寄稿論文 新光延試薬 | 東京化成工業
|
|
|
- さなえ いのら
- 4 years ago
- Views:
Transcription
1 DEAD TPP A Et C C Et Et C C Et 2 A A ex. ucleophiles (A) P 3 P 3 1 xygen itrogen Carbon Sulfur C 3 S Ts Tf Scheme 1. TPP DEAD TPP DEAD redox condensation Walden Bz Tf DEAD-TPP 87% Tf Bz Scheme 2.
2 pk a pk a (i) pk a < 11 Et (ii) 11 < pk a < 13 (pk a = 8.3) DEAD-TPP 91% Et Ts (pk a = 11.7) DEAD-TPP 51% Ts (iii) pk a > 13 Et Et (pk a = 13.3) DEAD-TPP 0% Et Et Scheme 3. path a Et C C Et P 3 Et desired reaction Et Et (path a) side reaction (path b) 3 P 3 Et Et 4 Et 4 A P 3 A P A 1 2 A Et C C Et 6 2 Scheme 4.
3 A A path b pk a A DEAD,,','-tetraisopropylazodicarboxamide TIPA 1,1'-(azodicarbonyl)dipiperidine ADDP,,','-tetramethylazodicarboxamide TMAD C C TIPA Et Et 4 7 C C ADDP δ ' ' 2 ' δ C C TMAD DTD Scheme 5. 1,6-dimethyl-1,5,7-hexahydro-1,4,6,7-tetrazocin-2,5-dione DTD DEAD TBP Bu 3 P PBu 3 PBu 3 PBu Scheme 6. DEAD Ts 10 (pk a = 11.7) C C - PBu C, 24 h Ar, dry in sealed tube 62% Ts Scheme 7.
4 ' C P 3 C ' ' C C ' 2 P 3 ' C " P 3 X C P 3 X C P Ylide osphorane Scheme 8. A A A-' X C 3 X P 3 A ' P 3 A ' A ' P 3 Scheme 9. (cyanomethylene)tributylphosphorane CMBP (cyanomethylene)trimethylphosphorane CMMP CMMP C PBu 3 C P 3 (cyanomethylene)tributylphosphorane (cyanomethylene)trimethylphosphorane ( CMBP ) ( CMMP ) Scheme 10. DEAD
5 DEAD DEAD C C C C C C 17 Scheme 11. CMBP CMMP CMBP CMMP mmol TF Wittig CMMP A C P' 3 A C 3 P' 3 CMBP: = Bu CMMP: = Scheme 12.
6 S 2 ' 1) Base 2) ''-X S 2 ' '' ' '' Scheme 13. pk a pk a pk a DEAD pk a TIPA ADDP TMAD DTD CMBP CMMP CMBP CMMP Table 1. eaction of -thyl-p-tosylamide (10). % yield - DEAD-TPP *) Ts 10 (pk a = 11.7) edox system, temp., 24 h edox system temp. TIPA-TBP ADDP-TBP TMAD-TBP DTD-TBP CMBP r.t. r.t. r.t. r.t. r.t. r.t. 100 C Ts CMMP r.t. 80 C *) The reaction was carried out in TF. pk a Ts 2 P 3 DEAD Ts P 3 18 TF, 0 C 98% 19 Scheme 14.
7 , CMMP CMBP Table 2. eaction of p-tosylamide (18). 18 (1.5 eq) CMBP, temp., 24 h Ts (Ts 2 ) r.t. 80 C yield (%) yield (%) 93 a) (22) 85 (12) a) : no experimental result pk a pk a pk a pk a 20 (pk a = 11.2) 51% Et 21 (pk a = 10.7) 42% Et Et Et Et 22 (pk a = 13.3) 0% Scheme 15. Et Et
8 pk a DTD CMBP DTD DTD CMBP CMMP CMMP CMMP CMMP cis Table 3. eaction of enylsulfonylacetonitrile (23). S 2 edox system (1.5equiv.), temp., 24 h S 2 S 2 % yield 23 (pk a = 12.0) edox system DEAD-TPP TMAD-TBP DTD-TBP CMBP r.t. r.t. r.t. r.t. 100 C 120 C CMMP 100 C 57 (22) 59 (3) 46 (51) 75 (21) 72 (28) 1) 64 (16) 52 (22) ex ) : no experimental result. S 2 CMMP, 100 C, 24 h S % 23 CMMP (3 equiv.), 100 C, 24 h C S % Scheme 16.
9 pk a pk a MT pk a CMBP CMMP Table 4. eaction of MT Sulfone (28). S S 2 Tol edox system (1.5equiv.), temp., 24 h S S 2 Tol 28 (pk a = 23.4) % yield edox system TMAD-TBP r.t. DTD-TBP r.t. r.t. CMBP 100 C 120 C 150 C CMMP 100 C ) 40 2) 41 1) < ex 1) : no experimental result <1 2 2) 56 2) ) Dimeric ether was obtained pk a S 2 (pk a = 23.4) CMMP TF, 80 C, 24 h S 2 90% C (pk a = 18.5) S 2 ex CMMP (3.0 equiv.) TF, 80 C, 24 h 100% C ex S 2 S 2 (pk a = 16.7) ex CMMP TF, 120 C, 24 h 100% ex S 2 Scheme 17.
10 pk a CMMP S 2 CMMP DME, 100 C, 24 h 100% Bu S 2 CMMP ex ex DME, 120 C, 24 h S 2 76% Scheme 18. Walden pk a pk a C C ' DEAD-TPP ' or ' Scheme 19. pk a C Bz 29 DEAD-TPP 27% C DEAD-TPP no reaction 30 Scheme 20.
11 TMAD p p p pk a p DEAD TMAD p DEAD 29 C TMAD-TBP 0 C, 10 min, then 60 C, 24 h = - : 98% (31 / 32 > 99.5 / 0.5) = 2 - : 28% (31 / 32 = 45 / 55) Scheme C TMAD-TBP 0 C, 10 min, then 60 C, 24 h 39% Scheme 22. Prashad CMBP 18 (2 equiv.) CMBP (3 equiv.), r.t. 71% Ts (1 equiv.) CMBP, r.t. (1 equiv.) CMBP, 100 C 71% Ts Scheme
12 Walden S C % ee 23 CMBP 120 C, 24 h, 79% S 2 C 6 13 C 6 13 >95% ee C C C % ee TolS 28 2 S CMBP C C C, 24 h, 98% ee 71% Scheme 24. C TBS S 2 12 CMMP TF, 100 C, 24 h 91% S 2 TBS 11 Ts TMAD-PBu 3 S 2 11, r.t., 24 h 100% 11 Theonelladine D S 2 Ts 11 TMAD-PBu 3 Tol., r.t. 84% Theonelladine C 2 11 Scheme 25. norfaranal norfaranal anti S S
13 MPM 23 CMMP Tol., 100 C, 24 h 79% MPM S 2 1) DEAD-P 3, C S 2 CMMP 2) 1 a, ex. / (1 / 3) 98% 100 C, 24 h 54% S 2 norfaranal Scheme S 1) Bn, TMAD-TPP, C 2 Cl 2 2) S, K 2 C 3, DMF > 95% Bn S 2 1) Bn, TMAD-TBP, TF 2) 95% TFA / water high yield S 2 2 Scheme 27. staff SUB GAT
14 1). Mitsunobu, Synthesis, 1981, 1. 2) D. L. ughes, The Mitsunobu eaction. rganic eactions, Vol. 42, eds. by P. Beak, et al., John Wiley & Sons, Inc., ew York, 1992, p ) M. L. Edwards, D. M. Stemerick, J.. McCarthy, Tetrahedron Lett., 31, 3417 (1990). 4) M. Wada,. Mitsunobu, Tetrahedron Lett., 13, 1279 (1972). 5) S. Itô, T. Tsunoda, Pure & Appl. Chem., 71, 1053 (1999). 6),,, 52, 113 (1994). 7) T. Tsunoda, Y. Yamamiya, S. Itô, Tetrahedron Lett., 34, 1639 (1993). 8) T. Tsunoda, J. tsuka, Y. Yamamiya, S. Itô, Chem. Lett., 1994, ) T. Tsunoda,. Kaku,,,','-Tetramethylazodicarboxamide. Electronic Encyclopedia of eagents for rganic Synthesis eds. by L. A. Paquette, et al., Wiley, 15 ctober ) T. Tsunoda, M. agaku, C. agino, Y. Kawamura, F. zaki,. ioki, S. Itô, Tetrahedron Lett., 36, 2531 (1995). 11) T. Tsunoda, F. zaki, S. Itô, Tetrahedron Lett., 35, 5081 (1994). 12) T. Tsunoda, C. agino, M. guri, S. Itô, Tetrahedron Lett., 37, 2459 (1996). 13) I. Sakamoto,. Kaku, T. Tsunoda, Chem. arm. Bull., 51, 474 (2003). 14) T. Tsunoda,. Takagi, D. Takaba,. Kaku, S. Itô, Tetrahedron Lett., 41, 235 (2000). 15) J.. enry, L.. Marcin, M. C. McIntosh, P. M. Scola, G. D. arris, Jr., S. M. Weinreb, Tetrahedron Lett., 30, 5709 (1989). 16) G. Dauphin, A. Kergomard, Bull. Soc. Chim. Fr., 1961, ) S. Bittner, Y. Assaf, P. Krief, M. Pomerantz, B. T. Ziemnicka, C. G. Smith, J. rg. Chem., 50, 1712 (1985). 18) T. Tsunoda,. Yamamoto, K. Goda, S. Itô, Tetrahedron Lett., 37, 2457 (1996). 19) S. Ji, L. B. Gortler, A. Waring, A. Battisti, S. Bank, W. D. Closson, P. Wriede, J. Am. Chem. Soc., 89, 5311 (1967); J. Kovacs, U.. Ghatak, J. rg. Chem., 31, 119 (1966); E.. Gold, E. Babad, J. rg. Chem., 37, 2208 (1972); E. Vedejs, S. Lin, J. rg. Chem., 59, 1602 (1994). 20) T. Tsunoda, K. Uemoto, T. htani,. Kaku, S. Itô, Tetrahedron Lett., 40, 7359 (1999). 21) K. Uemoto, A. Kawahito,. Matsushita, I. Sakamoto,. Kaku, T. Tsunoda, Tetrahedron Lett., 42, 905 (2001). 22) S. F. Martin, J. A. Dodge, Tetrahedron Lett., 32, 3017 (1991); J. A. Dodge, J. I. Trujillo, M. Presnell, J. rg. Chem., 59, 234 (1994). 23). Loibner, E. Zbiral, elv. Chim. Acta, 60, 417 (1977). 24) M. Saïah, M. Bessodes, K. Antonakis, Tetrahedron Lett., 33, 4317 (1992). 25) T. Tsunoda, Y. Yamamiya, Y. Kawamura, S. Itô, Tetrahedron Lett., 36, 2529 (1995). 26) M. Prashad, F. J. Kathawala, T. Scallen, J. d. Chem., 36, 1501 (1993). 27) T. Suzuki, J. zaki,. Sugawara, Agric. Biol. Chem., 47, 869 (1983). 28) E. edenström,.-e. ögberg, A.-B. Wassgren, G. Bergström, J. Löfqvist, B. ansson,. Anderbrant, Tetrahedron, 48, 3139 (1992). 29) J. Kobayashi, T. Murayama, Y. hizumi, T. Sasaki, T. hta, S. ozoe, Tetrahedron Lett., 30, 4833 (1989). 30) K. Mori,. Ueda, Tetrahedron Lett., 22, 461 (1981); K. Mori,. Ueda, Tetrahedron, 38, 1227 (1983); L. Poppe, L. ovák, P. Kolonits, Á. Bata, C. Szántay, Tetrahedron, 44, 1477 (1988). 31) S.. Chhabra, A. Mahajan, W. C. Chan, J. rg. Chem., 67, 4017 (2002). 32) J. J. Scicinski, M. D. Barker, P. J. Murrary, E. M. Jarvie, Bioorg. d. Chem. Lett., 8, 3609 (1998).
15 IUPAC IUPAC
TCIメール No.123 | 東京化成工業
Mitsunobu A A ew Mitsunobu eagents C C C C TMAD ADDP C PBu3 C P3 CMMP CMBP DEAD TPP A Et C C Et Et C C Et 2 A A ex. ucleophiles (A) P 3 P 3 1 xygen itrogen Carbon Sulfur C 3 C C S Ts Tf Scheme 1. TPP DEAD
寄稿論文 有機合成から現代の錬金術へ | 東京化成工業
FAMS MT FAMS S Formaldehyde Dimethyl Dithioacetal S-xide FAMS DMS α DMS SDMS H 3 SH 3 S K 2 3 or Pyr. H 3 SH 2 l 3 Sa H 3 SH 2 S 4 Finkelstein FAMS FAMS FAMS FAMS H 2 2 H 2 + MeSH H+ H 2 1 (FAMS) 5 MT
名称未設定
1 a C CF b c 4 5 Me Me S Jacobsen's catalyst Scheme 1. eagents and conditions: (a) C (1.5 equiv), Jacobsen's catalyst (0.05 equiv), toluene, 0 C, 40 h, then trifluoroacetic anhydride (4.0 equiv), 60 C,
寄稿論文 ボロンアルドール反応の新展開 | 東京化成工業
substrate control reagent control Tf Tf amine H n-u Tf Et 3 3 n-u Tf Et syn Tf anti n Tf, Amine (1.3eq) (1.5eq) CH Cl, -78 C n n Z E CH -78 C, 1h; 0 C, 1h n H Triflate Et Tf n-u Tf c-pen Tf Tf Amine Yield
Precisely Designed Catalysts News Letter Vol. 5 May, 2016
recisely Designed Catalysts ews Letter Vol. 5 May, 2016 E-mail: sawamura@sci.hokudai.ac.jp Silica-SMA Silica-TI S-T Figure 1 Si 3 Si Si Si Si 2 Silica-SMA Si 3 Si Si Si Si 2 Silica-TI t Bu S S S-T t Bu
寄稿論文 規則性無機ナノ空間が創り出す新しい触媒能 | 東京化成工業
MCM-41 M41 MCM-41 M41 2 3 m 2 /g nm nm Mn Ti Ti H N 2 S Ti-MCM-41, H H N H H 2 2 -Urea, CH 2 Cl 2, H 2 S + S 1b 2b 3b 54%, 58% ee Ti M41 H 2 As 4 ZP 4 ZP ZS ZS 5 Me Me Me Me M41 / 15 mg MeH 1.0 mmol 89%
Microsoft Word - R22.1.doc
22.1 S 2 2 peroxide 72% M.S. Kharasch,.C. own, J. Am. Chem. Soc., 61, 2142 (1939). C 3 C 2 C 2 C 3 2 C 3 C 2 CC 3 h C 3 C 2 C 2 C 2 70% 30% C 3 C 2 C 2 C 3 2 C 3 C 2 CC h 3 C 3 C 2 C 2 C 2 98% 2%. Sing,
寄稿論文 含窒素化合物の確実かつ簡便な合成法：Ns-strategy と高活性トリチル型レジン | 東京化成工業
s s-strategy ab 3 C LiAl 4 B 3 Ts s ps Ds 1 2 2 2 2 1 2 1 1 1 2 base 2 2 1 2 3 4 2 C 2 2 1 2 1 1 reductive amination 2 1 5 6 2 C 2 1 2 condensation 1 1 7 2 reduction 1 5 2 2 2 1 1 P Mitsunobu conditions
CTETS 7 8 9 11 Addition Rf Rf u Rf Rf u u : R, R 2, RS, X etc. Hydrolysisesterification Ewg Ewg H C 3 H C 2 R Ewg Ewg Ewg=C 3, C 2 R' etc. R=H or Alkyl Ewg Ewg RH Base Ewg Ewg R RH Base Ewg Ewg R R Amidation
寄稿論文 オキシム誘導体を用いる新しいC-N結合生成法 | 東京化成工業
Gabriel Beckmann sp 2 displacement Beckmann earrangement of ximes 2 S 4 2 ' ' ' Displacement on itrogen Atom of ximes Y u Y u S 2 n-bu 4 e 4 p 33% 10 mol% (n-bu) 4 e 4 5 mol% Ts 2 C 2 Cl 2, rt, 5 min e
寄稿論文 多環状エーテル系天然物の合成戦略 | 東京化成工業
Gymnodinium breve 1 2 3 4 Gambierdiscus toxicus 4 trans 1 Nicolaou 2 1 2 Rainier CTX3C C A K B C J D E F I G K J 1 I G Na 3 S F A B C D E C B A Na 3 S D C 2 3 W X Y V Z U A' T F' E' D' C' B' S R 4 Q P
寄稿論文 酸を用いない芳香族化合物の新しいニトロ化法 | 東京化成工業
Table 1. A List of Known itrating Agents itric acid Alone or in combination with H 2 S 4, H 3 P 4, H 4, HF(BF 3 ), CF 3 C 2 H, S 3 H, CF 3 S 3 H, FS 3 H(SbF 5 ), sulfonated resins, clays, molecular sieves,
1) K. J. Laidler, "Reaction Kinetics", Vol. II, Pergamon Press, New York (1963) Chap. 1 ; P. G. Ashmore, "Catalysis and Inhibition of Chemical Reactio
1) K. J. Laidler, "Reaction Kinetics", Vol. II, Pergamon Press, New York (1963) Chap. 1 ; P. G. Ashmore, "Catalysis and Inhibition of Chemical Reactions", Butterworths, London (1963) Chap. 7, p. 185. 2)
a b b c a c Ally anion type Propargyl/allenyl anion type a b c a b c a b c a b c a b c a b c b =,, or C a b c a b c b = Gothelf, K. V.; Jørgensen, K.
1 a b b c a c Ally anion type Propargyl/allenyl anion type a b c a b c a b c a b c a b c a b c b =,, or C a b c a b c b = Gothelf, K. V.; Jørgensen, K. A. Chem. ev. 1998, 98, 863-909 2 itrogen in the middle
Scheme 1 Scheme 2 Chart 1 Scheme ( 44 )
Catalytic Asymmetric Aldol Reactions in Aqueous Media Tomoaki Hamada, Kei Manabe, and Shu Kobayashi* Catalytic asymmetric aldol reactions in aqueous media have been developed using Pr(OTf)3 and chiral
水素移動型不斉還元触媒｜関東化学株式会社
99% yield, 96% ee (S/C = 1000) 89% yield, 99% ee (S/C = 300) >99% yield, 97% ee () X 78% yield, 95% ee () (S,S)-u cat X = C, 3, 2 = H, CH 3, F 67-100% yield, 92-98% ee (S/C = 100-1000) 100% yield dl:meso
124dr
,'-bis(salicylidene)ethylenediamine Scheme 1 2 2 2 2 2 2 2 2-2 2 n 5 5 5' 3 3' 3 1 1 1 1 1 1 1 = stereogenic center 1 = bulky and/or chiral substituent Scheme 1. ,,,, Fig. 1 stepped conformation 2 A achiral
Caloric Behavior of Chemical Oscillation Reactions Shuko Fujieda (Received December 16, 1996) Chemical oscillation behavior of Belousov- Zhabotinskii
Caloric Behavior of Chemical Oscillation Reactions Shuko Fujieda (Received December 16, 1996) Chemical oscillation behavior of Belousov- Zhabotinskii (BZ) and Briggs- Rauscher (BR) reactions was followed
4) H. Takayama et al.: J. Med. Chem., 45, 1949 (2002). 5) H. Takayama et al.: J. Am. Chem. Soc., 112, 8635 (2000). 6) H. Takayama et al.: Tetrahedron Lett., 42, 2995 (2001). 9) M. Kitajima et al: Chem.
PowerPoint プレゼンテーション
2004 3 3 2 3 4 5 6 7 8 9 10 T. Ito, A. Yamamoto, et al., J. Chem. Soc., Chem. Commun., 136 (1974) J. Chem. Soc., Dalton Trans., 1783 (1974) J. Chem. Soc., Dalton Trans., 1398 (1975) 11 T.Ito, A. Yamamoto,
20 15 14.6 15.3 14.9 15.7 16.0 15.7 13.4 14.5 13.7 14.2 10 10 13 16 19 22 1 70,000 60,000 50,000 40,000 30,000 20,000 10,000 0 2,500 59,862 56,384 2,000 42,662 44,211 40,639 37,323 1,500 33,408 34,472
- 2 -
- 2 - - 3 - (1) (2) (3) (1) - 4 - ~ - 5 - (2) - 6 - (1) (1) - 7 - - 8 - (i) (ii) (iii) (ii) (iii) (ii) 10 - 9 - (3) - 10 - (3) - 11 - - 12 - (1) - 13 - - 14 - (2) - 15 - - 16 - (3) - 17 - - 18 - (4) -
2 1980 8 4 4 4 4 4 3 4 2 4 4 2 4 6 0 0 6 4 2 4 1 2 2 1 4 4 4 2 3 3 3 4 3 4 4 4 4 2 5 5 2 4 4 4 0 3 3 0 9 10 10 9 1 1
1 1979 6 24 3 4 4 4 4 3 4 4 2 3 4 4 6 0 0 6 2 4 4 4 3 0 0 3 3 3 4 3 2 4 3? 4 3 4 3 4 4 4 4 3 3 4 4 4 4 2 1 1 2 15 4 4 15 0 1 2 1980 8 4 4 4 4 4 3 4 2 4 4 2 4 6 0 0 6 4 2 4 1 2 2 1 4 4 4 2 3 3 3 4 3 4 4
I? 3 1 3 1.1?................................. 3 1.2?............................... 3 1.3!................................... 3 2 4 2.1........................................ 4 2.2.......................................
1 (1) (2)
1 2 (1) (2) (3) 3-78 - 1 (1) (2) - 79 - i) ii) iii) (3) (4) (5) (6) - 80 - (7) (8) (9) (10) 2 (1) (2) (3) (4) i) - 81 - ii) (a) (b) 3 (1) (2) - 82 - - 83 - - 84 - - 85 - - 86 - (1) (2) (3) (4) (5) (6)
Vol.171 2004.9.15 14 100 5 10 15 52 53 55 1 7 55 58 63 3 26 53 3 6 9 2 3 6 9 6 52 53 55 3 9 5 1 7 10 14 4 12 8 11
Vol.170 2004.9.9 9 17 9 17 1000 8 10 9 17 14:00 17:00 30 28 Vol.171 2004.9.15 14 100 5 10 15 52 53 55 1 7 55 58 63 3 26 53 3 6 9 2 3 6 9 6 52 53 55 3 9 5 1 7 10 14 4 12 8 11 9.17 10 15 38 51 53 55 6 2
2 (March 13, 2010) N Λ a = i,j=1 x i ( d (a) i,j x j ), Λ h = N i,j=1 x i ( d (h) i,j x j ) B a B h B a = N i,j=1 ν i d (a) i,j, B h = x j N i,j=1 ν i
1. A. M. Turing [18] 60 Turing A. Gierer H. Meinhardt [1] : (GM) ) a t = D a a xx µa + ρ (c a2 h + ρ 0 (0 < x < l, t > 0) h t = D h h xx νh + c ρ a 2 (0 < x < l, t > 0) a x = h x = 0 (x = 0, l) a = a(x,
新技術説明会 様式例
1 効率的な不斉触媒反応を可能に する新しい C 配位子の開発 関西大学化学生命工学部化学 物質工学科 准教授坂口聡 新型インフルエンザ治療薬 タミフル オセルタミビルリン酸塩 ロッシュ社による製造法 シキミ酸 Ms Et Et V. Farina, J. D. Brown, Angew. Chem., Int. Ed. 2006, 45, 7330. 2 タミフルの新合成法 + C 2 C 2 CF
サイエンス<冬季>セミナー カルボニル・オレフィン化反応（1） | 東京化成工業
カルボニル オレフィン化反応 (1) 東京農工大学大学院工学研究院教授武田猛 1. はじめに 1953 Wittig 1 1) Wittig 2) C= C=C Wittig Wittig Horner Wadworth Emmons 3) Julia Julia Lythgoe Julia Kocienski 4) Peterson 5) cheme 1 R 3 PR 3 1 Wittig reaction
untitled
E-mail: khatano@fms.saitama-u.ac.jp Tel & Fax: 048-858-3535 Toxin Virus Bacterium Glycolipid Glycoprotein Vero toxin (Stx1 and Stx2) Side view Bottom view H H H H N H Grobotriaosyl Ceramide (Gb 3 : Galα1-4Galβ1-4Glcβ-Cer)
000_013_.....qx4
569 n STEPHENSON, 1945 ; JOHNSTON, 1959 ; BANAGE and VISSER, 1965 ; NORTON, 1978 ; CHITWOOD, 22 ; BANSAL and BAJAJ, 23 ; BROWNING et al., 24 ; MCELDERRY et al., 25 LINFORD et al., 1938 ; JOHNSON et al.,
1. Precise Determination of BaAl2O4 Cell and Certification of the Formation of Iron Bearing Solid Solution. By Hiroshi UCHIKAWA and Koichi TSUKIYAMA (
1. Precise Determination of BaAl2O4 Cell and Certification of the Formation of Iron Bearing Solid Solution. By Hiroshi UCHIKAWA and Koichi TSUKIYAMA (Central Research Laboratory, Onoda Cement Co., Ltd.,
新技術説明会 様式例
クロスカップリング用高活性ボロン酸 誘導体 有機トリオールボレート塩 北海道大学大学院工学研究院 フロンティア化学教育研究センター 特任准教授山本靖典 従来技術とその問題点 既にクロスカップリング反応をはじめ触媒的有機合成には有機ボロン酸誘導体が多用されるが 電子求引基を有するボロン酸やヘテロ芳香族ボロン酸は加水分解による脱ホウ素化が起こるため 塩基水溶液中行われる触媒反応において収率が極端に低下する問題があり
…h…L…–…†…fi…g1
21 1326 1328 2002 22 4375 4377 2003 34 6 848 849 2005 9 10 15 1067 1070 1996 49 133 166 2003 1 2 2 3 4 4 1 3 23 311 313 2004 5 1 118 7604 7607 1996 15 1 33 6627 6629 2000 12 649 155 167 2003 76 23 7007
市区長選挙における民主党の戦略
. , -,,, a, .......................................................... -,,, b b .............................. .. ,. %,,,,, JR TUBE TUBE TUBE TUBE ,. %,,,,,,,,,,,,,,,,,,,, ,. %,,, a, b - - -- pp a b
42 3 u = (37) MeV/c 2 (3.4) [1] u amu m p m n [1] m H [2] m p = (4) MeV/c 2 = (13) u m n = (4) MeV/c 2 =
![42 3 u = (37) MeV/c 2 (3.4) [1] u amu m p m n [1] m H [2] m p = (4) MeV/c 2 = (13) u m n = (4) MeV/c 2 =](/thumbs/73/68712188.jpg "42 3 u = (37) MeV/c 2 (3.4) [1] u amu m p m n [1] m H [2] m p = (4) MeV/c 2 = (13) u m n = (4) MeV/c 2 =")
3 3.1 3.1.1 kg m s J = kg m 2 s 2 MeV MeV [1] 1MeV=1 6 ev = 1.62 176 462 (63) 1 13 J (3.1) [1] 1MeV/c 2 =1.782 661 731 (7) 1 3 kg (3.2) c =1 MeV (atomic mass unit) 12 C u = 1 12 M(12 C) (3.3) 41 42 3 u
untitled
4,650 4,492 9,142 2,603 2,691 5,294 4,391 4,226 8,617 3,685 3,861 7,546 3,290 3,359 6,649 5,539 5,728 11,267 4,013 3,763 7,776 4,075 4,054 8,129 3,206 3,379 6,585 3,483 3,319 6,802 2,565 2,808 5,373 3,141
006 11 8 0 3 1 5 1.1..................... 5 1......................... 6 1.3.................... 6 1.4.................. 8 1.5................... 8 1.6................... 10 1.6.1......................
Syntheses of Medium-sized Ring Amines from Bicyclic Amines Yoshio ARATA* and Miyoji HANAOKA** Conversion of bicyclic amines into medium-sized ring ami
Syntheses of Medium-sized Ring Amines from Bicyclic Amines Yoshio ARATA* and Miyoji HANAOKA** Conversion of bicyclic amines into medium-sized ring amines (tertiary and secondary) by selective cleavage
Structure and Strength of Acid-Base in Aqueous Medium Aritsune KAJI* and Masaru NAKAHARA* * Department of Chemistry, Faculty of Science, Kyoto Univers
Structure and Strength of Acid-Base in Aqueous Medium Aritsune KAJI* and Masaru NAKAHARA* * Department of Chemistry, Faculty of Science, Kyoto University 1) J. Hayami, N. Ono, A. Kaji, Tetrahedron
<4D F736F F D2095BD90AC E937890B68A888F4B8AB E397C394EF82CC93AE8CFC82C98AD682B782E992B28DB895AA90CD2E646F6378>
29 5 IT 1,234 1,447 2,130 1,200 3,043 2 9,275 2,818 ICD-10 p.2 27 3 7,848 1,234 10 4,291 11.3% 10 33.3% 32.4%12.9% 32.2%26.9%18.5% 1,095 874 339 490 189 178 6,358 5,279 3,380 2,345 1,994 1,693 37.6 34.9
Activation and Control of Electron-Transfer Reactions by Noncovalent Bond
2 + 4e- + 4 + hν 2 2 1 2 20 J. Am. Chem. oc. Angew. Chem. Int. Ed. umber of Papers 15 10 5 0 1998 1999 2000 2001 2002 2003 Year : J. Am. Chem. oc. (Trost, B. M.; tanford University, UA) 3 π 1/2 k ET =
寄稿論文 カチオン性10族金属錯体を用いた不斉触媒反応の新展開：パラジウムエノラートを鍵とする反応を中心にして | 東京化成工業
Si Sn B Al Ti Cu La Zn Ca 4 Li Mg B Al Ti Zr M M = Si, Sn LA X ' LA = chiral Lewis acid X ' M X ' M = metals (La, Zn) with chiral ligands or chiral ammonium ions M' M' = late transition metals Mild reactivity?
１ 発病のとき
A A 1944 19 60 A 1 A 20 40 2 A 4 A A 23 6 A A 13 10 100 2 2 360 A 19 2 5 A A A A A TS TS A A A 194823 6 A A 23 A 361 A 3 2 4 2 16 9 A 7 18 A A 16 4 16 3 362 A A 6 A 6 4 A A 363 A 1 A A 1 A A 364 A 1 A
untitled
1 (1) (2) (3) (4) (1) (2) (3) (1) (2) (3) (1) (2) (3) (4) (5) (1) (2) (3) (1) (2) 10 11 12 2 2520159 3 (1) (2) (3) (4) (5) (6) 103 59529 600 12 42 4 42 68 53 53 C 30 30 5 56 6 (3) (1) 7 () () (()) () ()
微粒子合成化学・講義
http://www.tagen.tohoku.ac.jp/labo/muramatsu/mura/main.html E-mail: mura@tagen.tohoku.ac.jp 1 2 3 1m 10cm 1cm 1mm 100 m 10 m 1 m 100nm 10nm 1nm 1 100 m 10 m 1 m 1nm 100nm 10nm 4 5 6 7 1m 10cm 1cm 1mm 100
OSR 22 多段階合成
R 22 BIAP harpless K, 18 crown 6 toluene, reflux ( 2 ), 1 h 95% Tf toluene 0~15 C, 1 h Tf 99% Tf Mg, CF 3 80 C, 24 h K.W.C. Poon, P.A. Albiniak, G.B. Dudley, rg. ynth., Coll. Vol. 11, 947 (2009). C 2 K
土壌環境行政の最新動向（環境省 水・大気環境局土壌環境課）
201022 1 18801970 19101970 19201960 1970-2 1975 1980 1986 1991 1994 3 1999 20022009 4 5 () () () () ( ( ) () 6 7 Ex Ex Ex 8 25 9 10 11 16619 123 12 13 14 5 18() 15 187 1811 16 17 3,000 2241 18 19 ( 50
syuryoku
248 24622 24 P.5 EX P.212 2 P271 5. P.534 P.690 P.690 P.690 P.690 P.691 P.691 P.691 P.702 P.702 P.702 P.702 1S 30% 3 1S 3% 1S 30% 3 1S 3% P.702 P.702 P.702 P.702 45 60 P.702 P.702 P.704 H17.12.22 H22.4.1
124
[ ] [ ] 18 123 124 ( ) 125 126 127 128 5,683,062 2,306,419 18.2 14.0 12 5389 87 13 257 88 12 22 27 56.7 41.6 1 1.7 15 129 55 38.8 13.3 15 2004 15 1 3 84.8 29.3 1 23.9 38.0 10 10 35 35 15 5 56.5.31 55.4.1
44 4 I (1) ( ) (10 15 ) ( 17 ) ( 3 1 ) (2)
(1) I 44 II 45 III 47 IV 52 44 4 I (1) ( ) 1945 8 9 (10 15 ) ( 17 ) ( 3 1 ) (2) 45 II 1 (3) 511 ( 451 1 ) ( ) 365 1 2 512 1 2 365 1 2 363 2 ( ) 3 ( ) ( 451 2 ( 314 1 ) ( 339 1 4 ) 337 2 3 ) 363 (4) 46
寄稿論文 高い発ガン活性を示す鉄キレートお構造特性 | 東京化成工業
NTBI = nontransferrin-bound iron NTBI DNA H DNA 2 NTBI NTBI NTBI NTBI NTBI NTBI (nta) (nta) (nta) NTBI (nta) (nta) NTBI (nta)ntbi Fe-(nta) (nta) N(CH 2 CH) 3 HCCH 2 NHCH 2 CH 2 NHCH 2 CH (HCCH 2 ) 2 NH
SPring8菅野印刷.PDF
20021219Spring-8 Ah/kg Ah/dm 3 Li -3.01 540 3860 2090 Na -2.71 970 1160 1140 Al -1.66 2690 2980 8100 Zn -0.76 7140 820 5800 Fe -0.44 7850 960 7500 Cd -0.40 8650 480 4100 Pb -0.13 11340 260 2900 H 2 0
The Phase Behavior of Monooleoylglycerol-Water Systems Mivoshi Oil & Fat Co.. Ltd. Faculty of Science and Technology, Science University of Tokyo Inst
The Phase Behavior of Monooleoylglycerol-Water Systems Mivoshi Oil & Fat Co.. Ltd. Faculty of Science and Technology, Science University of Tokyo Institute of Colloid and Interface Science, Science University
1 2 3 4 5 1 1:30 NPO 16 1 19 16 2 17-6 - 10 2008 2010 120 150 IT( ) 60 21 40-7 - - 8-10 ( ) NPO 2 10 16:40-9 - 10 ii NPO NPO ( ) ( ) 11 12 13 14 15 22 26 27 28 29 30 31 32 33 34 m3 m3
The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Database Center for Life Science Online Service Key words Shigey
The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Key words Shigeyuki Kawai, Chikako Fukuda, Kousaku Murata E-mail : kawais@kais.kyoto-u.ac.jp, chikakko@kais.kyotou.ac.jp,
1) Dalton, A. J. et al. : J. Nat. Cancer Inst., 11 : 439, 1950. 2) Fawcett, D. W.: J. Nat. Cancer Inst., 15 :1475, 1955. 3) Oberling, C. et Rouiller, C.: Ann. d'anat. path., 1: 401, 1956. 4) Palade, G.
i ii i iii iv 1 3 3 10 14 17 17 18 22 23 28 29 31 36 37 39 40 43 48 59 70 75 75 77 90 95 102 107 109 110 118 125 128 130 132 134 48 43 43 51 52 61 61 64 62 124 70 58 3 10 17 29 78 82 85 102 95 109 iii
untitled
cm -1 = -1 cm -1 ( ) ( ) 1) 2) ( ) (T c ) MI 100%( 90% ) ( T c 9 K) (T c 23 K) (T c 135 K) (T c 40 K) (T c 33 K) (T c 14 K) BC - T c 30K + - - - + BC - + T c Little - T c 1000 K 酸化還元状態の制約 D 0 LUMO
ブラジル産ジョロウグモから単離された新規アシルポリアミンの構造決定
J. School Sci. Eng. Kinki Univ. 41 (2005) 23-29 Structural Determination of Novel Acylpolyamines from the Venom of Nephila clavipes, a Brazilian Joro spider Takahiro NISHIMARU*, Terumi NAKAJIMA * *, Yasuhiro
DS0 0/9/ a b c d u t (a) (b) (c) (d) [].,., Del Barrio [], Pilato [], [].,,. [],.,.,,.,.,,.,, 0%,..,,, 0,.,.,. (variable-latency unit)., (a) ( DFG ).,
![DS0 0/9/ a b c d u t (a) (b) (c) (d) [].,., Del Barrio [], Pilato [], [].,,. [],.,.,,.,.,,.,, 0%,..,,, 0,.,.,. (variable-latency unit)., (a) ( DFG ).,](/thumbs/70/62918164.jpg "DS0 0/9/ a b c d u t (a) (b) (c) (d) [].,., Del Barrio [], Pilato [], [].,,. [],.,.,,.,.,,.,, 0%,..,,, 0,.,.,. (variable-latency unit)., (a) ( DFG ).,")
DS0 0/9/,.,,.,,,.,.,.0%,.%.,,,, Speculative Execution in Distributed Controllers for High-Level Synthesis Shimizu iho Ishiura Nagisa bstract: This article proposes a method of incorporating speculative
, CH n. CH n, CP n,,,., CH n,,. RH n ( Cartan )., CH n., RH n CH n,,., RH n, CH n., RH n ( ), CH n ( 1.1 (v), (vi) )., RH n,, CH n,., CH n,. 1.2, CH n
( ), Jürgen Berndt,.,. 1, CH n.,,. 1.1 ([6]). CH n (n 2), : (i) CH k (k = 0,..., n 1) tube. (ii) RH n tube. (iii). (iv) ruled minimal, equidistant. (v) normally homogeneous submanifold F k tube. (vi) normally
untitled
1 1 Scheme 1 O 1 SCW + 420, 30 min, 035 g/ml 2 47% 3 31% 1 420, 30 min, 035 g/ml 3 31% 2 48% Scheme 1 Table 1 1 0 g/ml 420 30 min 1 16% 3 36% 5 11% 2 01 g/ml 1 44% 035 g/ml 2 48% 1 O Table 1 Reaction of
ISTC 3
B- I n t e r n a t i o n a l S t a n d a r s f o r Tu b e r c u l o s i s C a r (ÏS r c ) E d is i k e - 3 ) a =1 / < ' 3 I n t e r n a t i o n a l s t a n d a r d s f o r T B C a r e e «l i s i k e 3
Rate of Oxidation of Liquid Iron by Pure Oxygen Shiro BAN-YA and Jae-Dong SHIM Synopsis: The rate of oxidation of liquid iron by oxygen gas has been s
Rate of Oxidation of Liquid Iron by Pure Oxygen Shiro BAN-YA and Jae-Dong SHIM Synopsis: The rate of oxidation of liquid iron by oxygen gas has been studied using a volume constant technique. The process
Untitled
上原記念生命科学財団研究報告集, 25 (2011) 6. 新規多点制御型有機分子触媒の創製を基盤とするドミノ型反応の開発 笹井宏明 Key words: 不斉有機分子触媒, イソインドリン, テトラヒドロピリジン, ドミノ反応, 二重活性化 大阪大学産業科学研究所機能物質科学研究分野 緒言連続する反応を一つの容器内で単一の操作で進行させるドミノ型反応は, 多段階反応における中間体の単離精製を必要とせず,
タンパク質を物性科学的に見た場合、単なるアミド結合の集合体であると片づけるにはもったいなさすぎる
Precise Functional Analysis of Biological Macromolecules Promoted by the Encounter of Crystallographic and Spectroscopic Molecular Structure Analyses Takamitsu Kohzuma*, Sachiko Yanagisawa, and Tomotake
301-A2.pdf
301 21 1 (1),, (3), (4) 2 (1),, (3), (4), (5), (6), 3,?,?,??,?? 4 (1)!?, , 6 5 2 5 6 1205 22 1 (1) 60 (3) (4) (5) 2 (1) (3) (4) 3 (1) (3) (4) (5) (6) 4 (1) 5 (1) 6 331 331 7 A B A B A B A 23 1 2 (1) (3)