIMC 1 SPICE SPICE in vivo
61 2NSBEE LiF 3PIXE PIXE 4 WHO ISO PTB Gy 2NSBEE LiF 2MeV Li 3PIXE PIXE CdTe 4 WHO ISO Bqm 3 PTB IEC H18 H19 H20 H21 H (36 IF Σ(IFxHL IF Σ(IF B HeadFirst uthorcorresponding uthor 2IF HL
62 B H18 H19 H20 H21 H18 H19 H20 H21 H B 113C ICCHIBN ICCHIBN Ne Mg MeV 23 2 HIMC ICCHIBN
63 113C S H18 H19 H20 H21 H18 H19 H20 H21 H B 113C OpenPET OpenPET 21 S 3 H PDC 22 OpenPET 3 S 113C OpenPET 3 S
64 12 H18 H19 H20 H21 H18 H19 H20 H21 H B C YHOO!Japan
65 Q& PEC JPN JPN EXPERIENCE in ,890 3, ,231 11MRI
66 , F HIMC PDF IF HL 22 1 IF HL
67 2 21 X H18 H19 H20 H21 PET H18 H19 H20 H21 H HIMC P CD HIMC HIMC 700 PIXESPICE PIXE SPICE
68 HIMC H18 H19 H20 H21 H PIXESPICE 1 PIXESPICE PSTSPICE NSBEE 1 PIXESPICE 1 45PIXE SPICE PIXESPICE PSTSPICE NSBEE 1 CV
69 22 H18 H19 H20 H21 1 H18 H19 H20 H21 H IEJIC H KIRMS 16 16
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71 23 UNSCER H18 H19 H20 H21 IE H18 H19 H20 H21 H IE MOU , ( IE RNET REMT IE FNC
72 UNSCER IEICRP WHOREMPN IE IE1 IE 10 UNSCER IE- RCICRP IE IEPCT IERNETREMT 9IE IE IE WHOIE The 13th Coordination and Planning Meeting of the WHO REMPN Collaborating Centers and Liaison Institutions WHOISO WG18 IE 14th Summer Seminar on Radiation Measurement REMT (KIRMS) 2
73 II anytn23m0 T34N01M0 2 II 1 IE/RC RN Steering Committee Meeting & Workshop VEI/JE Follow-up Training Course on "Nuclear and Radiological Emergency Preparedness" IE Consultant's Neeting on Strengthening Biological Dosimeter FNC 1 II CERVIX-III Gr T2b-T4 N1 M0 II CERVIX-IV Cervix III 3any T N2-3 M0 II NPC-I NPC-I NPC-III T3-4 N0-1 M0 II NPC-II any T N2-3 M0 I/II NPC-III NPC-II 15 4 FNC 2010 FNC
74 TMN T T04 N N03 M M01 FNC 9 IE/RC / X / FNC H18 H19 H20 H21 H ) 3 (1) 4 (0) 2 (0) IF Σ(IFxHL) 2) IF Σ(IF ) 2)
75 24 S H18 H19 H20 H21 S S H18 H19 H20 H21 H B WBC PCCring i 3 19 WBC 21 REMT PEC
76 2 ii iii 2 8 i ii IETrainingCourseonMedicalResponsetoRadiationEmergencies KIRMS KIRMS NIRSKIRMS Joint SeminaronRadiationEmergencyMedicine2010 ISTCIE
77 NIRSIE Workshop on CytogeneticBiodosimetryforsia2011NIRSISTCWorkshopon CytogeneticBiodosimetryincooperationwithWHO17 30 NSCNIRS Workshop on MedicalResponsetoNuclearccidentsinsia
78 Radiation Emergency Medical ssistance TeamREMT 3 14th Summer seminar on radiation measurementremt PEC 6 JOC
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83 H18 H19 H20 H ,445,569 3,162, % %
84 03 H18 H19 H20 H H19 H20 H21 H
85 H18 H19 C H20 H peerreview Mo99Tc99m 21 99
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93 6 H18 H19 H20 H21 JE 1 IEIEC 1 1 IRSN 1 1 GHSG 48 BasicProgram 1 3 REMT TV 2 Leiden ICRUnnualMeeting TechnicalSupportWorkingGroupTSWG 14
94 3 3 3 IE Training Course on Medical Response to Radiation Emergencies KIRMS KIRMSNIRSKIRMSJointSeminar onradiationemergencymedicine2010 KIRMS ISTCIE KIRMS
95 NSCNIRS Workshop on Medical ResponsetoNuclearccidentsinsia 1N REMT REMT PEC N REMT 1 2
96 7 H18 H19 H20 H ISMS 3 SSO
97 8 CIO H18 H19 H20 H21 1 BRC CRbacillus MSM 1 CR bacillus 2 3 HP ICR C3HHeNrs 0 5 PCR 37 MSM SPICE NSBEEPIXE MSM 6 7 SD ICR 8 SPF F344N 38 ICR 8SPF SPF 1 SPF
98 9 1 2 NSBEE SPF300 3 PIXE PIXE 4 SPICE SPICE m X 2NSBEE SPF 360 Be LiF 3PIXE NIST 15 4SPICE 2m P1
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127 3 II 3.1 3.1.1 Φ(t) ϕ em = dφ dt (3.1) B( r) Φ = { B( r) n( r)}ds (3.2) S S n( r) Φ 128 3 II S 1, S 2 Φ 1, Φ 2 Φ 1 = { B( r) n( r)}ds S 1 Φ 2 = { B( r) n( r)}ds (3.3) S 2 S S 1 +S 2 { B( r) n( r)}ds
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現代物理化学 2-1(9)16.ppt
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物理化学I-第12回(13).ppt
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