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1 pp. T T B T T T NKT T Ig B BCR T TCR Generation of T-lineage cells and their functions Kazunori Onoé Division of Immunobiology, Department of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita-ku, Kita-, Nishi-, Sapporo, Japan MHC CD CD T T NK T B T B R.A. Good Good BMTSCID SCID
2 thymus T T B DC DC T professional APC Good SCID BMT T T CD Th CD Tc CD CD Treg NKT Th Th Th Th T T Th T TCR MHC MHC I II HLA HLA HLA MHC Tc TCR MHC I Th TCR II B T APC MHC Tc CD APC MHC I Th CD II TCR- -MHC T MHC T MHC MHC MHC NK NKT T T TCR
3 T APC MHC I II Tc Th TCR T DN CDdouble negativedp CDdouble positivesp CD CD single positive NKT T CD CD CD Th CD Tc TCR TCR T MHC positive selection T negative selection TCR
4 Thy T I-E MHC II Mls- DNP-Ficoll TNP-SRBC TCR T T T AKR MHC k BMHC b BMT B AKR B MHC b AKR MHC k B AKR MHC BMHC AKR MHC k BBR BBR AKR MHC B SRBC DNP-Ficoll SRBC Th B APC DNP-Ficoll Th B BAKR MHC SRBC BBR AKR MHC B DNP-Ficoll MHC Th APC B BAKR B AKR MHC k AKR
5 T B APC MHC k MHC k TCR T APC B B MHC b MHC k B Th BBR MHC k Th AKR MHC k BBR APC B BAKR T BMHC b B APC MHC k BBR B APC SRBC BAKR Th B MHC k BBR APC B SRBC TCR MHC TCR MHC T MHC b T MHC MHC k a posterio ri MHC MHC TCR α β β V D J C β VDJC β DNA junctional diversity α TCR T T TCR Vβ T Mls- a MHC II I-E β α Vβ T Mls- a I-E T Vβ Vβ T B I-E Mls- a
6 TCR Vβ I-E Mls- a Vβ T T Vβ BBR I-E Mls- a Vβ T AKR I-E Mls- a Vβ T BMT BBR AKR BMT Vβ T Vβ BBR BMT Vβ T BMT BBR AKR Vβ T T B BMT BBR BI-E BBR AKR BBR AKR Vβ T APC I- E APC BBR Mls- b BBR APC I-E Mls- a Vβ T Mls- a AKR T BBR APC I- E Mls- a Vβ T BMT Vβ T I-E B B APC I-E Mls- a Vβ T Mls- a programmed cell death T T NK T NKT NKT NK NK T TCR NKT TCR CD NKT CD NKT Fas L Fas death signal lpr Fas lpr gld FasL gld lpr
7 APC T Fas FasL NKT DC NKT NKT CD TCR NKT Fas NKT NKT DC CD NKT α-galactosylceramide α-galcer NKT Th Th Th IFN-γ Th IL- DC NKT Th Th DC IL- IFN-γ DC α-galcer NKT Th IL-DC NKT Th IFN-γ IFN-γ DC Th IL- DC NKT Th Th
8 DC NKT NKT Th SFD HFD IL- α- GalCer IL- α-galcer NKT IL-NKT IFN-γ α-galcer DC-NKT NKT NKT IFNγ NKT α-galcer IFN-γ IL- ThTh NKT NKT in vitro NKT T NKT NKT
9 Good, R.A., Dalmasso, A.P., Martinetz, C., Archer, O.K., Pierce, J.C., & Papermaster, B.W.J. Exp. Med.,,. Good, R.A.Immunology Today,,. pp. Harrington, L.E., Hatton, R.D., Mangan, P.R., Turner, H., Murphy, T.L., Murphy, K.M., & Weaver, C.T.Nat. Immunol.,,. Zinkernagel, R.M. & Doherty, P.C.Nature,,. Arase, H., Arase, N., Nakagawa, K., Good, R.A., & Onoé, K. Eur. J. Immunol.,, Diao, H., Kon, S., Iwabuchi, K., Kimura, C., Morimoto, J., Ito, D., Segawa, T., Hamuro, J., Nakayama, T., Taniguchi, M., Yagita, H., Van Kaer L., Onoé, K., Denhardt, D., Rittling, S., & Uede, T.Immunity,,. Onoé, K., Fernandes, G., & Good, R.A.J. Exp. Med.,,. Onoé, K., Yasumizu, R., Oh-ishi, T., Kakinuma, M., Good, R. A., & Morikawa, K.J. Exp. Med.,,. Onoé, K., Yasumizu, R., Noguchi, M., Iwabuchi, K., Ogasawara, M., Kakinuma, M., Okuyama, H., Good, R.A., & Morikawa, K.Immunobiology,,. Onoé, K., Gotohda, T., Nishihori, H., Aranami, T., Iwabuchi, C., Iclozan, C., Morohashi, T., Ogasawara, K., Good, R.A., & Iwabuchi, K.Transplant Immunol.,,. Fukushi, N., Wang, B., Arase, H., Ogasawara, K., Good, R.A., & Onoé, K.Eur. J. Immunol.,,. Onoé, K., Arase, N., Arase, H., Takayanagi, T., Nishihori, H., Iwabuchi, K., Ogasawara, K., & Good, R.A.Transplant Immunol.,,. Arase-Fukushi, N., Arase, H., Ogasawara, K., Good, R.A., & Onoé, K.J. Immunol.,,. Arase, H., Arase, N., Ogasawara, K., Good, R.A., & Onoé, K. Int. Immunol.,,. McCaughtry, T.M., Baldwin, T.A., Wilken, M.S., & Hogquist, K.A.J. Exp. Med.,,. Arase, H., Arase, N., Ogasawara, K., Good, R.A., & Onoé, K. Proc. Natl. Acad. Sci. U.S.A.,,. Arase, H., Arase, N., Kobayashi, Y., Nishimura, Y., Yonehara, S.,&Onoé,K.J. Exp. Med.,,. Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K. Ueno, H., Nakazawa, R., Sato, H., Kondo, E., Koseki, H., & Taniguchi, M.Science,,. van Kaer, L.Curr. Opin. Immunol.,,. Minami, K., Yanagawa, Y., Iwabuchi, K., Shinohara, N., Harabayashi, T., Nonomura, K., & Onoé, K.Blood,,. Miyamoto, K., Miyake, S., & Yamamura, T.Nature,,. Nakai, Y., Iwabuchi, K., Fujii, S., Ishimori, N., Watano, K., Mishima, T., Iwabuchi, C., Tanaka, S., Dashtsoodol, N., Nakayama, T., Taniguchi, M., Miyake, S., Yamamura, T., Kitabatake, A., Joyce, S., Van Kaer, L., & Onoé, K. Blood,,. Onoé, K., Yanagawa, Y., Minami, K., Iijima, N., & Iwabuchi, K.Immunol. Res.,,. Andoh, Y., Fujii, S., Iwabuchi, K., Yokota, T., Inoue, N., Nakai, Y., Mishima, T., Yamashita, T., Nakagawa, T., Kitabatake, A., Onoé, K., & Tsutsui, H.Coron. Artery Dis.,,. Miyazaki, Y., Iwabuchi, K., Iwata, D., Miyazaki, A., Kon, Y., Niino, M., Kikuchi, S., Yanagawa, Y., vankaer, J., Sasaki, H., & Onoé, K.Scand. J. Immunol.,,. Diao, H., Iwabuchi, K., Li, L., Onoe, K., Van Kaer, L., Kon, S., Saito, Y., Morimoto, J., Denhardt, D.T., Rittling, S., & Uede, T.Proc. Natl. Acad. Sci. U.S.A.,,.
本文／ＡＹ３８０Ｊ
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Kazumitsu Ueda, [Department of Applied Life Science, Kyoto University Graduate School of Agriculture, Kitashirakawa, Sakyo-ku, Kyoto 606-01, Japan] Molecular Mechanisms for Drug Transport by MDR1/P-glycoprotein
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pp. D- D-DAO DAO D- D- D- D- o- DAO-D- D-DAO DAO Hans Krebs FAD X DAO DAO DAO D- Structure and reaction mechanism of D-amino acid oxidase Yasuzo Nishina School of Health Sciences, Kumamoto University,
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上原記念生命科学財団研究報告集, 23(2009) 190. CD4 + ヘルパー T 細胞の選択的活性化 西川博嘉 Key words:cd4 + ヘルパー T 細胞,CD4 + 制御性 T 細胞, 癌 精巣抗原,co-stimulatory molecules, 抗体療法 三重大学大学院医学系研究科寄付講座がんワクチン講座 緒言 1991 年ヒト腫瘍抗原遺伝子の存在が報告されて以来, これらの腫瘍特異抗原を用いた悪性腫瘍に対する免疫療法が注目を集めている.
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Purinergic signaling mediates mast cell activation in intestinal inflammation Yosuke Kurashima, Hiroshi Kiyono and Jun Kunisawa Division of Mucosal Immunology, Department of Microbiology and Immunology,
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平成 17 年度免疫学追追試 以下の問いの中から 2 問を選び 解答せよ 問 1 B 細胞は 一度抗原に接触し分裂増殖すると その抗原に対する結合力が高く なることが知られている その機構を説明しなさい 問 2 生体内で T 細胞は自己抗原と反応しない その機構を説明しなさい 問 3 遅延型過敏反応によって引き起こされる疾患を 1 つ挙げ その発症機序を説明 しなさい 問 4 インフルエンザウイルスに感染したヒトが
日本皮膚科学会雑誌第121巻第11号
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